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Showing 1 to 12 of 2009 entries
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miR-20b-5p functions as tumor suppressor microRNA by targeting cyclinD1 in colon cancer.

Cell cycle (Georgetown, Tex.)

Yang H, Lin J, Jiang J, Ji J, Wang C, Zhang J.
PMID: 33044899
Cell Cycle. 2020 Nov;19(21):2939-2954. doi: 10.1080/15384101.2020.1829824. Epub 2020 Oct 12.

MicroRNA functions as an oncogenic regulator or tumor suppressor in various human tumors. Although bioinformatics analysis suggested that miRNA-20b-5p may be associated with the tumorigenesis, its role in colon cancer remains elusive. To investigate the role of miRNA-20b-5p, HCT116...

Mitochondrial stress delays tumorigenesis in a Li-Fraumeni syndrome mouse model.

Cell stress

Donnelly MP, Li J, Hwang PM.
PMID: 31225506
Cell Stress. 2019 Mar 21;3(4):115-117. doi: 10.15698/cst2019.04.182.

No abstract available.

Exome sequencing identifies RASSF1 and KLK3 germline variants in an Iranian multiple-case breast cancer family.

European journal of medical genetics

Radmanesh H, Liu D, Geffers R, Shandiz FH, Sadr-Nabavi A, Hillemanns P, Park-Simon TW, Dörk T.
PMID: 35032689
Eur J Med Genet. 2022 Jan 12;104425. doi: 10.1016/j.ejmg.2022.104425. Epub 2022 Jan 12.

Breast cancer is the most frequent malignancy among women in both developed and developing countries. Although several genes have been identified to harbor germline variants contributing to breast cancer risk, much of the heritability for breast cancer is yet...

Sequential acral lentiginous melanomas of the foot.

Case reports in dermatology

Uehara J, Ito Y, Takahashi I, Honma M, Ishida-Yamamoto A, Matsuo S, Iizuka H.
PMID: 21537371
Case Rep Dermatol. 2010 Dec 22;2(3):201-6. doi: 10.1159/000323467.

A 64-year-old Japanese woman had a lightly brown-blackish pigmented macule (1.2 cm in diameter) on the left sole of her foot. She received surgical excision following a diagnosis of acral lentiginous melanoma (ALM), which was confirmed histopathologically. One month...

HPV-p53-miR-34a axis in HPV-associated cancers.

Annals of translational medicine

Chen J, Zhao KN.
PMID: 26734641
Ann Transl Med. 2015 Dec;3(21):331. doi: 10.3978/j.issn.2305-5839.2015.09.39.

Human papillomaviruses (HPVs) are known to cause many cancers by altering multiple signalling pathways through their oncogene integration into host genome and expression. Studies have shown that many microRNAs (miRs) may function as oncogenes (called as oncomiRs) to promote...

miR-30e* is overexpressed in prostate cancer and promotes NF-κB-mediated proliferation and tumor growth.


Egan SM, Karasik E, Ellis L, Gollnick SO.
PMID: 28978058
Oncotarget. 2017 Jun 28;8(40):67626-67638. doi: 10.18632/oncotarget.18795. eCollection 2017 Sep 15.

According to the CDC prostate cancer (CaP) has the highest incidence and second highest mortality rate amongst cancers in American men. Constitutive NF-κB activation is a hallmark of CaP and this pathway drives many pro-tumorigenic characteristics of CaP cells,...

Hepatic injury is associated with cell cycle arrest and apoptosis with alteration of cyclin A and D1 in ammonium chloride-induced hyperammonemic rats.

Experimental and therapeutic medicine

Gao X, Fan L, Li H, Li J, Liu X, Sun R, Yu Z.
PMID: 26893626
Exp Ther Med. 2016 Feb;11(2):427-434. doi: 10.3892/etm.2015.2931. Epub 2015 Dec 11.

Hyperammonemia is considered to be central to the pathophysiology of hepatic encephalopathy in patients exhibiting hepatic failure (HF). It has previously been determined that hyperammonemia is a serious metabolic disorder commonly observed in patients with HF. However, it is...

Panduratin A Inhibits Cell Proliferation by Inducing G0/G1 Phase Cell Cycle Arrest and Induces Apoptosis in Breast Cancer Cells.

Biomolecules & therapeutics

Liu Q, Cao Y, Zhou P, Gui S, Wu X, Xia Y, Tu J.
PMID: 29301388
Biomol Ther (Seoul). 2018 May 01;26(3):328-334. doi: 10.4062/biomolther.2017.042.

Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin...

The Cell Cycle Regulators .

Cancer genomics & proteomics

El-Salahy E, Abou-Ghalia AH, Adli A, Kassim SK.
PMID: 31394712
Cancer Genomics Proteomics. 2005 Jul-Aug;2(4):239-245. Epub 2005 Jul 01.

Laryngeal squamous cell carcinoma (LSCC) is a frequent malignancy with a complex and undefined etiology to date. The recently identified cyclin-dependent kinase inhibitor p15

Peptide SA12 inhibits proliferation of breast cancer cell lines MCF-7 and MDA-MB-231 through G0/G1 phase cell cycle arrest.

OncoTargets and therapy

Yang L, Liu H, Long M, Wang X, Lin F, Gao Z, Zhang H.
PMID: 29750041
Onco Targets Ther. 2018 Apr 30;11:2409-2417. doi: 10.2147/OTT.S154337. eCollection 2018.

BACKGROUND: Targeted therapies have been proven as promising in the treatment of breast cancer and have improved survival and quality of life in advanced breast cancer. We previously identified a novel peptide SA12 which showed significant activity in the...

Metastatic HPV-related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment.

Clinical case reports

Perri F, Longo F, Della Vittoria Scarpati G, Pisconti S, Longo V, Addeo R, Carducci F, Buonerba C, Fulciniti F, Solla R.
PMID: 29375838
Clin Case Rep. 2017 Nov 24;6(1):56-62. doi: 10.1002/ccr3.1107. eCollection 2018 Jan.

Pretherapy assessment has a crucial role in the management of advanced oropharyngeal carcinoma. The case report represents an example of how translational research may help to optimize the therapeutic options and to choose a well-shaped therapy adapted to the...

Wnt5a Promotes Cortical Neuron Survival by Inhibiting Cell-Cycle Activation.

Frontiers in cellular neuroscience

Zhou L, Chen D, Huang XM, Long F, Cai H, Yao WX, Chen ZC, Liao ZJ, Deng ZZ, Tan S, Shan YL, Cai W, Wang YG, Yang RH, Jiang N, Peng T, Hong MF, Lu ZQ.
PMID: 29033786
Front Cell Neurosci. 2017 Sep 29;11:281. doi: 10.3389/fncel.2017.00281. eCollection 2017.

β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer's disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death of neurons. However, the signaling pathways mediating cell-cycle activation during neuron apoptosis...

Showing 1 to 12 of 2009 entries