Cell cycle (Georgetown, Tex.)
Yang H, Lin J, Jiang J, Ji J, Wang C, Zhang J.
Cell Cycle. 2020 Nov;19(21):2939-2954. doi: 10.1080/15384101.2020.1829824. Epub 2020 Oct 12.
MicroRNA functions as an oncogenic regulator or tumor suppressor in various human tumors. Although bioinformatics analysis suggested that miRNA-20b-5p may be associated with the tumorigenesis, its role in colon cancer remains elusive. To investigate the role of miRNA-20b-5p, HCT116...
Donnelly MP, Li J, Hwang PM.
Cell Stress. 2019 Mar 21;3(4):115-117. doi: 10.15698/cst2019.04.182.
No abstract available.
European journal of medical genetics
Radmanesh H, Liu D, Geffers R, Shandiz FH, Sadr-Nabavi A, Hillemanns P, Park-Simon TW, Dörk T.
Eur J Med Genet. 2022 Jan 12;104425. doi: 10.1016/j.ejmg.2022.104425. Epub 2022 Jan 12.
Breast cancer is the most frequent malignancy among women in both developed and developing countries. Although several genes have been identified to harbor germline variants contributing to breast cancer risk, much of the heritability for breast cancer is yet...
Case reports in dermatology
Uehara J, Ito Y, Takahashi I, Honma M, Ishida-Yamamoto A, Matsuo S, Iizuka H.
Case Rep Dermatol. 2010 Dec 22;2(3):201-6. doi: 10.1159/000323467.
A 64-year-old Japanese woman had a lightly brown-blackish pigmented macule (1.2 cm in diameter) on the left sole of her foot. She received surgical excision following a diagnosis of acral lentiginous melanoma (ALM), which was confirmed histopathologically. One month...
Annals of translational medicine
Chen J, Zhao KN.
Ann Transl Med. 2015 Dec;3(21):331. doi: 10.3978/j.issn.2305-5839.2015.09.39.
Human papillomaviruses (HPVs) are known to cause many cancers by altering multiple signalling pathways through their oncogene integration into host genome and expression. Studies have shown that many microRNAs (miRs) may function as oncogenes (called as oncomiRs) to promote...
Egan SM, Karasik E, Ellis L, Gollnick SO.
Oncotarget. 2017 Jun 28;8(40):67626-67638. doi: 10.18632/oncotarget.18795. eCollection 2017 Sep 15.
According to the CDC prostate cancer (CaP) has the highest incidence and second highest mortality rate amongst cancers in American men. Constitutive NF-κB activation is a hallmark of CaP and this pathway drives many pro-tumorigenic characteristics of CaP cells,...
Experimental and therapeutic medicine
Gao X, Fan L, Li H, Li J, Liu X, Sun R, Yu Z.
Exp Ther Med. 2016 Feb;11(2):427-434. doi: 10.3892/etm.2015.2931. Epub 2015 Dec 11.
Hyperammonemia is considered to be central to the pathophysiology of hepatic encephalopathy in patients exhibiting hepatic failure (HF). It has previously been determined that hyperammonemia is a serious metabolic disorder commonly observed in patients with HF. However, it is...
Biomolecules & therapeutics
Liu Q, Cao Y, Zhou P, Gui S, Wu X, Xia Y, Tu J.
Biomol Ther (Seoul). 2018 May 01;26(3):328-334. doi: 10.4062/biomolther.2017.042.
Because of the unsatisfactory treatment options for breast cancer (BC), there is a need to develop novel therapeutic approaches for this malignancy. One such strategy is chemotherapy using non-toxic dietary substances and botanical products. Studies have shown that Panduratin...
Cancer genomics & proteomics
El-Salahy E, Abou-Ghalia AH, Adli A, Kassim SK.
Cancer Genomics Proteomics. 2005 Jul-Aug;2(4):239-245. Epub 2005 Jul 01.
Laryngeal squamous cell carcinoma (LSCC) is a frequent malignancy with a complex and undefined etiology to date. The recently identified cyclin-dependent kinase inhibitor p15
OncoTargets and therapy
Yang L, Liu H, Long M, Wang X, Lin F, Gao Z, Zhang H.
Onco Targets Ther. 2018 Apr 30;11:2409-2417. doi: 10.2147/OTT.S154337. eCollection 2018.
BACKGROUND: Targeted therapies have been proven as promising in the treatment of breast cancer and have improved survival and quality of life in advanced breast cancer. We previously identified a novel peptide SA12 which showed significant activity in the...
Clinical case reports
Perri F, Longo F, Della Vittoria Scarpati G, Pisconti S, Longo V, Addeo R, Carducci F, Buonerba C, Fulciniti F, Solla R.
Clin Case Rep. 2017 Nov 24;6(1):56-62. doi: 10.1002/ccr3.1107. eCollection 2018 Jan.
Pretherapy assessment has a crucial role in the management of advanced oropharyngeal carcinoma. The case report represents an example of how translational research may help to optimize the therapeutic options and to choose a well-shaped therapy adapted to the...
Frontiers in cellular neuroscience
Zhou L, Chen D, Huang XM, Long F, Cai H, Yao WX, Chen ZC, Liao ZJ, Deng ZZ, Tan S, Shan YL, Cai W, Wang YG, Yang RH, Jiang N, Peng T, Hong MF, Lu ZQ.
Front Cell Neurosci. 2017 Sep 29;11:281. doi: 10.3389/fncel.2017.00281. eCollection 2017.
β-Amyloid protein (Aβ) is thought to cause neuronal loss in Alzheimer's disease (AD). Aβ treatment promotes the re-activation of a mitotic cycle and induces rapid apoptotic death of neurons. However, the signaling pathways mediating cell-cycle activation during neuron apoptosis...