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Expansion of B-1a Cells with Germline Heavy Chain Sequence in Lupus Mice.

Frontiers in immunology

Holodick NE, Zeumer L, Rothstein TL, Morel L.
PMID: 27047495
Front Immunol. 2016 Mar 24;7:108. doi: 10.3389/fimmu.2016.00108. eCollection 2016.

B6.Sle1.Sle2.Sle3 (B6.TC) lupus-prone mice carrying the NZB allele of Cdkn2c, encoding for the cyclin-dependent kinase inhibitor P18(INK4), accumulate B-1a cells due to a higher rate of proliferative self-renewal. However, it is unclear whether this affects primarily early-appearing B-1a cells...

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