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Showing 1 to 12 of 1835 entries
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Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G

STEM and diversify

Baysal BE.
GSID: 8WZHK0FLSjYJ
S Sharma, BE Baysal - PeerJ, 2017 - peerj.com

… that have a predicted stem-loop with the reactive C at the 3′-end of the loop. The size of the loop, the nucleotides immediately 5′ to the target cytosine and stability of the stem have a …

Transgenerational epigenetic instability is a source of novel methylation variants

diversity

Lewsey MG, O'Malley RC, Schmitz RJ, Schultz MD.
GSID: AV7yYbSxeUIJ
RJ Schmitz, MD Schultz, MG Lewsey, RC O'Malley… - Science, 2011 - science.org

Epigenetic information, which may affect an organism's phenotype, can be stored and stably inherited in the form of cytosine DNA methylation. Changes in DNA methylation can produce …

Spontaneous epigenetic variation in the Arabidopsis thaliana methylome

diversity

Becker C, Koenig D, Stegle O.
GSID: ESSihVZxRUoJ
C Becker, J Hagmann, J Müller, D Koenig, O Stegle… - Nature, 2011 - nature.com

Heritable epigenetic polymorphisms, such as differential cytosine methylation, can underlie phenotypic variation 1, 2. Moreover, wild strains of the plant Arabidopsis thaliana differ in …

Simultaneous determination of cytosine arabinoside and its metabolite uracil arabinoside in human plasma by LC-MS/MS: Application to pharmacokinetics …

discipline specific-education (e.g., chemistry education, biology education, economics education)

[No authors listed]
GSID: r81mkFsAmU8J
M Donnette, C Solas, M Giocanti, G Venton… - … of Chromatography B, 2019 - Elsevier

Purine analogs like aracytine (Arasingle bondC) are a mainstay for treating acute myeloid leukemia (AML). There are marked differences in drug dosing and scheduling depending on …

In planta assays involving epigenetically silenced genes reveal inhibition of cytosine methylation by genistein.

Plant methods

Arase S, Kasai M, Kanazawa A.
PMID: 22424588
Plant Methods. 2012 Mar 19;8:10. doi: 10.1186/1746-4811-8-10.

BACKGROUND: Cytosine methylation is involved in epigenetic control of gene expression in a wide range of organisms. An increasing number of examples indicate that changing the frequency of cytosine methylation in the genome is a feasible tool to engineer...

Clinical monitoring and correlates of nephropathy in SIV-infected macaques during high-dose antiretroviral therapy.

AIDS research and therapy

Sanders-Beer BE, Spano YY, Golighty D, Lara A, Hebblewaite D, Nieves-Duran L, Rhodes L, Mansfield KG.
PMID: 21255437
AIDS Res Ther. 2011 Jan 21;8(1):3. doi: 10.1186/1742-6405-8-3.

BACKGROUND: In many preclinical AIDS research studies, antiretroviral therapy (ART) is administered to experimentally simian immunodeficiency (SIV)-infected rhesus macaques for reduction of viral load to undetectable levels. Prolonged treatment of macaques with a high dose of PMPA (9-[2-(r)-(phosphonomethoxy) propyl]...

Fetal and neonatal programming of postnatal growth and feed efficiency in swine.

Journal of animal science and biotechnology

Ji Y, Wu Z, Dai Z, Wang X, Li J, Wang B, Wu G.
PMID: 28484595
J Anim Sci Biotechnol. 2017 May 05;8:42. doi: 10.1186/s40104-017-0173-5. eCollection 2017.

Maternal undernutrition or overnutrition during pregnancy alters organ structure, impairs prenatal and neonatal growth and development, and reduces feed efficiency for lean tissue gains in pigs. These adverse effects may be carried over to the next generation or beyond....

Nicotinamide metabolism regulates glioblastoma stem cell maintenance.

JCI insight

Jung J, Kim LJ, Wang X, Wu Q, Sanvoranart T, Hubert CG, Prager BC, Wallace LC, Jin X, Mack SC, Rich JN.
PMID: 28515364
JCI Insight. 2017 May 18;2(10). doi: 10.1172/jci.insight.90019. eCollection 2017 May 18.

Metabolic dysregulation promotes cancer growth through not only energy production, but also epigenetic reprogramming. Here, we report that a critical node in methyl donor metabolism, nicotinamide N-methyltransferase (NNMT), ranked among the most consistently overexpressed metabolism genes in glioblastoma relative...

MMP 9 Gene Promoter Polymorphism in Gastric Cancer.

Indian journal of clinical biochemistry : IJCB

Krishnaveni D, Bhayal AC, Sri Manjari K, Vidyasagar A, Uma Devi M, Ramanna M, Jyothy A, Nallari P, Venkateshwari A.
PMID: 26405384
Indian J Clin Biochem. 2012 Jul;27(3):259-64. doi: 10.1007/s12291-012-0210-2. Epub 2012 Apr 18.

Matrix metalloproteinase-9 (gelatinase B) plays a key role in cancer invasion and metastasis by degrading the extracellular matrix and basement membrane barriers. A cytosine (C) > thymidine (T) single nucleotide polymorphism (SNP) at position -1562 in the MMP-9 promoter...

Tumor Necrosis Factor Gene Polymorphisms in Advanced Non-exudative Age-related Macular Degeneration.

Journal of ophthalmic & vision research

Bonyadi MH, Bonyadi M, Ahmadieh H, Fotuhi N, Shoeibi N, Saadat S, Yagubi Z.
PMID: 26425318
J Ophthalmic Vis Res. 2015 Apr-Jun;10(2):155-9. doi: 10.4103/2008-322X.163781.

PURPOSE: To investigate tumor necrosis factor (TNF)-α gene polymorphisms in advanced dry-type age-related macular degeneration (AMD) in a population from Northeastern Iran.METHODS: In this case-control study, 50 patients with geographic macular atrophy and 73 gender-matched controls were enrolled. Genomic...

Self-assembled nanohelix from a bolaamphiphilic diacetylene via hydrogelation and selective responsiveness towards amino acids and nucleobases.

Nanoscale

Meng Y, Jiang J, Liu M.
PMID: 28513697
Nanoscale. 2017 Jun 01;9(21):7199-7206. doi: 10.1039/c7nr02126g.

A bolaamphiphile with diacteylene mesogen unit and l-glutamic acid as the terminal group was newly designed and its self-assembly was investigated. The compound formed hydrogels with water upon heating and cooling. The as-formed gel could be switched to a...

Metastatic Ovarian Cancer Can Be Efficiently Treated by Genetically Modified Mesenchymal Stromal Cells.

Stem cells and development

Toro L, Bohovic R, Matuskova M, Smolkova B, Kucerova L.
PMID: 27539058
Stem Cells Dev. 2016 Nov 01;25(21):1640-1651. doi: 10.1089/scd.2016.0064. Epub 2016 Aug 16.

Due to late diagnosis, often recurrence, formation of metastases and resistance to commonly used chemotherapeutics human ovarian carcinoma represents a serious disease with high mortality. Adipose tissue-derived mesenchymal stromal cells (AT-MSC) can serve as vehicles for therapeutic genes and...

Showing 1 to 12 of 1835 entries