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The mechanisms of human lymphoid chromosomal translocations and their medical relevance.

Critical reviews in biochemistry and molecular biology

Liu D, Lieber MR.
PMID: 34875186
Crit Rev Biochem Mol Biol. 2021 Dec 07;1-17. doi: 10.1080/10409238.2021.2004576. Epub 2021 Dec 07.

The most common human lymphoid chromosomal translocations involve concurrent failures of the recombination activating gene (RAG) complex and Activation-Induced Deaminase (AID). These are two enzymes that are normally expressed for purposes of the two site-specific DNA recombination processes: V(D)J...

4-Alkyloxyimino-cytosine nucleotides: tethering approaches to molecular probes for the P2Y.

MedChemComm

Jayasekara PS, Barrett MO, Ball CB, Brown KA, Kozma E, Costanzi S, Squarcialupi L, Balasubramanian R, Maruoka H, Jacobson KA.
PMID: 26161252
Medchemcomm. 2013 May 30;4:1156-1165. doi: 10.1039/C3MD00132F.

4-Alkyloxyimino derivatives of pyrimidine nucleotides display high potency as agonists of certain G protein-coupled P2Y receptors (P2YRs). In an effort to functionalize a P2Y

ADMIRE: analysis and visualization of differential methylation in genomic regions using the Infinium HumanMethylation450 Assay.

Epigenetics & chromatin

Preussner J, Bayer J, Kuenne C, Looso M.
PMID: 26628921
Epigenetics Chromatin. 2015 Dec 01;8:51. doi: 10.1186/s13072-015-0045-1. eCollection 2015.

BACKGROUND: DNA methylation at cytosine nucleotides constitutes epigenetic gene regulation impacting cellular development and a wide range of diseases. Cytosine bases of the DNA are converted to 5-methylcytosine by the methyltransferase enzyme, acting as a reversible regulator of gene...

High information throughput analysis of nucleotides and their isotopically enriched isotopologues by direct-infusion FTICR-MS.

Metabolomics : Official journal of the Metabolomic Society

Lorkiewicz P, Higashi RM, Lane AN, Fan TW.
PMID: 23101002
Metabolomics. 2012;8(5):930-939. doi: 10.1007/s11306-011-0388-y. Epub 2011 Dec 09.

Fourier transform-ion cyclotron resonance-mass spectrometry (FTICR-MS) is capable of acquiring unmatched quality of isotopologue data for stable isotope resolved metabolomics (SIRM). This capability drives the need for a continuous ion introduction for obtaining optimal isotope ratios. Here we report...

Showing 1 to 4 of 4 entries