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Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line.

Toxicology reports

Simon BR, Wilson MJ, Blake DA, Yu H, Wickliffe JK.
PMID: 25170436
Toxicol Rep. 2014 Jul 14;1:391-400. doi: 10.1016/j.toxrep.2014.07.003.

Previously, we demonstrated the sensitivity of RPTEC/TERT1 cells, an immortalized human renal proximal tubule epithelial cell line, to two common environmental carcinogens, cadmium (Cd) and benzo[a]pyrene (B[a]P). Here, we measured BPDE-DNA adducts using a competitive ELISA method after cells...

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Simon BR, Wilson MJ, Blake DA, et al. Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line. Toxicol Rep. 2014;1:391-400doi: 10.1016/j.toxrep.2014.07.003.
Simon, B. R., Wilson, M. J., Blake, D. A., Yu, H., & Wickliffe, J. K. (2014). Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line. Toxicology reports, 1391-400. https://doi.org/10.1016/j.toxrep.2014.07.003
Simon, Bridget R, et al. "Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line." Toxicology reports vol. 1 (2014): 391-400. doi: https://doi.org/10.1016/j.toxrep.2014.07.003
Simon BR, Wilson MJ, Blake DA, Yu H, Wickliffe JK. Cadmium alters the formation of benzo[a]pyrene DNA adducts in the RPTEC/TERT1 human renal proximal tubule epithelial cell line. Toxicol Rep. 2014 Jul 14;1:391-400. doi: 10.1016/j.toxrep.2014.07.003. PMID: 25170436; PMCID: PMC4142648.
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High excision repair cross-complementation group 1 expression is associated with favorable prognostic factors in breast cancer.

Oncology letters

Kim DH, Lee H, Kim DH, Chae SW, Sohn JH, Kim K, Do SI.
PMID: 28943968
Oncol Lett. 2017 Oct;14(4):4995-5003. doi: 10.3892/ol.2017.6737. Epub 2017 Aug 09.

Distortion of DNA can inhibit transcription and replication, resulting in cell death. The nucleotide excision repair (NER) pathway recognizes and repairs DNA adducts. Excision repair cross-complementation group 1 (ERCC1) is a nuclease that serves a vital role in the...

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Kim DH, Lee H, Kim DH, et al. High excision repair cross-complementation group 1 expression is associated with favorable prognostic factors in breast cancer. Oncol Lett. 2017;14(4):4995-5003doi: 10.3892/ol.2017.6737.
Kim, D. H., Lee, H., Kim, D. H., Chae, S. W., Sohn, J. H., Kim, K., & Do, S. I. (2017). High excision repair cross-complementation group 1 expression is associated with favorable prognostic factors in breast cancer. Oncology letters, 14(4), 4995-5003. https://doi.org/10.3892/ol.2017.6737
Kim, Dong Hyun, et al. "High excision repair cross-complementation group 1 expression is associated with favorable prognostic factors in breast cancer." Oncology letters vol. 14,4 (2017): 4995-5003. doi: https://doi.org/10.3892/ol.2017.6737
Kim DH, Lee H, Kim DH, Chae SW, Sohn JH, Kim K, Do SI. High excision repair cross-complementation group 1 expression is associated with favorable prognostic factors in breast cancer. Oncol Lett. 2017 Oct;14(4):4995-5003. doi: 10.3892/ol.2017.6737. Epub 2017 Aug 09. PMID: 28943968; PMCID: PMC5594248.
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DNA Damage and Inflammation in the Rat Quartz Model: Differences in Inflammatory Response and Formation of Oxidative DNA Adducts to High and Low Dose of DQ12 Quartz.

Inhalation toxicology

Bruch J, Seiler F, Rehn B.
PMID: 26368618
Inhal Toxicol. 2000 Jan;12:205-13. doi: 10.1080/08958378.2000.11463215.

Chronic exposure to poorly soluble particles such as quartz and diesel soot produces dose-dependent inflammatory responses in the rat lung. It has been shown that the inflammation in the rat lung causes persistent oxidative DNA damage and mutations in...

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Bruch J, Seiler F, Rehn B. DNA Damage and Inflammation in the Rat Quartz Model: Differences in Inflammatory Response and Formation of Oxidative DNA Adducts to High and Low Dose of DQ12 Quartz. Inhal Toxicol. 2000;12:205-13doi: 10.1080/08958378.2000.11463215.
Bruch, J., Seiler, F., & Rehn, B. (2000). DNA Damage and Inflammation in the Rat Quartz Model: Differences in Inflammatory Response and Formation of Oxidative DNA Adducts to High and Low Dose of DQ12 Quartz. Inhalation toxicology, 12205-13. https://doi.org/10.1080/08958378.2000.11463215
Bruch, J, et al. "DNA Damage and Inflammation in the Rat Quartz Model: Differences in Inflammatory Response and Formation of Oxidative DNA Adducts to High and Low Dose of DQ12 Quartz." Inhalation toxicology vol. 12 (2000): 205-13. doi: https://doi.org/10.1080/08958378.2000.11463215
Bruch J, Seiler F, Rehn B. DNA Damage and Inflammation in the Rat Quartz Model: Differences in Inflammatory Response and Formation of Oxidative DNA Adducts to High and Low Dose of DQ12 Quartz. Inhal Toxicol. 2000 Jan;12:205-13. doi: 10.1080/08958378.2000.11463215. PMID: 26368618.
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ERCC1 Expression in Metastatic Triple Negative Breast Cancer Patients Treated with Platinum-Based Chemotherapy.

Asian Pacific journal of cancer prevention : APJCP

EL Baiomy MA, El Kashef WF.
PMID: 28345838
Asian Pac J Cancer Prev. 2017 Feb 01;18(2):507-513. doi: 10.22034/APJCP.2017.18.2.507.

Background: Possible targeted therapies for metastatic triple negative breast cancer (TNBC) include cytotoxic chemotherapy that causes interstrand breaks (platinum-based drugs). The excision repair cross-complementation 1 (ERCC1) enzyme plays an essential role in the nucleotide excision repair pathway, removing platinum-induced...

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EL Baiomy MA, El Kashef WF. ERCC1 Expression in Metastatic Triple Negative Breast Cancer Patients Treated with Platinum-Based Chemotherapy. Asian Pac J Cancer Prev. 2017;18(2):507-513doi: 10.22034/APJCP.2017.18.2.507.
EL Baiomy, M. A., & El Kashef, W. F. (2017). ERCC1 Expression in Metastatic Triple Negative Breast Cancer Patients Treated with Platinum-Based Chemotherapy. Asian Pacific journal of cancer prevention : APJCP, 18(2), 507-513. https://doi.org/10.22034/APJCP.2017.18.2.507
EL Baiomy, Mohamed Ali, and El Kashef, Wagdi F. "ERCC1 Expression in Metastatic Triple Negative Breast Cancer Patients Treated with Platinum-Based Chemotherapy." Asian Pacific journal of cancer prevention : APJCP vol. 18,2 (2017): 507-513. doi: https://doi.org/10.22034/APJCP.2017.18.2.507
EL Baiomy MA, El Kashef WF. ERCC1 Expression in Metastatic Triple Negative Breast Cancer Patients Treated with Platinum-Based Chemotherapy. Asian Pac J Cancer Prev. 2017 Feb 01;18(2):507-513. doi: 10.22034/APJCP.2017.18.2.507. PMID: 28345838; PMCID: PMC5454751.
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Tumor Prevalence in Mummichogs from the Delaware Estuary Watershed.

Journal of aquatic animal health

Pinkney AE, Harshbarger JC.
PMID: 26599160
J Aquat Anim Health. 2006 Dec;18(4):244-51. doi: 10.1577/H05-053.1.

Mummichogs Fundulus heteroclitus were collected in 2002-2004 from six locations within the Delaware Estuary watershed and examined histopathologically. The objective was to compare the prevalence of skin and liver tumors in fish from locations with a range of sediment...

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Pinkney AE, Harshbarger JC. Tumor Prevalence in Mummichogs from the Delaware Estuary Watershed. J Aquat Anim Health. 2006;18(4):244-51doi: 10.1577/H05-053.1.
Pinkney, A. E., & Harshbarger, J. C. (2006). Tumor Prevalence in Mummichogs from the Delaware Estuary Watershed. Journal of aquatic animal health, 18(4), 244-51. https://doi.org/10.1577/H05-053.1
Pinkney, Alfred E, and Harshbarger, John C. "Tumor Prevalence in Mummichogs from the Delaware Estuary Watershed." Journal of aquatic animal health vol. 18,4 (2006): 244-51. doi: https://doi.org/10.1577/H05-053.1
Pinkney AE, Harshbarger JC. Tumor Prevalence in Mummichogs from the Delaware Estuary Watershed. J Aquat Anim Health. 2006 Dec;18(4):244-51. doi: 10.1577/H05-053.1. PMID: 26599160.
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Cellular and Molecular Targets of Benzo[a]pyrene and Metal Toxicity in Xenopus laevis Embryos and in Hep G2 Cells.

Alternatives to laboratory animals : ATLA

Camatini M, Bonfanti P, Colombo A, Urani C, Crippa S.
PMID: 25470671
Altern Lab Anim. 1999 May-Jun;27(3):325-37. doi: 10.1177/026119299902700321.

This paper describes the use of two in vitro systems (stage 35 Xenopus laevis embryos and the human hepatoblastoma cell line, Hep G2) to study effects of some environmental contaminants (benzo[a]pyrene, copper and zinc), which are representative of chemicals...

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Camatini M, Bonfanti P, Colombo A, et al. Cellular and Molecular Targets of Benzo[a]pyrene and Metal Toxicity in Xenopus laevis Embryos and in Hep G2 Cells. Altern Lab Anim. 1999;27(3):325-37doi: 10.1177/026119299902700321.
Camatini, M., Bonfanti, P., Colombo, A., Urani, C., & Crippa, S. (1999). Cellular and Molecular Targets of Benzo[a]pyrene and Metal Toxicity in Xenopus laevis Embryos and in Hep G2 Cells. Alternatives to laboratory animals : ATLA, 27(3), 325-37. https://doi.org/10.1177/026119299902700321
Camatini, M, et al. "Cellular and Molecular Targets of Benzo[a]pyrene and Metal Toxicity in Xenopus laevis Embryos and in Hep G2 Cells." Alternatives to laboratory animals : ATLA vol. 27,3 (1999): 325-37. doi: https://doi.org/10.1177/026119299902700321
Camatini M, Bonfanti P, Colombo A, Urani C, Crippa S. Cellular and Molecular Targets of Benzo[a]pyrene and Metal Toxicity in Xenopus laevis Embryos and in Hep G2 Cells. Altern Lab Anim. 1999 May-Jun;27(3):325-37. doi: 10.1177/026119299902700321. PMID: 25470671.
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DNA adducts as early bioindicators of chemical exposure.

Environmental monitoring and assessment

Giam CS, Holliday TL, Zheng Y, Williams JL, Ahmed MS.
PMID: 24233950
Environ Monit Assess. 1991 Oct;19(1):335-40. doi: 10.1007/BF00401322.

Sensitive analytical methods indicate the presence of hundreds of chemical contaminants in our environment. However, concentration of these pollutants is usually at the low parts per million or parts per billion level. At such low levels, toxicants induce long-term...

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Giam CS, Holliday TL, Zheng Y, et al. DNA adducts as early bioindicators of chemical exposure. Environ Monit Assess. 1991;19(1):335-40doi: 10.1007/BF00401322.
Giam, C. S., Holliday, T. L., Zheng, Y., Williams, J. L., & Ahmed, M. S. (1991). DNA adducts as early bioindicators of chemical exposure. Environmental monitoring and assessment, 19(1), 335-40. https://doi.org/10.1007/BF00401322
Giam, C S, et al. "DNA adducts as early bioindicators of chemical exposure." Environmental monitoring and assessment vol. 19,1 (1991): 335-40. doi: https://doi.org/10.1007/BF00401322
Giam CS, Holliday TL, Zheng Y, Williams JL, Ahmed MS. DNA adducts as early bioindicators of chemical exposure. Environ Monit Assess. 1991 Oct;19(1):335-40. doi: 10.1007/BF00401322. PMID: 24233950.
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Multiscale design of cell-type-specific pharmacokinetic/pharmacodynamic models for personalized medicine: application to temozolomide in brain tumors.

CPT: pharmacometrics & systems pharmacology

Ballesta A, Zhou Q, Zhang X, Lv H, Gallo JM.
PMID: 24785551
CPT Pharmacometrics Syst Pharmacol. 2014 Apr 30;3:e112. doi: 10.1038/psp.2014.9.

Optimizing anticancer therapeutics needs to account for variable drug responses in heterogeneous cell populations within the tumor as well as in organs of toxicity. To address cell heterogeneity, we propose a multiscale modeling approach-from in vitro to preclinical and...

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Ballesta A, Zhou Q, Zhang X, et al. Multiscale design of cell-type-specific pharmacokinetic/pharmacodynamic models for personalized medicine: application to temozolomide in brain tumors. CPT Pharmacometrics Syst Pharmacol. 2014;3:e112doi: 10.1038/psp.2014.9.
Ballesta, A., Zhou, Q., Zhang, X., Lv, H., & Gallo, J. M. (2014). Multiscale design of cell-type-specific pharmacokinetic/pharmacodynamic models for personalized medicine: application to temozolomide in brain tumors. CPT: pharmacometrics & systems pharmacology, 3e112. https://doi.org/10.1038/psp.2014.9
Ballesta, A, et al. "Multiscale design of cell-type-specific pharmacokinetic/pharmacodynamic models for personalized medicine: application to temozolomide in brain tumors." CPT: pharmacometrics & systems pharmacology vol. 3 (2014): e112. doi: https://doi.org/10.1038/psp.2014.9
Ballesta A, Zhou Q, Zhang X, Lv H, Gallo JM. Multiscale design of cell-type-specific pharmacokinetic/pharmacodynamic models for personalized medicine: application to temozolomide in brain tumors. CPT Pharmacometrics Syst Pharmacol. 2014 Apr 30;3:e112. doi: 10.1038/psp.2014.9. PMID: 24785551; PMCID: PMC4017092.
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Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers.

Food science & nutrition

Wang MY, Peng L, Jensen CJ, Deng S, West BJ.
PMID: 24804023
Food Sci Nutr. 2013 Mar;1(2):141-9. doi: 10.1002/fsn3.21. Epub 2013 Jan 07.

Food plants provide important phytochemicals which help improve or maintain health through various biological activities, including antioxidant effects. Cigarette smoke-induced oxidative stress leads to the formation of lipid hydroperoxides (LOOHs) and their decomposition product malondialdehyde (MDA), both of which...

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Wang MY, Peng L, Jensen CJ, et al. Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers. Food Sci Nutr. 2013;1(2):141-9doi: 10.1002/fsn3.21.
Wang, M. Y., Peng, L., Jensen, C. J., Deng, S., & West, B. J. (2013). Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers. Food science & nutrition, 1(2), 141-9. https://doi.org/10.1002/fsn3.21
Wang, Mian-Ying, et al. "Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers." Food science & nutrition vol. 1,2 (2013): 141-9. doi: https://doi.org/10.1002/fsn3.21
Wang MY, Peng L, Jensen CJ, Deng S, West BJ. Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers. Food Sci Nutr. 2013 Mar;1(2):141-9. doi: 10.1002/fsn3.21. Epub 2013 Jan 07. PMID: 24804023; PMCID: PMC3967752.
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XPC codon 939 polymorphism is associated with susceptibility to DNA damage induced by aflatoxin B1 exposure.

International journal of clinical and experimental medicine

Long XD, Huang HD, Huang XY, Yao JG, Xia Q.
PMID: 25785113
Int J Clin Exp Med. 2015 Jan 15;8(1):1197-204. eCollection 2015.

Aflatoxin B1 (AFB1), resulting in the formation of AFB1-DNA adducts, is a known human carcinogen. AFB1-exposure individuals with inherited susceptible carcinogen-repairing genotypes may experience an increased risk of genotoxicity. This study was aimed to investigate whether DNA repair gene...

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Long XD, Huang HD, Huang XY, et al. XPC codon 939 polymorphism is associated with susceptibility to DNA damage induced by aflatoxin B1 exposure. Int J Clin Exp Med. 2015;8(1):1197-204
Long, X. D., Huang, H. D., Huang, X. Y., Yao, J. G., & Xia, Q. (2015). XPC codon 939 polymorphism is associated with susceptibility to DNA damage induced by aflatoxin B1 exposure. International journal of clinical and experimental medicine, 8(1), 1197-204.
Long, Xi-Dai, et al. "XPC codon 939 polymorphism is associated with susceptibility to DNA damage induced by aflatoxin B1 exposure." International journal of clinical and experimental medicine vol. 8,1 (2015): 1197-204.
Long XD, Huang HD, Huang XY, Yao JG, Xia Q. XPC codon 939 polymorphism is associated with susceptibility to DNA damage induced by aflatoxin B1 exposure. Int J Clin Exp Med. 2015 Jan 15;8(1):1197-204. eCollection 2015. PMID: 25785113; PMCID: PMC4358568.
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Detection of DNA adducts in declining hop plants grown on fields formerly treated with heptachlor, a persistent insecticide.

Environmental pollution (Barking, Essex : 1987)

Laouedj A, Schenk C, Pfohl-Leszkowicz A, Keith G, Schontz D, Guillemaut P, Rether B.
PMID: 15091476
Environ Pollut. 1995;90(3):409-14. doi: 10.1016/0269-7491(94)00093-s.

Hop decline was observed in Alsace, eastern France, in reparcelled sugar beet fields formerly abundantly treated with an insecticide, heptachlor. Leaves were collected from 'declining hops' grown in an heptachlor-contaminated area and from 'healthy hops' grown in a soil...

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Laouedj A, Schenk C, Pfohl-Leszkowicz A, et al. Detection of DNA adducts in declining hop plants grown on fields formerly treated with heptachlor, a persistent insecticide. Environ Pollut. 1995;90(3):409-14doi: 10.1016/0269-7491(94)00093-s.
Laouedj, A., Schenk, C., Pfohl-Leszkowicz, A., Keith, G., Schontz, D., Guillemaut, P., & Rether, B. (1995). Detection of DNA adducts in declining hop plants grown on fields formerly treated with heptachlor, a persistent insecticide. Environmental pollution (Barking, Essex : 1987), 90(3), 409-14. https://doi.org/10.1016/0269-7491(94)00093-s
Laouedj, A, et al. "Detection of DNA adducts in declining hop plants grown on fields formerly treated with heptachlor, a persistent insecticide." Environmental pollution (Barking, Essex : 1987) vol. 90,3 (1995): 409-14. doi: https://doi.org/10.1016/0269-7491(94)00093-s
Laouedj A, Schenk C, Pfohl-Leszkowicz A, Keith G, Schontz D, Guillemaut P, Rether B. Detection of DNA adducts in declining hop plants grown on fields formerly treated with heptachlor, a persistent insecticide. Environ Pollut. 1995;90(3):409-14. doi: 10.1016/0269-7491(94)00093-s. PMID: 15091476.
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Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes.

Metal-based drugs

Brabec V, Boudny V.
PMID: 18476231
Met Based Drugs. 1994;1(2):195-200. doi: 10.1155/MBD.1994.195.

The effects produced in DNA by monofunctional or interstrand adducts of platinum(II) complexes have been summarized. The monofunctional adducts destabilize DNA in a sequence-dependent manner via conformational distortions, which may have a denaturational character. It has been suggested that...

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Brabec V, Boudny V. Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes. Met Based Drugs. 1994;1(2):195-200doi: 10.1155/MBD.1994.195.
Brabec, V., & Boudny, V. (1994). Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes. Metal-based drugs, 1(2), 195-200. https://doi.org/10.1155/MBD.1994.195
Brabec, V, and Boudny, V. "Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes." Metal-based drugs vol. 1,2 (1994): 195-200. doi: https://doi.org/10.1155/MBD.1994.195
Brabec V, Boudny V. Monofunctional and Interstrand DNA Adducts of Platinum(II) Complexes. Met Based Drugs. 1994;1(2):195-200. doi: 10.1155/MBD.1994.195. PMID: 18476231; PMCID: PMC2364885.
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Showing 1 to 12 of 379 entries