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Showing 1 to 5 of 5 entries
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Of fish and men: clonal lineage analysis identifies divergence in myocardial development.

Circulation research

Sharma A, Wu SM.
PMID: 23410876
Circ Res. 2013 Feb 15;112(4):583-5. doi: 10.1161/CIRCRESAHA.113.300964.

No abstract available.

Massive expansion and cryopreservation of functional human induced pluripotent stem cell-derived cardiomyocytes.

STAR protocols

Maas RGC, Lee S, Harakalova M, Snijders Blok CJB, Goodyer WR, Hjortnaes J, Doevendans PAFM, Van Laake LW, van der Velden J, Asselbergs FW, Wu JC, Sluijter JPG, Wu SM, Buikema JW.
PMID: 33615277
STAR Protoc. 2021 Feb 09;2(1):100334. doi: 10.1016/j.xpro.2021.100334. eCollection 2021 Mar 19.

Since the discovery of human induced pluripotent stem cells (hiPSCs), numerous strategies have been established to efficiently derive cardiomyocytes from hiPSCs (hiPSC-CMs). Here, we describe a cost-effective strategy for the subsequent massive expansion (>250-fold) of high-purity hiPSC-CMs relying on...

Promises and pitfalls in cell replacement therapy for heart failure.

Drug discovery today. Disease mechanisms

Krane M, Wernet O, Wu SM.
PMID: 21180399
Drug Discov Today Dis Mech. 2010;7(2):e109-e115. doi: 10.1016/j.ddmec.2010.07.004.

Symptomatic heart failure is a complex clinical syndrome with a poor prognosis. Many efforts have been made to develop new therapeutic strategies to improve prognosis associated with heart failure. In this context, different stem cell populations for cardiac regenerative...

Induced pluripotent stem cell modeling of complex genetic diseases.

Drug discovery today. Disease models

Hinson JT, Nakamura K, Wu SM.
PMID: 23690830
Drug Discov Today Dis Models. 2012;9(4):e147-e152. doi: 10.1016/j.ddmod.2012.04.002.

The study of complex disease genetics by genome-wide association studies (GWAS) has led to hundreds of genomic loci associated with disease traits in humans. However, the functional consequences of most loci are largely undefined. We discuss here the potential...

Somatic Cell Reprogramming into Cardiovascular Lineages.

Journal of cardiovascular pharmacology and therapeutics

Chen JX, Plonowska K, Wu SM.
PMID: 24764131
J Cardiovasc Pharmacol Ther. 2014 Jul;19(4):340-349. doi: 10.1177/1074248414527641. Epub 2014 Apr 23.

Ischemic cardiac disease is the leading cause of death in the developed world. The inability of the adult mammalian heart to adequately repair itself has motivated stem cell researchers to explore various strategies to regenerate cardiomyocytes after myocardial infarction....

Showing 1 to 5 of 5 entries