Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 3 of 3 entries
Sorted by: Best Match Show Resources per page
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.

ACS medicinal chemistry letters

Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E.
PMID: 22662288
ACS Med Chem Lett. 2012 Apr 03;3(5):402-406. doi: 10.1021/ml300038t.

We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo-acids bind to the active site Mg(2+)/Asp...

Cite
Zhang Y, Fu-Yang Lin, Li K, et al. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett. 2012;3(5):402-406doi: 10.1021/ml300038t.
Zhang, Y., Fu-Yang Lin, Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V., & Oldfield, E. (2012). HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS medicinal chemistry letters, 3(5), 402-406. https://doi.org/10.1021/ml300038t
Zhang, Yonghui, et al. "HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis." ACS medicinal chemistry letters vol. 3,5 (2012): 402-406. doi: https://doi.org/10.1021/ml300038t
Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett. 2012 Apr 03;3(5):402-406. doi: 10.1021/ml300038t. PMID: 22662288; PMCID: PMC3363326.
Copy Download .nbib Format: NLM
Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics.

Tetrahedron

Maxson T, Mitchell DA.
PMID: 27429480
Tetrahedron. 2016 Jun 23;72(25):3609-3624. doi: 10.1016/j.tet.2015.09.069. Epub 2015 Oct 09.

Antibiotics are a cornerstone of modern medicine and have significantly reduced the burden of infectious diseases. However, commonly used broad-spectrum antibiotics can cause major collateral damage to the human microbiome, causing complications ranging from antibiotic-associated colitis to the rapid...

Cite
Maxson T, Mitchell DA. Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics. Tetrahedron. 2015;72(25):3609-3624doi: 10.1016/j.tet.2015.09.069.
Maxson, T., & Mitchell, D. A. (2016). Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics. Tetrahedron, 72(25), 3609-3624. https://doi.org/10.1016/j.tet.2015.09.069
Maxson, Tucker, and Mitchell, Douglas A. "Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics." Tetrahedron vol. 72,25 (2016): 3609-3624. doi: https://doi.org/10.1016/j.tet.2015.09.069
Maxson T, Mitchell DA. Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics. Tetrahedron. 2016 Jun 23;72(25):3609-3624. doi: 10.1016/j.tet.2015.09.069. Epub 2015 Oct 09. PMID: 27429480; PMCID: PMC4941824.
Copy Download .nbib Format: NLM
Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide.

Acta crystallographica. Section E, Crystallographic communications

Maxson T, Bertke JA, Gray DL, Mitchell DA.
PMID: 26594520
Acta Crystallogr E Crystallogr Commun. 2015 Oct 31;71:1401-7. doi: 10.1107/S2056989015020046. eCollection 2015 Nov 01.

The crystal structure and absolute configuration of the two new title nelfinavir analogs, C24H35ClN4O5, (I), and C27H39ClN4O5, (II), have been determined. Each of these mol-ecules exhibits a number of disordered moieties. There are intra-molecular N-H⋯O hydrogen bonds in both...

Cite
Maxson T, Bertke JA, Gray DL, et al. Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide. Acta Crystallogr E Crystallogr Commun. 2015;71:1401-7doi: 10.1107/S2056989015020046.
Maxson, T., Bertke, J. A., Gray, D. L., & Mitchell, D. A. (2015). Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide. Acta crystallographica. Section E, Crystallographic communications, 711401-7. https://doi.org/10.1107/S2056989015020046
Maxson, Tucker, et al. "Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide." Acta crystallographica. Section E, Crystallographic communications vol. 71 (2015): 1401-7. doi: https://doi.org/10.1107/S2056989015020046
Maxson T, Bertke JA, Gray DL, Mitchell DA. Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolidin-2-yl]-2-hy-droxy-eth-yl}deca-hydro-iso-quinoline-3-carboxamide. Acta Crystallogr E Crystallogr Commun. 2015 Oct 31;71:1401-7. doi: 10.1107/S2056989015020046. eCollection 2015 Nov 01. PMID: 26594520; PMCID: PMC4645022.
Copy Download .nbib Format: NLM
Showing 1 to 3 of 3 entries