Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 1 of 1 entries
Sorted by: Best Match Show Resources per page
HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis.

ACS medicinal chemistry letters

Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E.
PMID: 22662288
ACS Med Chem Lett. 2012 Apr 03;3(5):402-406. doi: 10.1021/ml300038t.

We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo-acids bind to the active site Mg(2+)/Asp...

Cite
Zhang Y, Fu-Yang Lin, Li K, et al. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett. 2012;3(5):402-406doi: 10.1021/ml300038t.
Zhang, Y., Fu-Yang Lin, Li, K., Zhu, W., Liu, Y. L., Cao, R., Pang, R., Lee, E., Axelson, J., Hensler, M., Wang, K., Molohon, K. J., Wang, Y., Mitchell, D. A., Nizet, V., & Oldfield, E. (2012). HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS medicinal chemistry letters, 3(5), 402-406. https://doi.org/10.1021/ml300038t
Zhang, Yonghui, et al. "HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis." ACS medicinal chemistry letters vol. 3,5 (2012): 402-406. doi: https://doi.org/10.1021/ml300038t
Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, Oldfield E. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. ACS Med Chem Lett. 2012 Apr 03;3(5):402-406. doi: 10.1021/ml300038t. PMID: 22662288; PMCID: PMC3363326.
Copy Download .nbib Format: NLM
Showing 1 to 1 of 1 entries