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Showing 1 to 12 of 127 entries
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Practical method for the definition of chromatographic peak parameters in preparative liquid chromatography.

Journal of separation science

Jin G, Guo Z, Xiao Y, Yan J, Dong X, Shen A, Wang C, Liang X.
PMID: 27545853
J Sep Sci. 2016 Oct;39(20):3917-3926. doi: 10.1002/jssc.201600579. Epub 2016 Oct 04.

A practical method was established for the definition of chromatographic parameters in preparative liquid chromatography. The parameters contained both the peak broadening level under different amounts of sample loading and the concentration distribution of the target compound in the...

The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds.

Behavioural pharmacology

Baker LE, Riddle EE, Saunders RB, Appel JB.
PMID: 11224173
Behav Pharmacol. 1993 Feb;4(1):69-79.

The involvement of monoamine neurotransmitter uptake in the discriminative stimulus effects of cocaine was examined in rats (n = 48) trained to discriminate 10mg/kg of this substance from saline in a two-level, water-reinforced (FR 20), drug discrimination situation. Compounds...

[Chronic pain treatment with antidepressants--metaanalysis].

Schmerz (Berlin, Germany)

Feuerstein TJ.
PMID: 12799822
Schmerz. 1997 Jun 13;11(3):213-26. doi: 10.1007/s004829700027.

Both preclinical and clinical evidence support the usefulness of antidepressants in chronic pain treatment. Monoamine uptake inhibitors influence the neurotransmissions of noradrenaline (NA) and/or serotonin (5-HT); their effect on nociception is thought to take place predominantly within the spinal...

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayés M, Rabasseda X, Prous JR.
PMID: 16082422
Methods Find Exp Clin Pharmacol. 2005 Jun;27(5):331-72.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables have been retrieved from the Clinical Trials Knowledge Area of Prous Science Integrity, the drug...

Analysis by liquid chromatography of desipramine in aqueous solutions and plasma application of dichlorotriazinylaminofluorescein (DTAF) as a pre-column fluorescent derivatising agent for selected secondary amines.

Journal of pharmaceutical and biomedical analysis

Siegler R, Sternson LA.
PMID: 16867394
J Pharm Biomed Anal. 1988;6(5):485-92. doi: 10.1016/0731-7085(88)80015-3.

Dichlorotriazinylaminofluorescein (DTAF) has been proposed as a fluorescent derivatising agent for secondary aliphatic amines. In this report, its applicability as a pre-column reagent is demonstrated by its use in the analysis of aqueous solutions and plasma samples of the...

Antinociceptive efficacy of antidepressants: assessment of five antidepressants and four monoamine receptors in rats.

Journal of anesthesia

Otsuka N, Kiuchi Y, Yokogawa F, Masuda Y, Oguchi K, Hosoyamada A.
PMID: 14566514
J Anesth. 2001;15(3):154-8. doi: 10.1007/s005400170018.

PURPOSE: For assessment of the antinociceptive potency of antidepressants, we compared the antinociceptive effects of serotonin selective reuptake inhibitors (SSRIs) and classical tricyclic antidepressants (TCAs) in rats. We also attempted to elucidate the monoamine receptor subtypes predominantly involved in...

Association of PDE11A global haplotype with major depression and antidepressant drug response.

Neuropsychiatric disease and treatment

Luo HR, Wu GS, Dong C, Arcos-Burgos M, Ribeiro L, Licinio J, Wong ML.
PMID: 19557111
Neuropsychiatr Dis Treat. 2009;5:163-70. doi: 10.2147/ndt.s4771. Epub 2009 Apr 08.

Cyclic nucleotide phosphodiesterases (PDEs) hydrolyze the intracellular second messengers cAMP and cGMP to their corresponding monophosphates. PDEs play an important role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. We have previously shown that the individual...

Sudden death and tricyclic antidepressants: clinical considerations for children.

Journal of child and adolescent psychopharmacology

Popper CW, Elliott GR.
PMID: 19630660
J Child Adolesc Psychopharmacol. 1990;1(2):125-32. doi: 10.1089/cap.1990.1.125.

ABSTRACT The sudden collapse and death in three prepubertal children during routine treatment with desipramine was recently reported in brief statements. Insufficient clinical information is available to infer a cause-and-effect relationship between the therapeutic use of desipramine and sudden...

Differential regulation of neuropeptide Y and catecholamine production in superior cervical ganglion cultures.

Molecular and cellular neurosciences

Marek KL, Mains RE.
PMID: 19912776
Mol Cell Neurosci. 1990 Dec;1(3):262-9. doi: 10.1016/1044-7431(90)90008-r.

Primary cultures of newborn rat superior cervical ganglion (SCG) neurons grown in complete serum-free medium have been used to study the regulation of catecholamine and neuropeptide Y (NPY) production. The levels of mRNA for preproNPY and for tyrosine hydroxylase...

Unilateral decortication affects muscarinic cholinergic receptor binding in rat basal forebrain.

Neurochemistry international

Schliebs R, Stewart MG.
PMID: 20504543
Neurochem Int. 1990;16(1):81-7. doi: 10.1016/0197-0186(90)90126-e.

The distribution of muscarinic acetylcholine receptors (including the M(1)-receptor subtype), beta-adreno receptors, and noradrenaline uptake sites was studied in cholinergic basal forebrain nuclei (medial and lateral septum, ventral and dorsal limb of the diagonal band, substantia innominata and nucleus...

Plasma Norepinephrine in Hypertensive Rats Reflects α(2)-Adrenoceptor Release Control Only When Re-Uptake is Inhibited.

Frontiers in neurology

Berg T, Walaas SI, Roberg BÅ, Huynh TT, Jensen J.
PMID: 23162530
Front Neurol. 2012 Nov 08;3:160. doi: 10.3389/fneur.2012.00160. eCollection 2012.

UNLABELLED: α(2)-adrenoceptors (AR) lower central sympathetic output and peripheral catecholamine release, thereby protecting against sympathetic hyperactivity and hypertension. Norepinephrine re-uptake-transporter effectively (NET) removes norepinephrine from the synapse. Overflow to plasma will therefore not reflect release. Here we tested if...

Effects of Hypericum perforatum L. and Hypericum calycinum L. extracts on the central nervous system in mice.

Phytomedicine : international journal of phytotherapy and phytopharmacology

Oztürk Y, Aydin S, Beis R, Başer KH, Berberoĝlu H.
PMID: 23194961
Phytomedicine. 1996 Sep;3(2):139-46. doi: 10.1016/S0944-7113(96)80027-4.

Hypericum species have been used as herbal remedies for the therapy of various diseases since ancient times. It has been reported that Hypericum perforatum is a useful herbal remedy for the treatment of neurological disorders such as coxalgia, menopausal...

Showing 1 to 12 of 127 entries