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Mechanistic Insights into the Post-Cyclization Isomerization in Gold-Catalyzed 7-exo-dig-Hydroarylations.

Chemistry (Weinheim an der Bergstrasse, Germany)

Pflästerer D, Schumacher S, Rudolph M, Hashmi AS.
PMID: 26118364
Chemistry. 2015 Aug 03;21(32):11585-9. doi: 10.1002/chem.201501075. Epub 2015 Jun 26.

The subsequent double-bond isomerization in the synthesis of dibenzocycloheptenes and their heteroaromatic analogues was investigated. In the case of biphenyls, a basic additive completely prevented an isomerization to the thermodynamic product. With electron-rich intramolecular heteroaromatic nucleophiles, the isomerization was...

Prevention of the emergence of drug resistance in bacteria by acridines, phenothiazines, and dibenzocycloheptenes.

Applied microbiology

Heller CS, Sevag MG.
PMID: 16349689
Appl Microbiol. 1966 Nov;14(6):879-85. doi: 10.1128/am.14.6.879-885.1966.

It has been found that, like Atabrine, the phenothiazine tranquilizers promazine, chlorpromazine, promethazine, levopromethazine, and Stelazine; the antidepressants (dibenz-azepine and dibenzocycloheptene derivatives) Tofranil, Pertofrane, cyclobenzaprine, Elavil, protriptyline, and 3-chlorodibenzocycloheptene; and the acridine derivatives acridine orange, acriflavin, SKF no. 16214-A2,...

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