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Studies on the System Regulating Proton Movement across the Chloroplast Envelope : Effects of ATPase Inhibitors, Mg, and an Amine Anesthetic on Stromal pH and Photosynthesis.

Plant physiology

Peters JS, Berkowitz GA.
PMID: 16668116
Plant Physiol. 1991 Apr;95(4):1229-36. doi: 10.1104/pp.95.4.1229.

Studies were undertaken to further characterize the spinach (Spinacea oleracea) chloroplast envelope system, which facilitates H(+) movement into and out of the stroma, and, hence, modulates photosynthetic activity by regulating stromal pH. It was demonstrated that high envelope-bound Mg(2+)...

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Peters JS, Berkowitz GA. Studies on the System Regulating Proton Movement across the Chloroplast Envelope : Effects of ATPase Inhibitors, Mg, and an Amine Anesthetic on Stromal pH and Photosynthesis. Plant Physiol. 1991;95(4):1229-36doi: 10.1104/pp.95.4.1229.
Peters, J. S., & Berkowitz, G. A. (1991). Studies on the System Regulating Proton Movement across the Chloroplast Envelope : Effects of ATPase Inhibitors, Mg, and an Amine Anesthetic on Stromal pH and Photosynthesis. Plant physiology, 95(4), 1229-36. https://doi.org/10.1104/pp.95.4.1229
Peters, J S, and Berkowitz, G A. "Studies on the System Regulating Proton Movement across the Chloroplast Envelope : Effects of ATPase Inhibitors, Mg, and an Amine Anesthetic on Stromal pH and Photosynthesis." Plant physiology vol. 95,4 (1991): 1229-36. doi: https://doi.org/10.1104/pp.95.4.1229
Peters JS, Berkowitz GA. Studies on the System Regulating Proton Movement across the Chloroplast Envelope : Effects of ATPase Inhibitors, Mg, and an Amine Anesthetic on Stromal pH and Photosynthesis. Plant Physiol. 1991 Apr;95(4):1229-36. doi: 10.1104/pp.95.4.1229. PMID: 16668116; PMCID: PMC1077677.
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Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.

ACS medicinal chemistry letters

Wang HY, Xin W, Zhou M, Stueckle TA, Rojanasakul Y, O'Doherty GA.
PMID: 21643465
ACS Med Chem Lett. 2011 Jan 13;2(1):73-78. doi: 10.1021/ml100219d.

A stereochemically diverse array of monosaccharide analogues of the trisaccharide based cardiac glycoside natural product digitoxin has been synthesized using a de novo asymmetric approach. The analogues were tested for cytotoxicity against the NCI panel of 60 human cancer...

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Wang HY, Xin W, Zhou M, et al. Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell. ACS Med Chem Lett. 2011;2(1):73-78doi: 10.1021/ml100219d.
Wang, H. Y., Xin, W., Zhou, M., Stueckle, T. A., Rojanasakul, Y., & O'Doherty, G. A. (2011). Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell. ACS medicinal chemistry letters, 2(1), 73-78. https://doi.org/10.1021/ml100219d
Wang, Hua-Yu Leo, et al. "Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell." ACS medicinal chemistry letters vol. 2,1 (2011): 73-78. doi: https://doi.org/10.1021/ml100219d
Wang HY, Xin W, Zhou M, Stueckle TA, Rojanasakul Y, O'Doherty GA. Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell. ACS Med Chem Lett. 2011 Jan 13;2(1):73-78. doi: 10.1021/ml100219d. PMID: 21643465; PMCID: PMC3105780.
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Cryopreservation of Digitalis lanata cell cultures.

Planta medica

Diettrich B, Popov AS, Pfeiffer B, Neumann D, Butenko R, Luckner M.
PMID: 17396948
Planta Med. 1982 Oct;46(2):82-7. doi: 10.1055/s-2007-970026.

Suspension cultures of Digitalis lanata strain I were grown in a medium containing 3% mannitol. For cryopreservation cell suspensions were treated with a mixture of sucrose-glycerol (20%/20 V%), cooled slowly (about 1 degrees C/min) till -100 degrees C and...

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Diettrich B, Popov AS, Pfeiffer B, et al. Cryopreservation of Digitalis lanata cell cultures. Planta Med. 1982;46(2):82-7doi: 10.1055/s-2007-970026.
Diettrich, B., Popov, A. S., Pfeiffer, B., Neumann, D., Butenko, R., & Luckner, M. (1982). Cryopreservation of Digitalis lanata cell cultures. Planta medica, 46(2), 82-7. https://doi.org/10.1055/s-2007-970026
Diettrich, B, et al. "Cryopreservation of Digitalis lanata cell cultures." Planta medica vol. 46,2 (1982): 82-7. doi: https://doi.org/10.1055/s-2007-970026
Diettrich B, Popov AS, Pfeiffer B, Neumann D, Butenko R, Luckner M. Cryopreservation of Digitalis lanata cell cultures. Planta Med. 1982 Oct;46(2):82-7. doi: 10.1055/s-2007-970026. PMID: 17396948.
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Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression.

Journal of carcinogenesis

Yang QF, Dalgard CL, Eidelman O, Jozwik C, Pollard BS, Srivastava M, Pollard HB.
PMID: 23858296
J Carcinog. 2013 May 20;12:8. doi: 10.4103/1477-3163.112268. Print 2013.

BACKGROUND: Cardiac glycosides such as digitoxin have been shown to directly cause apoptotic death of cancer cells both in vitro, and in vivo. However, the mechanism connecting cardiac glycoside action to apoptosis is not known. It has been reported...

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Yang QF, Dalgard CL, Eidelman O, et al. Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression. J Carcinog. 2013;12:8doi: 10.4103/1477-3163.112268.
Yang, Q. F., Dalgard, C. L., Eidelman, O., Jozwik, C., Pollard, B. S., Srivastava, M., & Pollard, H. B. (2013). Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression. Journal of carcinogenesis, 128. https://doi.org/10.4103/1477-3163.112268
Yang, Qing Feng, et al. "Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression." Journal of carcinogenesis vol. 12 (2013): 8. doi: https://doi.org/10.4103/1477-3163.112268
Yang QF, Dalgard CL, Eidelman O, Jozwik C, Pollard BS, Srivastava M, Pollard HB. Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression. J Carcinog. 2013 May 20;12:8. doi: 10.4103/1477-3163.112268. Print 2013. PMID: 23858296; PMCID: PMC3709410.
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Seasonal and intraplant variation of cardenolide content in the California milkweed,Asclepias eriocarpa, and implications for plant defense.

Journal of chemical ecology

Nelson CJ, Seiber JN, Brower LP.
PMID: 24420825
J Chem Ecol. 1981 Nov;7(6):981-1010. doi: 10.1007/BF00987622.

Root, stem, leaf, and latex samples ofAsclepias eriocarpa collected from three plots in one population at 12 monthly intervals were assayed for total cardenolide content by spectroassay and for individual cardenolides by thin-layer chromatography. From May to September mean...

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Nelson CJ, Seiber JN, Brower LP. Seasonal and intraplant variation of cardenolide content in the California milkweed,Asclepias eriocarpa, and implications for plant defense. J Chem Ecol. 1981;7(6):981-1010doi: 10.1007/BF00987622.
Nelson, C. J., Seiber, J. N., & Brower, L. P. (1981). Seasonal and intraplant variation of cardenolide content in the California milkweed,Asclepias eriocarpa, and implications for plant defense. Journal of chemical ecology, 7(6), 981-1010. https://doi.org/10.1007/BF00987622
Nelson, C J, et al. "Seasonal and intraplant variation of cardenolide content in the California milkweed,Asclepias eriocarpa, and implications for plant defense." Journal of chemical ecology vol. 7,6 (1981): 981-1010. doi: https://doi.org/10.1007/BF00987622
Nelson CJ, Seiber JN, Brower LP. Seasonal and intraplant variation of cardenolide content in the California milkweed,Asclepias eriocarpa, and implications for plant defense. J Chem Ecol. 1981 Nov;7(6):981-1010. doi: 10.1007/BF00987622. PMID: 24420825.
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Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer.

Frontiers in oncology

Pollard BS, Suckow MA, Wolter WR, Starr JM, Eidelman O, Dalgard CL, Kumar P, Battacharyya S, Srivastava M, Biswas R, Wilkerson MD, Zhang X, Yang Q, Pollard HB.
PMID: 31428571
Front Oncol. 2019 Aug 02;9:630. doi: 10.3389/fonc.2019.00630. eCollection 2019.

Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor suppressor, but in advanced metastatic disease it switches...

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Pollard BS, Suckow MA, Wolter WR, et al. Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer. Front Oncol. 2019;9:630doi: 10.3389/fonc.2019.00630.
Pollard, B. S., Suckow, M. A., Wolter, W. R., Starr, J. M., Eidelman, O., Dalgard, C. L., Kumar, P., Battacharyya, S., Srivastava, M., Biswas, R., Wilkerson, M. D., Zhang, X., Yang, Q., & Pollard, H. B. (2019). Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer. Frontiers in oncology, 9630. https://doi.org/10.3389/fonc.2019.00630
Pollard, Bette S, et al. "Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer." Frontiers in oncology vol. 9 (2019): 630. doi: https://doi.org/10.3389/fonc.2019.00630
Pollard BS, Suckow MA, Wolter WR, Starr JM, Eidelman O, Dalgard CL, Kumar P, Battacharyya S, Srivastava M, Biswas R, Wilkerson MD, Zhang X, Yang Q, Pollard HB. Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer. Front Oncol. 2019 Aug 02;9:630. doi: 10.3389/fonc.2019.00630. eCollection 2019. PMID: 31428571; PMCID: PMC6687970.
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Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca.

Journal of cellular biochemistry

Valadares JMM, Bajaj SO, Li H, Wang HL, Silva SC, Garcia IJP, Pereira DG, Azalim P, Quintas LEM, Noël F, Cortes VF, O'Doherty GA, Barbosa LA.
PMID: 34553411
J Cell Biochem. 2021 Dec;122(12):1903-1914. doi: 10.1002/jcb.30150. Epub 2021 Sep 22.

Cardiac glycosides, such as digoxin and digitoxin, are compounds that interact with Na

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Valadares JMM, Bajaj SO, Li H, et al. Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca. J Cell Biochem. 2021;122(12):1903-1914doi: 10.1002/jcb.30150.
Valadares, J. M. M., Bajaj, S. O., Li, H., Wang, H. L., Silva, S. C., Garcia, I. J. P., Pereira, D. G., Azalim, P., Quintas, L. E. M., Noël, F., Cortes, V. F., O'Doherty, G. A., & Barbosa, L. A. (2021). Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca. Journal of cellular biochemistry, 122(12), 1903-1914. https://doi.org/10.1002/jcb.30150
Valadares, Jéssica Martins de Moura, et al. "Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca." Journal of cellular biochemistry vol. 122,12 (2021): 1903-1914. doi: https://doi.org/10.1002/jcb.30150
Valadares JMM, Bajaj SO, Li H, Wang HL, Silva SC, Garcia IJP, Pereira DG, Azalim P, Quintas LEM, Noël F, Cortes VF, O'Doherty GA, Barbosa LA. Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca. J Cell Biochem. 2021 Dec;122(12):1903-1914. doi: 10.1002/jcb.30150. Epub 2021 Sep 22. PMID: 34553411; PMCID: PMC8671332.
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Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells.

Chemico-biological interactions

Mi C, Cao X, Ma K, Wei M, Xu W, Lin Y, Zhang J, Wang TY.
PMID: 34717917
Chem Biol Interact. 2021 Oct 28;351:109729. doi: 10.1016/j.cbi.2021.109729. Epub 2021 Oct 28.

Colon cancer patients with mutant KRAS are resistant to cetuximab, an antibody directed against the epidermal growth factor receptor. New treatment options are needed to improve survival in patients with KRAS mutated colorectal cancer. Digitoxin is a cardiotonic drug,...

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Mi C, Cao X, Ma K, et al. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chem Biol Interact. 2021;351:109729doi: 10.1016/j.cbi.2021.109729.
Mi, C., Cao, X., Ma, K., Wei, M., Xu, W., Lin, Y., Zhang, J., & Wang, T. Y. (2021). Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions, 351109729. https://doi.org/10.1016/j.cbi.2021.109729
Mi, Chunliu, et al. "Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells." Chemico-biological interactions vol. 351 (2021): 109729. doi: https://doi.org/10.1016/j.cbi.2021.109729
Mi C, Cao X, Ma K, Wei M, Xu W, Lin Y, Zhang J, Wang TY. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chem Biol Interact. 2021 Oct 28;351:109729. doi: 10.1016/j.cbi.2021.109729. Epub 2021 Oct 28. PMID: 34717917.
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Multipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated-Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Mu W, Chu Q, Yang H, Guan L, Fu S, Gao T, Sang X, Zhang Z, Liang S, Liu Y, Zhang N.
PMID: 35032117
Adv Sci (Weinh). 2022 Jan 14;e2101472. doi: 10.1002/advs.202101472. Epub 2022 Jan 14.

Eliminating primary tumor ("roots") and inhibiting associated-circulating tumor cells (associated-CTCs, "seeds") are vital issues that need to be urgently addressed in cancer therapy. Associated-CTCs, which include single CTCs, CTC clusters, and CTC-neutrophil clusters, are essential executors in metastasis and...

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Mu W, Chu Q, Yang H, et al. Multipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated-Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC. Adv Sci (Weinh). 2022;e2101472doi: 10.1002/advs.202101472.
Mu, W., Chu, Q., Yang, H., Guan, L., Fu, S., Gao, T., Sang, X., Zhang, Z., Liang, S., Liu, Y., & Zhang, N. (2022). Multipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated-Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e2101472. https://doi.org/10.1002/advs.202101472
Mu, Weiwei, et al. "Multipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated-Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC." Advanced science (Weinheim, Baden-Wurttemberg, Germany) vol. (2022): e2101472. doi: https://doi.org/10.1002/advs.202101472
Mu W, Chu Q, Yang H, Guan L, Fu S, Gao T, Sang X, Zhang Z, Liang S, Liu Y, Zhang N. Multipoint Costriking Nanodevice Eliminates Primary Tumor Cells and Associated-Circulating Tumor Cells for Enhancing Metastasis Inhibition and Therapeutic Effect on HCC. Adv Sci (Weinh). 2022 Jan 14;e2101472. doi: 10.1002/advs.202101472. Epub 2022 Jan 14. PMID: 35032117.
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The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis.

Cancers

Kenny HA, Hart PC, Kordylewicz K, Lal M, Shen M, Kara B, Chen YJ, Grassl N, Alharbi Y, Pattnaik BR, Watters KM, Patankar MS, Ferrer M, Lengyel E.
PMID: 34439084
Cancers (Basel). 2021 Aug 04;13(16). doi: 10.3390/cancers13163931.

The high mortality of OvCa is caused by the wide dissemination of cancer within the abdominal cavity. OvCa cells metastasize to the peritoneum, which is covered by mesothelial cells, and invade into the underlying stroma, composed of extracellular matrices...

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Kenny HA, Hart PC, Kordylewicz K, et al. The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis. Cancers (Basel). 2021;13(16)doi: 10.3390/cancers13163931.
Kenny, H. A., Hart, P. C., Kordylewicz, K., Lal, M., Shen, M., Kara, B., Chen, Y. J., Grassl, N., Alharbi, Y., Pattnaik, B. R., Watters, K. M., Patankar, M. S., Ferrer, M., & Lengyel, E. (2021). The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis. Cancers, 13(16), . https://doi.org/10.3390/cancers13163931
Kenny, Hilary A, et al. "The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis." Cancers vol. 13,16 (2021). doi: https://doi.org/10.3390/cancers13163931
Kenny HA, Hart PC, Kordylewicz K, Lal M, Shen M, Kara B, Chen YJ, Grassl N, Alharbi Y, Pattnaik BR, Watters KM, Patankar MS, Ferrer M, Lengyel E. The Natural Product β-Escin Targets Cancer and Stromal Cells of the Tumor Microenvironment to Inhibit Ovarian Cancer Metastasis. Cancers (Basel). 2021 Aug 04;13(16). doi: 10.3390/cancers13163931. PMID: 34439084; PMCID: PMC8394501.
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Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells.

Chemico-biological interactions

Mi C, Cao X, Ma K, Wei M, Xu W, Lin Y, Zhang J, Wang TY.
PMID: 34717917
Chem Biol Interact. 2021 Oct 28;351:109729. doi: 10.1016/j.cbi.2021.109729. Epub 2021 Oct 28.

Colon cancer patients with mutant KRAS are resistant to cetuximab, an antibody directed against the epidermal growth factor receptor. New treatment options are needed to improve survival in patients with KRAS mutated colorectal cancer. Digitoxin is a cardiotonic drug,...

Cite
Mi C, Cao X, Ma K, et al. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chem Biol Interact. 2021;351:109729doi: 10.1016/j.cbi.2021.109729.
Mi, C., Cao, X., Ma, K., Wei, M., Xu, W., Lin, Y., Zhang, J., & Wang, T. Y. (2021). Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions, 351109729. https://doi.org/10.1016/j.cbi.2021.109729
Mi, Chunliu, et al. "Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells." Chemico-biological interactions vol. 351 (2021): 109729. doi: https://doi.org/10.1016/j.cbi.2021.109729
Mi C, Cao X, Ma K, Wei M, Xu W, Lin Y, Zhang J, Wang TY. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chem Biol Interact. 2021 Oct 28;351:109729. doi: 10.1016/j.cbi.2021.109729. Epub 2021 Oct 28. PMID: 34717917.
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Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells.

Chemico-biological interactions

Mi C, Cao X, Ma K, Wei M, Xu W, Lin Y, Zhang J, Wang TY.
PMID: 34717917
Chem Biol Interact. 2021 Oct 28;351:109729. doi: 10.1016/j.cbi.2021.109729. Epub 2021 Oct 28.

Colon cancer patients with mutant KRAS are resistant to cetuximab, an antibody directed against the epidermal growth factor receptor. New treatment options are needed to improve survival in patients with KRAS mutated colorectal cancer. Digitoxin is a cardiotonic drug,...

Cite
Mi C, Cao X, Ma K, et al. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chem Biol Interact. 2021;351:109729doi: 10.1016/j.cbi.2021.109729.
Mi, C., Cao, X., Ma, K., Wei, M., Xu, W., Lin, Y., Zhang, J., & Wang, T. Y. (2021). Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chemico-biological interactions, 351109729. https://doi.org/10.1016/j.cbi.2021.109729
Mi, Chunliu, et al. "Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells." Chemico-biological interactions vol. 351 (2021): 109729. doi: https://doi.org/10.1016/j.cbi.2021.109729
Mi C, Cao X, Ma K, Wei M, Xu W, Lin Y, Zhang J, Wang TY. Digitoxin promotes apoptosis and inhibits proliferation and migration by reducing HIF-1α and STAT3 in KRAS mutant human colon cancer cells. Chem Biol Interact. 2021 Oct 28;351:109729. doi: 10.1016/j.cbi.2021.109729. Epub 2021 Oct 28. PMID: 34717917.
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Showing 1 to 12 of 58 entries