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Showing 1 to 12 of 15 entries
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The interpretation of uterine artery pulsatility index in normal and hypertensive pregnancy.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

Grunewald C, Kublickas M, Nisell H, Nylund L, Westgren M.
PMID: 12797128
Ultrasound Obstet Gynecol. 1994 Nov 01;4(6):476-9. doi: 10.1046/j.1469-0705.1994.04060476.x.

The Doppler flow velocity pulsatility index (PI) of the uteroplacental vascular bed is of debatable value for the interpretation of hemodynamic changes, when these are due both to pathological alterations in the vasculature, as in mild pre-eclampsia, and to...

Effect of dihydralazine on the fluidity of erythrocyte membranes.

Biochemistry and molecular biology international

Maliszewska-Mazur M, Sikorski AF, Jezierski A.
PMID: 19856285
Biochem Mol Biol Int. 1997 Jul;42(4):693-9. doi: 10.1080/15216549700203111.

Dihydralazine, a drug used in the treatment of chronic hypertension was found to affect the mobility of fatty acid hydrocarbon chains followed by spin-labelling technique with the use of 5-, 12- and 16-doxylstearate. The effect of this drug on...

Autoantibodies and defined target autoantigens in autoimmune hepatitis: an overview.

European journal of internal medicine

Dalekos GN, Zachou K, Liaskos C, Gatselis N.
PMID: 12144908
Eur J Intern Med. 2002 Aug;13(5):293-303. doi: 10.1016/s0953-6205(02)00089-4.

Autoimmune hepatitis (AIH) is a disease of unknown aetiology characterised by hypergammaglobulinaemia, non-organ and liver-related autoantibodies, association with HLA-DR3 or DR4 and a favourable response to immunosuppression. The current classification of AIH and the several autoantibodies/target autoantigens found in...

Autoantibodies and autoantigens in autoimmune hepatitis: important tools in clinical practice and to study pathogenesis of the disease.

Journal of autoimmune diseases

Zachou K, Rigopoulou E, Dalekos GN.
PMID: 15679907
J Autoimmune Dis. 2004 Oct 15;1(1):2. doi: 10.1186/1740-2557-1-2.

Autoimmune hepatitis (AIH) is a chronic necroinflammatory disease of the liver characterized by hypergammaglobulinemia, characteristic autoantibodies, association with HLA DR3 or DR4 and a favorable response to immunosuppressive treatment. The etiology is unknown. The detection of non-organ and liver-related...

Flow-injection stopped-flow kinetic spectrophotometric determination of drugs, based on micellar-catalysed reaction with 1-fluoro-2,4-dinitrobenzene.

Talanta

Georgiou CA, Koupparis MA, Hadjiioannou TP.
PMID: 18965207
Talanta. 1991 Jul;38(7):689-96. doi: 10.1016/0039-9140(91)80187-5.

A flow-injection stopped-flow kinetic spectrophotometric method for the determination of hydrazines, hydrazides, amines and amino-acids, based on the cetyltrimethylammonium bromide catalysed reaction with 1-fluoro-2,4-dinitrobenzene is described. With the proposed method dihydralazine, isoniazid, levodopa and aspartame can be determined at...

Simultaneous spectrophotometric determination of diuretics by using multivariate calibration methods.

Talanta

Luis ML, Fraga JM, Jiménez F, Jiménez AI, Arias JJ.
PMID: 18968165
Talanta. 2001 Jan 05;53(4):761-70. doi: 10.1016/s0039-9140(00)00538-5.

The wavelength range and number of factors used in partial least-squares (PLS) calibration for the resolution of the dihydralazine (DHZ)-hydrochlorothiazide (HCT) binary mixture and the dihydralazine-hydrochlorothiazide-reserpine ternary mixture were optimized in terms of the relative standard error (R.S.E.) and...

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.

ACS chemical biology

Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL.
PMID: 34904435
ACS Chem Biol. 2021 Dec 14; doi: 10.1021/acschembio.1c00721. Epub 2021 Dec 14.

Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a promising target for antiviral therapy. However, no potent...

Medication Safety in Intravenous Therapy: A Compatibility Study of Clonidine with Drugs Frequently Used in Intensive Care.

Pharmaceutics

Koller AK, Krebs S, Dörje F.
PMID: 33374362
Pharmaceutics. 2020 Dec 24;13(1). doi: 10.3390/pharmaceutics13010021.

The intravenous pharmacotherapy of critically ill patients is extremely challenging due to the high number of drugs administered. We therefore evaluated the physicochemical compatibility of combinations of clonidine with drugs frequently used in an intensive care unit setting. Amiodarone,...

Renin Secretion in Advanced Diabetic Nephropathy.

Scandinavian journal of urology and nephrology

Björck S, Delin K, Herlitz H, Larsson O, Aurell M.
PMID: 27786005
Scand J Urol Nephrol. 1984 Jul;18:53-57. doi: 10.1080/00365599.1984.11783716.

Low basal and stimulated plasma renin activity (PRA) levels have been reported in patients witn diabetic nephropathy (DN). We have measured PRA before and after stimulation with captopril in 28 patients with DN and in 25 control patients. Renal...

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.

ACS chemical biology

Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL.
PMID: 34904435
ACS Chem Biol. 2021 Dec 14; doi: 10.1021/acschembio.1c00721. Epub 2021 Dec 14.

Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a promising target for antiviral therapy. However, no potent...

Kinetics and Characterization of Degradation Products of Dihydralazine and Hydrochlorothiazide in Binary Mixture by HPLC-UV, LC-DAD and LC-MS Methods.

Chromatographia

Gumieniczek A, Galeza J, Mroczek T, Wojtanowski K, Lipska K, Pietras R.
PMID: 30220731
Chromatographia. 2018;81(8):1147-1162. doi: 10.1007/s10337-018-3555-8. Epub 2018 Jun 25.

Dihydralazine and hydrochlorothiazide were stored at high temperature and humidity, under UV/Vis light and different pH, as individual drugs and the mixture. Then, a sensitive and selective HPLC-UV method was developed for simultaneous determination of dihydralazine and hydrochlorothiazide in...

Thermodynamic and Kinetic Studies of the Radical Scavenging Behavior of Hydralazine and Dihydralazine: Theoretical Insights.

The journal of physical chemistry. B

Boulebd H, Khodja IA, Bay MV, Hoa NT, Mechler A, Vo QV.
PMID: 32315525
J Phys Chem B. 2020 May 21;124(20):4123-4131. doi: 10.1021/acs.jpcb.0c02439. Epub 2020 May 06.

Hydralazine (HZ) and dihydralazine (DHZ) are phthalazine derivatives substituted at position 1 (HZ) or positions 1 and 4 (DHZ) by a hydrazinyl substituent. These compounds are widely used for treating hypertension and heart failure, essentially acting as vasodilators on...

Showing 1 to 12 of 15 entries