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Dihydroergotoxine treatment improves active avoidance performance and increases dopamine-stimulated adenylate cyclase activity, in young and aged rats.

Behavioural pharmacology

Florio T, Ventra C, Rapanà A, Scorziello A, Cocozza Di Montanara E, Marino A, Schettini G.
PMID: 11224045
Behav Pharmacol. 1991 Feb;2(1):31-36.

Dihydroergotoxine (DHET) improved the acquisition of a conditioned avoidance response in both young and old rats, although old animals, reached a lower percentage of conditioned responses than did young rats. DHET dose-dependently reduced locomotor activity in aged animals, while,...

Effects of chronic codergocrine mesylate administration on the brain somatostatinergic system in aged rats.

Archives of gerontology and geriatrics

Tanaka K, Ogawa N, Asanuma M, Hirata H, Kondo Y, Chou HH, Mori A.
PMID: 15374370
Arch Gerontol Geriatr. 1992 Sep-Oct;15(2):133-9. doi: 10.1016/0167-4943(92)90013-t.

Codergocrine mesylate (dihydroergotoxine; DHET), which is an ergot derivative, has been reported to counteract some age-induced impairments in brain function, but the mechanism of these effects is not known. We examined the effect of chronic DHET administration on the...

Showing 1 to 2 of 2 entries