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Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy.

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India

Shukla J, Mittal BR.
PMID: 26430311
Indian J Nucl Med. 2015 Oct-Dec;30(4):295-302. doi: 10.4103/0972-3919.164015.

Dimercaptosuccinic acid (DMSA) is an analog of dimercaprol used as metal chelating moiety in variety of conditions. In nuclear medicine itself two types of Tc-99m DMSA complexes are used, trivalent and pentavalent forms. In this review, we have discussed...

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Shukla J, Mittal BR. Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy. Indian J Nucl Med. 2015;30(4):295-302doi: 10.4103/0972-3919.164015.
Shukla, J., & Mittal, B. R. (2015). Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy. Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India, 30(4), 295-302. https://doi.org/10.4103/0972-3919.164015
Shukla, Jaya, and Mittal, Bhagwant Rai. "Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy." Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India vol. 30,4 (2015): 295-302. doi: https://doi.org/10.4103/0972-3919.164015
Shukla J, Mittal BR. Dimercaptosuccinic acid: A multifunctional cost effective agent for imaging and therapy. Indian J Nucl Med. 2015 Oct-Dec;30(4):295-302. doi: 10.4103/0972-3919.164015. PMID: 26430311; PMCID: PMC4579612.
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Unilateral rubral tremors in Wilson's disease treated with dimercaprol.

Annals of Indian Academy of Neurology

Chakor RT, Bharote H, Eklare N, Tamboli K.
PMID: 25745328
Ann Indian Acad Neurol. 2015 Jan-Mar;18(1):115-6. doi: 10.4103/0972-2327.144286.

Tremors are reported as the most frequent neurological manifestation of Wilson's disease (WD) in some series. Postural tremors, rest tremors, action tremors and wing-beating (rubral) tremors are the different types of tremors seen in WD. We report a patient...

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Chakor RT, Bharote H, Eklare N, et al. Unilateral rubral tremors in Wilson's disease treated with dimercaprol. Ann Indian Acad Neurol. 2015;18(1):115-6doi: 10.4103/0972-2327.144286.
Chakor, R. T., Bharote, H., Eklare, N., & Tamboli, K. (2015). Unilateral rubral tremors in Wilson's disease treated with dimercaprol. Annals of Indian Academy of Neurology, 18(1), 115-6. https://doi.org/10.4103/0972-2327.144286
Chakor, Rahul T, et al. "Unilateral rubral tremors in Wilson's disease treated with dimercaprol." Annals of Indian Academy of Neurology vol. 18,1 (2015): 115-6. doi: https://doi.org/10.4103/0972-2327.144286
Chakor RT, Bharote H, Eklare N, Tamboli K. Unilateral rubral tremors in Wilson's disease treated with dimercaprol. Ann Indian Acad Neurol. 2015 Jan-Mar;18(1):115-6. doi: 10.4103/0972-2327.144286. PMID: 25745328; PMCID: PMC4350197.
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Inhibition of lipase and inflammatory mediators by Chlorella lipid extracts for antiacne treatment.

Journal of advanced pharmaceutical technology & research

Sibi G.
PMID: 25709963
J Adv Pharm Technol Res. 2015 Jan-Mar;6(1):7-12. doi: 10.4103/2231-4040.150364.

Acne vulgaris is a chronic inflammatory disease, and its treatment is challenging due to the multifactorial etiology and emergence of antibiotic-resistant Propionibacterium acnes strains. This study was focused to reduce antibiotics usage and find an alternate therapeutic source for...

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Sibi G. Inhibition of lipase and inflammatory mediators by Chlorella lipid extracts for antiacne treatment. J Adv Pharm Technol Res. 2015;6(1):7-12doi: 10.4103/2231-4040.150364.
Sibi, G. (2015). Inhibition of lipase and inflammatory mediators by Chlorella lipid extracts for antiacne treatment. Journal of advanced pharmaceutical technology & research, 6(1), 7-12. https://doi.org/10.4103/2231-4040.150364
Sibi, G. "Inhibition of lipase and inflammatory mediators by Chlorella lipid extracts for antiacne treatment." Journal of advanced pharmaceutical technology & research vol. 6,1 (2015): 7-12. doi: https://doi.org/10.4103/2231-4040.150364
Sibi G. Inhibition of lipase and inflammatory mediators by Chlorella lipid extracts for antiacne treatment. J Adv Pharm Technol Res. 2015 Jan-Mar;6(1):7-12. doi: 10.4103/2231-4040.150364. PMID: 25709963; PMCID: PMC4330611.
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THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS : I. ANTICOAGULANT EFFECTS OF ARSENIC AZOPROTEINS IN VIVO AND IN VITRO: COMPARISON OF ARSENICALS AS ANTICOAGULANTS AND AS ANTILYMPHOMA AGENTS: MOLECULAR STRUCTURE IN RELATION TO ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES.

The Journal of experimental medicine

Broome JD, Kidd JG.
PMID: 19867291
J Exp Med. 1964 Sep 01;120(3):449-66. doi: 10.1084/jem.120.3.449.

Experiments given in this paper have shown that 4-arsonophenylazoproteins possess marked anticoagulant activity both in vivo and in vitro. Mice and rabbits given moderate amounts of the arsenic azoprotein, for example, often bled to death from injuries that proved...

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Broome JD, Kidd JG. THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS : I. ANTICOAGULANT EFFECTS OF ARSENIC AZOPROTEINS IN VIVO AND IN VITRO: COMPARISON OF ARSENICALS AS ANTICOAGULANTS AND AS ANTILYMPHOMA AGENTS: MOLECULAR STRUCTURE IN RELATION TO ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES. J Exp Med. 1964;120(3):449-66doi: 10.1084/jem.120.3.449.
Broome, J. D., & Kidd, J. G. (1964). THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS : I. ANTICOAGULANT EFFECTS OF ARSENIC AZOPROTEINS IN VIVO AND IN VITRO: COMPARISON OF ARSENICALS AS ANTICOAGULANTS AND AS ANTILYMPHOMA AGENTS: MOLECULAR STRUCTURE IN RELATION TO ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES. The Journal of experimental medicine, 120(3), 449-66. https://doi.org/10.1084/jem.120.3.449
Broome, J D, and Kidd, J G. "THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS : I. ANTICOAGULANT EFFECTS OF ARSENIC AZOPROTEINS IN VIVO AND IN VITRO: COMPARISON OF ARSENICALS AS ANTICOAGULANTS AND AS ANTILYMPHOMA AGENTS: MOLECULAR STRUCTURE IN RELATION TO ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES." The Journal of experimental medicine vol. 120,3 (1964): 449-66. doi: https://doi.org/10.1084/jem.120.3.449
Broome JD, Kidd JG. THE ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES OF ARSENIC AZOPROTEINS : I. ANTICOAGULANT EFFECTS OF ARSENIC AZOPROTEINS IN VIVO AND IN VITRO: COMPARISON OF ARSENICALS AS ANTICOAGULANTS AND AS ANTILYMPHOMA AGENTS: MOLECULAR STRUCTURE IN RELATION TO ANTICOAGULANT AND ANTILYMPHOMA PROPERTIES. J Exp Med. 1964 Sep 01;120(3):449-66. doi: 10.1084/jem.120.3.449. PMID: 19867291; PMCID: PMC2137767.
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Cross-linked chitosan aerogel modified with Au: Synthesis, characterization and catalytic application.

Carbohydrate polymers

Keshipour S, Mirmasoudi SS.
PMID: 29891323
Carbohydr Polym. 2018 Sep 15;196:494-500. doi: 10.1016/j.carbpol.2018.05.068. Epub 2018 May 24.

Dimercaprol as the chelating agent of Au(III) was loaded on chitosan aerogel. Dimercaprol supported on chitosan aerogel efficiently was complexed with Au(III). The new organometallic compound showed good catalytic activity in the oxidation reaction of some aliphatic alcohols, benzyl...

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Keshipour S, Mirmasoudi SS. Cross-linked chitosan aerogel modified with Au: Synthesis, characterization and catalytic application. Carbohydr Polym. 2018;196:494-500doi: 10.1016/j.carbpol.2018.05.068.
Keshipour, S., & Mirmasoudi, S. S. (2018). Cross-linked chitosan aerogel modified with Au: Synthesis, characterization and catalytic application. Carbohydrate polymers, 196494-500. https://doi.org/10.1016/j.carbpol.2018.05.068
Keshipour, Sajjad, and Mirmasoudi, Seyyedeh Sahra. "Cross-linked chitosan aerogel modified with Au: Synthesis, characterization and catalytic application." Carbohydrate polymers vol. 196 (2018): 494-500. doi: https://doi.org/10.1016/j.carbpol.2018.05.068
Keshipour S, Mirmasoudi SS. Cross-linked chitosan aerogel modified with Au: Synthesis, characterization and catalytic application. Carbohydr Polym. 2018 Sep 15;196:494-500. doi: 10.1016/j.carbpol.2018.05.068. Epub 2018 May 24. PMID: 29891323.
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Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms.

Acta pharmaceutica Sinica. B

Xie C, Slagboom J, Albulescu LO, Somsen GW, Vonk FJ, Casewell NR, Kool J.
PMID: 33163338
Acta Pharm Sin B. 2020 Oct;10(10):1835-1845. doi: 10.1016/j.apsb.2020.09.005. Epub 2020 Sep 15.

Repurposing small molecule drugs and drug candidates is considered as a promising approach to revolutionise the treatment of snakebite envenoming. In this study, we investigated the inhibiting effects of the small molecules varespladib (nonspecific phospholipase A

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Xie C, Slagboom J, Albulescu LO, et al. Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms. Acta Pharm Sin B. 2020;10(10):1835-1845doi: 10.1016/j.apsb.2020.09.005.
Xie, C., Slagboom, J., Albulescu, L. O., Somsen, G. W., Vonk, F. J., Casewell, N. R., & Kool, J. (2020). Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms. Acta pharmaceutica Sinica. B, 10(10), 1835-1845. https://doi.org/10.1016/j.apsb.2020.09.005
Xie, Chunfang, et al. "Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms." Acta pharmaceutica Sinica. B vol. 10,10 (2020): 1835-1845. doi: https://doi.org/10.1016/j.apsb.2020.09.005
Xie C, Slagboom J, Albulescu LO, Somsen GW, Vonk FJ, Casewell NR, Kool J. Neutralising effects of small molecule toxin inhibitors on nanofractionated coagulopathic Crotalinae snake venoms. Acta Pharm Sin B. 2020 Oct;10(10):1835-1845. doi: 10.1016/j.apsb.2020.09.005. Epub 2020 Sep 15. PMID: 33163338; PMCID: PMC7606088.
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Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts.

Technology in cancer research & treatment

Tang R, Zhu J, Liu Y, Wu N, Han J.
PMID: 34433326
Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211036324. doi: 10.1177/15330338211036324.

OBJECTIVE: To investigate the efficacy of a formula comprising arsenic trioxide and dimercaprol (BAL-ATO) as a radiosensitizing agent in model mice with pancreatic cancer xenografts.METHODS: Female BALB/c nude mice bearing SW1990 human pancreatic cancer xenografts were divided into four...

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Tang R, Zhu J, Liu Y, et al. Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts. Technol Cancer Res Treat. 2021;20:15330338211036324doi: 10.1177/15330338211036324.
Tang, R., Zhu, J., Liu, Y., Wu, N., & Han, J. (2021). Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts. Technology in cancer research & treatment, 2015330338211036324. https://doi.org/10.1177/15330338211036324
Tang, Renyan, et al. "Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts." Technology in cancer research & treatment vol. 20 (2021): 15330338211036324. doi: https://doi.org/10.1177/15330338211036324
Tang R, Zhu J, Liu Y, Wu N, Han J. Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts. Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211036324. doi: 10.1177/15330338211036324. PMID: 34433326; PMCID: PMC8404670.
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[Arterial hypertension due to mercury intoxication with clinical and laboratorial syndrome simulating pheochromocytoma].

Jornal de pediatria

de Oliveira JJ, Silva SR.
PMID: 14688974
J Pediatr (Rio J). 1996 Jan-Feb;72(1):40-3. doi: 10.2223/jped.601.

A 17-year-old boy was admitted to hospital because of severe hypertension (200/130 mmHg), headache, irritability, sweating, etc. Initial biochemical tests suggested pheochromocytoma, being treated with nifedipina, clonidina and propranolol. On reporting exposure to mercury vapour, he underwent twenty-four-hour urine...

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de Oliveira JJ, Silva SR. Hipertensão arterial secundária a intoxicação por mercúrio com síndrome clínico-laboratorial simulando feocromocitoma. [Arterial hypertension due to mercury intoxication with clinical and laboratorial syndrome simulating pheochromocytoma]. J Pediatr (Rio J). 1996;72(1):40-3doi: 10.2223/jped.601.
de Oliveira, J. J., & Silva, S. R. (1996). Hipertensão arterial secundária a intoxicação por mercúrio com síndrome clínico-laboratorial simulando feocromocitoma. [Arterial hypertension due to mercury intoxication with clinical and laboratorial syndrome simulating pheochromocytoma]. Jornal de pediatria, 72(1), 40-3. https://doi.org/10.2223/jped.601
de Oliveira, J J, and Silva, S R. "Hipertensão arterial secundária a intoxicação por mercúrio com síndrome clínico-laboratorial simulando feocromocitoma." [Arterial hypertension due to mercury intoxication with clinical and laboratorial syndrome simulating pheochromocytoma]. Jornal de pediatria vol. 72,1 (1996): 40-3. doi: https://doi.org/10.2223/jped.601
de Oliveira JJ, Silva SR. Hipertensão arterial secundária a intoxicação por mercúrio com síndrome clínico-laboratorial simulando feocromocitoma. [Arterial hypertension due to mercury intoxication with clinical and laboratorial syndrome simulating pheochromocytoma]. J Pediatr (Rio J). 1996 Jan-Feb;72(1):40-3. doi: 10.2223/jped.601. Portuguese. PMID: 14688974.
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Treatment and toxicokinetics of acute pediatric arsenic ingestion: danger of arsenic insecticides in children.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies

Stephanopoulos DE, Willman DA, Shevlin D, Pinter L, Gummin DD.
PMID: 12793928
Pediatr Crit Care Med. 2002 Jan;3(1):74-80. doi: 10.1097/00130478-200201000-00017.

OBJECTIVES: To describe the toxicokinetics and management of acute pediatric arsenic ingestion.DESIGN: Case report and literature review.SETTING: Tertiary pediatric intensive care unit, St. John's Children's Hospital, Springfield, IL.PATIENT: A 22-month-old boy ingested approximately twice the estimated lethal dose of...

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Stephanopoulos DE, Willman DA, Shevlin D, et al. Treatment and toxicokinetics of acute pediatric arsenic ingestion: danger of arsenic insecticides in children. Pediatr Crit Care Med. 2002;3(1):74-80doi: 10.1097/00130478-200201000-00017.
Stephanopoulos, D. E., Willman, D. A., Shevlin, D., Pinter, L., & Gummin, D. D. (2002). Treatment and toxicokinetics of acute pediatric arsenic ingestion: danger of arsenic insecticides in children. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 3(1), 74-80. https://doi.org/10.1097/00130478-200201000-00017
Stephanopoulos, Dimitrios E, et al. "Treatment and toxicokinetics of acute pediatric arsenic ingestion: danger of arsenic insecticides in children." Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies vol. 3,1 (2002): 74-80. doi: https://doi.org/10.1097/00130478-200201000-00017
Stephanopoulos DE, Willman DA, Shevlin D, Pinter L, Gummin DD. Treatment and toxicokinetics of acute pediatric arsenic ingestion: danger of arsenic insecticides in children. Pediatr Crit Care Med. 2002 Jan;3(1):74-80. doi: 10.1097/00130478-200201000-00017. PMID: 12793928.
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Severe Abdominal Pain Caused by Lead Toxicity without Response to Oral Chelators: A Case Report.

Middle East journal of digestive diseases

Vossoughinia H, Pourakbar A, Esfandiari S, Sharifianrazavi M.
PMID: 26933485
Middle East J Dig Dis. 2016 Jan;8(1):67-72. doi: 10.15171/mejdd.2016.10.

A 19-year-old woman was referred to the Emergency Surgery Department with severe abdominal pain, icterus, and anemia. The patient's clinical and paraclinical findings in addition to her occupational and social history, convinced us to assay blood lead level (BLL),...

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Vossoughinia H, Pourakbar A, Esfandiari S, et al. Severe Abdominal Pain Caused by Lead Toxicity without Response to Oral Chelators: A Case Report. Middle East J Dig Dis. 2016;8(1):67-72doi: 10.15171/mejdd.2016.10.
Vossoughinia, H., Pourakbar, A., Esfandiari, S., & Sharifianrazavi, M. (2016). Severe Abdominal Pain Caused by Lead Toxicity without Response to Oral Chelators: A Case Report. Middle East journal of digestive diseases, 8(1), 67-72. https://doi.org/10.15171/mejdd.2016.10
Vossoughinia, Hassan, et al. "Severe Abdominal Pain Caused by Lead Toxicity without Response to Oral Chelators: A Case Report." Middle East journal of digestive diseases vol. 8,1 (2016): 67-72. doi: https://doi.org/10.15171/mejdd.2016.10
Vossoughinia H, Pourakbar A, Esfandiari S, Sharifianrazavi M. Severe Abdominal Pain Caused by Lead Toxicity without Response to Oral Chelators: A Case Report. Middle East J Dig Dis. 2016 Jan;8(1):67-72. doi: 10.15171/mejdd.2016.10. PMID: 26933485; PMCID: PMC4773087.
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Effects of lipopolysaccharide and chelator on mercury content in the cerebrum of thimerosal-administered mice.

Environmental toxicology and pharmacology

Minami T, Oda K, Gima N, Yamazaki H.
PMID: 21783828
Environ Toxicol Pharmacol. 2007 Nov;24(3):316-20. doi: 10.1016/j.etap.2007.08.004. Epub 2007 Aug 19.

Thimerosal is one of the best-known preservative agents for vaccines in the world but a relationship between its use and autism has long been suspected so that its effects on the brain need more detailed research. We here examined...

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Minami T, Oda K, Gima N, et al. Effects of lipopolysaccharide and chelator on mercury content in the cerebrum of thimerosal-administered mice. Environ Toxicol Pharmacol. 2007;24(3):316-20doi: 10.1016/j.etap.2007.08.004.
Minami, T., Oda, K., Gima, N., & Yamazaki, H. (2007). Effects of lipopolysaccharide and chelator on mercury content in the cerebrum of thimerosal-administered mice. Environmental toxicology and pharmacology, 24(3), 316-20. https://doi.org/10.1016/j.etap.2007.08.004
Minami, Takeshi, et al. "Effects of lipopolysaccharide and chelator on mercury content in the cerebrum of thimerosal-administered mice." Environmental toxicology and pharmacology vol. 24,3 (2007): 316-20. doi: https://doi.org/10.1016/j.etap.2007.08.004
Minami T, Oda K, Gima N, Yamazaki H. Effects of lipopolysaccharide and chelator on mercury content in the cerebrum of thimerosal-administered mice. Environ Toxicol Pharmacol. 2007 Nov;24(3):316-20. doi: 10.1016/j.etap.2007.08.004. Epub 2007 Aug 19. PMID: 21783828.
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Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic .

Biomedicines

Xie C, Albulescu LO, Bittenbinder MA, Somsen GW, Vonk FJ, Casewell NR, Kool J.
PMID: 32825484
Biomedicines. 2020 Aug 20;8(9). doi: 10.3390/biomedicines8090297.

Animal-derived antivenoms are the only specific therapies currently available for the treatment of snake envenoming, but these products have a number of limitations associated with their efficacy, safety and affordability for use in tropical snakebite victims. Small molecule drugs...

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Xie C, Albulescu LO, Bittenbinder MA, et al. Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic . Biomedicines. 2020;8(9)doi: 10.3390/biomedicines8090297.
Xie, C., Albulescu, L. O., Bittenbinder, M. A., Somsen, G. W., Vonk, F. J., Casewell, N. R., & Kool, J. (2020). Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic . Biomedicines, 8(9), . https://doi.org/10.3390/biomedicines8090297
Xie, Chunfang, et al. "Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic ." Biomedicines vol. 8,9 (2020). doi: https://doi.org/10.3390/biomedicines8090297
Xie C, Albulescu LO, Bittenbinder MA, Somsen GW, Vonk FJ, Casewell NR, Kool J. Neutralizing Effects of Small Molecule Inhibitors and Metal Chelators on Coagulopathic . Biomedicines. 2020 Aug 20;8(9). doi: 10.3390/biomedicines8090297. PMID: 32825484; PMCID: PMC7555180.
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