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Showing 1 to 4 of 4 entries
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Cocaine Addiction: Neurobiology and Related Current Research in Pharmacotherapy.

Substance abuse

Panikkar GP.
PMID: 12511828
Subst Abus. 1999 Sep;20(3):149-166. doi: 10.1080/08897079909511403.

In this article, recent research studies in the field of cocaine addiction are reviewed, with an eye toward emergent options for treatment innovation. Particular attention is paid to the neurobiology and specific neurotransmitter and receptor mechanisms involved in cocaine...

DAT Conformation Does Not Predict the Ability of Atypical Dopamine Uptake Inhibitors to Substitute for Cocaine.

Journal of alcoholism and drug dependence

Hiranita T.
PMID: 27588299
J Alcohol Drug Depend. 2016;4(4). doi: 10.4172/2329-6488.1000e132. Epub 2016 Aug 08.

No abstract available.

Hybrid dopamine uptake blocker-serotonin releaser ligands: a new twist on transporter-focused therapeutics.

ACS medicinal chemistry letters

Blough BE, Landavazo A, Partilla JS, Baumann MH, Decker AM, Page KM, Rothman RB.
PMID: 24944732
ACS Med Chem Lett. 2014 Apr 15;5(6):623-7. doi: 10.1021/ml500113s. eCollection 2014 Jun 12.

As part of our program to study neurotransmitter releasers, we report herein a class of hybrid dopamine reuptake inhibitors that display serotonin releasing activity. Hybrid compounds are interesting since they increase the design potential of transporter related compounds and...

Evidence for a functional coupling between dopamine reuptake and tyrosine hydroxylation in striatal nerve terminals.

Neurochemistry international

Maura G, Raiteri M.
PMID: 20487872
Neurochem Int. 1982;4(4):225-31. doi: 10.1016/0197-0186(82)90058-4.

In rat striatal synaptosomes incubated with [(14)C]tyrosine, the evolution of (14)CO(2), taken as a measure of dopamine synthesis, was inhibited by exogenous dopamine and by the dopaminergic receptor agonist ADTN. The inhibition was not counteracted by dopaminergic receptor antagonists...

Showing 1 to 4 of 4 entries