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A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning.

Frontiers in behavioral neuroscience

Votinov M, Pripfl J, Windischberger C, Moser E, Sailer U, Lamm C.
PMID: 26190983
Front Behav Neurosci. 2015 Jul 03;9:172. doi: 10.3389/fnbeh.2015.00172. eCollection 2015.

Whether the opioid system plays a role in the ability to flexibly adapt behavior is still unclear. We used fMRI to investigate the effect of a nucleotide tandem repeat (68-bp VNTR) functional polymorphism of the prodynorphin (PDYN) gene on...

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Votinov M, Pripfl J, Windischberger C, et al. A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning. Front Behav Neurosci. 2015;9:172doi: 10.3389/fnbeh.2015.00172.
Votinov, M., Pripfl, J., Windischberger, C., Moser, E., Sailer, U., & Lamm, C. (2015). A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning. Frontiers in behavioral neuroscience, 9172. https://doi.org/10.3389/fnbeh.2015.00172
Votinov, Mikhail, et al. "A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning." Frontiers in behavioral neuroscience vol. 9 (2015): 172. doi: https://doi.org/10.3389/fnbeh.2015.00172
Votinov M, Pripfl J, Windischberger C, Moser E, Sailer U, Lamm C. A functional polymorphism in the prodynorphin gene affects cognitive flexibility and brain activation during reversal learning. Front Behav Neurosci. 2015 Jul 03;9:172. doi: 10.3389/fnbeh.2015.00172. eCollection 2015. PMID: 26190983; PMCID: PMC4490246.
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The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential.

Frontiers in molecular neuroscience

Burtscher J, Schwarzer C.
PMID: 28824375
Front Mol Neurosci. 2017 Aug 07;10:245. doi: 10.3389/fnmol.2017.00245. eCollection 2017.

Temporal lobe epilepsy is considered to be one of the most common and severe forms of focal epilepsies. Patients often develop cognitive deficits and emotional blunting along the progression of the disease. The high incidence of resistance to antiepileptic...

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Burtscher J, Schwarzer C. The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential. Front Mol Neurosci. 2017;10:245doi: 10.3389/fnmol.2017.00245.
Burtscher, J., & Schwarzer, C. (2017). The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential. Frontiers in molecular neuroscience, 10245. https://doi.org/10.3389/fnmol.2017.00245
Burtscher, Johannes, and Schwarzer, Christoph. "The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential." Frontiers in molecular neuroscience vol. 10 (2017): 245. doi: https://doi.org/10.3389/fnmol.2017.00245
Burtscher J, Schwarzer C. The Opioid System in Temporal Lobe Epilepsy: Functional Role and Therapeutic Potential. Front Mol Neurosci. 2017 Aug 07;10:245. doi: 10.3389/fnmol.2017.00245. eCollection 2017. PMID: 28824375; PMCID: PMC5545604.
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Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway.

Cell & bioscience

Liu L, Xu Y, Dai H, Tan S, Mao X, Chen Z.
PMID: 32206297
Cell Biosci. 2020 Mar 17;10:42. doi: 10.1186/s13578-020-00387-2. eCollection 2020.

BACKGROUND: Microglia-mediated neuroinflammation is associated with epilepsy. Switching microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype represents a novel therapeutic strategy for mitigating epileptogenesis. We previously found that dynorphins protected against epilepsy via activation of...

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Liu L, Xu Y, Dai H, et al. Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway. Cell Biosci. 2020;10:42doi: 10.1186/s13578-020-00387-2.
Liu, L., Xu, Y., Dai, H., Tan, S., Mao, X., & Chen, Z. (2020). Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway. Cell & bioscience, 1042. https://doi.org/10.1186/s13578-020-00387-2
Liu, Lin, et al. "Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway." Cell & bioscience vol. 10 (2020): 42. doi: https://doi.org/10.1186/s13578-020-00387-2
Liu L, Xu Y, Dai H, Tan S, Mao X, Chen Z. Dynorphin activation of kappa opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway. Cell Biosci. 2020 Mar 17;10:42. doi: 10.1186/s13578-020-00387-2. eCollection 2020. PMID: 32206297; PMCID: PMC7079364.
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Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations.

Computational and structural biotechnology journal

Perini DA, Aguilella-Arzo M, Alcaraz A, Perálvarez-Marín A, Queralt-Martín M.
PMID: 35024095
Comput Struct Biotechnol J. 2021 Dec 16;20:230-240. doi: 10.1016/j.csbj.2021.12.021. eCollection 2022.

Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death. Previous studies have suggested that Dynorphin A (DynA) mediates...

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Perini DA, Aguilella-Arzo M, Alcaraz A, et al. Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Comput Struct Biotechnol J. 2021;20:230-240doi: 10.1016/j.csbj.2021.12.021.
Perini, D. A., Aguilella-Arzo, M., Alcaraz, A., Perálvarez-Marín, A., & Queralt-Martín, M. (2022). Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Computational and structural biotechnology journal, 20230-240. https://doi.org/10.1016/j.csbj.2021.12.021
Perini, D Aurora, et al. "Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations." Computational and structural biotechnology journal vol. 20 (2022): 230-240. doi: https://doi.org/10.1016/j.csbj.2021.12.021
Perini DA, Aguilella-Arzo M, Alcaraz A, Perálvarez-Marín A, Queralt-Martín M. Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Comput Struct Biotechnol J. 2021 Dec 16;20:230-240. doi: 10.1016/j.csbj.2021.12.021. eCollection 2022. PMID: 35024095; PMCID: PMC8718563.
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BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER.

Annals of Ibadan postgraduate medicine

Shrihari TG.
PMID: 32669986
Ann Ib Postgrad Med. 2019 Dec;17(2):111-114.

AIM: Endorphins are endogenous morphine, neuropeptides, produced in the pituitary gland in response to stress and pain. There are three types of endorphins beta-endorphins, enkephalins, and dynorphins binds to mu, kappa, and delta receptors situated on nervous system and...

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Shrihari TG. BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER. Ann Ib Postgrad Med. 2019;17(2):111-114
Shrihari, T. G. (2019). BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER. Annals of Ibadan postgraduate medicine, 17(2), 111-114.
Shrihari, T G. "BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER." Annals of Ibadan postgraduate medicine vol. 17,2 (2019): 111-114.
Shrihari TG. BETA ENDORPHINS - HOLISTIC THERAPEUTIC APPROACH TO CANCER. Ann Ib Postgrad Med. 2019 Dec;17(2):111-114. PMID: 32669986; PMCID: PMC7358813.
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Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders.

Frontiers in pharmacology

Butelman ER, Kreek MJ.
PMID: 26441647
Front Pharmacol. 2015 Sep 08;6:190. doi: 10.3389/fphar.2015.00190. eCollection 2015.

Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum. Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus implicates the KOPr system and its endogenous agonist ligands (the dynorphins) in higher...

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Butelman ER, Kreek MJ. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015;6:190doi: 10.3389/fphar.2015.00190.
Butelman, E. R., & Kreek, M. J. (2015). Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Frontiers in pharmacology, 6190. https://doi.org/10.3389/fphar.2015.00190
Butelman, Eduardo R, and Kreek, Mary Jeanne. "Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders." Frontiers in pharmacology vol. 6 (2015): 190. doi: https://doi.org/10.3389/fphar.2015.00190
Butelman ER, Kreek MJ. Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015 Sep 08;6:190. doi: 10.3389/fphar.2015.00190. eCollection 2015. PMID: 26441647; PMCID: PMC4561799.
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Corrigendum: Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders.

Frontiers in pharmacology

Butelman ER, Kreek MJ.
PMID: 26648869
Front Pharmacol. 2015 Nov 30;6:285. doi: 10.3389/fphar.2015.00285. eCollection 2015.

[This corrects the article on p. 190 in vol. 6, PMID: 26441647.].

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Butelman ER, Kreek MJ. Corrigendum: Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015;6:285doi: 10.3389/fphar.2015.00285.
Butelman, E. R., & Kreek, M. J. (2015). Corrigendum: Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Frontiers in pharmacology, 6285. https://doi.org/10.3389/fphar.2015.00285
Butelman, Eduardo R, and Kreek, Mary Jeanne. "Corrigendum: Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders." Frontiers in pharmacology vol. 6 (2015): 285. doi: https://doi.org/10.3389/fphar.2015.00285
Butelman ER, Kreek MJ. Corrigendum: Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disorders. Front Pharmacol. 2015 Nov 30;6:285. doi: 10.3389/fphar.2015.00285. eCollection 2015. PMID: 26648869; PMCID: PMC4663718.
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Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations.

Computational and structural biotechnology journal

Perini DA, Aguilella-Arzo M, Alcaraz A, Perálvarez-Marín A, Queralt-Martín M.
PMID: 35024095
Comput Struct Biotechnol J. 2021 Dec 16;20:230-240. doi: 10.1016/j.csbj.2021.12.021. eCollection 2022.

Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death. Previous studies have suggested that Dynorphin A (DynA) mediates...

Cite
Perini DA, Aguilella-Arzo M, Alcaraz A, et al. Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Comput Struct Biotechnol J. 2021;20:230-240doi: 10.1016/j.csbj.2021.12.021.
Perini, D. A., Aguilella-Arzo, M., Alcaraz, A., Perálvarez-Marín, A., & Queralt-Martín, M. (2022). Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Computational and structural biotechnology journal, 20230-240. https://doi.org/10.1016/j.csbj.2021.12.021
Perini, D Aurora, et al. "Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations." Computational and structural biotechnology journal vol. 20 (2022): 230-240. doi: https://doi.org/10.1016/j.csbj.2021.12.021
Perini DA, Aguilella-Arzo M, Alcaraz A, Perálvarez-Marín A, Queralt-Martín M. Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Comput Struct Biotechnol J. 2021 Dec 16;20:230-240. doi: 10.1016/j.csbj.2021.12.021. eCollection 2022. PMID: 35024095; PMCID: PMC8718563.
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Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations.

Computational and structural biotechnology journal

Perini DA, Aguilella-Arzo M, Alcaraz A, Perálvarez-Marín A, Queralt-Martín M.
PMID: 35024095
Comput Struct Biotechnol J. 2021 Dec 16;20:230-240. doi: 10.1016/j.csbj.2021.12.021. eCollection 2022.

Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell death. Previous studies have suggested that Dynorphin A (DynA) mediates...

Cite
Perini DA, Aguilella-Arzo M, Alcaraz A, et al. Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Comput Struct Biotechnol J. 2021;20:230-240doi: 10.1016/j.csbj.2021.12.021.
Perini, D. A., Aguilella-Arzo, M., Alcaraz, A., Perálvarez-Marín, A., & Queralt-Martín, M. (2022). Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Computational and structural biotechnology journal, 20230-240. https://doi.org/10.1016/j.csbj.2021.12.021
Perini, D Aurora, et al. "Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations." Computational and structural biotechnology journal vol. 20 (2022): 230-240. doi: https://doi.org/10.1016/j.csbj.2021.12.021
Perini DA, Aguilella-Arzo M, Alcaraz A, Perálvarez-Marín A, Queralt-Martín M. Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations. Comput Struct Biotechnol J. 2021 Dec 16;20:230-240. doi: 10.1016/j.csbj.2021.12.021. eCollection 2022. PMID: 35024095; PMCID: PMC8718563.
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Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies.

Frontiers in pharmacology

Befort K.
PMID: 25698968
Front Pharmacol. 2015 Feb 05;6:6. doi: 10.3389/fphar.2015.00006. eCollection 2015.

The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins, and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes for their synthesis and their degradation and two...

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Befort K. Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies. Front Pharmacol. 2015;6:6doi: 10.3389/fphar.2015.00006.
Befort, K. (2015). Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies. Frontiers in pharmacology, 66. https://doi.org/10.3389/fphar.2015.00006
Befort, Katia. "Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies." Frontiers in pharmacology vol. 6 (2015): 6. doi: https://doi.org/10.3389/fphar.2015.00006
Befort K. Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies. Front Pharmacol. 2015 Feb 05;6:6. doi: 10.3389/fphar.2015.00006. eCollection 2015. PMID: 25698968; PMCID: PMC4318341.
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Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats.

Toxicology

Cattani D, Struyf N, Steffensen V, Bergquist J, Zamoner A, Brittebo E, Andersson M.
PMID: 34474092
Toxicology. 2021 Sep;461:152922. doi: 10.1016/j.tox.2021.152922. Epub 2021 Aug 30.

Glyphosate, the most used herbicide worldwide, has been suggested to induce neurotoxicity and behavioral changes in rats after developmental exposure. Studies of human glyphosate intoxication have reported adverse effects on the nervous system, particularly in substantia nigra (SN). Here...

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Cattani D, Struyf N, Steffensen V, et al. Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats. Toxicology. 2021;461:152922doi: 10.1016/j.tox.2021.152922.
Cattani, D., Struyf, N., Steffensen, V., Bergquist, J., Zamoner, A., Brittebo, E., & Andersson, M. (2021). Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats. Toxicology, 461152922. https://doi.org/10.1016/j.tox.2021.152922
Cattani, Daiane, et al. "Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats." Toxicology vol. 461 (2021): 152922. doi: https://doi.org/10.1016/j.tox.2021.152922
Cattani D, Struyf N, Steffensen V, Bergquist J, Zamoner A, Brittebo E, Andersson M. Perinatal exposure to a glyphosate-based herbicide causes dysregulation of dynorphins and an increase of neural precursor cells in the brain of adult male rats. Toxicology. 2021 Sep;461:152922. doi: 10.1016/j.tox.2021.152922. Epub 2021 Aug 30. PMID: 34474092.
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New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease.

Journal of clinical medicine

Giannaccare G, Ghelardini C, Mancini A, Scorcia V, Di Cesare Mannelli L.
PMID: 35011849
J Clin Med. 2021 Dec 25;11(1). doi: 10.3390/jcm11010108.

Ocular discomfort and eye pain are frequently reported by patients with dry eye disease (DED), and their management remains a real therapeutic challenge for the Ophthalmologist. In DED patients, injury at the level of each structure of the ocular...

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Giannaccare G, Ghelardini C, Mancini A, et al. New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease. J Clin Med. 2021;11(1)doi: 10.3390/jcm11010108.
Giannaccare, G., Ghelardini, C., Mancini, A., Scorcia, V., & Di Cesare Mannelli, L. (2021). New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease. Journal of clinical medicine, 11(1), . https://doi.org/10.3390/jcm11010108
Giannaccare, Giuseppe, et al. "New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease." Journal of clinical medicine vol. 11,1 (2021). doi: https://doi.org/10.3390/jcm11010108
Giannaccare G, Ghelardini C, Mancini A, Scorcia V, Di Cesare Mannelli L. New Perspectives in the Pathophysiology and Treatment of Pain in Patients with Dry Eye Disease. J Clin Med. 2021 Dec 25;11(1). doi: 10.3390/jcm11010108. PMID: 35011849; PMCID: PMC8745516.
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Showing 1 to 12 of 26 entries