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Engineering Escherichia coli for anaerobic alkane activation: Biosynthesis of (1-methylalkyl)succinates.

Biotechnology and bioengineering

Wang Y, Nguyen N, Lee SH, Wang Q, May JA, Gonzalez R, Cirino PC.
PMID: 34633065
Biotechnol Bioeng. 2022 Jan;119(1):315-320. doi: 10.1002/bit.27956. Epub 2021 Oct 16.

In anoxic environments, microbial activation of alkanes for subsequent metabolism occurs most commonly through the addition of fumarate to a subterminal carbon, producing an alkylsuccinate. Alkylsuccinate synthases are complex, multi-subunit enzymes that utilize a catalytic glycyl radical and require...

Rate Dependence on Inductive and Resonance Effects for the Organocatalyzed Enantioselective Conjugate Addition of Alkenyl and Alkynyl Boronic Acids to β-Indolyl Enones and β-Pyrrolyl Enones.

Molecules (Basel, Switzerland)

Boylan A, Nguyen TS, Lundy BJ, Li JY, Vallakati R, Sundstrom S, May JA.
PMID: 33799473
Molecules. 2021 Mar 14;26(6). doi: 10.3390/molecules26061615.

Two key factors bear on reaction rates for the conjugate addition of alkenyl boronic acids to heteroaryl-appended enones: the proximity of inductively electron-withdrawing heteroatoms to the site of bond formation and the resonance contribution of available heteroatom lone pairs...

Showing 1 to 2 of 2 entries