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Showing 1 to 11 of 11 entries
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Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes.

Hepatology research : the official journal of the Japan Society of Hepatology

Minagawa T, Yamazaki K, Masugi Y, Tsujikawa H, Ojima H, Hibi T, Abe Y, Yagi H, Kitago M, Shinoda M, Itano O, Kitagawa Y, Sakamoto M.
PMID: 31702093
Hepatol Res. 2020 Mar;50(3):353-364. doi: 10.1111/hepr.13445. Epub 2019 Dec 26.

AIM: Sorafenib inhibits multiple kinase signaling pathways, including the rat sarcoma virus (Ras)/rapidly accelerated fibrosarcoma (Raf)/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, and is a promising therapy for hepatocellular carcinoma (HCC). However, the role of ERK activation...

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Minagawa T, Yamazaki K, Masugi Y, et al. Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes. Hepatol Res. 2019;50(3):353-364doi: 10.1111/hepr.13445.
Minagawa, T., Yamazaki, K., Masugi, Y., Tsujikawa, H., Ojima, H., Hibi, T., Abe, Y., Yagi, H., Kitago, M., Shinoda, M., Itano, O., Kitagawa, Y., & Sakamoto, M. (2020). Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes. Hepatology research : the official journal of the Japan Society of Hepatology, 50(3), 353-364. https://doi.org/10.1111/hepr.13445
Minagawa, Takuya, et al. "Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes." Hepatology research : the official journal of the Japan Society of Hepatology vol. 50,3 (2020): 353-364. doi: https://doi.org/10.1111/hepr.13445
Minagawa T, Yamazaki K, Masugi Y, Tsujikawa H, Ojima H, Hibi T, Abe Y, Yagi H, Kitago M, Shinoda M, Itano O, Kitagawa Y, Sakamoto M. Activation of extracellular signal-regulated kinase is associated with hepatocellular carcinoma with aggressive phenotypes. Hepatol Res. 2020 Mar;50(3):353-364. doi: 10.1111/hepr.13445. Epub 2019 Dec 26. PMID: 31702093.
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Oncogenic Ras downregulates .

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Jun S, Kim SW, Kim B, Chang IY, Park SJ.
PMID: 32395078
Korean J Physiol Pharmacol. 2020 May 01;24(3):267-276. doi: 10.4196/kjpp.2020.24.3.267.

In the present study, we investigated the effect of oncogenic H-Ras on rat mdr1b expression in NIH3T3 cells. The constitutive expression of H-Ras

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Jun S, Kim SW, Kim B, et al. Oncogenic Ras downregulates . Korean J Physiol Pharmacol. 2020;24(3):267-276doi: 10.4196/kjpp.2020.24.3.267.
Jun, S., Kim, S. W., Kim, B., Chang, I. Y., & Park, S. J. (2020). Oncogenic Ras downregulates . The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 24(3), 267-276. https://doi.org/10.4196/kjpp.2020.24.3.267
Jun, Semo, et al. "Oncogenic Ras downregulates ." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 24,3 (2020): 267-276. doi: https://doi.org/10.4196/kjpp.2020.24.3.267
Jun S, Kim SW, Kim B, Chang IY, Park SJ. Oncogenic Ras downregulates . Korean J Physiol Pharmacol. 2020 May 01;24(3):267-276. doi: 10.4196/kjpp.2020.24.3.267. PMID: 32395078; PMCID: PMC7193907.
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Oncogenic Ras downregulates .

The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology

Jun S, Kim SW, Kim B, Chang IY, Park SJ.
PMID: 32392918
Korean J Physiol Pharmacol. 2020 May 01;24(3):267-276. doi: 10.4196/kjpp.2020.24.3.267.

In the present study, we investigated the effect of oncogenic H-

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Jun S, Kim SW, Kim B, et al. Oncogenic Ras downregulates . Korean J Physiol Pharmacol. 2020;24(3):267-276doi: 10.4196/kjpp.2020.24.3.267.
Jun, S., Kim, S. W., Kim, B., Chang, I. Y., & Park, S. J. (2020). Oncogenic Ras downregulates . The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 24(3), 267-276. https://doi.org/10.4196/kjpp.2020.24.3.267
Jun, Semo, et al. "Oncogenic Ras downregulates ." The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology vol. 24,3 (2020): 267-276. doi: https://doi.org/10.4196/kjpp.2020.24.3.267
Jun S, Kim SW, Kim B, Chang IY, Park SJ. Oncogenic Ras downregulates . Korean J Physiol Pharmacol. 2020 May 01;24(3):267-276. doi: 10.4196/kjpp.2020.24.3.267. PMID: 32392918.
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CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury.

Microbes and infection

Du Y, Zhang H, Guo Y, Song K, Zeng L, Chen Y, Xie Z, Li R.
PMID: 34098107
Microbes Infect. 2021 Nov-Dec;23(9):104845. doi: 10.1016/j.micinf.2021.104845. Epub 2021 Jun 11.

As a disease with high mortality, many cytokines and signaling pathways are associated with sepsis. The pro-inflammatory cytokines and chemokines are participating in the pathogenesis of sepsis, especially in early stage. Moreover, the releases and expressions of cytokines are...

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Du Y, Zhang H, Guo Y, et al. CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury. Microbes Infect. 2021;23(9):104845doi: 10.1016/j.micinf.2021.104845.
Du, Y., Zhang, H., Guo, Y., Song, K., Zeng, L., Chen, Y., Xie, Z., & Li, R. (2021). CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury. Microbes and infection, 23(9), 104845. https://doi.org/10.1016/j.micinf.2021.104845
Du, Yuna, et al. "CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury." Microbes and infection vol. 23,9 (2021): 104845. doi: https://doi.org/10.1016/j.micinf.2021.104845
Du Y, Zhang H, Guo Y, Song K, Zeng L, Chen Y, Xie Z, Li R. CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury. Microbes Infect. 2021 Nov-Dec;23(9):104845. doi: 10.1016/j.micinf.2021.104845. Epub 2021 Jun 11. PMID: 34098107.
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siRNA-Mediated Suppression of Synuclein γ Inhibits MDA-MB-231 Cell Migration and Proliferation by Downregulating the Phosphorylation of AKT and ERK.

Journal of breast cancer

He J, Xie N, Yang J, Guan H, Chen W, Wu H, Yuan Z, Wang K, Li G, Sun J, Yu L.
PMID: 25320617
J Breast Cancer. 2014 Sep;17(3):200-6. doi: 10.4048/jbc.2014.17.3.200. Epub 2014 Sep 30.

PURPOSE: Synuclein-γ (SNCG), which was initially identified as breast cancer specific gene 1, is highly expressed in advanced breast cancers, but not in normal or benign breast tissue. This study aimed to evaluate the effects of SNCG siRNA-treatment on...

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He J, Xie N, Yang J, et al. siRNA-Mediated Suppression of Synuclein γ Inhibits MDA-MB-231 Cell Migration and Proliferation by Downregulating the Phosphorylation of AKT and ERK. J Breast Cancer. 2014;17(3):200-6doi: 10.4048/jbc.2014.17.3.200.
He, J., Xie, N., Yang, J., Guan, H., Chen, W., Wu, H., Yuan, Z., Wang, K., Li, G., Sun, J., & Yu, L. (2014). siRNA-Mediated Suppression of Synuclein γ Inhibits MDA-MB-231 Cell Migration and Proliferation by Downregulating the Phosphorylation of AKT and ERK. Journal of breast cancer, 17(3), 200-6. https://doi.org/10.4048/jbc.2014.17.3.200
He, Jingsong, et al. "siRNA-Mediated Suppression of Synuclein γ Inhibits MDA-MB-231 Cell Migration and Proliferation by Downregulating the Phosphorylation of AKT and ERK." Journal of breast cancer vol. 17,3 (2014): 200-6. doi: https://doi.org/10.4048/jbc.2014.17.3.200
He J, Xie N, Yang J, Guan H, Chen W, Wu H, Yuan Z, Wang K, Li G, Sun J, Yu L. siRNA-Mediated Suppression of Synuclein γ Inhibits MDA-MB-231 Cell Migration and Proliferation by Downregulating the Phosphorylation of AKT and ERK. J Breast Cancer. 2014 Sep;17(3):200-6. doi: 10.4048/jbc.2014.17.3.200. Epub 2014 Sep 30. PMID: 25320617; PMCID: PMC4197349.
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Biliverdin reductase: a target for cancer therapy?.

Frontiers in pharmacology

Gibbs PE, Miralem T, Maines MD.
PMID: 26089799
Front Pharmacol. 2015 Jun 03;6:119. doi: 10.3389/fphar.2015.00119. eCollection 2015.

Biliverdin reductase (BVR) is a multifunctional protein that is the primary source of the potent antioxidant, bilirubin. BVR regulates activities/functions in the insulin/IGF-1/IRK/PI3K/MAPK pathways. Activation of certain kinases in these pathways is/are hallmark(s) of cancerous cells. The protein is...

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Gibbs PE, Miralem T, Maines MD. Biliverdin reductase: a target for cancer therapy?. Front Pharmacol. 2015;6:119doi: 10.3389/fphar.2015.00119.
Gibbs, P. E., Miralem, T., & Maines, M. D. (2015). Biliverdin reductase: a target for cancer therapy?. Frontiers in pharmacology, 6119. https://doi.org/10.3389/fphar.2015.00119
Gibbs, Peter E M, et al. "Biliverdin reductase: a target for cancer therapy?." Frontiers in pharmacology vol. 6 (2015): 119. doi: https://doi.org/10.3389/fphar.2015.00119
Gibbs PE, Miralem T, Maines MD. Biliverdin reductase: a target for cancer therapy?. Front Pharmacol. 2015 Jun 03;6:119. doi: 10.3389/fphar.2015.00119. eCollection 2015. PMID: 26089799; PMCID: PMC4452799.
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CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury.

Microbes and infection

Du Y, Zhang H, Guo Y, Song K, Zeng L, Chen Y, Xie Z, Li R.
PMID: 34098107
Microbes Infect. 2021 Nov-Dec;23(9):104845. doi: 10.1016/j.micinf.2021.104845. Epub 2021 Jun 11.

As a disease with high mortality, many cytokines and signaling pathways are associated with sepsis. The pro-inflammatory cytokines and chemokines are participating in the pathogenesis of sepsis, especially in early stage. Moreover, the releases and expressions of cytokines are...

Cite
Du Y, Zhang H, Guo Y, et al. CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury. Microbes Infect. 2021;23(9):104845doi: 10.1016/j.micinf.2021.104845.
Du, Y., Zhang, H., Guo, Y., Song, K., Zeng, L., Chen, Y., Xie, Z., & Li, R. (2021). CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury. Microbes and infection, 23(9), 104845. https://doi.org/10.1016/j.micinf.2021.104845
Du, Yuna, et al. "CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury." Microbes and infection vol. 23,9 (2021): 104845. doi: https://doi.org/10.1016/j.micinf.2021.104845
Du Y, Zhang H, Guo Y, Song K, Zeng L, Chen Y, Xie Z, Li R. CD38 deficiency up-regulated IL-1β and MCP-1 through TLR4/ERK/NF-κB pathway in sepsis pulmonary injury. Microbes Infect. 2021 Nov-Dec;23(9):104845. doi: 10.1016/j.micinf.2021.104845. Epub 2021 Jun 11. PMID: 34098107.
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Impaired Expression of MAPK Is Associated with the Downregulation of TNF-α, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease.

Tuberculosis and respiratory diseases

Sim YS, Kim SY, Kim EJ, Shin SJ, Koh WJ.
PMID: 23227067
Tuberc Respir Dis (Seoul). 2012 Mar;72(3):275-83. doi: 10.4046/trd.2012.72.3.275. Epub 2012 Mar 31.

BACKGROUND: Healthy individuals who develop nontuberculous mycobacteria (NTM) lung disease are likely to have specific susceptibility factors which can lead to a NTM infection. The aim of the present study was to investigate the mechanism underlying innate immune responses,...

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Sim YS, Kim SY, Kim EJ, et al. Impaired Expression of MAPK Is Associated with the Downregulation of TNF-α, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease. Tuberc Respir Dis (Seoul). 2012;72(3):275-83doi: 10.4046/trd.2012.72.3.275.
Sim, Y. S., Kim, S. Y., Kim, E. J., Shin, S. J., & Koh, W. J. (2012). Impaired Expression of MAPK Is Associated with the Downregulation of TNF-α, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease. Tuberculosis and respiratory diseases, 72(3), 275-83. https://doi.org/10.4046/trd.2012.72.3.275
Sim, Yun Su, et al. "Impaired Expression of MAPK Is Associated with the Downregulation of TNF-α, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease." Tuberculosis and respiratory diseases vol. 72,3 (2012): 275-83. doi: https://doi.org/10.4046/trd.2012.72.3.275
Sim YS, Kim SY, Kim EJ, Shin SJ, Koh WJ. Impaired Expression of MAPK Is Associated with the Downregulation of TNF-α, IL-6, and IL-10 in Mycobacterium abscessus Lung Disease. Tuberc Respir Dis (Seoul). 2012 Mar;72(3):275-83. doi: 10.4046/trd.2012.72.3.275. Epub 2012 Mar 31. PMID: 23227067; PMCID: PMC3510277.
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Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways.

Annals of dermatology

Joo HJ, Jeong KH, Kim JE, Kang H.
PMID: 29200764
Ann Dermatol. 2017 Dec;29(6):747-754. doi: 10.5021/ad.2017.29.6.747. Epub 2017 Oct 30.

BACKGROUND: The human dermal papilla cells (hDPCs) play an important role in regulation of hair cycling and growth.OBJECTIVE: The aim of this study was to investigate the effect of different wavelengths of light-emitting diode (LED) irradiation on the proliferation...

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Joo HJ, Jeong KH, Kim JE, et al. Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways. Ann Dermatol. 2017;29(6):747-754doi: 10.5021/ad.2017.29.6.747.
Joo, H. J., Jeong, K. H., Kim, J. E., & Kang, H. (2017). Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways. Annals of dermatology, 29(6), 747-754. https://doi.org/10.5021/ad.2017.29.6.747
Joo, Hong Jin, et al. "Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways." Annals of dermatology vol. 29,6 (2017): 747-754. doi: https://doi.org/10.5021/ad.2017.29.6.747
Joo HJ, Jeong KH, Kim JE, Kang H. Various Wavelengths of Light-Emitting Diode Light Regulate the Proliferation of Human Dermal Papilla Cells and Hair Follicles via Wnt/β-Catenin and the Extracellular Signal-Regulated Kinase Pathways. Ann Dermatol. 2017 Dec;29(6):747-754. doi: 10.5021/ad.2017.29.6.747. Epub 2017 Oct 30. PMID: 29200764; PMCID: PMC5705357.
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The proper concentrations of dextrose and lidocaine in regenerative injection therapy: .

The Korean journal of pain

Woo MS, Park J, Ok SH, Park M, Sohn JT, Cho MS, Shin IW, Kim YA.
PMID: 33380564
Korean J Pain. 2021 Jan 01;34(1):19-26. doi: 10.3344/kjp.2021.34.1.19.

BACKGROUND: Prolotherapy is a proliferation therapy as an alternative medicine. A combination of dextrose solution and lidocaine is usually used in prolotherapy. The concentrations of dextrose and lidocaine used in the clinical field are very high (dextrose 10%-25%, lidocaine...

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Woo MS, Park J, Ok SH, et al. The proper concentrations of dextrose and lidocaine in regenerative injection therapy: . Korean J Pain. 2021;34(1):19-26doi: 10.3344/kjp.2021.34.1.19.
Woo, M. S., Park, J., Ok, S. H., Park, M., Sohn, J. T., Cho, M. S., Shin, I. W., & Kim, Y. A. (2021). The proper concentrations of dextrose and lidocaine in regenerative injection therapy: . The Korean journal of pain, 34(1), 19-26. https://doi.org/10.3344/kjp.2021.34.1.19
Woo, Min Seok, et al. "The proper concentrations of dextrose and lidocaine in regenerative injection therapy: ." The Korean journal of pain vol. 34,1 (2021): 19-26. doi: https://doi.org/10.3344/kjp.2021.34.1.19
Woo MS, Park J, Ok SH, Park M, Sohn JT, Cho MS, Shin IW, Kim YA. The proper concentrations of dextrose and lidocaine in regenerative injection therapy: . Korean J Pain. 2021 Jan 01;34(1):19-26. doi: 10.3344/kjp.2021.34.1.19. PMID: 33380564; PMCID: PMC7783851.
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Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway.

Journal of bone metabolism

Jeong BC, Oh SH, Lee MN, Koh JT.
PMID: 33317230
J Bone Metab. 2020 Nov;27(4):267-279. doi: 10.11005/jbm.2020.27.4.267. Epub 2020 Nov 30.

BACKGROUND: Macrophage-stimulating protein (MSP; also known as macrophage stimulating 1 and hepatocyte growth factor-like protein) has been shown to play a crucial role in calcium homeostasis and skeletal mineralization in zebrafish. However, the precise role of MSP in osteoblasts...

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Jeong BC, Oh SH, Lee MN, et al. Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway. J Bone Metab. 2020;27(4):267-279doi: 10.11005/jbm.2020.27.4.267.
Jeong, B. C., Oh, S. H., Lee, M. N., & Koh, J. T. (2020). Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway. Journal of bone metabolism, 27(4), 267-279. https://doi.org/10.11005/jbm.2020.27.4.267
Jeong, Byung-Chul, et al. "Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway." Journal of bone metabolism vol. 27,4 (2020): 267-279. doi: https://doi.org/10.11005/jbm.2020.27.4.267
Jeong BC, Oh SH, Lee MN, Koh JT. Macrophage-Stimulating Protein Enhances Osteoblastic Differentiation via the Recepteur d'Origine Nantais Receptor and Extracellular Signal-Regulated Kinase Signaling Pathway. J Bone Metab. 2020 Nov;27(4):267-279. doi: 10.11005/jbm.2020.27.4.267. Epub 2020 Nov 30. PMID: 33317230; PMCID: PMC7746481.
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Showing 1 to 11 of 11 entries