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Showing 1 to 10 of 10 entries
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Cardiovascular Risk Factors from Early Life Predict Future Adult Cardiac Structural and Functional Abnormalities: A Systematic Review of the Published Literature.

Journal of cardiology and therapeutics

Ghosh AK, Francis DP, Chaturvedi N, Kuh D, Mayet J, Hughes AD, Hardy RJ.
PMID: 27294103
J Cardiol Ther. 2014 Jul;2(2):78-87. doi: 10.12970/2311-052X.2014.02.02.4.

BACKGROUND: Clinical practice evaluates cardiovascular risk based on current risk factor (RF) levels [Blood pressure (BP), body mass index (BMI) and glycaemic control] largely disregarding previous risk-factor history over the totality of the life course. RFs are related to...

Automated speckle tracking algorithm to aid on-axis imaging in echocardiography.

Journal of medical imaging (Bellingham, Wash.)

Dhutia NM, Cole GD, Zolgharni M, Manisty CH, Willson K, Parker KH, Hughes AD, Francis DP.
PMID: 26158075
J Med Imaging (Bellingham). 2014 Oct;1(3):037001. doi: 10.1117/1.JMI.1.3.037001. Epub 2014 Nov 25.

Obtaining a "correct" view in echocardiography is a subjective process in which an operator attempts to obtain images conforming to consensus standard views. Real-time objective quantification of image alignment may assist less experienced operators, but no reliable index yet...

Distinct impacts of heart rate and right atrial-pacing on left atrial mechanical activation and optimal AV delay in CRT.

Pacing and clinical electrophysiology : PACE

Kyriacou A, Rajkumar CA, Pabari PA, Sohaib SMA, Willson K, Peters NS, Lim PB, Kanagaratnam P, Hughes AD, Mayet J, Whinnett ZI, Francis DP.
PMID: 29856077
Pacing Clin Electrophysiol. 2018 Jun 01; doi: 10.1111/pace.13401. Epub 2018 Jun 01.

BACKGROUND: Controversy exists regarding how atrial activation mode and heart rate affect optimal atrioventricular (AV) delay in cardiac resynchronization therapy. We studied these questions using high-reproducibility hemodynamic and echocardiographic measurements.METHODS: Twenty patients were hemodynamically optimized using noninvasive beat-to-beat blood...

Effects of disease severity distribution on the performance of quantitative diagnostic methods and proposal of a novel 'V-plot' methodology to display accuracy values.

Open heart

Petraco R, Dehbi HM, Howard JP, Shun-Shin MJ, Sen S, Nijjer SS, Mayet J, Davies JE, Francis DP.
PMID: 29387424
Open Heart. 2018 Jan 20;5(1):e000663. doi: 10.1136/openhrt-2017-000663. eCollection 2018.

BACKGROUND: Diagnostic accuracy is widely accepted by researchers and clinicians as an optimal expression of a test's performance. The aim of this study was to evaluate the effects of disease severity distribution on values of diagnostic accuracy as well...

Aortic Stiffness Is Related to the Ischemic Brain Injury Biomarker N-Methyl-D-aspartate Receptor Antibody Levels in Aortic Valve Replacement.

Neurology research international

Kidher E, Patel VM, Nihoyannopoulos P, Anderson JR, Chukwuemeka A, Francis DP, Ashrafian H, Athanasiou T.
PMID: 25054065
Neurol Res Int. 2014;2014:970793. doi: 10.1155/2014/970793. Epub 2014 Jun 26.

Background. Aortic stiffness changes the flow pattern of circulating blood causing microvascular damage to different end-organ tissues, such as brain cells. The relationship between aortic stiffness measured by pulse wave velocity (PWV) and serum ischemic brain injury biomarker N-methyl-D-aspartate...

Novel cardiac pacemaker-based human model of periodic breathing to develop real-time, pre-emptive technology for carbon dioxide stabilisation.

Open heart

Baruah R, Giannoni A, Willson K, Manisty CH, Mebrate Y, Kyriacou A, Yadav H, Unsworth B, Sutton R, Mayet J, Hughes AD, Francis DP.
PMID: 25332798
Open Heart. 2014 Aug 12;1(1):e000055. doi: 10.1136/openhrt-2014-000055. eCollection 2014.

BACKGROUND: Constant flow and concentration CO2 has previously been efficacious in attenuating ventilatory oscillations in periodic breathing (PB) where oscillations in CO2 drive ventilatory oscillations. However, it has the undesirable effect of increasing end-tidal CO2, and ventilation. We tested,...

Left ventricular scar and the acute hemodynamic effects of multivein and multipolar pacing in cardiac resynchronization.

International journal of cardiology. Heart & vasculature

Jackson T, Lenarczyk R, Sterlinski M, Sokal A, Francis D, Whinnett Z, Van Heuverswyn F, Vanderheyden M, Heynens J, Stegemann B, Cornelussen R, Rinaldi CA.
PMID: 29946558
Int J Cardiol Heart Vasc. 2018 Apr 10;19:14-19. doi: 10.1016/j.ijcha.2018.03.006. eCollection 2018 Jun.

BACKGROUND: We sought to determine whether presence, amount and distribution of scar impacts the degree of acute hemodynamic response (AHR) with multisite pacing.Multi-vein pacing (MVP) or multipolar pacing (MPP) with a multi-electrode left ventricular (LV) lead may offer benefits...

Authors' reply to Perry.

BMJ (Clinical research ed.)

Francis DP, Cole GD.
PMID: 27072360
BMJ. 2016 Apr 12;353:i2031. doi: 10.1136/bmj.i2031.

No abstract available.

Physiology of oxygen uptake kinetics: Insights from incremental cardiopulmonary exercise testing in the Study of Health in Pomerania.

IJC metabolic & endocrine

Barron AJ, Dhutia NM, Gläser S, Koch B, Ewert R, Obst A, Dörr M, Völzke H, Francis DP, Wensel R.
PMID: 26339572
IJC Metab Endocr. 2015 Jun;7:3-9. doi: 10.1016/j.ijcme.2015.02.002.

BACKGROUND: Cardiopulmonary exercise testing allows for assessment of cardiac and respiratory limitation, but is often affected by patient effort. Indices of oxygen kinetics, including the oxygen uptake efficiency slope (OUES), oxygen uptake-work-rate slope (VOMETHODS: 1708 volunteers from the population-based...

The ischaemic constellation: an alternative to the ischaemic cascade-implications for the validation of new ischaemic tests.

Open heart

Maznyczka A, Sen S, Cook C, Francis DP.
PMID: 26196015
Open Heart. 2015 Jul 14;2(1):e000178. doi: 10.1136/openhrt-2014-000178. eCollection 2015.

The ischaemic cascade is the concept that progressive myocardial oxygen supply-demand mismatch causes a consistent sequence of events, starting with metabolic alterations and followed sequentially by myocardial perfusion abnormalities, wall motion abnormalities, ECG changes, and angina. This concept would...

Showing 1 to 10 of 10 entries