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Neuroendocrine response to fenfluramine challenge in boys: Associations with aggressive behavior and adverse rearing

STEM and boys

Coplan JD, Pine DS.
GSID: gGMscegh2SMJ
DS Pine, JD Coplan, GA Wasserman… - Archives of General …, 1997 - jamanetwork.com

… to fenfluramine hydrochloride challenge in young boys who show clinically significant … Approximately 2 years later, these boys underwent a reassessment of psychiatric status and …

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Pine, D. S., Coplan, J. D., Wasserman, G. A., Miller, L. S., Fried, J. E., Davies, M., ... & Parsons, B. (1997). Neuroendocrine response to fenfluramine challenge in boys: Associations with aggressive behavior and adverse rearing. Archives of General Psychiatry, 54(9), 839-846.
Pine, Daniel S., et al. "Neuroendocrine response to fenfluramine challenge in boys: Associations with aggressive behavior and adverse rearing." Archives of General Psychiatry 54.9 (1997): 839-846.
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The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei.

Neurochemical research

Neckers LM, Bertilsson L, Costa E.
PMID: 24271241
Neurochem Res. 1976 Feb;1(1):29-35. doi: 10.1007/BF00965628.

A single injection of fenfluramine orp-chloroamphetamine (PCA) (100 μmol/kg intraperitoneally) decreases the serotonin (5HT) content and the tryptophan hydroxylase activity in various areas of the rat brain. Other reports have shown that a single injection of fenfluramine or PCA...

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Neckers LM, Bertilsson L, Costa E. The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei. Neurochem Res. 1976;1(1):29-35doi: 10.1007/BF00965628.
Neckers, L. M., Bertilsson, L., & Costa, E. (1976). The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei. Neurochemical research, 1(1), 29-35. https://doi.org/10.1007/BF00965628
Neckers, L M, et al. "The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei." Neurochemical research vol. 1,1 (1976): 29-35. doi: https://doi.org/10.1007/BF00965628
Neckers LM, Bertilsson L, Costa E. The action of fenfluramine andp-chloramphetamine on serotonergic mechanisms: A comparative study in rat brain nuclei. Neurochem Res. 1976 Feb;1(1):29-35. doi: 10.1007/BF00965628. PMID: 24271241.
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Differential effects of d-fenfluramine, l-fenfluramine and d-amphetamine on the microstructure of human eating behaviour.

Behavioural pharmacology

McGuirk J, Goodall E, Silverstone T, Willner P.
PMID: 11224055
Behav Pharmacol. 1991 Apr;2(2):113-119.

An observational technique, demonstrated to provide reliable data under a variety of conditions, was used to evaluate the effects of d-fenfluramine, l-fenfluramine, d-amphetamine, and fenfluramine-amphetamine combinations on eating behaviour in human subjects. Following an overnight fast, subjects ate lunch...

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McGuirk J, Goodall E, Silverstone T, et al. Differential effects of d-fenfluramine, l-fenfluramine and d-amphetamine on the microstructure of human eating behaviour. Behav Pharmacol. 1991;2(2):113-119
McGuirk, J., Goodall, E., Silverstone, T., & Willner, P. (1991). Differential effects of d-fenfluramine, l-fenfluramine and d-amphetamine on the microstructure of human eating behaviour. Behavioural pharmacology, 2(2), 113-119.
McGuirk, J., et al. "Differential effects of d-fenfluramine, l-fenfluramine and d-amphetamine on the microstructure of human eating behaviour." Behavioural pharmacology vol. 2,2 (1991): 113-119.
McGuirk J, Goodall E, Silverstone T, Willner P. Differential effects of d-fenfluramine, l-fenfluramine and d-amphetamine on the microstructure of human eating behaviour. Behav Pharmacol. 1991 Apr;2(2):113-119. PMID: 11224055.
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Fenfluramines and Heart Valves.

Obesity surgery

Deitel M.
PMID: 11054906
Obes Surg. 2000 Oct;10(5):387-388. doi: 10.1381/096089200321594237.

No abstract available.

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Deitel M. Fenfluramines and Heart Valves. Obes Surg. 2000;10(5):387-388doi: 10.1381/096089200321594237.
Deitel, M. (2000). Fenfluramines and Heart Valves. Obesity surgery, 10(5), 387-388. https://doi.org/10.1381/096089200321594237
Deitel. "Fenfluramines and Heart Valves." Obesity surgery vol. 10,5 (2000): 387-388. doi: https://doi.org/10.1381/096089200321594237
Deitel M. Fenfluramines and Heart Valves. Obes Surg. 2000 Oct;10(5):387-388. doi: 10.1381/096089200321594237. PMID: 11054906.
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Fenfluramine challenge in anxious children.

Human psychopharmacology

Sallee FR, Vrindavanam NS, Liu H, Sethuraman G, Sine L.
PMID: 12404615
Hum Psychopharmacol. 2000 Dec;15(8):619-629. doi: 10.1002/hup.219.

The study objective was to determine if serotonergic challenge with oral racemic fenfluramine would differentiate between childhood anxiety disorders in comparison to normal controls. Subjects were 24 children with anxiety diagnoses (DSM-IIIR) by structured interview, and 14 normal controls...

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Sallee FR, Vrindavanam NS, Liu H, et al. Fenfluramine challenge in anxious children. Hum Psychopharmacol. 2000;15(8):619-629doi: 10.1002/hup.219.
Sallee, F. R., Vrindavanam, N. S., Liu, H., Sethuraman, G., & Sine, L. (2000). Fenfluramine challenge in anxious children. Human psychopharmacology, 15(8), 619-629. https://doi.org/10.1002/hup.219
Sallee, Floyd R, et al. "Fenfluramine challenge in anxious children." Human psychopharmacology vol. 15,8 (2000): 619-629. doi: https://doi.org/10.1002/hup.219
Sallee FR, Vrindavanam NS, Liu H, Sethuraman G, Sine L. Fenfluramine challenge in anxious children. Hum Psychopharmacol. 2000 Dec;15(8):619-629. doi: 10.1002/hup.219. PMID: 12404615.
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Fenfluramine-Phentermine (Fen-Phen) and Seizures: Evidence for an Association.

Epilepsy & behavior : E&B

Spencer DC, Hwang J, Morrell MJ.
PMID: 12737835
Epilepsy Behav. 2000 Dec;1(6):448-452. doi: 10.1006/ebeh.2000.0132.

Fenfluramine-phentermine combination therapy ("fen-phen") became a popular treatment for obesity in the 1990s. Although this treatment causes cardiac toxicity, use of these medications has not previously been associated with seizures. We report five cases with apparent association between use...

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Spencer DC, Hwang J, Morrell MJ. Fenfluramine-Phentermine (Fen-Phen) and Seizures: Evidence for an Association. Epilepsy Behav. 2000;1(6):448-452doi: 10.1006/ebeh.2000.0132.
Spencer, D. C., Hwang, J., & Morrell, M. J. (2000). Fenfluramine-Phentermine (Fen-Phen) and Seizures: Evidence for an Association. Epilepsy & behavior : E&B, 1(6), 448-452. https://doi.org/10.1006/ebeh.2000.0132
Spencer, David C., et al. "Fenfluramine-Phentermine (Fen-Phen) and Seizures: Evidence for an Association." Epilepsy & behavior : E&B vol. 1,6 (2000): 448-452. doi: https://doi.org/10.1006/ebeh.2000.0132
Spencer DC, Hwang J, Morrell MJ. Fenfluramine-Phentermine (Fen-Phen) and Seizures: Evidence for an Association. Epilepsy Behav. 2000 Dec;1(6):448-452. doi: 10.1006/ebeh.2000.0132. PMID: 12737835.
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Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA).

Behavioural pharmacology

Baker LE, Broadbent J, Michael EK, Matthews PK, Metosh CA, Saunders RB, West WB, Appel JB.
PMID: 11224335
Behav Pharmacol. 1995 Apr;6(3):263-275.

The discriminative stimulus effects of the stereoisomers of 3,4-methylenedioxymethamphetamine (MDMA) were studied in rats trained to discriminate 1.25mg/kg of (+)-MDMA or 3.5mg/kg of (-)-MDMA from saline, in a two lever, water-reinforced, drug discrimination situation. The isomers of MDMA and...

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Baker LE, Broadbent J, Michael EK, et al. Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA). Behav Pharmacol. 1995;6(3):263-275
Baker, L. E., Broadbent, J., Michael, E. K., Matthews, P. K., Metosh, C. A., Saunders, R. B., West, W. B., & Appel, J. B. (1995). Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA). Behavioural pharmacology, 6(3), 263-275.
Baker, L.E., et al. "Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA)." Behavioural pharmacology vol. 6,3 (1995): 263-275.
Baker LE, Broadbent J, Michael EK, Matthews PK, Metosh CA, Saunders RB, West WB, Appel JB. Assessment of the discriminative stimulus effects of the optical isomers of ecstasy (3,4-methylenedioxymethamphetamine; MDMA). Behav Pharmacol. 1995 Apr;6(3):263-275. PMID: 11224335.
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Effect of an herbal extract Number Ten (NT) on body weight in rats.

Chinese medicine

York DA, Thomas S, Greenway FL, Liu Z, Rood JC.
PMID: 17868447
Chin Med. 2007 Sep 14;2:10. doi: 10.1186/1749-8546-2-10.

BACKGROUND: Chinese herbal extract Number Ten (NT) is a dietary herbal formulation prepared from rhubarb, ginger, astragalus, red sage and tumeric. This study tested the effectiveness of NT in reducing body weight gain in rats.METHODS: Sixty female Wistar rats...

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York DA, Thomas S, Greenway FL, et al. Effect of an herbal extract Number Ten (NT) on body weight in rats. Chin Med. 2007;2:10doi: 10.1186/1749-8546-2-10.
York, D. A., Thomas, S., Greenway, F. L., Liu, Z., & Rood, J. C. (2007). Effect of an herbal extract Number Ten (NT) on body weight in rats. Chinese medicine, 210. https://doi.org/10.1186/1749-8546-2-10
York, David A, et al. "Effect of an herbal extract Number Ten (NT) on body weight in rats." Chinese medicine vol. 2 (2007): 10. doi: https://doi.org/10.1186/1749-8546-2-10
York DA, Thomas S, Greenway FL, Liu Z, Rood JC. Effect of an herbal extract Number Ten (NT) on body weight in rats. Chin Med. 2007 Sep 14;2:10. doi: 10.1186/1749-8546-2-10. PMID: 17868447; PMCID: PMC2034566.
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Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin.

Neurochemistry international

Mennini T, Borroni E, Samanin R, Garattini S.
PMID: 20487825
Neurochem Int. 1981;3(5):289-94. doi: 10.1016/0197-0186(81)90015-2.

The effect of various drugs on the release of [(3)H]-serotonin from synaptosomes of reserpine-treated rats was compared with that obtained with synaptosomes of untreated animals. The increase in [(3)H]-serotonin release induced by d-fenfluramine was virtually abolished by reserpine; the...

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Mennini T, Borroni E, Samanin R, et al. Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin. Neurochem Int. 1981;3(5):289-94doi: 10.1016/0197-0186(81)90015-2.
Mennini, T., Borroni, E., Samanin, R., & Garattini, S. (1981). Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin. Neurochemistry international, 3(5), 289-94. https://doi.org/10.1016/0197-0186(81)90015-2
Mennini, T, et al. "Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin." Neurochemistry international vol. 3,5 (1981): 289-94. doi: https://doi.org/10.1016/0197-0186(81)90015-2
Mennini T, Borroni E, Samanin R, Garattini S. Evidence of the existence of two different intraneuronal pools from which pharmacological agents can release serotonin. Neurochem Int. 1981;3(5):289-94. doi: 10.1016/0197-0186(81)90015-2. PMID: 20487825.
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Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings.

Neurochemistry international

Maura G, Gemignani A, Versace P, Martire M, Raiteri M.
PMID: 20487871
Neurochem Int. 1982;4(4):219-24. doi: 10.1016/0197-0186(82)90057-2.

The release of serotonin elicited by Ca(2+)-dependent stimuli (depolarization, ionophore A23187) from rat brain synaptosomes previously labelled with the radioactive indoleamine was not affected by the presence of the serotonin carrier blocker chlorimipramine. In contrast, other releasing stimuli, such...

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Maura G, Gemignani A, Versace P, et al. Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings. Neurochem Int. 1982;4(4):219-24doi: 10.1016/0197-0186(82)90057-2.
Maura, G., Gemignani, A., Versace, P., Martire, M., & Raiteri, M. (1982). Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings. Neurochemistry international, 4(4), 219-24. https://doi.org/10.1016/0197-0186(82)90057-2
Maura, G, et al. "Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings." Neurochemistry international vol. 4,4 (1982): 219-24. doi: https://doi.org/10.1016/0197-0186(82)90057-2
Maura G, Gemignani A, Versace P, Martire M, Raiteri M. Carrier-mediated and carrier-independent release of serotonin from isolated central nerve endings. Neurochem Int. 1982;4(4):219-24. doi: 10.1016/0197-0186(82)90057-2. PMID: 20487871.
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Dose related effect of fenfluramine and norfenfluramine on glucose uptake into human isolated skeletal muscle.

British journal of clinical pharmacology

Kirby MJ.
PMID: 22454939
Br J Clin Pharmacol. 1974 Dec;1(6):511-2. doi: 10.1111/j.1365-2125.1974.tb01703.x.

No abstract available.

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Kirby MJ. Dose related effect of fenfluramine and norfenfluramine on glucose uptake into human isolated skeletal muscle. Br J Clin Pharmacol. 1974;1(6):511-2doi: 10.1111/j.1365-2125.1974.tb01703.x.
Kirby, M. J. (1974). Dose related effect of fenfluramine and norfenfluramine on glucose uptake into human isolated skeletal muscle. British journal of clinical pharmacology, 1(6), 511-2. https://doi.org/10.1111/j.1365-2125.1974.tb01703.x
Kirby, M J. "Dose related effect of fenfluramine and norfenfluramine on glucose uptake into human isolated skeletal muscle." British journal of clinical pharmacology vol. 1,6 (1974): 511-2. doi: https://doi.org/10.1111/j.1365-2125.1974.tb01703.x
Kirby MJ. Dose related effect of fenfluramine and norfenfluramine on glucose uptake into human isolated skeletal muscle. Br J Clin Pharmacol. 1974 Dec;1(6):511-2. doi: 10.1111/j.1365-2125.1974.tb01703.x. PMID: 22454939; PMCID: PMC1402531.
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The usefulness of fenfluramine in treating simple obesity.

Canadian family physician Medecin de famille canadien

Sedgwick JP.
PMID: 20468731
Can Fam Physician. 1972 Feb;18(2):55-7.

Obesity represents a major problem in the western world today. Dietary restriction continues to play a major part in the treatment and management of this condition, and its importance lies not only in obtaining a weight loss but in...

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Sedgwick JP. The usefulness of fenfluramine in treating simple obesity. Can Fam Physician. 1972;18(2):55-7
Sedgwick, J. P. (1972). The usefulness of fenfluramine in treating simple obesity. Canadian family physician Medecin de famille canadien, 18(2), 55-7.
Sedgwick, J P. "The usefulness of fenfluramine in treating simple obesity." Canadian family physician Medecin de famille canadien vol. 18,2 (1972): 55-7.
Sedgwick JP. The usefulness of fenfluramine in treating simple obesity. Can Fam Physician. 1972 Feb;18(2):55-7. PMID: 20468731; PMCID: PMC2370375.
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Showing 1 to 12 of 120 entries