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Showing 1 to 12 of 40 entries
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β2-AGONISTS IN CHILDHOOD ASTHMA.

Journal of biological regulators and homeostatic agents

Miraglia Del Giudice M, Campana G, Galdo F, De Vivo D, Cuppari C, Coronella A, Maiello N.
PMID: 26634602
J Biol Regul Homeost Agents. 2015 Apr-Jun;29(2):137-41.

β2-agonists reduce airflow limitation by improving airway diameter as a consequence of a direct action on airway smooth muscle. β;2-agonists can be broadly classified according to their duration of action: short-acting β2-agonists (SABAs), including albuterol, terbutaline and fenoterol, have...

The Effects of β (2) -Adrenoreceptor Activation on the Contractility, Ca-Signals and Nitric Oxide Production in the Mouse Atria.

Acta naturae

Odnoshivkina YG, Petrov AM, Zefirov AL.
PMID: 22649689
Acta Naturae. 2011 Apr;3(2):103-12.

The effects of the selective β(2)-adrenoreceptor agonist (fenoterol) on the functioning of mouse atrial were studied using both tensometry and fluorescent methods. It has been demonstrated that with the use of a high concentration of fenoterol (in the range...

Preparation and evaluation of fenoterol hydrobromide suppositories.

Drug discoveries & therapeutics

Ghorab D, Refai H, Tag R.
PMID: 22466443
Drug Discov Ther. 2011 Dec;5(6):311-8. doi: 10.5582/ddt.2011.v5.6.311.

Fenoterol HBr is a bronchodilator known to be subject to first pass effect after oral administration. The aim of this study was to prepare and evaluate fenoterol HBr suppositories. Suppositories were prepared by a fusion method using different fatty...

A prospective study of adverse drug reactions as a cause of admission to a paediatric hospital.

British journal of clinical pharmacology

Martínez-Mir I, García-López M, Palop V, Ferrer JM, Estañ L, Rubio E, Morales-Olivas FJ.
PMID: 8877022
Br J Clin Pharmacol. 1996 Sep;42(3):319-24. doi: 10.1046/j.1365-2125.1996.04076.x.
Free PMC Article

1. A total of 512 consecutive paediatric hospital admissions of children 2 years old or less were evaluated to assess the extent and pattern of admission caused by suspected adverse drug reactions (ADRs). the proportion of suspected ADRs related...

Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.

Biochemical pharmacology

Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M.
PMID: 34902340
Biochem Pharmacol. 2021 Dec 10;197:114871. doi: 10.1016/j.bcp.2021.114871. Epub 2021 Dec 10.

Stereoselectivity is important in many pharmacological processes but its impact on drug membrane transport is scarcely understood. Recent studies showed strong stereoselective effects in the cellular uptake of fenoterol by the organic cation transporters OCT1 and OCT2. To provide...

Molecular basis for stereoselective transport of fenoterol by the organic cation transporters 1 and 2.

Biochemical pharmacology

Gebauer L, Arul Murugan N, Jensen O, Brockmöller J, Rafehi M.
PMID: 34902340
Biochem Pharmacol. 2021 Dec 10;197:114871. doi: 10.1016/j.bcp.2021.114871. Epub 2021 Dec 10.

Stereoselectivity is important in many pharmacological processes but its impact on drug membrane transport is scarcely understood. Recent studies showed strong stereoselective effects in the cellular uptake of fenoterol by the organic cation transporters OCT1 and OCT2. To provide...

Comparison efficacy of randomized nebulized magnesium sulfate and ipratropium bromide/fenoterol in children with moderate to severe asthma exacerbation.

Asian Pacific journal of allergy and immunology

Wongwaree S, Daengsuwan T.
PMID: 31421659
Asian Pac J Allergy Immunol. 2019 Aug 18; doi: 10.12932/AP-190717-0118. Epub 2019 Aug 18.

BACKGROUND: In Thailand, nebulized ipratropium bromide/fenoterol, is commonly used in addition to salbutamol for severe asthma exacerbation. Recently, nebulized MgSO4 is indicated in GINA 2015 as an additive treatment for severe cases. However, there is limited data showed the...

Clinical efficacy and safety of the combination of ipratropium bromide and fenoterol inhaled via the Respimat Soft Mist inhaler for relief of airflow obstruction.

Expert review of respiratory medicine

Vincken W.
PMID: 20477218
Expert Rev Respir Med. 2008 Feb;2(1):11-26. doi: 10.1586/17476348.2.1.11.

Bronchodilators are key drugs in symptomatic as well as maintenance treatment of obstructive lung diseases such as chronic obstructive pulmonary disease and asthma. The short-acting anticholinergic ipratropium bromide and the short-acting beta(2)-adrenergic receptor agonist fenoterol hydrobromide have been available...

Safety of bronchodilator reversibility test in elderly subjects: a prospective study.

Postepy dermatologii i alergologii

Dor-Wojnarowska A, Parużyńska A, Kulczak A, Majewska-Pulsakowska M, Szymala-Pędzik M, Machaj Z, Sobieszczańska M, Poręba M.
PMID: 34408593
Postepy Dermatol Alergol. 2021 Apr;38(2):256-261. doi: 10.5114/ada.2020.92515. Epub 2020 Feb 19.

INTRODUCTION: The reversibility test measures an increase in ventilation parameters after the administration of 400 mg of a short-acting β-agonist (SABA). It is worth noting that a typical dosage, applied as a rescue medicine for bronchospastic dyspnoea, is significantly...

Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport.

Frontiers in pharmacology

Jensen O, Matthaei J, Klemp HG, Meyer MJ, Brockmöller J, Tzvetkov MV.
PMID: 34040533
Front Pharmacol. 2021 May 10;12:674559. doi: 10.3389/fphar.2021.674559. eCollection 2021.

Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse OCT1 suggested an OCT1-mediated efflux of IBC....

Fenoterol and dobutamine as SARS-CoV-2 main protease inhibitors: A virtual screening study.

Journal of molecular structure

Bolelli K, Ertan-Bolelli T, Unsalan O, Altunayar-Unsalan C.
PMID: 33071354
J Mol Struct. 2021 Mar 15;1228:129449. doi: 10.1016/j.molstruc.2020.129449. Epub 2020 Oct 13.

Global health is under heavy threat by a worldwide pandemic caused by a new type of coronavirus (COVID-19) since its rapid spread in China in 2019 [1]. Currently, there are no approved specific drugs and effective treatment for COVID-19...

Validation of Fenoterol to Study β2-Adrenoceptor Function in the Rat Urinary Bladder.

Pharmacology

Erdogan BR, Yesilyurt ZE, Arioglu-Inan E, Michel MC.
PMID: 34781292
Pharmacology. 2021 Nov 15;1-6. doi: 10.1159/000519720. Epub 2021 Nov 15.

Fenoterol is a β2-adrenoceptor (AR)-selective agonist that is commonly used to investigate relaxation responses mediated by β2-AR in smooth muscle preparations. Some data have questioned this because fenoterol had low potency in the rat urinary bladder when a muscarinic...

Showing 1 to 12 of 40 entries