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Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis.

Biomedicines

Kwofie SK, Broni E, Yunus FU, Nsoh J, Adoboe D, Miller WA, Wilson MD.
PMID: 34829911
Biomedicines. 2021 Nov 13;9(11). doi: 10.3390/biomedicines9111682.

Onchocerciasis is the leading cause of blindness and severe skin lesions which remain a major public health problem, especially in tropical areas. The widespread use of antibiotics and the long duration required for effective treatment continues to add to...

Cite
Kwofie SK, Broni E, Yunus FU, et al. Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis. Biomedicines. 2021;9(11)doi: 10.3390/biomedicines9111682.
Kwofie, S. K., Broni, E., Yunus, F. U., Nsoh, J., Adoboe, D., Miller, W. A., & Wilson, M. D. (2021). Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis. Biomedicines, 9(11), . https://doi.org/10.3390/biomedicines9111682
Kwofie, Samuel K, et al. "Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis." Biomedicines vol. 9,11 (2021). doi: https://doi.org/10.3390/biomedicines9111682
Kwofie SK, Broni E, Yunus FU, Nsoh J, Adoboe D, Miller WA, Wilson MD. Molecular Docking Simulation Studies Identifies Potential Natural Product Derived-Antiwolbachial Compounds as Filaricides against Onchocerciasis. Biomedicines. 2021 Nov 13;9(11). doi: 10.3390/biomedicines9111682. PMID: 34829911; PMCID: PMC8615632.
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Transglutaminase as a target for novel anti-filarial agents.

Indian journal of clinical biochemistry : IJCB

Mehta K.
PMID: 23100889
Indian J Clin Biochem. 1997 Dec;12:23-5. doi: 10.1007/BF02873049.

A rational approach for developing effective filaricides awaits greater knowledge on the biochemical pathways operating in filarial parasites. For example, metabolic pathways or key enzymes that are so pivotal to the parasite that their interruption or inhibition causes spontaneous...

Cite
Mehta K. Transglutaminase as a target for novel anti-filarial agents. Indian J Clin Biochem. 1997;12:23-5doi: 10.1007/BF02873049.
Mehta, K. (1997). Transglutaminase as a target for novel anti-filarial agents. Indian journal of clinical biochemistry : IJCB, 1223-5. https://doi.org/10.1007/BF02873049
Mehta, K. "Transglutaminase as a target for novel anti-filarial agents." Indian journal of clinical biochemistry : IJCB vol. 12 (1997): 23-5. doi: https://doi.org/10.1007/BF02873049
Mehta K. Transglutaminase as a target for novel anti-filarial agents. Indian J Clin Biochem. 1997 Dec;12:23-5. doi: 10.1007/BF02873049. PMID: 23100889; PMCID: PMC3454285.
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