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Showing 1 to 12 of 433 entries
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Clinical asthma phenotypes and therapeutic responses.

ISRN pediatrics

Zedan M, Attia G, Zedan MM, Osman A, Abo-Elkheir N, Maysara N, Barakat T, Gamil N.
PMID: 23606983
ISRN Pediatr. 2013 Mar 31;2013:824781. doi: 10.1155/2013/824781. Print 2013.

Asthma is a heterogeneous disease that means not all asthmatics respond to the same treatment. We hypothesize an approach to characterize asthma phenotypes based on symptomatology (shortness of breath (SOB), cough, and wheezy phenotypes) in correlation with airway inflammatory...

Effects of low-dose clarithromycin added to fluticasone on inflammatory markers and pulmonary function among children with asthma: A randomized clinical trial.

Allergy & rhinology (Providence, R.I.)

Wan KS, Liu YC, Huang CS, Su YM.
PMID: 28107143
Allergy Rhinol (Providence). 2016 Jan 01;7(3):131-134. doi: 10.2500/ar.2016.7.0168.

BACKGROUND: Macrolides exert anti-inflammatory and immunomodulatory effects beyond their purely antibacterial action, as demonstrated by several bronchial inflammatory disorders, including asthma.METHODS: Fifty-eight children with newly diagnosed mild persistent asthma were selected by using the Global Initiative for Asthma guidelines...

Impact of Nonadherence to Inhaled Corticosteroid/LABA Therapy on COPD Exacerbation Rates and Healthcare Costs in a Commercially Insured US Population.

American health & drug benefits

Davis JR, Wu B, Kern DM, Tunceli O, Fox KM, Horton J, Legg RF, Trudo F.
PMID: 28626506
Am Health Drug Benefits. 2017 Apr;10(2):92-102.

BACKGROUND: Evidence of poor patient adherence to medications for chronic obstructive pulmonary disease (COPD) is well-documented, but its impact on disease exacerbation rates and associated healthcare costs remains unclear.OBJECTIVE: To assess the association between adherence levels to different inhaled...

Instant velocity and consistency of emitted cloud change by the different levels of canister filling with Metered Dose Inhalers (MDIs), but not with Soft Mist Inhalers (SMIs): a bench study.

Multidisciplinary respiratory medicine

Dal Negro RW, Longo P, Ziani OV, Bonadiman L, Turco P.
PMID: 28560037
Multidiscip Respir Med. 2017 May 29;12:13. doi: 10.1186/s40248-017-0096-1. eCollection 2017.

BACKGROUND: Inhalation is the preferred route for respiratory drug delivery, but several factors contribute to the variability of the respirable dose fraction. Instant velocity and the dynamic characteristics of the droplet cloud represent crucial factors. Aim was to measure...

Maternal inhaled fluticasone propionate intake during pregnancy is detected in neonatal cord blood.

Bioanalysis

Battista MC, Boutin M, Venne P, Blais L, Bérard A, Lacroix M, Patenaude J, Guillemette L, Cossette B, Hivert MF, Auray-Blais C.
PMID: 27349687
Bioanalysis. 2016 Jul;8(14):1441-1450. doi: 10.4155/bio-2016-0065. Epub 2016 Jun 28.

BACKGROUND: Despite recommendations to use inhaled corticosteroids as treatment to control asthma during pregnancy, it is unknown whether inhaled fluticasone propionate (FP) reaches the fetus. Results & methodology: We collected maternal blood on the morning following delivery. FP was...

The effect of long-term use of intranasal steroids on intraocular pressure.

Clinical ophthalmology (Auckland, N.Z.)

Şimşek A, Bayraktar C, Doğan S, Karataş M, Sarıkaya Y.
PMID: 27354761
Clin Ophthalmol. 2016 Jun 10;10:1079-82. doi: 10.2147/OPTH.S106392. eCollection 2016.

Long-term use of topical nasal steroids (especially older generation steroids) has been shown to elevate intraocular pressure (IOP), but newer intranasal steroids are thought to have a minimal effect on IOP because of their low bioavailability. This study aimed...

Clinical efficacy of tiotropium in children with asthma.

Pakistan journal of medical sciences

Huang J, Chen Y, Long Z, Zhou X, Shu J.
PMID: 27182262
Pak J Med Sci. 2016 Mar-Apr;32(2):462-5. doi: 10.12669/pjms.322.8836.

OBJECTIVE: To investigate the clinical efficacy of tiotropium in children with asthma.METHODS: Eighty children with newly diagnosed moderate persistent asthma were enrolled into this study. The children were randomly assigned to the fluticasone propionate aerosol group or the fluticasone...

Systemic effects of inhaled corticosteroids: an overview.

The open respiratory medicine journal

Pandya D, Puttanna A, Balagopal V.
PMID: 25674175
Open Respir Med J. 2014 Dec 31;8:59-65. doi: 10.2174/1874306401408010059. eCollection 2014.

Inhaled corticosteroids (ICS) are common medications, used in respiratory medicine for controlling conditions such as asthma and other obstructive airway diseases. The systemic effects of oral corticosteroids are well known and established; inhaled steroids have been known to cause...

Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Bayes M, Rabasseda X, Prous JR.
PMID: 11980386
Methods Find Exp Clin Pharmacol. 2002 Jan-Feb;24(1):37-55.

Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses, which has been retrieved from the Clinical Studies knowledge area of Prous Science Integrity, the world's first drug discovery and development...

Adding intranasal fluticasone to cefuroxime resolved acute rhinosinusitis.

ACP journal club

Willett LR.
PMID: 12093213
ACP J Club. 2002 Jul-Aug;137(1):14.

No abstract available.

Fluticasone Propionate Reduces Oral Prednisone Use While it Improves Asthma Control.

American journal of therapeutics

Noonan M, Chervinsky P, Busse WW, Weisberg SC, Pinnas J, De Boisblanc BP, Boltansky H, Pearlman D, Repsher L, Kellerman D.
PMID: 11862281
Am J Ther. 1996 Jul;3(7):497-505. doi: 10.1097/00045391-199607000-00005.

This study examined the effect of fluticasone propionate aerosol on oral prednisone requirements in patients with severe asthma. Ninety-six patients dependent on oral prednisone were treated with placebo or fluticasone propionate aerosol (750 or 1000 &mgr;g twice daily) for...

Pneumonia in elderly patients with chronic obstructive pulmonary disease.

Current infectious disease reports

Ernst P, Suissa S.
PMID: 18510885
Curr Infect Dis Rep. 2008 May;10(3):223-8. doi: 10.1007/s11908-008-0037-4.

This article reviews the association between pneumonia and chronic obstructive pulmonary disease (COPD) and the possible role of inhaled corticosteroids in increasing the risk of pneumonia in patients with COPD. An increased risk of pneumonia with inhaled corticosteroids was...

Showing 1 to 12 of 433 entries