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Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs.

Molecular therapy. Methods & clinical development

Jaén ML, Vilà L, Elias I, Jimenez V, Rodó J, Maggioni L, Ruiz-de Gopegui R, Garcia M, Muñoz S, Callejas D, Ayuso E, Ferré T, Grifoll I, Andaluz A, Ruberte J, Haurigot V, Bosch F.
PMID: 28626777
Mol Ther Methods Clin Dev. 2017 Apr 05;6:1-7. doi: 10.1016/j.omtm.2017.03.008. eCollection 2017 Sep 15.

Diabetes is a complex metabolic disease that exposes patients to the deleterious effects of hyperglycemia on various organs. Achievement of normoglycemia with exogenous insulin treatment requires the use of high doses of hormone, which increases the risk of life-threatening...

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Jaén ML, Vilà L, Elias I, et al. Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs. Mol Ther Methods Clin Dev. 2017;6:1-7doi: 10.1016/j.omtm.2017.03.008.
Jaén, M. L., Vilà, L., Elias, I., Jimenez, V., Rodó, J., Maggioni, L., Ruiz-de Gopegui, R., Garcia, M., Muñoz, S., Callejas, D., Ayuso, E., Ferré, T., Grifoll, I., Andaluz, A., Ruberte, J., Haurigot, V., & Bosch, F. (2017). Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs. Molecular therapy. Methods & clinical development, 61-7. https://doi.org/10.1016/j.omtm.2017.03.008
Jaén, Maria Luisa, et al. "Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs." Molecular therapy. Methods & clinical development vol. 6 (2017): 1-7. doi: https://doi.org/10.1016/j.omtm.2017.03.008
Jaén ML, Vilà L, Elias I, Jimenez V, Rodó J, Maggioni L, Ruiz-de Gopegui R, Garcia M, Muñoz S, Callejas D, Ayuso E, Ferré T, Grifoll I, Andaluz A, Ruberte J, Haurigot V, Bosch F. Long-Term Efficacy and Safety of Insulin and Glucokinase Gene Therapy for Diabetes: 8-Year Follow-Up in Dogs. Mol Ther Methods Clin Dev. 2017 Apr 05;6:1-7. doi: 10.1016/j.omtm.2017.03.008. eCollection 2017 Sep 15. PMID: 28626777; PMCID: PMC5466581.
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Effect of vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, serum lipids, and body mass index: a randomized, double-blinded, placebo-controlled trial among healthy immigrants living in Norway.

BMJ open diabetes research & care

Madar AA, Knutsen KV, Stene LC, Brekke M, Meyer HE, Lagerløv P.
PMID: 25452867
BMJ Open Diabetes Res Care. 2014 Oct 13;2(1):e000026. doi: 10.1136/bmjdrc-2014-000026. eCollection 2014.

OBJECTIVE: Despite the suggested role of vitamin D in the prevention of diabetes and cardiovascular disease or its risk factors, the evidence is not consistent and there is a paucity of randomized controlled trials in this field. We aimed...

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Madar AA, Knutsen KV, Stene LC, et al. Effect of vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, serum lipids, and body mass index: a randomized, double-blinded, placebo-controlled trial among healthy immigrants living in Norway. BMJ Open Diabetes Res Care. 2014;2(1):e000026doi: 10.1136/bmjdrc-2014-000026.
Madar, A. A., Knutsen, K. V., Stene, L. C., Brekke, M., Meyer, H. E., & Lagerløv, P. (2014). Effect of vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, serum lipids, and body mass index: a randomized, double-blinded, placebo-controlled trial among healthy immigrants living in Norway. BMJ open diabetes research & care, 2(1), e000026. https://doi.org/10.1136/bmjdrc-2014-000026
Madar, Ahmed A, et al. "Effect of vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, serum lipids, and body mass index: a randomized, double-blinded, placebo-controlled trial among healthy immigrants living in Norway." BMJ open diabetes research & care vol. 2,1 (2014): e000026. doi: https://doi.org/10.1136/bmjdrc-2014-000026
Madar AA, Knutsen KV, Stene LC, Brekke M, Meyer HE, Lagerløv P. Effect of vitamin D3 supplementation on glycated hemoglobin (HbA1c), fructosamine, serum lipids, and body mass index: a randomized, double-blinded, placebo-controlled trial among healthy immigrants living in Norway. BMJ Open Diabetes Res Care. 2014 Oct 13;2(1):e000026. doi: 10.1136/bmjdrc-2014-000026. eCollection 2014. PMID: 25452867; PMCID: PMC4212570.
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Glycated albumin is the preferred marker for assessing glycaemic control in advanced chronic kidney disease.

NDT plus

Vos FE, Schollum JB, Walker RJ.
PMID: 25984197
NDT Plus. 2011 Dec;4(6):368-75. doi: 10.1093/ndtplus/sfr140.

Diabetic nephropathy is the most common aetiology of end-stage kidney disease (ESKD). Strict glycaemic control reduces the development and progression of diabetes-related complications, and there is evidence that improved metabolic control improves outcomes in diabetic subjects with advanced chronic...

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Vos FE, Schollum JB, Walker RJ. Glycated albumin is the preferred marker for assessing glycaemic control in advanced chronic kidney disease. NDT Plus. 2011;4(6):368-75doi: 10.1093/ndtplus/sfr140.
Vos, F. E., Schollum, J. B., & Walker, R. J. (2011). Glycated albumin is the preferred marker for assessing glycaemic control in advanced chronic kidney disease. NDT plus, 4(6), 368-75. https://doi.org/10.1093/ndtplus/sfr140
Vos, Frederiek E, et al. "Glycated albumin is the preferred marker for assessing glycaemic control in advanced chronic kidney disease." NDT plus vol. 4,6 (2011): 368-75. doi: https://doi.org/10.1093/ndtplus/sfr140
Vos FE, Schollum JB, Walker RJ. Glycated albumin is the preferred marker for assessing glycaemic control in advanced chronic kidney disease. NDT Plus. 2011 Dec;4(6):368-75. doi: 10.1093/ndtplus/sfr140. PMID: 25984197; PMCID: PMC4421676.
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Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels.

AIDS research and treatment

Duran L, Rodriguez C, Drozd D, Nance RM, Delaney JA, Burkholder G, Mugavero MJ, Willig JH, Warriner AH, Crane PK, Atkinson BE, Harrington RD, Dhanireddy S, Saag MS, Kitahata MM, Crane HM.
PMID: 26273478
AIDS Res Treat. 2015;2015:478750. doi: 10.1155/2015/478750. Epub 2015 Jul 26.

Fructosamine is an alternative method to hemoglobin A1c (HbA1c) for determining average glycemia. However, its use has not been extensively evaluated in persons living with HIV (PLWH). We examined the relationship between HbA1c and fructosamine values, specifically focusing on...

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Duran L, Rodriguez C, Drozd D, et al. Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels. AIDS Res Treat. 2015;2015:478750doi: 10.1155/2015/478750.
Duran, L., Rodriguez, C., Drozd, D., Nance, R. M., Delaney, J. A., Burkholder, G., Mugavero, M. J., Willig, J. H., Warriner, A. H., Crane, P. K., Atkinson, B. E., Harrington, R. D., Dhanireddy, S., Saag, M. S., Kitahata, M. M., & Crane, H. M. (2015). Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels. AIDS research and treatment, 2015478750. https://doi.org/10.1155/2015/478750
Duran, Luisa, et al. "Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels." AIDS research and treatment vol. 2015 (2015): 478750. doi: https://doi.org/10.1155/2015/478750
Duran L, Rodriguez C, Drozd D, Nance RM, Delaney JA, Burkholder G, Mugavero MJ, Willig JH, Warriner AH, Crane PK, Atkinson BE, Harrington RD, Dhanireddy S, Saag MS, Kitahata MM, Crane HM. Fructosamine and Hemoglobin A1c Correlations in HIV-Infected Adults in Routine Clinical Care: Impact of Anemia and Albumin Levels. AIDS Res Treat. 2015;2015:478750. doi: 10.1155/2015/478750. Epub 2015 Jul 26. PMID: 26273478; PMCID: PMC4529884.
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Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?.

Journal of laboratory physicians

Gorar S, Alioglu B, Ademoglu E, Uyar S, Bekdemir H, Candan Z, Saglam B, Koc G, Culha C, Aral Y.
PMID: 27365919
J Lab Physicians. 2016 Jul-Dec;8(2):101-5. doi: 10.4103/0974-2727.180790.

CONTEXT: Impact of gestational diabetes mellitus (GDM) on the coagulation system, dynamics involved at a pathophysiological level and the exact mechanism remain unclear.AIMS: To evaluate the association between diabetes-related parameters and hemostatic factors to search for a tendency of...

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Gorar S, Alioglu B, Ademoglu E, et al. Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?. J Lab Physicians. 2016;8(2):101-5doi: 10.4103/0974-2727.180790.
Gorar, S., Alioglu, B., Ademoglu, E., Uyar, S., Bekdemir, H., Candan, Z., Saglam, B., Koc, G., Culha, C., & Aral, Y. (2016). Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?. Journal of laboratory physicians, 8(2), 101-5. https://doi.org/10.4103/0974-2727.180790
Gorar, Suheyla, et al. "Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?." Journal of laboratory physicians vol. 8,2 (2016): 101-5. doi: https://doi.org/10.4103/0974-2727.180790
Gorar S, Alioglu B, Ademoglu E, Uyar S, Bekdemir H, Candan Z, Saglam B, Koc G, Culha C, Aral Y. Is There a Tendency for Thrombosis in Gestational Diabetes Mellitus?. J Lab Physicians. 2016 Jul-Dec;8(2):101-5. doi: 10.4103/0974-2727.180790. PMID: 27365919; PMCID: PMC4866379.
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Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory.

Nutrition & metabolism

Yonamine CY, Pinheiro-Machado E, Michalani ML, Freitas HS, Okamoto MM, Corrêa-Giannella ML, Machado UF.
PMID: 27366200
Nutr Metab (Lond). 2016 Jun 29;13:44. doi: 10.1186/s12986-016-0103-0. eCollection 2016.

BACKGROUND: Resveratrol is a natural polyphenol that has been proposed to improve glycemic control in diabetes, by mechanisms that involve improvement in insulin secretion and activity. In type 1 diabetes (T1D), in which insulin therapy is obligatory, resveratrol treatment...

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Yonamine CY, Pinheiro-Machado E, Michalani ML, et al. Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Nutr Metab (Lond). 2016;13:44doi: 10.1186/s12986-016-0103-0.
Yonamine, C. Y., Pinheiro-Machado, E., Michalani, M. L., Freitas, H. S., Okamoto, M. M., Corrêa-Giannella, M. L., & Machado, U. F. (2016). Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Nutrition & metabolism, 1344. https://doi.org/10.1186/s12986-016-0103-0
Yonamine, Caio Yogi, et al. "Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory." Nutrition & metabolism vol. 13 (2016): 44. doi: https://doi.org/10.1186/s12986-016-0103-0
Yonamine CY, Pinheiro-Machado E, Michalani ML, Freitas HS, Okamoto MM, Corrêa-Giannella ML, Machado UF. Resveratrol improves glycemic control in insulin-treated diabetic rats: participation of the hepatic territory. Nutr Metab (Lond). 2016 Jun 29;13:44. doi: 10.1186/s12986-016-0103-0. eCollection 2016. PMID: 27366200; PMCID: PMC4928352.
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Fructosamine levels demonstrate improved glycemic control for some children attending a diabetes summer camp.

Pediatric diabetes

Post EM, Moore JD, Ihrke J, Aisenberg J.
PMID: 15016217
Pediatr Diabetes. 2000 Dec;1(4):204-8. doi: 10.1046/j.1399543x.2000.010406.x.

Residential summer camps for youths with diabetes may have a positive effect on glycemic control. Hemoglobin A1c (HbA1c) is considered the best measure of control, but it reflects too long a period to evaluate a camp session. The fructosamine...

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Post EM, Moore JD, Ihrke J, et al. Fructosamine levels demonstrate improved glycemic control for some children attending a diabetes summer camp. Pediatr Diabetes. 2000;1(4):204-8doi: 10.1046/j.1399543x.2000.010406.x.
Post, E. M., Moore, J. D., Ihrke, J., & Aisenberg, J. (2000). Fructosamine levels demonstrate improved glycemic control for some children attending a diabetes summer camp. Pediatric diabetes, 1(4), 204-8. https://doi.org/10.1046/j.1399543x.2000.010406.x
Post, E M, et al. "Fructosamine levels demonstrate improved glycemic control for some children attending a diabetes summer camp." Pediatric diabetes vol. 1,4 (2000): 204-8. doi: https://doi.org/10.1046/j.1399543x.2000.010406.x
Post EM, Moore JD, Ihrke J, Aisenberg J. Fructosamine levels demonstrate improved glycemic control for some children attending a diabetes summer camp. Pediatr Diabetes. 2000 Dec;1(4):204-8. doi: 10.1046/j.1399543x.2000.010406.x. PMID: 15016217.
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Early and advanced glycation end-products are increased in dietary copper deficiency.

The Journal of nutritional biochemistry

Saari JT, Dahlen GM.
PMID: 15539292
J Nutr Biochem. 1999 Apr;10(4):210-4. doi: 10.1016/s0955-2863(98)00100-4.

The hypothesis that nonenzymatic glycosylation of proteins (glycation) contributes to damage associated with dietary copper deficiency has depended largely on indirect evidence. Thus far, the observation of an elevated percentage of glycated hemoglobin in copper-deficient rats has provided the...

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Saari JT, Dahlen GM. Early and advanced glycation end-products are increased in dietary copper deficiency. J Nutr Biochem. 1999;10(4):210-4doi: 10.1016/s0955-2863(98)00100-4.
Saari, J. T., & Dahlen, G. M. (1999). Early and advanced glycation end-products are increased in dietary copper deficiency. The Journal of nutritional biochemistry, 10(4), 210-4. https://doi.org/10.1016/s0955-2863(98)00100-4
Saari, J T, and Dahlen, G M. "Early and advanced glycation end-products are increased in dietary copper deficiency." The Journal of nutritional biochemistry vol. 10,4 (1999): 210-4. doi: https://doi.org/10.1016/s0955-2863(98)00100-4
Saari JT, Dahlen GM. Early and advanced glycation end-products are increased in dietary copper deficiency. J Nutr Biochem. 1999 Apr;10(4):210-4. doi: 10.1016/s0955-2863(98)00100-4. PMID: 15539292.
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Increased non-enzymatic glycation of plasma proteins and hemoglobin in non-diabetic patients with acute myocardial infarction (MI).

Journal of clinical and diagnostic research : JCDR

Parthibane V, Selvaraj N, Sathiyapriya V, Bobby Z, Rajappa M.
PMID: 24551614
J Clin Diagn Res. 2013 Dec;7(12):2692-3. doi: 10.7860/JCDR/2013/7331.3884. Epub 2013 Nov 11.

BACKGROUND: Glycation is known to play a key role in complications of many pathophysiological processes. The present study was carried out to assess whether there are abnormalities of non-enzymatic glycation of proteins and hemoglobin in acute Myocardial Infarction (MI)...

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Parthibane V, Selvaraj N, Sathiyapriya V, et al. Increased non-enzymatic glycation of plasma proteins and hemoglobin in non-diabetic patients with acute myocardial infarction (MI). J Clin Diagn Res. 2013;7(12):2692-3doi: 10.7860/JCDR/2013/7331.3884.
Parthibane, V., Selvaraj, N., Sathiyapriya, V., Bobby, Z., & Rajappa, M. (2013). Increased non-enzymatic glycation of plasma proteins and hemoglobin in non-diabetic patients with acute myocardial infarction (MI). Journal of clinical and diagnostic research : JCDR, 7(12), 2692-3. https://doi.org/10.7860/JCDR/2013/7331.3884
Parthibane, V, et al. "Increased non-enzymatic glycation of plasma proteins and hemoglobin in non-diabetic patients with acute myocardial infarction (MI)." Journal of clinical and diagnostic research : JCDR vol. 7,12 (2013): 2692-3. doi: https://doi.org/10.7860/JCDR/2013/7331.3884
Parthibane V, Selvaraj N, Sathiyapriya V, Bobby Z, Rajappa M. Increased non-enzymatic glycation of plasma proteins and hemoglobin in non-diabetic patients with acute myocardial infarction (MI). J Clin Diagn Res. 2013 Dec;7(12):2692-3. doi: 10.7860/JCDR/2013/7331.3884. Epub 2013 Nov 11. PMID: 24551614; PMCID: PMC3919377.
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Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients.

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

Rizk SM, Sabri NA.
PMID: 23964162
Saudi Pharm J. 2009 Jul;17(3):199-207. doi: 10.1016/j.jsps.2009.08.008. Epub 2009 Aug 07.

BACKGROUND: The incidence of cardiovascular disease in patients with type 2 diabetes mellitus is approximately twice as high as in the non-diabetic population.AIM: To investigate the hypoglycemic and hypocholesterolemic effects of Daflon(®) 500 mg (DF) administration together with its...

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Rizk SM, Sabri NA. Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients. Saudi Pharm J. 2009;17(3):199-207doi: 10.1016/j.jsps.2009.08.008.
Rizk, S. M., & Sabri, N. A. (2009). Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society, 17(3), 199-207. https://doi.org/10.1016/j.jsps.2009.08.008
Rizk, Sherine Maher, and Sabri, Nagwa Ali. "Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients." Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society vol. 17,3 (2009): 199-207. doi: https://doi.org/10.1016/j.jsps.2009.08.008
Rizk SM, Sabri NA. Evaluation of clinical activity and safety of Daflon 500 mg in type 2 diabetic female patients. Saudi Pharm J. 2009 Jul;17(3):199-207. doi: 10.1016/j.jsps.2009.08.008. Epub 2009 Aug 07. PMID: 23964162; PMCID: PMC3731024.
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Altered fructosamine and lipid fractions in subclinical hypothyroidism.

Journal of clinical and diagnostic research : JCDR

Udupa SV, Manjrekar PA, Udupa VA, Vivian D.
PMID: 23449765
J Clin Diagn Res. 2013 Jan;7(1):18-22. doi: 10.7860/JCDR/2012/5011.2660. Epub 2013 Jan 01.

BACKGROUND: Thyroid function disorders lead to changes in the lipoprotein metabolism.OBJECTIVES: To study the lipid and the glycaemic abnormalities in the subclinical hypothyroidism cases and to compare the same with the euthyroid, overt hypothyroid and the hyperthyroid subjects.METHODOLOGY: Four...

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Udupa SV, Manjrekar PA, Udupa VA, et al. Altered fructosamine and lipid fractions in subclinical hypothyroidism. J Clin Diagn Res. 2013;7(1):18-22doi: 10.7860/JCDR/2012/5011.2660.
Udupa, S. V., Manjrekar, P. A., Udupa, V. A., & Vivian, D. (2013). Altered fructosamine and lipid fractions in subclinical hypothyroidism. Journal of clinical and diagnostic research : JCDR, 7(1), 18-22. https://doi.org/10.7860/JCDR/2012/5011.2660
Udupa, Sridevi V, et al. "Altered fructosamine and lipid fractions in subclinical hypothyroidism." Journal of clinical and diagnostic research : JCDR vol. 7,1 (2013): 18-22. doi: https://doi.org/10.7860/JCDR/2012/5011.2660
Udupa SV, Manjrekar PA, Udupa VA, Vivian D. Altered fructosamine and lipid fractions in subclinical hypothyroidism. J Clin Diagn Res. 2013 Jan;7(1):18-22. doi: 10.7860/JCDR/2012/5011.2660. Epub 2013 Jan 01. PMID: 23449765; PMCID: PMC3576741.
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Effect of a short-term exercise program on glycemic control measured by fructosamine test in type 2 diabetes patients.

Diabetology & metabolic syndrome

Moura BP, Amorim PR, Silva BP, Franceschini SC, Reis JS, Marins JC.
PMID: 24512719
Diabetol Metab Syndr. 2014 Feb 11;6(1):16. doi: 10.1186/1758-5996-6-16.

BACKGROUND: Glycated hemoglobin (A1C) and Fasting Plasma Glucose (FPG) are the two monitoring blood glucose tests most frequently used. However, both methods are shown to be insensitive to detect glycemic variations in short duration periods. Therefore, we aimed to...

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Moura BP, Amorim PR, Silva BP, et al. Effect of a short-term exercise program on glycemic control measured by fructosamine test in type 2 diabetes patients. Diabetol Metab Syndr. 2014;6(1):16doi: 10.1186/1758-5996-6-16.
Moura, B. P., Amorim, P. R., Silva, B. P., Franceschini, S. C., Reis, J. S., & Marins, J. C. (2014). Effect of a short-term exercise program on glycemic control measured by fructosamine test in type 2 diabetes patients. Diabetology & metabolic syndrome, 6(1), 16. https://doi.org/10.1186/1758-5996-6-16
Moura, Bruno P, et al. "Effect of a short-term exercise program on glycemic control measured by fructosamine test in type 2 diabetes patients." Diabetology & metabolic syndrome vol. 6,1 (2014): 16. doi: https://doi.org/10.1186/1758-5996-6-16
Moura BP, Amorim PR, Silva BP, Franceschini SC, Reis JS, Marins JC. Effect of a short-term exercise program on glycemic control measured by fructosamine test in type 2 diabetes patients. Diabetol Metab Syndr. 2014 Feb 11;6(1):16. doi: 10.1186/1758-5996-6-16. PMID: 24512719; PMCID: PMC3925446.
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