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Showing 1 to 12 of 36 entries
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First Base-Free Catalytic Wittig Reaction.

Organic letters

Schirmer ML, Adomeit S, Werner T.
PMID: 26020449
Org Lett. 2015 Jun 19;17(12):3078-81. doi: 10.1021/acs.orglett.5b01352. Epub 2015 May 28.

The first base-free catalytic Wittig reaction utilizing readily available Bu3P (5 mol %) as an organocatalyst is reported. The initial Michael addition of the phosphine to a suitable acceptor substituted alkene ultimately results in the formation of an ylide...

Diastereoselective addition of monoorganocuprates to a chiral fumarate: reaction development and synthesis of (-)-dihydroprotolichesterinic acid.

Tetrahedron

Hethcox JC, Shanahan CS, Martin SF.
PMID: 26273115
Tetrahedron. 2015 Sep 16;71(37):6361-6368. doi: 10.1016/j.tet.2015.05.023.

Recent studies of diastereoselective conjugate additions of monoorganocuprates, Li[RCuI], to chiral γ-alkoxycrotonates and fumarates are disclosed. This methodology was applied to the shortest total synthesis of (-)-dihydroprotolichesterinic acid to date, but several attempts to prepare other succinate-derived natural products,...

Effects of fumarates on circulating and CNS myeloid cells in multiple sclerosis.

Annals of clinical and translational neurology

Michell-Robinson MA, Moore CS, Healy LM, Osso LA, Zorko N, Grouza V, Touil H, Poliquin-Lasnier L, Trudelle AM, Giacomini PS, Bar-Or A, Antel JP.
PMID: 26783548
Ann Clin Transl Neurol. 2015 Dec 02;3(1):27-41. doi: 10.1002/acn3.270. eCollection 2016 Jan.

OBJECTIVE: Dimethyl fumarate (DMF), a therapy for relapsing-remitting multiple sclerosis (RRMS), is implicated as acting on inflammatory and antioxidant responses within both systemic immune and/or central nervous system (CNS) compartments. Orally administered DMF is rapidly metabolized to monomethyl fumarate...

Organic acids for performance enhancement in pig diets.

Nutrition research reviews

Partanen KH, Mroz Z.
PMID: 19087448
Nutr Res Rev. 1999 Jun;12(1):117-45. doi: 10.1079/095442299108728884.

Organic acids and their salts appear to be potential alternatives to prophylactic in-feed antibiotics and growth promoters in order to improve the performance of weaned piglets, fattening pigs and reproductive sows, although their growth-promoting effects are generally less than...

Fumarates in dermatology.

Indian dermatology online journal

Rajagopalan M.
PMID: 23130242
Indian Dermatol Online J. 2011 Jul;2(2):119-20.

No abstract available.

Investigating discrepancies between experimental solid-state NMR and GIPAW calculation: NC-N .

Solid state nuclear magnetic resonance

Corlett EK, Blade H, Hughes LP, Sidebottom PJ, Walker D, Walton RI, Brown SP.
PMID: 32590237
Solid State Nucl Magn Reson. 2020 Aug;108:101662. doi: 10.1016/j.ssnmr.2020.101662. Epub 2020 Apr 10.

An NMR crystallography analysis is presented for four solid-state structures of pyridine fumarates and their cocrystals, using crystal structures deposited in the Cambridge Crystallographic Data Centre, CCDC. Experimental one-dimensional one-pulse

Co-crystals, Salts or Mixtures of Both? The Case of Tenofovir Alafenamide Fumarates.

Pharmaceutics

Lengauer H, Makuc D, Šterk D, Perdih F, Pichler A, Trdan Lušin T, Plavec J, Časar Z.
PMID: 32290280
Pharmaceutics. 2020 Apr 10;12(4). doi: 10.3390/pharmaceutics12040342.

Tenofovir alafenamide fumarate (TAF) is the newest prodrug of tenofovir that constitutes several drug products used for the treatment of HIV/AIDS. Although the solid-state properties of its predecessor tenofovir disoproxil fumarate have been investigated and described in the literature,...

[Hospital, aims and organization].

Arquivos de higiene e saude publica

GUMARAES C.
PMID: 13709742
Arq Hig Saude Publica. 1961 Jun;26:141-5.

No abstract available.

Fumaric acid esters in the management of psoriasis.

Psoriasis (Auckland, N.Z.)

Balak DM.
PMID: 29387578
Psoriasis (Auckl). 2015 Jan 05;5:9-23. doi: 10.2147/PTT.S51490. eCollection 2015.

Fumaric acid esters (FAE) are small molecules with immunomodulating, anti-inflammatory, and anti-oxidative effects. FAE were introduced as a systemic psoriasis treatment in 1959 and empirically developed further between 1970 and 1990 in Germany, Switzerland, and the Netherlands. The development...

Effects of fumarates on inflammatory human astrocyte responses and oligodendrocyte differentiation.

Annals of clinical and translational neurology

Galloway DA, Williams JB, Moore CS.
PMID: 28589165
Ann Clin Transl Neurol. 2017 May 04;4(6):381-391. doi: 10.1002/acn3.414. eCollection 2017 Jun.

OBJECTIVE: Dimethyl fumarate (DMF) is a fumaric acid ester approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). In both the brain and periphery, DMF and its metabolite monomethyl fumarate (MMF) exert anti-inflammatory and antioxidant effects. Our aim was...

Drug-induced Fanconi syndrome associated with fumaric acid esters treatment for psoriasis: a case series.

Clinical kidney journal

Balak DM, Bouwes Bavinck JN, de Vries AP, Hartman J, Neumann HA, Zietse R, Thio HB.
PMID: 26798466
Clin Kidney J. 2016 Feb;9(1):82-9. doi: 10.1093/ckj/sfv114. Epub 2015 Nov 10.

BACKGROUND: Fumaric acid esters (FAEs), an oral immunomodulating treatment for psoriasis and multiple sclerosis, have been anecdotally associated with proximal renal tubular dysfunction due to a drug-induced Fanconi syndrome. Few data are available on clinical outcomes of FAE-induced Fanconi...

A new polymorph of bis(2-aminopyridinium) fumarate-fumaric acid (1/1) from powder X-ray diffraction.

Acta crystallographica. Section C, Crystal structure communications

Dong S, Tao Y, Shen X, Pan Z.
PMID: 23907885
Acta Crystallogr C. 2013 Aug;69:896-900. doi: 10.1107/S0108270113017423. Epub 2013 Jul 13.

A new polymorph of bis(2-aminopyridinium) fumarate-fumaric acid (1/1), 2C₅H₇N₂⁺∙C₄H₂O₄²⁻-·C₄H₄O₄, was obtained and its crystal structure determined by powder X-ray diffraction. The new polymorph (form II) crystallizes in the triclinic system (space group P-1), while the previous reported polymorph [form...

Showing 1 to 12 of 36 entries