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Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder.

Communications biology

de Jong S, Diniz MJA, Saloma A, Gadelha A, Santoro ML, Ota VK, Noto C, Curtis C, Newhouse SJ, Patel H, Hall LS, O Reilly PF, Belangero SI, Bressan RA, Breen G.
PMID: 30320231
Commun Biol. 2018 Oct 08;1:163. doi: 10.1038/s42003-018-0155-y. eCollection 2018.

Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores...

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