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Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum.

PLoS clinical trials

Dunyo S, Ord R, Hallett R, Jawara M, Walraven G, Mesa E, Coleman R, Sowe M, Alexander N, Targett GA, Pinder M, Sutherland CJ.
PMID: 16871319
PLoS Clin Trials. 2006 Jul 21;1(3):e14. doi: 10.1371/journal.pctr.0010014.

OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence of parasites carrying alleles...

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Dunyo S, Ord R, Hallett R, et al. Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. PLoS Clin Trials. 2006;1(3):e14doi: 10.1371/journal.pctr.0010014.
Dunyo, S., Ord, R., Hallett, R., Jawara, M., Walraven, G., Mesa, E., Coleman, R., Sowe, M., Alexander, N., Targett, G. A., Pinder, M., & Sutherland, C. J. (2006). Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. PLoS clinical trials, 1(3), e14. https://doi.org/10.1371/journal.pctr.0010014
Dunyo, Samuel, et al. "Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum." PLoS clinical trials vol. 1,3 (2006): e14. doi: https://doi.org/10.1371/journal.pctr.0010014
Dunyo S, Ord R, Hallett R, Jawara M, Walraven G, Mesa E, Coleman R, Sowe M, Alexander N, Targett GA, Pinder M, Sutherland CJ. Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. PLoS Clin Trials. 2006 Jul 21;1(3):e14. doi: 10.1371/journal.pctr.0010014. PMID: 16871319; PMCID: PMC1513406.
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Using verbal autopsy to assess the prevalence of HIV infection among deaths in the ART period in rural Uganda: a prospective cohort study, 2006-2008.

Population health metrics

Mayanja BN, Baisley K, Nalweyiso N, Kibengo FM, Mugisha JO, Van der Paal L, Maher D, Kaleebu P.
PMID: 21816100
Popul Health Metr. 2011 Aug 04;9:36. doi: 10.1186/1478-7954-9-36.

BACKGROUND: Verbal autopsy is important for detecting causes of death including HIV in areas with inadequate vital registration systems. Before antiretroviral therapy (ART) introduction, a verbal autopsy study in rural Uganda found that half of adult deaths assessed were...

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Mayanja BN, Baisley K, Nalweyiso N, et al. Using verbal autopsy to assess the prevalence of HIV infection among deaths in the ART period in rural Uganda: a prospective cohort study, 2006-2008. Popul Health Metr. 2011;9:36doi: 10.1186/1478-7954-9-36.
Mayanja, B. N., Baisley, K., Nalweyiso, N., Kibengo, F. M., Mugisha, J. O., Van der Paal, L., Maher, D., & Kaleebu, P. (2011). Using verbal autopsy to assess the prevalence of HIV infection among deaths in the ART period in rural Uganda: a prospective cohort study, 2006-2008. Population health metrics, 936. https://doi.org/10.1186/1478-7954-9-36
Mayanja, Billy N, et al. "Using verbal autopsy to assess the prevalence of HIV infection among deaths in the ART period in rural Uganda: a prospective cohort study, 2006-2008." Population health metrics vol. 9 (2011): 36. doi: https://doi.org/10.1186/1478-7954-9-36
Mayanja BN, Baisley K, Nalweyiso N, Kibengo FM, Mugisha JO, Van der Paal L, Maher D, Kaleebu P. Using verbal autopsy to assess the prevalence of HIV infection among deaths in the ART period in rural Uganda: a prospective cohort study, 2006-2008. Popul Health Metr. 2011 Aug 04;9:36. doi: 10.1186/1478-7954-9-36. PMID: 21816100; PMCID: PMC3160929.
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The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study.

Emerging themes in epidemiology

Bottomley C, Bojang A, Smith PG, Darboe O, Antonio M, Foster-Nyarko E, Kampmann B, Greenwood B, D'Alessandro U, Roca A.
PMID: 25642277
Emerg Themes Epidemiol. 2015 Jan 16;12(1):1. doi: 10.1186/s12982-014-0022-3. eCollection 2015.

BACKGROUND: There is increasing evidence that childhood vaccines have effects that extend beyond their target disease. The objective of this study was to assess the effects of routine childhood vaccines on bacterial carriage in the nasopharynx.METHODS: A cohort of...

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Bottomley C, Bojang A, Smith PG, et al. The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study. Emerg Themes Epidemiol. 2015;12(1):1doi: 10.1186/s12982-014-0022-3.
Bottomley, C., Bojang, A., Smith, P. G., Darboe, O., Antonio, M., Foster-Nyarko, E., Kampmann, B., Greenwood, B., D'Alessandro, U., & Roca, A. (2015). The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study. Emerging themes in epidemiology, 12(1), 1. https://doi.org/10.1186/s12982-014-0022-3
Bottomley, Christian, et al. "The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study." Emerging themes in epidemiology vol. 12,1 (2015): 1. doi: https://doi.org/10.1186/s12982-014-0022-3
Bottomley C, Bojang A, Smith PG, Darboe O, Antonio M, Foster-Nyarko E, Kampmann B, Greenwood B, D'Alessandro U, Roca A. The impact of childhood vaccines on bacterial carriage in the nasopharynx: a longitudinal study. Emerg Themes Epidemiol. 2015 Jan 16;12(1):1. doi: 10.1186/s12982-014-0022-3. eCollection 2015. PMID: 25642277; PMCID: PMC4312604.
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Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum.

PLoS clinical trials

Hallett RL, Dunyo S, Ord R, Jawara M, Pinder M, Randall A, Alloueche A, Walraven G, Targett GA, Alexander N, Sutherland CJ.
PMID: 16871318
PLoS Clin Trials. 2006 Jul 21;1(3):e15. doi: 10.1371/journal.pctr.0010015.

OBJECTIVES: In the Gambia, chloroquine (CQ) plus sulphadoxine-pyrimethamine (SP) is the first-line antimalarial treatment. Plasmodium falciparum parasites carrying mutations associated with resistance to each of these drugs were present in 2001 but did not cause a significant loss of...

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Hallett RL, Dunyo S, Ord R, et al. Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum. PLoS Clin Trials. 2006;1(3):e15doi: 10.1371/journal.pctr.0010015.
Hallett, R. L., Dunyo, S., Ord, R., Jawara, M., Pinder, M., Randall, A., Alloueche, A., Walraven, G., Targett, G. A., Alexander, N., & Sutherland, C. J. (2006). Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum. PLoS clinical trials, 1(3), e15. https://doi.org/10.1371/journal.pctr.0010015
Hallett, Rachel L, et al. "Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum." PLoS clinical trials vol. 1,3 (2006): e15. doi: https://doi.org/10.1371/journal.pctr.0010015
Hallett RL, Dunyo S, Ord R, Jawara M, Pinder M, Randall A, Alloueche A, Walraven G, Targett GA, Alexander N, Sutherland CJ. Chloroquine/sulphadoxine-pyrimethamine for gambian children with malaria: transmission to mosquitoes of multidrug-resistant Plasmodium falciparum. PLoS Clin Trials. 2006 Jul 21;1(3):e15. doi: 10.1371/journal.pctr.0010015. PMID: 16871318; PMCID: PMC1513405.
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Long-term impact of malaria chemoprophylaxis on cognitive abilities and educational attainment: follow-up of a controlled trial.

PLoS clinical trials

Jukes MC, Pinder M, Grigorenko EL, Smith HB, Walraven G, Bariau EM, Sternberg RJ, Drake LJ, Milligan P, Cheung YB, Greenwood BM, Bundy DA.
PMID: 17013430
PLoS Clin Trials. 2006 Aug 18;1(4):e19. doi: 10.1371/journal.pctr.0010019.

OBJECTIVES: We investigated the long-term impact of early childhood malaria prophylaxis on cognitive and educational outcomes.DESIGN: This was a household-based cluster-controlled intervention trial.SETTING: The study was conducted in 15 villages situated between 32 km to the east and 22...

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Jukes MC, Pinder M, Grigorenko EL, et al. Long-term impact of malaria chemoprophylaxis on cognitive abilities and educational attainment: follow-up of a controlled trial. PLoS Clin Trials. 2006;1(4):e19doi: 10.1371/journal.pctr.0010019.
Jukes, M. C., Pinder, M., Grigorenko, E. L., Smith, H. B., Walraven, G., Bariau, E. M., Sternberg, R. J., Drake, L. J., Milligan, P., Cheung, Y. B., Greenwood, B. M., & Bundy, D. A. (2006). Long-term impact of malaria chemoprophylaxis on cognitive abilities and educational attainment: follow-up of a controlled trial. PLoS clinical trials, 1(4), e19. https://doi.org/10.1371/journal.pctr.0010019
Jukes, Matthew C H, et al. "Long-term impact of malaria chemoprophylaxis on cognitive abilities and educational attainment: follow-up of a controlled trial." PLoS clinical trials vol. 1,4 (2006): e19. doi: https://doi.org/10.1371/journal.pctr.0010019
Jukes MC, Pinder M, Grigorenko EL, Smith HB, Walraven G, Bariau EM, Sternberg RJ, Drake LJ, Milligan P, Cheung YB, Greenwood BM, Bundy DA. Long-term impact of malaria chemoprophylaxis on cognitive abilities and educational attainment: follow-up of a controlled trial. PLoS Clin Trials. 2006 Aug 18;1(4):e19. doi: 10.1371/journal.pctr.0010019. PMID: 17013430; PMCID: PMC1851720.
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Exit interviews administered to patients participating in the COSTOP placebo controlled randomised trial in Uganda.

Contemporary clinical trials communications

Nunn A, Anywaine Z, Seeley J, Munderi P, Levin J, Kasirye R, Kamali A, Abaasa A, Grosskurth H.
PMID: 27536738
Contemp Clin Trials Commun. 2016 Aug 15;3:142-146. doi: 10.1016/j.conctc.2016.05.008.

INTRODUCTION: COSTOP was a randomised controlled trial designed to assess the risks and benefits to HIV-infected participants stabilised on anti-retroviral treatment of stopping cotrimoxazole (CTX). In order to assess the extent to which patients may have had access to...

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Nunn A, Anywaine Z, Seeley J, et al. Exit interviews administered to patients participating in the COSTOP placebo controlled randomised trial in Uganda. Contemp Clin Trials Commun. 2016;3:142-146doi: 10.1016/j.conctc.2016.05.008.
Nunn, A., Anywaine, Z., Seeley, J., Munderi, P., Levin, J., Kasirye, R., Kamali, A., Abaasa, A., & Grosskurth, H. (2016). Exit interviews administered to patients participating in the COSTOP placebo controlled randomised trial in Uganda. Contemporary clinical trials communications, 3142-146. https://doi.org/10.1016/j.conctc.2016.05.008
Nunn, Andrew, et al. "Exit interviews administered to patients participating in the COSTOP placebo controlled randomised trial in Uganda." Contemporary clinical trials communications vol. 3 (2016): 142-146. doi: https://doi.org/10.1016/j.conctc.2016.05.008
Nunn A, Anywaine Z, Seeley J, Munderi P, Levin J, Kasirye R, Kamali A, Abaasa A, Grosskurth H. Exit interviews administered to patients participating in the COSTOP placebo controlled randomised trial in Uganda. Contemp Clin Trials Commun. 2016 Aug 15;3:142-146. doi: 10.1016/j.conctc.2016.05.008. PMID: 27536738; PMCID: PMC4918030.
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ZAMSTAR, The Zambia South Africa TB and HIV Reduction Study: design of a 2 x 2 factorial community randomized trial.

Trials

Ayles HM, Sismanidis C, Beyers N, Hayes RJ, Godfrey-Faussett P.
PMID: 18992133
Trials. 2008 Nov 07;9:63. doi: 10.1186/1745-6215-9-63.

BACKGROUND: TB and HIV form a deadly synergy in much of the developing world, especially Africa. Interventions to reduce the impact of these diseases at community level are urgently needed. This paper presents the design of a community randomised...

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Ayles HM, Sismanidis C, Beyers N, et al. ZAMSTAR, The Zambia South Africa TB and HIV Reduction Study: design of a 2 x 2 factorial community randomized trial. Trials. 2008;9:63doi: 10.1186/1745-6215-9-63.
Ayles, H. M., Sismanidis, C., Beyers, N., Hayes, R. J., & Godfrey-Faussett, P. (2008). ZAMSTAR, The Zambia South Africa TB and HIV Reduction Study: design of a 2 x 2 factorial community randomized trial. Trials, 963. https://doi.org/10.1186/1745-6215-9-63
Ayles, Helen M, et al. "ZAMSTAR, The Zambia South Africa TB and HIV Reduction Study: design of a 2 x 2 factorial community randomized trial." Trials vol. 9 (2008): 63. doi: https://doi.org/10.1186/1745-6215-9-63
Ayles HM, Sismanidis C, Beyers N, Hayes RJ, Godfrey-Faussett P. ZAMSTAR, The Zambia South Africa TB and HIV Reduction Study: design of a 2 x 2 factorial community randomized trial. Trials. 2008 Nov 07;9:63. doi: 10.1186/1745-6215-9-63. PMID: 18992133; PMCID: PMC2585552.
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Geographical disparities in core population coverage indicators for roll back malaria in Malawi.

International journal for equity in health

Kazembe LN, Appleton CC, Kleinschmidt I.
PMID: 17610730
Int J Equity Health. 2007 Jul 04;6:5. doi: 10.1186/1475-9276-6-5.

BACKGROUND: Implementation of known effective interventions would necessitate the reduction of malaria burden by half by the year 2010. Identifying geographical disparities of coverage of these interventions at small area level is useful to inform where greatest scaling-up efforts...

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Kazembe LN, Appleton CC, Kleinschmidt I. Geographical disparities in core population coverage indicators for roll back malaria in Malawi. Int J Equity Health. 2007;6:5doi: 10.1186/1475-9276-6-5.
Kazembe, L. N., Appleton, C. C., & Kleinschmidt, I. (2007). Geographical disparities in core population coverage indicators for roll back malaria in Malawi. International journal for equity in health, 65. https://doi.org/10.1186/1475-9276-6-5
Kazembe, Lawrence N, et al. "Geographical disparities in core population coverage indicators for roll back malaria in Malawi." International journal for equity in health vol. 6 (2007): 5. doi: https://doi.org/10.1186/1475-9276-6-5
Kazembe LN, Appleton CC, Kleinschmidt I. Geographical disparities in core population coverage indicators for roll back malaria in Malawi. Int J Equity Health. 2007 Jul 04;6:5. doi: 10.1186/1475-9276-6-5. PMID: 17610730; PMCID: PMC1934906.
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Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: a prospective cohort study.

AIDS research and therapy

Amuron B, Levin J, Birunghi J, Namara G, Coutinho A, Grosskurth H, Jaffar S.
PMID: 22018282
AIDS Res Ther. 2011 Oct 22;8:39. doi: 10.1186/1742-6405-8-39.

BACKGROUND: There have been few reports of long-term survival of HIV-infected patients on antiretroviral therapy (ART) in Africa managed under near normal health service conditions.METHODS: Participants starting ART between February 2005 and December 2006 in The AIDS Support (TASO)...

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Amuron B, Levin J, Birunghi J, et al. Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: a prospective cohort study. AIDS Res Ther. 2011;8:39doi: 10.1186/1742-6405-8-39.
Amuron, B., Levin, J., Birunghi, J., Namara, G., Coutinho, A., Grosskurth, H., & Jaffar, S. (2011). Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: a prospective cohort study. AIDS research and therapy, 839. https://doi.org/10.1186/1742-6405-8-39
Amuron, Barbara, et al. "Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: a prospective cohort study." AIDS research and therapy vol. 8 (2011): 39. doi: https://doi.org/10.1186/1742-6405-8-39
Amuron B, Levin J, Birunghi J, Namara G, Coutinho A, Grosskurth H, Jaffar S. Mortality in an antiretroviral therapy programme in Jinja, south-east Uganda: a prospective cohort study. AIDS Res Ther. 2011 Oct 22;8:39. doi: 10.1186/1742-6405-8-39. PMID: 22018282; PMCID: PMC3210087.
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Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum.

PLoS clinical trials

Dunyo S, Milligan P, Edwards T, Sutherland C, Targett G, Pinder M.
PMID: 17013431
PLoS Clin Trials. 2006 Aug 18;1(4):e20. doi: 10.1371/journal.pctr.0010020.

OBJECTIVES: Treatment of Plasmodium falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a sharp rise in the prevalence and density of gametocytes. We did a randomized trial to determine the effect of treatment of asymptomatic infections with SP or...

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Dunyo S, Milligan P, Edwards T, et al. Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum. PLoS Clin Trials. 2006;1(4):e20doi: 10.1371/journal.pctr.0010020.
Dunyo, S., Milligan, P., Edwards, T., Sutherland, C., Targett, G., & Pinder, M. (2006). Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum. PLoS clinical trials, 1(4), e20. https://doi.org/10.1371/journal.pctr.0010020
Dunyo, Samuel, et al. "Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum." PLoS clinical trials vol. 1,4 (2006): e20. doi: https://doi.org/10.1371/journal.pctr.0010020
Dunyo S, Milligan P, Edwards T, Sutherland C, Targett G, Pinder M. Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum. PLoS Clin Trials. 2006 Aug 18;1(4):e20. doi: 10.1371/journal.pctr.0010020. PMID: 17013431; PMCID: PMC1851719.
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A cluster-randomised trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings.

The open AIDS journal

Amuron B, Coutinho A, Grosskurth H, Nabiryo C, Birungi J, Namara G, Levin J, Smith PG, Jaffar S.
PMID: 18923692
Open AIDS J. 2007;1:21-7. doi: 10.2174/1874613600701010021. Epub 2007 Dec 13.

The scale-up of antiretroviral therapy is progressing rapidly in Africa but with a limited evidence-base. We report the baseline results from a large pragmatic cluster-randomised trial comparing different strategies of ART delivery. The trial is integrated in normal health...

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Amuron B, Coutinho A, Grosskurth H, et al. A cluster-randomised trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings. Open AIDS J. 2007;1:21-7doi: 10.2174/1874613600701010021.
Amuron, B., Coutinho, A., Grosskurth, H., Nabiryo, C., Birungi, J., Namara, G., Levin, J., Smith, P. G., & Jaffar, S. (2007). A cluster-randomised trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings. The open AIDS journal, 121-7. https://doi.org/10.2174/1874613600701010021
Amuron, Barbara, et al. "A cluster-randomised trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings." The open AIDS journal vol. 1 (2007): 21-7. doi: https://doi.org/10.2174/1874613600701010021
Amuron B, Coutinho A, Grosskurth H, Nabiryo C, Birungi J, Namara G, Levin J, Smith PG, Jaffar S. A cluster-randomised trial to compare home-based with health facility-based antiretroviral treatment in Uganda: study design and baseline findings. Open AIDS J. 2007;1:21-7. doi: 10.2174/1874613600701010021. Epub 2007 Dec 13. PMID: 18923692; PMCID: PMC2556195.
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Innovative approaches to clinical data management in resource limited settings using open-source technologies.

PLoS neglected tropical diseases

Omollo R, Ochieng M, Mutinda B, Omollo T, Owiti R, Okeyo S, Wasunna M, Edwards T.
PMID: 25210976
PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3134. doi: 10.1371/journal.pntd.0003134. eCollection 2014 Sep.

No abstract available.

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Omollo R, Ochieng M, Mutinda B, et al. Innovative approaches to clinical data management in resource limited settings using open-source technologies. PLoS Negl Trop Dis. 2014;8(9):e3134doi: 10.1371/journal.pntd.0003134.
Omollo, R., Ochieng, M., Mutinda, B., Omollo, T., Owiti, R., Okeyo, S., Wasunna, M., & Edwards, T. (2014). Innovative approaches to clinical data management in resource limited settings using open-source technologies. PLoS neglected tropical diseases, 8(9), e3134. https://doi.org/10.1371/journal.pntd.0003134
Omollo, Raymond, et al. "Innovative approaches to clinical data management in resource limited settings using open-source technologies." PLoS neglected tropical diseases vol. 8,9 (2014): e3134. doi: https://doi.org/10.1371/journal.pntd.0003134
Omollo R, Ochieng M, Mutinda B, Omollo T, Owiti R, Okeyo S, Wasunna M, Edwards T. Innovative approaches to clinical data management in resource limited settings using open-source technologies. PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3134. doi: 10.1371/journal.pntd.0003134. eCollection 2014 Sep. PMID: 25210976; PMCID: PMC4161312.
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