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Paper microfluidic implementation of loop mediated isothermal amplification for early diagnosis of hepatitis C virus.

Nature communications

Witkowska McConnell W, Davis C, Sabir SR, Garrett A, Bradley-Stewart A, Jajesniak P, Reboud J, Xu G, Yang Z, Gunson R, Thomson EC, Cooper JM.
PMID: 34848705
Nat Commun. 2021 Nov 30;12(1):6994. doi: 10.1038/s41467-021-27076-z.

The early diagnosis of active hepatitis C virus (HCV) infection remains a significant barrier to the treatment of the disease and to preventing the associated significant morbidity and mortality seen, worldwide. Current testing is delayed due to the high...

Genomics of disease risk in globally diverse populations.

Nature reviews. Genetics

Gurdasani D, Barroso I, Zeggini E, Sandhu MS.
PMID: 31235872
Nat Rev Genet. 2019 Sep;20(9):520-535. doi: 10.1038/s41576-019-0144-0. Epub 2019 Jun 24.

Risk of disease is multifactorial and can be shaped by socio-economic, demographic, cultural, environmental and genetic factors. Our understanding of the genetic determinants of disease risk has greatly advanced with the advent of genome-wide association studies (GWAS), which detect...

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