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Showing 1 to 8 of 8 entries
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Zolpidem dependence, abuse and withdrawal: A case report.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Heydari M, Isfeedvajani MS.
PMID: 24520235
J Res Med Sci. 2013 Nov;18(11):1006-7.

Zolpidem, a nonbenzodiazepine hypnotic, binds to the benzodiazepine binding site on the gamma-aminobutyric acid type A (GABA-A) receptors. Many studies have reported efficacy and safety of zolpidem in treatment of insomnia, low abuse, and dependence capability. However, many cases...

Neurosteroids and GABA-A Receptor Function.

Frontiers in endocrinology

Wang M.
PMID: 22654809
Front Endocrinol (Lausanne). 2011 Oct 04;2:44. doi: 10.3389/fendo.2011.00044. eCollection 2011.

Neurosteroids represent a class of endogenous steroids that are synthesized in the brain, the adrenals, and the gonads and have potent and selective effects on the GABAA-receptor. 3α-hydroxy A-ring reduced metabolites of progesterone, deoxycorticosterone, and testosterone are positive modulators...

Effects of competitive and noncompetitive GABA(A) antagonists on the acquisition of a discrimination in squirrel monkeys.

Behavioural pharmacology

Pakarinen ED, Moerschbaecher JM.
PMID: 11224323
Behav Pharmacol. 1995 Mar;6(2):156-166.

There is evidence that low doses of convulsant agents may enhance acquisition under various behavioral procedures. The following experiments were undertaken to establish whether the putative GABA(A) antagonist pentylenetetrazole, and known GABA(A) receptor antagonists picrotoxin, picrotoxinin and bicuculine, might...

The pharmacological profile of GABA receptors on cultured insect neurones.

Journal of insect physiology

Aydar E, Beadle DJ.
PMID: 12770368
J Insect Physiol. 1999 Mar;45(3):213-219. doi: 10.1016/s0022-1910(98)00114-0.

Neuronal cultures of the cockroach, Periplaneta americana, were used to study the pharmacological profile of GABA receptors using the whole-cell-voltage clamp technique. The results indicated that insect GABA receptors are linked to a chloride channel that can be activated...

Role of anticonvulsant and antiepileptogenic neurosteroids in the pathophysiology and treatment of epilepsy.

Frontiers in endocrinology

Reddy DS.
PMID: 22654805
Front Endocrinol (Lausanne). 2011 Oct 05;2:38. doi: 10.3389/fendo.2011.00038. eCollection 2011.

This review highlights the role of major endogenous neurosteroids in seizure disorders and the promise of neurosteroid replacement therapy in epilepsy. Neurosteroids are endogenous modulators of seizure susceptibility. Neurosteroids such as allopregnanolone (3α-hydroxy-5α-pregnane-20-one) and allotetrahydrodeoxycorticosterone (3α,21-dihydroxy-5α-pregnan-20-one) are positive modulators...

The interaction of a benzodiazepine receptor antagonist (Ro15-1788) with GABA and GABA receptor antagonists at the GABA(A) receptor chloride-ionophore complex.

Neurochemistry international

Malatynska E, Dilsaver SC, Knapp RJ, Giroux ML, Ikeda M, Yamamura HI.
PMID: 20504718
Neurochem Int. 1991;18(3):405-10. doi: 10.1016/0197-0186(91)90173-b.

The effect of the GABA(A) receptor antagonists bicuculline and SR 95531 was compared with that of the antidepressants amoxapine and amitriptyline on GABA-stimulated (36)CL(?) uptake using membrane vesicles from the rat cerebral cortex. The interaction of Ro15-1788 with these...

Modulation of Purkinje cell complex spike waveform by synchrony levels in the olivocerebellar system.

Frontiers in systems neuroscience

Lang EJ, Tang T, Suh CY, Xiao J, Kotsurovskyy Y, Blenkinsop TA, Marshall SP, Sugihara I.
PMID: 25400556
Front Syst Neurosci. 2014 Oct 30;8:210. doi: 10.3389/fnsys.2014.00210. eCollection 2014.

Purkinje cells (PCs) generate complex spikes (CSs) when activated by the olivocerebellar system. Unlike most spikes, the CS waveform is highly variable, with the number, amplitude, and timing of the spikelets that comprise it varying with each occurrence. This...

Similarities in Mechanisms and Treatments for Epileptic and Nonepileptic Myoclonus.

Epilepsy currents

Krauss GL, Mathews GC.
PMID: 15309099
Epilepsy Curr. 2003 Jan;3(1):19-21. doi: 10.1046/j.1535-7597.2003.03107.x.

Myoclonus is a disordered movement that may be an ictal phenomenon or may be due to various injuries in brain and spinal cord motor structures. Many epileptic and nonepileptic myoclonic conditions are associated with abnormalities in inhibitory neurotransmission. gamma-Aminobutyric...

Showing 1 to 8 of 8 entries