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Showing 1 to 12 of 670 entries
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Galectin-3 Regulates Atrial Fibrillation Remodeling and Predicts Catheter Ablation Outcomes.

JACC. Basic to translational science

Takemoto Y, Ramirez RJ, Yokokawa M, Kaur K, Ponce-Balbuena D, Sinno MC, Willis BC, Ghanbari H, Ennis SR, Guerrero-Serna G, Henzi BC, Latchamsetty R, Ramos-Mondragon R, Musa H, Martins RP, Pandit SV, Noujaim SF, Crawford T, Jongnarangsin K, Pelosi F, Bogun F, Chugh A, Berenfeld O, Morady F, Oral H, Jalife J.
PMID: 27525318
JACC Basic Transl Sci. 2016 Apr;1(3):143-154. doi: 10.1016/j.jacbts.2016.03.003.

OBJECTIVES: To determine whether Gal-3 mediates sustained atrial fibrillation (AF)-induced atrial structural and electrical remodeling and contributes to AF perpetuation.BACKGROUND: Galectin-3 (Gal-3) mediates extracellular matrix remodeling in heart failure, but its role in AF progression remains unexplored.METHODS: We examined...

Pharmacological Inhibition of Gal-3 in Mesenchymal Stem Cells Enhances Their Capacity to Promote Alternative Activation of Macrophages in Dextran Sulphate Sodium-Induced Colitis.

Stem cells international

Simovic Markovic B, Nikolic A, Gazdic M, Nurkovic J, Djordjevic I, Arsenijevic N, Stojkovic M, Lukic ML, Volarevic V.
PMID: 27057168
Stem Cells Int. 2016;2016:2640746. doi: 10.1155/2016/2640746. Epub 2016 Jan 04.

Transplantation of mesenchymal stem cells (MSCs) reduces the severity of dextran sulphate sodium- (DSS-) induced colitis. MSCs are able to secrete Galectin-3 (Gal-3), a protein known to affect proliferation, adhesion, and migration of immune cells. We investigate whether newly...

Synergistic interaction between galectin-3 and carcinoembryonic antigen promotes colorectal cancer metastasis.

Oncotarget

Wu KL, Huang EY, Yeh WL, Hsiao CC, Kuo CM.
PMID: 28977916
Oncotarget. 2017 Jun 27;8(37):61935-61943. doi: 10.18632/oncotarget.18721. eCollection 2017 Sep 22.

In this study, we investigated the role of galectin-3 and carcinoembryonic antigen (CEA) in metastasis and survival of colorectal cancer (CRC) patients. CEA interacted with galectin-3 at the cell surface and cytoplasm of Caco2 and DLD1 CRC cells. Knocking...

Sensitivity and Specificity of Galectin-3 and Glypican-3 in Follicular-Patterned and Other Thyroid Neoplasms.

Journal of clinical and diagnostic research : JCDR

Al-Sharaky DR, Younes SF.
PMID: 27134876
J Clin Diagn Res. 2016 Mar;10(3):EC06-10. doi: 10.7860/JCDR/2016/18375.7430. Epub 2016 Mar 01.

INTRODUCTION: Diagnosing follicular-patterned thyroid neoplasm can be quiet challenging in some cases, where an immunohistochemical profiling becomes mandatory. Galectin-3 may be a helpful tool for classical PTC diagnosis, but it cannot be considered as a diagnostic marker of malignancy....

The role of galectin-3 in the tumorigenesis and progression of pituitary tumors.

Oncology letters

Diao B, Liu Y, Xu GZ, Zhang Y, Xie J, Gong J.
PMID: 29545898
Oncol Lett. 2018 Apr;15(4):4919-4925. doi: 10.3892/ol.2018.7931. Epub 2018 Feb 02.

Galectin-3 (Gal-3), a β-galactoside-binding protein, has been implicated in cell proliferation, cell adhesion, and the progression and metastasis of various types of cancer. The present study investigated the involvement of Gal-3 in the tumorigenesis and progression of pituitary tumors...

Galectin-3 and Venous Thromboembolism Incidence: the Atherosclerosis Risk in Communities (ARIC) Study.

Research and practice in thrombosis and haemostasis

Fashanu OE, Heckbert SR, Aguilar D, Jensen PN, Ballantyne CM, Basu S, Hoogeveen RC, deFilippi C, Cushman M, Folsom AR.
PMID: 29152608
Res Pract Thromb Haemost. 2017 Oct;1(2):223-230. doi: 10.1002/rth2.12038. Epub 2017 Sep 04.

BACKGROUND: The inflammatory biomarker galectin-3 contributes to pathologic conditions such as heart failure and stimulates murine thrombogenesis. Its association with venous thromboembolism (VTE) has been sparsely studied.OBJECTIVES: To assess the prospective association of plasma galectin-3 and the METHODS: We...

Perigastric lymph node metastasis from papillary thyroid carcinoma in a patient with early gastric cancer: the first case report.

Journal of gastric cancer

Jeong GA, Kim HC, Kim HK, Cho GS.
PMID: 25328769
J Gastric Cancer. 2014 Sep;14(3):215-9. doi: 10.5230/jgc.2014.14.3.215. Epub 2014 Sep 30.

Distant metastasis from papillary thyroid carcinoma (PTC), particularly from papillary thyroid microcarcinoma, is rare. We present a case of perigastric lymph node metastasis from PTC in a patient with early gastric cancer and breast cancer. During post-surgical follow-up for...

Different protein composition and functional properties of adeno-associated virus-6 vector manufactured from the culture medium and cell lysates.

Molecular therapy. Methods & clinical development

Denard J, Jenny C, Blouin V, Moullier P, Svinartchouk F.
PMID: 26015972
Mol Ther Methods Clin Dev. 2014 Jul 30;1:14031. doi: 10.1038/mtm.2014.31. eCollection 2014.

Vectors based on recombinant adeno-associated viruses (rAAV) attract a growing interest for human gene therapy. Recently, it was shown that many rAAV serotypes produced by transient transfection of human embryonic kidney 293 cell line (HEK293) are efficiently released into...

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.

Cell reports

Burguillos MA, Svensson M, Schulte T, Boza-Serrano A, Garcia-Quintanilla A, Kavanagh E, Santiago M, Viceconte N, Oliva-Martin MJ, Osman AM, Salomonsson E, Amar L, Persson A, Blomgren K, Achour A, Englund E, Leffler H, Venero JL, Joseph B, Deierborg T.
PMID: 25753426
Cell Rep. 2015 Mar 10;10(9):1626-1638. doi: 10.1016/j.celrep.2015.02.012. Epub 2015 Mar 05.

Inflammatory response induced by microglia plays a critical role in the demise of neuronal populations in neuroinflammatory diseases. Although the role of toll-like receptor 4 (TLR4) in microglia's inflammatory response is fully acknowledged, little is known about endogenous ligands...

Atractylochromene Is a Repressor of Wnt/β-Catenin Signaling in Colon Cancer Cells.

Biomolecules & therapeutics

Shim AR, Dong GZ, Lee HJ, Ryu JH.
PMID: 25593640
Biomol Ther (Seoul). 2015 Jan;23(1):26-30. doi: 10.4062/biomolther.2014.095. Epub 2015 Jan 01.

Wnt/β-catenin signaling pathway was mutated in about 90% of the sporadic and hereditary colorectal cancers. The abnormally activated β-catenin increases the cancer cell proliferation, differentiation and metastasis through increasing the expression of its oncogenic target genes. In this study,...

Biomarkers Beyond the Natriuretic Peptides for Chronic Heart Failure: Galectin-3 and Soluble ST2.

EJIFCC

Wu AH.
PMID: 27683422
EJIFCC. 2012 Oct 12;23(3):98-102. eCollection 2012 Oct.

B-type natriuretic peptide (BNP) and NT-proBNP are widely used plasma biomarkers for the diagnosis of acute decompensated heart failure and prognosis for future cardiac disease. The clinical performance of these tests for management of chronic heart failure is somewhat...

Traditional Chinese medicine baoxin decoction improves cardiac fibrosis of rats with dilated cardiomyopathy.

Experimental and therapeutic medicine

Sun R, Wang J, Zheng Y, Li X, Xie T, Li R, Liu M, Cao Y, Lu L, Zhang Q, Zhang P.
PMID: 28565783
Exp Ther Med. 2017 May;13(5):1900-1906. doi: 10.3892/etm.2017.4223. Epub 2017 Mar 10.

We investigated the effect of baoxin decoction (BXD) on myocardial fibrosis and clarified the possible mechanism of action. Dilated myocardiopathy was induced by doxorubicin injected intraperitoneally for 6 weeks. Rats that demonstrated dilated myocardiopathy were randomly divided into five...

Showing 1 to 12 of 670 entries