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In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology.

Annals of neurology

Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B.
PMID: 26946517
Ann Neurol. 2016 May;79(5):794-805. doi: 10.1002/ana.24630. Epub 2016 Apr 18.

OBJECTIVE: Neuromyelitis optica (NMO) is an autoimmune disease of the central nervous system, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover,...

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Herwerth M, Kalluri SR, Srivastava R, et al. In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol. 2016;79(5):794-805doi: 10.1002/ana.24630.
Herwerth, M., Kalluri, S. R., Srivastava, R., Kleele, T., Kenet, S., Illes, Z., Merkler, D., Bennett, J. L., Misgeld, T., & Hemmer, B. (2016). In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Annals of neurology, 79(5), 794-805. https://doi.org/10.1002/ana.24630
Herwerth, Marina, et al. "In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology." Annals of neurology vol. 79,5 (2016): 794-805. doi: https://doi.org/10.1002/ana.24630
Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B. In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol. 2016 May;79(5):794-805. doi: 10.1002/ana.24630. Epub 2016 Apr 18. PMID: 26946517; PMCID: PMC5021140.
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Ultra high-field (7 T) multi-resolution fMRI data for orientation decoding in visual cortex.

Data in brief

Sengupta A, Yakupov R, Speck O, Pollmann S, Hanke M.
PMID: 28616455
Data Brief. 2017 May 24;13:219-222. doi: 10.1016/j.dib.2017.05.014. eCollection 2017 Aug.

Multivariate pattern classification methods have been successfully applied to decode orientation of visual grating stimuli from BOLD fMRI activity recorded in human visual cortex (Kamitani and Tong, 2005; Haynes and Rees, 2005) [12], [10]. Though there has been extensive...

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Sengupta A, Yakupov R, Speck O, et al. Ultra high-field (7 T) multi-resolution fMRI data for orientation decoding in visual cortex. Data Brief. 2017;13:219-222doi: 10.1016/j.dib.2017.05.014.
Sengupta, A., Yakupov, R., Speck, O., Pollmann, S., & Hanke, M. (2017). Ultra high-field (7 T) multi-resolution fMRI data for orientation decoding in visual cortex. Data in brief, 13219-222. https://doi.org/10.1016/j.dib.2017.05.014
Sengupta, Ayan, et al. "Ultra high-field (7 T) multi-resolution fMRI data for orientation decoding in visual cortex." Data in brief vol. 13 (2017): 219-222. doi: https://doi.org/10.1016/j.dib.2017.05.014
Sengupta A, Yakupov R, Speck O, Pollmann S, Hanke M. Ultra high-field (7 T) multi-resolution fMRI data for orientation decoding in visual cortex. Data Brief. 2017 May 24;13:219-222. doi: 10.1016/j.dib.2017.05.014. eCollection 2017 Aug. PMID: 28616455; PMCID: PMC5459569.
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Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings.

Alzheimer's & dementia (Amsterdam, Netherlands)

Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA.
PMID: 30976649
Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec.

Advances in technology enable increasing amounts of data collection from individuals for biomedical research. Such technologies, for example, in genetics and medical imaging, have also led to important scientific discoveries about health and disease. The combination of multiple types...

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Adams HHH, Roshchupkin GV, DeCarli C, et al. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019;11:286-290doi: 10.1016/j.dadm.2019.02.003.
Adams, H. H. H., Roshchupkin, G. V., DeCarli, C., Franke, B., Grabe, H. J., Habes, M., Jahanshad, N., Medland, S. E., Niessen, W., Satizabal, C. L., Schmidt, R., Seshadri, S., Teumer, A., Thompson, P. M., Vernooij, M. W., Wittfeld, K., & Ikram, M. A. (2019). Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimer's & dementia (Amsterdam, Netherlands), 11286-290. https://doi.org/10.1016/j.dadm.2019.02.003
Adams, Hieab H H, et al. "Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 11 (2019): 286-290. doi: https://doi.org/10.1016/j.dadm.2019.02.003
Adams HHH, Roshchupkin GV, DeCarli C, Franke B, Grabe HJ, Habes M, Jahanshad N, Medland SE, Niessen W, Satizabal CL, Schmidt R, Seshadri S, Teumer A, Thompson PM, Vernooij MW, Wittfeld K, Ikram MA. Full exploitation of high dimensionality in brain imaging: The JPND working group statement and findings. Alzheimers Dement (Amst). 2019 Mar 30;11:286-290. doi: 10.1016/j.dadm.2019.02.003. eCollection 2019 Dec. PMID: 30976649; PMCID: PMC6441785.
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Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking.

Frontiers in aging neuroscience

Elshehabi M, Maier KS, Hasmann SE, Nussbaum S, Herbst H, Heger T, Berg D, Hobert MA, Maetzler W.
PMID: 26858638
Front Aging Neurosci. 2016 Jan 27;8:4. doi: 10.3389/fnagi.2016.00004. eCollection 2016.

BACKGROUND: In Parkinson's disease (PD), the effects of dopaminergic medication on straight walking and turning were mainly investigated under single tasking (ST) conditions. However, multitasking situations are considered more daily relevant.METHODS: Thirty-nine early-to-moderate PD patients performed the following standardized...

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Elshehabi M, Maier KS, Hasmann SE, et al. Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking. Front Aging Neurosci. 2016;8:4doi: 10.3389/fnagi.2016.00004.
Elshehabi, M., Maier, K. S., Hasmann, S. E., Nussbaum, S., Herbst, H., Heger, T., Berg, D., Hobert, M. A., & Maetzler, W. (2016). Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking. Frontiers in aging neuroscience, 84. https://doi.org/10.3389/fnagi.2016.00004
Elshehabi, Morad, et al. "Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking." Frontiers in aging neuroscience vol. 8 (2016): 4. doi: https://doi.org/10.3389/fnagi.2016.00004
Elshehabi M, Maier KS, Hasmann SE, Nussbaum S, Herbst H, Heger T, Berg D, Hobert MA, Maetzler W. Limited Effect of Dopaminergic Medication on Straight Walking and Turning in Early-to-Moderate Parkinson's Disease during Single and Dual Tasking. Front Aging Neurosci. 2016 Jan 27;8:4. doi: 10.3389/fnagi.2016.00004. eCollection 2016. PMID: 26858638; PMCID: PMC4728201.
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Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women.

Metabolites

Eick C, Klinger-König J, Zylla S, Hannemann A, Budde K, Henning AK, Pietzner M, Nauck M, Völzke H, Grabe HJ, Hertel J.
PMID: 33805221
Metabolites. 2021 Mar 24;11(4). doi: 10.3390/metabo11040193.

The use of oral contraceptives (OCs) has been associated with elevated blood cortisol concentrations. However, metabolic downstream effects of OC intake are not well described. Here, we aimed to determine if the blood metabolome is associated with the use...

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Eick C, Klinger-König J, Zylla S, et al. Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women. Metabolites. 2021;11(4)doi: 10.3390/metabo11040193.
Eick, C., Klinger-König, J., Zylla, S., Hannemann, A., Budde, K., Henning, A. K., Pietzner, M., Nauck, M., Völzke, H., Grabe, H. J., & Hertel, J. (2021). Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women. Metabolites, 11(4), . https://doi.org/10.3390/metabo11040193
Eick, Clara, et al. "Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women." Metabolites vol. 11,4 (2021). doi: https://doi.org/10.3390/metabo11040193
Eick C, Klinger-König J, Zylla S, Hannemann A, Budde K, Henning AK, Pietzner M, Nauck M, Völzke H, Grabe HJ, Hertel J. Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women. Metabolites. 2021 Mar 24;11(4). doi: 10.3390/metabo11040193. PMID: 33805221; PMCID: PMC8064380.
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[No title available]

Frontiers in cell and developmental biology

Brockmann K.
PMID: 33102473
Front Cell Dev Biol. 2020 Sep 25;8:562522. doi: 10.3389/fcell.2020.562522. eCollection 2020.

With disease-modifying compounds targeting alpha-synuclein available in clinical trials, patient stratification according to alpha-synuclein-specific enrichment strategies is a much-needed prerequisite. Such a scenario will be exemplified for

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Brockmann K. . Front Cell Dev Biol. 2020;8:562522doi: 10.3389/fcell.2020.562522.
Brockmann, K. (2020). . Frontiers in cell and developmental biology, 8562522. https://doi.org/10.3389/fcell.2020.562522
Brockmann, Kathrin. "." Frontiers in cell and developmental biology vol. 8 (2020): 562522. doi: https://doi.org/10.3389/fcell.2020.562522
Brockmann K. . Front Cell Dev Biol. 2020 Sep 25;8:562522. doi: 10.3389/fcell.2020.562522. eCollection 2020. PMID: 33102473; PMCID: PMC7545538.
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Clinical Characteristics and Outcome of Patients With Hemorrhagic Transformation After Intravenous Thrombolysis in the WAKE-UP Trial.

Frontiers in neurology

Jensen M, Schlemm E, Cheng B, Lettow I, Quandt F, Boutitie F, Ebinger M, Endres M, Fiebach JB, Fiehler J, Galinovic I, Thijs V, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Simonsen CZ, Gerloff C, Thomalla G.
PMID: 32982951
Front Neurol. 2020 Aug 28;11:957. doi: 10.3389/fneur.2020.00957. eCollection 2020.

No abstract available.

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Jensen M, Schlemm E, Cheng B, et al. Clinical Characteristics and Outcome of Patients With Hemorrhagic Transformation After Intravenous Thrombolysis in the WAKE-UP Trial. Front Neurol. 2020;11:957doi: 10.3389/fneur.2020.00957.
Jensen, M., Schlemm, E., Cheng, B., Lettow, I., Quandt, F., Boutitie, F., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Galinovic, I., Thijs, V., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Simonsen, C. Z., Gerloff, C., & Thomalla, G. (2020). Clinical Characteristics and Outcome of Patients With Hemorrhagic Transformation After Intravenous Thrombolysis in the WAKE-UP Trial. Frontiers in neurology, 11957. https://doi.org/10.3389/fneur.2020.00957
Jensen, Märit, et al. "Clinical Characteristics and Outcome of Patients With Hemorrhagic Transformation After Intravenous Thrombolysis in the WAKE-UP Trial." Frontiers in neurology vol. 11 (2020): 957. doi: https://doi.org/10.3389/fneur.2020.00957
Jensen M, Schlemm E, Cheng B, Lettow I, Quandt F, Boutitie F, Ebinger M, Endres M, Fiebach JB, Fiehler J, Galinovic I, Thijs V, Lemmens R, Muir KW, Nighoghossian N, Pedraza S, Simonsen CZ, Gerloff C, Thomalla G. Clinical Characteristics and Outcome of Patients With Hemorrhagic Transformation After Intravenous Thrombolysis in the WAKE-UP Trial. Front Neurol. 2020 Aug 28;11:957. doi: 10.3389/fneur.2020.00957. eCollection 2020. PMID: 32982951; PMCID: PMC7483750.
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Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range.

GeroScience

Kilimann I, Wucherer D, Ittermann T, Völzke H, Bülow R, Hoffmann W, Grabe HJ, Wittfeld K, Teipel SJ.
PMID: 34940948
Geroscience. 2021 Dec 23; doi: 10.1007/s11357-021-00497-w. Epub 2021 Dec 23.

Many medications of different indications have a relevant anticholinergic activity. The anticholinergic burden of medication has been shown to have significant effects on the cognition and the risk for cognitive impairment and dementia particularly in older patients. So far,...

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Kilimann I, Wucherer D, Ittermann T, et al. Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range. Geroscience. 2021;doi: 10.1007/s11357-021-00497-w.
Kilimann, I., Wucherer, D., Ittermann, T., Völzke, H., Bülow, R., Hoffmann, W., Grabe, H. J., Wittfeld, K., & Teipel, S. J. (2021). Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range. GeroScience, . https://doi.org/10.1007/s11357-021-00497-w
Kilimann, Ingo, et al. "Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range." GeroScience vol. (2021). doi: https://doi.org/10.1007/s11357-021-00497-w
Kilimann I, Wucherer D, Ittermann T, Völzke H, Bülow R, Hoffmann W, Grabe HJ, Wittfeld K, Teipel SJ. Inverse association between the anticholinergic burden and hippocampus volume in a population-based cohort across the entire adult age range. Geroscience. 2021 Dec 23; doi: 10.1007/s11357-021-00497-w. Epub 2021 Dec 23. PMID: 34940948.
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Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial.

Frontiers in neurology

Dörr J, Wernecke KD, Würfel J, Bellmann-Strobl J, Siffrin V, Sättler MB, Simons M, Linsa A, Tumani H, Paul F.
PMID: 30356868
Front Neurol. 2018 Oct 09;9:842. doi: 10.3389/fneur.2018.00842. eCollection 2018.

Central nervous system inflammation and neurodegeneration are the pathophysiological hallmarks of multiple sclerosis (MS). While inflammation can readily be targeted by current disease modifying drugs, neurodegeneration is by far less accessible to treatment. Based on suggested additional neuroprotective capacities...

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Dörr J, Wernecke KD, Würfel J, et al. Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial. Front Neurol. 2018;9:842doi: 10.3389/fneur.2018.00842.
Dörr, J., Wernecke, K. D., Würfel, J., Bellmann-Strobl, J., Siffrin, V., Sättler, M. B., Simons, M., Linsa, A., Tumani, H., & Paul, F. (2018). Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial. Frontiers in neurology, 9842. https://doi.org/10.3389/fneur.2018.00842
Dörr, Jan, et al. "Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial." Frontiers in neurology vol. 9 (2018): 842. doi: https://doi.org/10.3389/fneur.2018.00842
Dörr J, Wernecke KD, Würfel J, Bellmann-Strobl J, Siffrin V, Sättler MB, Simons M, Linsa A, Tumani H, Paul F. Disease Modification in Multiple Sclerosis by Flupirtine-Results of a Randomized Placebo Controlled Phase II Trial. Front Neurol. 2018 Oct 09;9:842. doi: 10.3389/fneur.2018.00842. eCollection 2018. PMID: 30356868; PMCID: PMC6190842.
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Effects of alternating current stimulation on the healthy and diseased brain.

Frontiers in neuroscience

Abd Hamid AI, Gall C, Speck O, Antal A, Sabel BA.
PMID: 26578858
Front Neurosci. 2015 Oct 27;9:391. doi: 10.3389/fnins.2015.00391. eCollection 2015.

Cognitive and neurological dysfunctions can severely impact a patient's daily activities. In addition to medical treatment, non-invasive transcranial alternating current stimulation (tACS) has been proposed as a therapeutic technique to improve the functional state of the brain. Although during...

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Abd Hamid AI, Gall C, Speck O, et al. Effects of alternating current stimulation on the healthy and diseased brain. Front Neurosci. 2015;9:391doi: 10.3389/fnins.2015.00391.
Abd Hamid, A. I., Gall, C., Speck, O., Antal, A., & Sabel, B. A. (2015). Effects of alternating current stimulation on the healthy and diseased brain. Frontiers in neuroscience, 9391. https://doi.org/10.3389/fnins.2015.00391
Abd Hamid, Aini Ismafairus, et al. "Effects of alternating current stimulation on the healthy and diseased brain." Frontiers in neuroscience vol. 9 (2015): 391. doi: https://doi.org/10.3389/fnins.2015.00391
Abd Hamid AI, Gall C, Speck O, Antal A, Sabel BA. Effects of alternating current stimulation on the healthy and diseased brain. Front Neurosci. 2015 Oct 27;9:391. doi: 10.3389/fnins.2015.00391. eCollection 2015. PMID: 26578858; PMCID: PMC4621306.
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Microstructural plasticity in nociceptive pathways after spinal cord injury.

Journal of neurology, neurosurgery, and psychiatry

Kyathanahally SP, Azzarito M, Rosner J, Calhoun VD, Blaiotta C, Ashburner J, Weiskopf N, Wiech K, Friston K, Ziegler G, Freund P.
PMID: 34039630
J Neurol Neurosurg Psychiatry. 2021 May 26; doi: 10.1136/jnnp-2020-325580. Epub 2021 May 26.

OBJECTIVE: To track the interplay between (micro-) structural changes along the trajectories of nociceptive pathways and its relation to the presence and intensity of neuropathic pain (NP) after spinal cord injury (SCI).METHODS: A quantitative neuroimaging approach employing a multiparametric...

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Kyathanahally SP, Azzarito M, Rosner J, et al. Microstructural plasticity in nociceptive pathways after spinal cord injury. J Neurol Neurosurg Psychiatry. 2021;doi: 10.1136/jnnp-2020-325580.
Kyathanahally, S. P., Azzarito, M., Rosner, J., Calhoun, V. D., Blaiotta, C., Ashburner, J., Weiskopf, N., Wiech, K., Friston, K., Ziegler, G., & Freund, P. (2021). Microstructural plasticity in nociceptive pathways after spinal cord injury. Journal of neurology, neurosurgery, and psychiatry, . https://doi.org/10.1136/jnnp-2020-325580
Kyathanahally, Sreenath P, et al. "Microstructural plasticity in nociceptive pathways after spinal cord injury." Journal of neurology, neurosurgery, and psychiatry vol. (2021). doi: https://doi.org/10.1136/jnnp-2020-325580
Kyathanahally SP, Azzarito M, Rosner J, Calhoun VD, Blaiotta C, Ashburner J, Weiskopf N, Wiech K, Friston K, Ziegler G, Freund P. Microstructural plasticity in nociceptive pathways after spinal cord injury. J Neurol Neurosurg Psychiatry. 2021 May 26; doi: 10.1136/jnnp-2020-325580. Epub 2021 May 26. PMID: 34039630; PMCID: PMC8292587.
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Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson's Disease.

Journal of personalized medicine

Dehestani M, Liu H, Gasser T.
PMID: 34683174
J Pers Med. 2021 Oct 15;11(10). doi: 10.3390/jpm11101030.

Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the loss of dopaminergic neurons. The vast majority of PD patients develop the disease sporadically and it is assumed that the cause lies in polygenic and environmental...

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Dehestani M, Liu H, Gasser T. Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson's Disease. J Pers Med. 2021;11(10)doi: 10.3390/jpm11101030.
Dehestani, M., Liu, H., & Gasser, T. (2021). Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson's Disease. Journal of personalized medicine, 11(10), . https://doi.org/10.3390/jpm11101030
Dehestani, Mohammad, et al. "Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson's Disease." Journal of personalized medicine vol. 11,10 (2021). doi: https://doi.org/10.3390/jpm11101030
Dehestani M, Liu H, Gasser T. Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson's Disease. J Pers Med. 2021 Oct 15;11(10). doi: 10.3390/jpm11101030. PMID: 34683174; PMCID: PMC8539098.
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