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Showing 1 to 12 of 27 entries
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Molecular and cellular biology of small intestinal differentiation, gene expression and hormonal responses.

Current opinion in gastroenterology

Walters JR.
PMID: 15703549
Curr Opin Gastroenterol. 2003 Mar;19(2):106-12. doi: 10.1097/00001574-200303000-00002.

Many recent publications have looked at the function of the small intestine at the molecular and cellular level. Hundreds of genes are expressed predominantly in the gastrointestinal tract and many are found in only one segment. The developmental interactions...

Sitagliptin: an oral agent for glucose control.

Expert review of endocrinology & metabolism

Bardsley JK, Ratner RE.
PMID: 30764059
Expert Rev Endocrinol Metab. 2008 Nov;3(6):691-697. doi: 10.1586/17446651.3.6.691.

Sitagliptin (Januviaâ„¢) is a new oral agent approved by the US FDA to treat Type 2 diabetes. This is the first approved agent in a new class of antihyperglycemics, dipeptidyl peptidase (DPP)-4 inhibitors. Sitagliptin selectively inhibits the action of...

Cost of Achieving HbA1c Treatment Targets and Weight Loss Responses with Once-Weekly Semaglutide Versus Dulaglutide in the United States.

Diabetes therapy : research, treatment and education of diabetes and related disorders

Wilkinson L, Hunt B, Johansen P, Iyer NN, Dang-Tan T, Pollock RF.
PMID: 29557057
Diabetes Ther. 2018 Jun;9(3):951-961. doi: 10.1007/s13300-018-0402-8. Epub 2018 Mar 19.

INTRODUCTION: The National Health and Nutrition Examination Surveys show that many people with type 2 diabetes (T2D) in the USA fail to achieve recommended treatment targets. In the SUSTAIN 7 randomized controlled trial, once-weekly semaglutide (0.5 and 1.0 mg)...

Role of DPP-4 and SGLT2 Inhibitors Connected to Alzheimer Disease in Type 2 Diabetes Mellitus.

Frontiers in neuroscience

Sim AY, Barua S, Kim JY, Lee YH, Lee JE.
PMID: 34489627
Front Neurosci. 2021 Aug 11;15:708547. doi: 10.3389/fnins.2021.708547. eCollection 2021.

Alzheimer's disease (AD) is characterized by memory loss and cognitive decline. Additionally, abnormal extracellular amyloid plaques accumulation and nerve damage caused by intracellular neurofibrillary tangles, and tau protein are characteristic of AD. Furthermore, AD is associated with oxidative stress,...

Dietary carbohydrate modifies the density of L cells in the chicken ileum.

The Journal of veterinary medical science

Salahuddin M, Hiramatsu K, Nishimoto I, Kita K.
PMID: 34980756
J Vet Med Sci. 2021 Dec 29; doi: 10.1292/jvms.21-0572. Epub 2021 Dec 29.

Glucagon-like peptides (GLPs) are secreted from intestinal L cells and stimulate various physiological functions in the gastrointestinal tract. The secretion of GLPs is influenced by macronutrient ingestion. This study aims to clarify the effects of dietary carbohydrate (CHO) on...

Potent Prearranged Positive Allosteric Modulators of the Glucagon-like Peptide-1 Receptor.

ChemistryOpen

Jones BJ, Scopelliti R, Tomas A, Bloom SR, Hodson DJ, Broichhagen J.
PMID: 28794944
ChemistryOpen. 2017 Jun 05;6(4):501-505. doi: 10.1002/open.201700062. eCollection 2017 Aug.

Drugs that allosterically modulate G protein-coupled receptor (GPCR) activity display higher specificity and may improve disease treatment. However, the rational design of compounds that target the allosteric site is difficult, as conformations required for receptor activation are poorly understood....

The impact of type 2 diabetes on bone metabolism.

Diabetology & metabolic syndrome

Sanches CP, Vianna AGD, Barreto FC.
PMID: 29075333
Diabetol Metab Syndr. 2017 Oct 19;9:85. doi: 10.1186/s13098-017-0278-1. eCollection 2017.

Diabetes complications and osteoporotic fractures are two of the most important causes of morbidity and mortality in older patients and share many features including genetic susceptibility, molecular mechanisms, and environmental factors. Type 2 diabetes mellitus (T2DM) compromises bone microarchitecture...

Altered islet prohormone processing: a cause or consequence of diabetes?.

Physiological reviews

Ramzy A, Kieffer TJ.
PMID: 34280055
Physiol Rev. 2022 Jan 01;102(1):155-208. doi: 10.1152/physrev.00008.2021. Epub 2021 Jul 19.

Peptide hormones are first produced as larger precursor prohormones that require endoproteolytic cleavage to liberate the mature hormones. A structurally conserved but functionally distinct family of nine prohormone convertase enzymes (PCs) are responsible for cleavage of protein precursors, of...

Distinct Identity of GLP-1R, GLP-2R, and GIPR Expressing Cells and Signaling Circuits Within the Gastrointestinal Tract.

Frontiers in cell and developmental biology

Morrow NM, Hanson AA, Mulvihill EE.
PMID: 34660576
Front Cell Dev Biol. 2021 Sep 29;9:703966. doi: 10.3389/fcell.2021.703966. eCollection 2021.

Enteroendocrine cells directly integrate signals of nutrient content within the gut lumen with distant hormonal responses and nutrient disposal via the production and secretion of peptides, including glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide 1 (GLP-1) and glucagon-like peptide 2...

Comparison of the effects of intracerebroventricular administration of glucagon-like peptides 1 and 2 on hypothalamic appetite regulating factors and sleep-like behavior in chicks.

Neuroscience letters

Kewan A, Shimatani T, Saneyasu T, Kamisoyama H, Honda K.
PMID: 34838926
Neurosci Lett. 2022 Jan 18;768:136362. doi: 10.1016/j.neulet.2021.136362. Epub 2021 Nov 25.

Glucagon-like peptide (GLP)-1 and GLP-2, proglucagon-derived brain-gut peptides, function as anorexigenic neuropeptides in mammals. We previously showed that central administration of GLP-1 and GLP-2 potently suppressed food intake in chicks. GLP-1 and GLP-2 specifically activate their receptors GLP-1 receptor...

The Multicenter, Open-Label, Observational LEAD-Ph Study: Real-World Safety and Effectiveness of Liraglutide in Filipino Participants with Type 2 Diabetes.

Journal of the ASEAN Federation of Endocrine Societies

Jimeno C, Kho S, de Los Santos GK, Buena-Bobis N, Villa M.
PMID: 33442116
J ASEAN Fed Endocr Soc. 2018;33(2):114-123. doi: 10.15605/jafes.033.02.02. Epub 2018 Oct 09.

OBJECTIVE: Assess safety and effectiveness of liraglutide among Filipino participants with type 2 diabetes (T2D) in routine clinical practice.METHODOLOGY: A 26-week, prospective, multicenter, open-label, observational study was conducted in adults with T2D prescribed liraglutide (1.2 mg or 1.8 mg)...

Comparison of the effects of intracerebroventricular administration of glucagon-like peptides 1 and 2 on hypothalamic appetite regulating factors and sleep-like behavior in chicks.

Neuroscience letters

Kewan A, Shimatani T, Saneyasu T, Kamisoyama H, Honda K.
PMID: 34838926
Neurosci Lett. 2021 Nov 25;768:136362. doi: 10.1016/j.neulet.2021.136362. Epub 2021 Nov 25.

Glucagon-like peptide (GLP)-1 and GLP-2, proglucagon-derived brain-gut peptides, function as anorexigenic neuropeptides in mammals. We previously showed that central administration of GLP-1 and GLP-2 potently suppressed food intake in chicks. GLP-1 and GLP-2 specifically activate their receptors GLP-1 receptor...

Showing 1 to 12 of 27 entries