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Showing 1 to 12 of 93 entries
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A Triterpenoid Inhibited Hormone-Induced Adipocyte Differentiation and Alleviated Dexamethasone-Induced Insulin Resistance in 3T3-L1 adipocytes.

Natural products and bioprospecting

Qin JH, Ma JZ, Yang XW, Hu YJ, Zhou J, Fu LC, Tian RH, Liu S, Xu G, Shen XL.
PMID: 26077651
Nat Prod Bioprospect. 2015 Jun;5(3):159-66. doi: 10.1007/s13659-015-0063-5. Epub 2015 Jun 16.

6α-Hydroxylup-20(29)-en-3-on-28-oic acid (1), a natural triterpenoid, was found to possess the ability in a dose-dependent manner inhibiting hormone-induced adipocyte differentiation in 3T3-L1 preadipocytes, and restoring glucose consuming ability in dexamethasone (DXM)-induced insulin resistant 3T3-L1 adipocytes. Compound 1 was also...

Antihyperglycemic effect of Annona squamosa hexane extract in type 2 diabetes animal model: PTP1B inhibition, a possible mechanism of action?.

Indian journal of pharmacology

Davis JA, Sharma S, Mittra S, Sujatha S, Kanaujia A, Shukla G, Katiyar C, Lakshmi BS, Bansal VS, Bhatnagar PK.
PMID: 22701240
Indian J Pharmacol. 2012 May;44(3):326-32. doi: 10.4103/0253-7613.96304.

AIM: The mechanism of action of Annona squamosa hexane extract in mediating antihyperglycemic and antitriglyceridimic effect were investigated in this study.MATERIALS AND METHODS: The effects of extract on glucose uptake, insulin receptor-β (IR-β), insulin receptor substrate-1 (IRS-1) phosphorylation and...

Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats.

Diabetology & metabolic syndrome

Guo Z, Qi W, Yu Y, Du S, Wu J, Liu J.
PMID: 24576329
Diabetol Metab Syndr. 2014 Feb 28;6(1):29. doi: 10.1186/1758-5996-6-29.

BACKGROUND: This study investigated the effect of exenatide on the cardiac expression of adiponectin receptor 1 and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase subunits and heart function in streptozotocin-induced diabetic rats.METHODS: Male Sprague-Dawley rats were randomly divided into four...

Relevant Networks involving the p53 Signalling Pathway in Renal Cell Carcinoma.

International journal of biomedical science : IJBS

Villaamil VM, Gallego GA, Caínzos IS, Ruvira LV, Valladares-Ayerbes M, Aparicio LM.
PMID: 23675247
Int J Biomed Sci. 2011 Dec;7(4):273-82.

INTRODUCTION: Renal cell carcinoma is the most common type of kidney cancer. A better understanding of the critical pathways and interactions associated with alterations in renal function and renal tumour properties is required. Our final goal is to combine...

Antidiabetic properties of the ethanolic extract of Rhus coriaria fruits in rats.

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Mohammadi S, Montasser Kouhsari S, Monavar Feshani A.
PMID: 22615627
Daru. 2010;18(4):270-5.

BACKGROUND AND THE PURPOSE OF THE STUDY: Fruits of Rhus coriaria L. (Anacardiaceae) are traditionally used as a table spice in Iran and are highly recommended for diabetic patients. The purpose of this study was to determine the antidiabetic...

Effect of type 2 diabetes mellitus caveolin-3 K15N mutation on glycometabolism.

Experimental and therapeutic medicine

Huang Y, Deng Y, Shang L, Yang L, Huang J, Ma J, Liao X, Zhou H, Xian J, Liang G, Huang Q.
PMID: 31572504
Exp Ther Med. 2019 Oct;18(4):2531-2539. doi: 10.3892/etm.2019.7840. Epub 2019 Aug 02.

Caveolin-3 (CAV3) is a muscle-specific protein present within the muscle cell membrane that affects signaling pathways, including the insulin signaling pathway. A previous assessment of patients with newly developed type 2 diabetes (T2DM) demonstrated that CAV3 gene mutations may...

Swimming intervention alleviates insulin resistance and chronic inflammation in metabolic syndrome.

Experimental and therapeutic medicine

Tan J, Guo L.
PMID: 30651765
Exp Ther Med. 2019 Jan;17(1):57-62. doi: 10.3892/etm.2018.6900. Epub 2018 Oct 30.

In view of the high incidence of metabolic syndrome and the role of exercise in promoting metabolic disorders, the present study aimed to investigate the therapeutic effects of swimming intervention on metabolic syndrome. In the present study, a total...

A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.

The Journal of biological chemistry

Reilly AM, Yan S, Huang M, Abhyankar SD, Conley JM, Bone RN, Stull ND, Horan DJ, Roh HC, Robling AG, Ericsson AC, Dong XC, Evans-Molina C, Ren H.
PMID: 34801552
J Biol Chem. 2021 Nov 18;298(1):101431. doi: 10.1016/j.jbc.2021.101431. Epub 2021 Nov 18.

Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin receptor knockout (GIRKO) in the muscle,...

A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.

The Journal of biological chemistry

Reilly AM, Yan S, Huang M, Abhyankar SD, Conley JM, Bone RN, Stull ND, Horan DJ, Roh HC, Robling AG, Ericsson AC, Dong XC, Evans-Molina C, Ren H.
PMID: 34801552
J Biol Chem. 2021 Nov 18;298(1):101431. doi: 10.1016/j.jbc.2021.101431. Epub 2021 Nov 18.

Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin receptor knockout (GIRKO) in the muscle,...

Lipoxin A4 promotes adipogenic differentiation and browning of mouse embryonic fibroblasts.

In vitro cellular & developmental biology. Animal

Wang Q, Jin F, Zhang J, Li Z, Yu D.
PMID: 34811702
In Vitro Cell Dev Biol Anim. 2021 Nov 22; doi: 10.1007/s11626-021-00617-y. Epub 2021 Nov 22.

Recently, it has been irrefutably discovered that brown adipocytes dissipate energy as heat and protect against obesity. Researchers make great efforts to explore approaches for its activation. Lipoxin A4 (LXA4) has been proven to reverse adipose tissue inflammation and...

A high-fat diet catalyzes progression to hyperglycemia in mice with selective impairment of insulin action in Glut4-expressing tissues.

The Journal of biological chemistry

Reilly AM, Yan S, Huang M, Abhyankar SD, Conley JM, Bone RN, Stull ND, Horan DJ, Roh HC, Robling AG, Ericsson AC, Dong XC, Evans-Molina C, Ren H.
PMID: 34801552
J Biol Chem. 2021 Nov 18;298(1):101431. doi: 10.1016/j.jbc.2021.101431. Epub 2021 Nov 18.

Insulin resistance impairs postprandial glucose uptake through glucose transporter type 4 (GLUT4) and is the primary defect preceding type 2 diabetes. We previously generated an insulin-resistant mouse model with human GLUT4 promoter-driven insulin receptor knockout (GIRKO) in the muscle,...

Electroacupuncture at Bilateral ST36 Acupoints: Inducing the Hypoglycemic Effect through Enhancing Insulin Signal Proteins in a Streptozotocin-Induced Rat Model during Isoflurane Anesthesia.

Evidence-based complementary and alternative medicine : eCAM

Man KM, Lee YC, Chen YI, Chen YH, Chang SL, Huang CC.
PMID: 34659435
Evid Based Complement Alternat Med. 2021 Oct 06;2021:5852599. doi: 10.1155/2021/5852599. eCollection 2021.

In rats with 2-deoxy-2-(3-(methyl-3-nitrosoureido)-d-glucopyranose streptozotocin- (STZ-) induced insulin-dependent diabetes (IDDM), continuous 15 Hz electrical stimulation at bilateral ST36 acupoints for 30 and 60 minutes has been shown to prevent hyperglycemia. We hypothesized that the mechanism of action in STZ-induced...

Showing 1 to 12 of 93 entries