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UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3β/β-catenin pathway in hepatocellular carcinoma cells.

Anti-cancer drugs

Wu L, Guo H, Sun H, Zhang W, Sun C, Wang J.
PMID: 27669172
Anticancer Drugs. 2016 Nov;27(10):988-1000. doi: 10.1097/CAD.0000000000000416.

UNC119 (uncoordinated 119 or retinal protein 4), specifically expressed in the photoreceptors in the retina, has recently been found to be upregulated in hepatocellular carcinoma (HCC) tissues, predicting a poor prognosis. However, the biological role of UNC119 in cancer...

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Wu L, Guo H, Sun H, et al. UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3β/β-catenin pathway in hepatocellular carcinoma cells. Anticancer Drugs. 2016;27(10):988-1000doi: 10.1097/CAD.0000000000000416.
Wu, L., Guo, H., Sun, H., Zhang, W., Sun, C., & Wang, J. (2016). UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3β/β-catenin pathway in hepatocellular carcinoma cells. Anti-cancer drugs, 27(10), 988-1000. https://doi.org/10.1097/CAD.0000000000000416
Wu, Lili, et al. "UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3β/β-catenin pathway in hepatocellular carcinoma cells." Anti-cancer drugs vol. 27,10 (2016): 988-1000. doi: https://doi.org/10.1097/CAD.0000000000000416
Wu L, Guo H, Sun H, Zhang W, Sun C, Wang J. UNC119 mediates gambogic acid-induced cell-cycle dysregulation through the Gsk3β/β-catenin pathway in hepatocellular carcinoma cells. Anticancer Drugs. 2016 Nov;27(10):988-1000. doi: 10.1097/CAD.0000000000000416. PMID: 27669172.
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Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology

Agrawal R, Kalmady SV, Venkatasubramanian G.
PMID: 28449558
Clin Psychopharmacol Neurosci. 2017 May 31;15(2):115-125. doi: 10.9758/cpn.2017.15.2.115.

OBJECTIVE: Deficient brain-derived neurotrophic factor (BDNF) is one of the important mechanisms underlying the neuroplasticity abnormalities in schizophrenia. Aberration in BDNF signaling pathways directly or circuitously influences neurotransmitters like glutamate and gamma-aminobutyric acid (GABA). For the first time, this...

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Agrawal R, Kalmady SV, Venkatasubramanian G. . Clin Psychopharmacol Neurosci. 2017;15(2):115-125doi: 10.9758/cpn.2017.15.2.115.
Agrawal, R., Kalmady, S. V., & Venkatasubramanian, G. (2017). . Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 15(2), 115-125. https://doi.org/10.9758/cpn.2017.15.2.115
Agrawal, Rimjhim, et al. "." Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology vol. 15,2 (2017): 115-125. doi: https://doi.org/10.9758/cpn.2017.15.2.115
Agrawal R, Kalmady SV, Venkatasubramanian G. . Clin Psychopharmacol Neurosci. 2017 May 31;15(2):115-125. doi: 10.9758/cpn.2017.15.2.115. PMID: 28449558; PMCID: PMC5426484.
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The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat.

Iranian journal of pharmaceutical research : IJPR

Rahimi HR, Ghahremani MH, Dehpour AR, Sharifzadeh M, Ejtemaei-Mehr S, Razmi A, Ostad SN.
PMID: 26664379
Iran J Pharm Res. 2015;14(4):1123-35.

Lithium (Li), a glycogen synthase kinase-3β (GSK-3β) inhibitor, has used to attenuate the cannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this are unclear. Recent studies indicate the involvement of upstream extracellular signal kinase1/2 (ERK1/2) and downstream GSK-3β pathways...

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Rahimi HR, Ghahremani MH, Dehpour AR, et al. The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat. Iran J Pharm Res. 2015;14(4):1123-35
Rahimi, H. R., Ghahremani, M. H., Dehpour, A. R., Sharifzadeh, M., Ejtemaei-Mehr, S., Razmi, A., & Ostad, S. N. (2015). The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat. Iranian journal of pharmaceutical research : IJPR, 14(4), 1123-35.
Rahimi, Hamid Reza, et al. "The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat." Iranian journal of pharmaceutical research : IJPR vol. 14,4 (2015): 1123-35.
Rahimi HR, Ghahremani MH, Dehpour AR, Sharifzadeh M, Ejtemaei-Mehr S, Razmi A, Ostad SN. The Neuroprotective Effect of Lithium in cannabinoid Dependence is Mediated through Modulation of Cyclic AMP, ERK1/2 and GSK-3β Phosphorylation in Cerebellar Granular Neurons of Rat. Iran J Pharm Res. 2015;14(4):1123-35. PMID: 26664379; PMCID: PMC4673940.
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Expression of Genes Encoding the Enzymes for Glycogen and Trehalose Metabolism in L3 and L4 Larvae of Anisakis simplex.

Journal of parasitology research

Łopieńska-Biernat E, Zaobidna EA, Dmitryjuk M.
PMID: 26783451
J Parasitol Res. 2015;2015:438145. doi: 10.1155/2015/438145. Epub 2015 Dec 08.

Trehalose and glycogen metabolism plays an important role in supporting life processes in many nematodes, including Anisakis simplex. Nematodes, cosmopolitan helminths parasitizing sea mammals and humans, cause a disease known as anisakiasis. The aim of this study was to...

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Łopieńska-Biernat E, Zaobidna EA, Dmitryjuk M. Expression of Genes Encoding the Enzymes for Glycogen and Trehalose Metabolism in L3 and L4 Larvae of Anisakis simplex. J Parasitol Res. 2015;2015:438145doi: 10.1155/2015/438145.
Łopieńska-Biernat, E., Zaobidna, E. A., & Dmitryjuk, M. (2015). Expression of Genes Encoding the Enzymes for Glycogen and Trehalose Metabolism in L3 and L4 Larvae of Anisakis simplex. Journal of parasitology research, 2015438145. https://doi.org/10.1155/2015/438145
Łopieńska-Biernat, E, et al. "Expression of Genes Encoding the Enzymes for Glycogen and Trehalose Metabolism in L3 and L4 Larvae of Anisakis simplex." Journal of parasitology research vol. 2015 (2015): 438145. doi: https://doi.org/10.1155/2015/438145
Łopieńska-Biernat E, Zaobidna EA, Dmitryjuk M. Expression of Genes Encoding the Enzymes for Glycogen and Trehalose Metabolism in L3 and L4 Larvae of Anisakis simplex. J Parasitol Res. 2015;2015:438145. doi: 10.1155/2015/438145. Epub 2015 Dec 08. PMID: 26783451; PMCID: PMC4689960.
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Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway.

Experimental and therapeutic medicine

Liu X, Liu C, Zhang X, Zhao J, Xu J.
PMID: 25667611
Exp Ther Med. 2015 Mar;9(3):667-674. doi: 10.3892/etm.2015.2211. Epub 2015 Jan 23.

Urocortin has been shown to exert powerful protective effects on various cardiovascular disease models. However, the role and mechanism of urocortin in protecting against diabetic cardiomyopathy (DCM) has not yet been elucidated. In the present study, the effects of...

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Liu X, Liu C, Zhang X, et al. Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway. Exp Ther Med. 2015;9(3):667-674doi: 10.3892/etm.2015.2211.
Liu, X., Liu, C., Zhang, X., Zhao, J., & Xu, J. (2015). Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway. Experimental and therapeutic medicine, 9(3), 667-674. https://doi.org/10.3892/etm.2015.2211
Liu, Xinyu, et al. "Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway." Experimental and therapeutic medicine vol. 9,3 (2015): 667-674. doi: https://doi.org/10.3892/etm.2015.2211
Liu X, Liu C, Zhang X, Zhao J, Xu J. Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway. Exp Ther Med. 2015 Mar;9(3):667-674. doi: 10.3892/etm.2015.2211. Epub 2015 Jan 23. PMID: 25667611; PMCID: PMC4316969.
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Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells.

Oncology letters

Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, Yang Z, Cao R, Tao H, Wang X, Zhou J.
PMID: 26870186
Oncol Lett. 2016 Jan;11(1):182-188. doi: 10.3892/ol.2015.3854. Epub 2015 Nov 02.

The present study investigated the anti-tumor activity of N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 (TRPM8) in prostate cancer (PCa) DU145 cells. TRPM8 expression in DU145 and normal prostate...

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Liu T, Fang Z, Wang G, et al. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2015;11(1):182-188doi: 10.3892/ol.2015.3854.
Liu, T., Fang, Z., Wang, G., Shi, M., Wang, X., Jiang, K., Yang, Z., Cao, R., Tao, H., Wang, X., & Zhou, J. (2016). Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncology letters, 11(1), 182-188. https://doi.org/10.3892/ol.2015.3854
Liu, Tao, et al. "Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells." Oncology letters vol. 11,1 (2016): 182-188. doi: https://doi.org/10.3892/ol.2015.3854
Liu T, Fang Z, Wang G, Shi M, Wang X, Jiang K, Yang Z, Cao R, Tao H, Wang X, Zhou J. Anti-tumor activity of the TRPM8 inhibitor BCTC in prostate cancer DU145 cells. Oncol Lett. 2016 Jan;11(1):182-188. doi: 10.3892/ol.2015.3854. Epub 2015 Nov 02. PMID: 26870186; PMCID: PMC4727066.
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Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer.

Experimental and therapeutic medicine

Wu F, Chen J, Fan LM, Liu K, Zhang N, Li SW, Zhu H, Gao HC.
PMID: 28672902
Exp Ther Med. 2017 Jul;14(1):127-130. doi: 10.3892/etm.2017.4494. Epub 2017 May 22.

The aim of the present study was to investigate the effect of rutin treatment on the expression of glycogen synthase kinase (GSK)-3β and tumor necrosis factor (TNF)-α in A549 human lung carcinoma cells. The A549 cells were divided into...

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Wu F, Chen J, Fan LM, et al. Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer. Exp Ther Med. 2017;14(1):127-130doi: 10.3892/etm.2017.4494.
Wu, F., Chen, J., Fan, L. M., Liu, K., Zhang, N., Li, S. W., Zhu, H., & Gao, H. C. (2017). Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer. Experimental and therapeutic medicine, 14(1), 127-130. https://doi.org/10.3892/etm.2017.4494
Wu, Fei, et al. "Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer." Experimental and therapeutic medicine vol. 14,1 (2017): 127-130. doi: https://doi.org/10.3892/etm.2017.4494
Wu F, Chen J, Fan LM, Liu K, Zhang N, Li SW, Zhu H, Gao HC. Analysis of the effect of rutin on GSK-3β and TNF-α expression in lung cancer. Exp Ther Med. 2017 Jul;14(1):127-130. doi: 10.3892/etm.2017.4494. Epub 2017 May 22. PMID: 28672902; PMCID: PMC5488604.
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IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways.

International journal of clinical and experimental medicine

Xie Q, Sun Z, Chen M, Zhong Q, Yang T, Yi J.
PMID: 26550160
Int J Clin Exp Med. 2015 Aug 15;8(8):12498-508. eCollection 2015.

BACKGROUND: Therapeutic myocardial angiogenesis is an important compensatory mechanism in severely coronary stenosis. Previous studies demonstrated that interleukin-8 (IL-8) not only plays an important role in inflammation, but also a potent angiogenic factor through p38 mitogen-activated protein kinase (p38MAPK),...

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Xie Q, Sun Z, Chen M, et al. IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways. Int J Clin Exp Med. 2015;8(8):12498-508
Xie, Q., Sun, Z., Chen, M., Zhong, Q., Yang, T., & Yi, J. (2015). IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways. International journal of clinical and experimental medicine, 8(8), 12498-508.
Xie, Qiying, et al. "IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways." International journal of clinical and experimental medicine vol. 8,8 (2015): 12498-508.
Xie Q, Sun Z, Chen M, Zhong Q, Yang T, Yi J. IL-8 up-regulates proliferative angiogenesis in ischemic myocardium in rabbits through phosphorylation of Akt/GSK-3β(ser9) dependent pathways. Int J Clin Exp Med. 2015 Aug 15;8(8):12498-508. eCollection 2015. PMID: 26550160; PMCID: PMC4612845.
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Genetics of Lafora progressive myoclonic epilepsy: current perspectives.

The application of clinical genetics

Kecmanović M, Keckarević-Marković M, Keckarević D, Stevanović G, Jović N, Romac S.
PMID: 27194917
Appl Clin Genet. 2016 May 02;9:49-53. doi: 10.2147/TACG.S57890. eCollection 2016.

Lafora disease (LD) is a fatal neurodegenerative disorder caused by loss-of-function mutations in either laforin glycogen phosphatase gene (EPM2A) or malin E3 ubiquitin ligase gene (NHLRC1). LD is associated with gradual accumulation of Lafora bodies (LBs). LBs are aggregates...

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Kecmanović M, Keckarević-Marković M, Keckarević D, et al. Genetics of Lafora progressive myoclonic epilepsy: current perspectives. Appl Clin Genet. 2016;9:49-53doi: 10.2147/TACG.S57890.
Kecmanović, M., Keckarević-Marković, M., Keckarević, D., Stevanović, G., Jović, N., & Romac, S. (2016). Genetics of Lafora progressive myoclonic epilepsy: current perspectives. The application of clinical genetics, 949-53. https://doi.org/10.2147/TACG.S57890
Kecmanović, Miljana, et al. "Genetics of Lafora progressive myoclonic epilepsy: current perspectives." The application of clinical genetics vol. 9 (2016): 49-53. doi: https://doi.org/10.2147/TACG.S57890
Kecmanović M, Keckarević-Marković M, Keckarević D, Stevanović G, Jović N, Romac S. Genetics of Lafora progressive myoclonic epilepsy: current perspectives. Appl Clin Genet. 2016 May 02;9:49-53. doi: 10.2147/TACG.S57890. eCollection 2016. PMID: 27194917; PMCID: PMC4859416.
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Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review.

Therapeutic advances in chronic disease

Iadarola ND, Niciu MJ, Richards EM, Vande Voort JL, Ballard ED, Lundin NB, Nugent AC, Machado-Vieira R, Zarate CA.
PMID: 25954495
Ther Adv Chronic Dis. 2015 May;6(3):97-114. doi: 10.1177/2040622315579059.

Current pharmacotherapies for major depressive disorder (MDD) and bipolar depression (BDep) have a distinct lag of onset that can generate great distress and impairment in patients. Furthermore, as demonstrated by several real-world effectiveness trials, their efficacy is limited. All...

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Iadarola ND, Niciu MJ, Richards EM, et al. Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Ther Adv Chronic Dis. 2015;6(3):97-114doi: 10.1177/2040622315579059.
Iadarola, N. D., Niciu, M. J., Richards, E. M., Vande Voort, J. L., Ballard, E. D., Lundin, N. B., Nugent, A. C., Machado-Vieira, R., & Zarate, C. A. (2015). Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Therapeutic advances in chronic disease, 6(3), 97-114. https://doi.org/10.1177/2040622315579059
Iadarola, Nicolas D, et al. "Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review." Therapeutic advances in chronic disease vol. 6,3 (2015): 97-114. doi: https://doi.org/10.1177/2040622315579059
Iadarola ND, Niciu MJ, Richards EM, Vande Voort JL, Ballard ED, Lundin NB, Nugent AC, Machado-Vieira R, Zarate CA. Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review. Ther Adv Chronic Dis. 2015 May;6(3):97-114. doi: 10.1177/2040622315579059. PMID: 25954495; PMCID: PMC4416968.
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Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway.

Evidence-based complementary and alternative medicine : eCAM

Xian YF, Lin ZX, Mao QQ, Chen JN, Su ZR, Lai XP, Ip PS.
PMID: 24319473
Evid Based Complement Alternat Med. 2013;2013:163057. doi: 10.1155/2013/163057. Epub 2013 Nov 06.

The neurotoxicity of amyloid- β (A β ) has been implicated as a critical cause of Alzheimer's disease. Isorhynchophylline (IRN), an oxindole alkaloid isolated from Uncaria rhynchophylla, exerts neuroprotective effect against Aβ 25-35-induced neurotoxicity in vitro. However, the exact...

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Xian YF, Lin ZX, Mao QQ, et al. Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:163057doi: 10.1155/2013/163057.
Xian, Y. F., Lin, Z. X., Mao, Q. Q., Chen, J. N., Su, Z. R., Lai, X. P., & Ip, P. S. (2013). Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM, 2013163057. https://doi.org/10.1155/2013/163057
Xian, Yan-Fang, et al. "Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway." Evidence-based complementary and alternative medicine : eCAM vol. 2013 (2013): 163057. doi: https://doi.org/10.1155/2013/163057
Xian YF, Lin ZX, Mao QQ, Chen JN, Su ZR, Lai XP, Ip PS. Isorhynchophylline Protects PC12 Cells Against Beta-Amyloid-Induced Apoptosis via PI3K/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2013;2013:163057. doi: 10.1155/2013/163057. Epub 2013 Nov 06. PMID: 24319473; PMCID: PMC3836301.
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Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training.

Physiological reports

Broholm C, Mathur N, Hvid T, Grøndahl TS, Frøsig C, Pedersen BK, Lindegaard B.
PMID: 24303139
Physiol Rep. 2013 Aug;1(3):e00060. doi: 10.1002/phy2.60. Epub 2013 Aug 22.

Human immunodeficiency virus (HIV)-infected patients with lipodystrophy have decreased insulin-stimulated glucose uptake. Both endurance and resistance training improve insulin-stimulated glucose uptake in skeletal muscle of HIV-infected patients, but the mechanisms are unknown. This study aims to identify the molecular...

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Broholm C, Mathur N, Hvid T, et al. Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training. Physiol Rep. 2013;1(3):e00060doi: 10.1002/phy2.60.
Broholm, C., Mathur, N., Hvid, T., Grøndahl, T. S., Frøsig, C., Pedersen, B. K., & Lindegaard, B. (2013). Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training. Physiological reports, 1(3), e00060. https://doi.org/10.1002/phy2.60
Broholm, Christa, et al. "Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training." Physiological reports vol. 1,3 (2013): e00060. doi: https://doi.org/10.1002/phy2.60
Broholm C, Mathur N, Hvid T, Grøndahl TS, Frøsig C, Pedersen BK, Lindegaard B. Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training. Physiol Rep. 2013 Aug;1(3):e00060. doi: 10.1002/phy2.60. Epub 2013 Aug 22. PMID: 24303139; PMCID: PMC3835015.
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Showing 1 to 12 of 1101 entries