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Gossypol-a new antifertility agent for males

STEM and males

[No authors listed]
GSID: aZVxf5wiRxYJ
CGMAA National - Chinese Medical Journal, 1978 - medcentral.net

… Gossypol is a yellowish phenolic compound isolated from the seed, stem or root of the cotton … Further investigations carried out in the 1960's revealed that males were more susceptible …

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National, C. G. O. M. A. A. (1978). Gossypol-a new antifertility agent for males. Chinese Medical Journal, 4(06), 417-428.
National, Coordinating Group on Male Antifertility Agents. "Gossypol-a new antifertility agent for males." Chinese Medical Journal 4.06 (1978): 417-428.
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Correction: BNIP3 Regulates AT101 [(-)-Gossypol] Induced Death in Malignant Peripheral Nerve Sheath Tumor Cells.

PloS one

Kaza N, Kohli L, Graham CD, Klocke BJ, Carroll SL, Roth KA.
PMID: 26312998
PLoS One. 2015 Aug 27;10(8):e0137153. doi: 10.1371/journal.pone.0137153. eCollection 2015.

No abstract available.

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Kaza N, Kohli L, Graham CD, et al. Correction: BNIP3 Regulates AT101 [(-)-Gossypol] Induced Death in Malignant Peripheral Nerve Sheath Tumor Cells. PLoS One. 2015;10(8):e0137153doi: 10.1371/journal.pone.0137153.
Kaza, N., Kohli, L., Graham, C. D., Klocke, B. J., Carroll, S. L., & Roth, K. A. (2015). Correction: BNIP3 Regulates AT101 [(-)-Gossypol] Induced Death in Malignant Peripheral Nerve Sheath Tumor Cells. PloS one, 10(8), e0137153. https://doi.org/10.1371/journal.pone.0137153
Kaza, Niroop, et al. "Correction: BNIP3 Regulates AT101 [(-)-Gossypol] Induced Death in Malignant Peripheral Nerve Sheath Tumor Cells." PloS one vol. 10,8 (2015): e0137153. doi: https://doi.org/10.1371/journal.pone.0137153
Kaza N, Kohli L, Graham CD, Klocke BJ, Carroll SL, Roth KA. Correction: BNIP3 Regulates AT101 [(-)-Gossypol] Induced Death in Malignant Peripheral Nerve Sheath Tumor Cells. PLoS One. 2015 Aug 27;10(8):e0137153. doi: 10.1371/journal.pone.0137153. eCollection 2015. PMID: 26312998; PMCID: PMC4552425.
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Niemann-Pick C2 Proteins: A New Function for an Old Family.

Frontiers in physiology

Zhu J, Guo M, Ban L, Song LM, Liu Y, Pelosi P, Wang G.
PMID: 29472868
Front Physiol. 2018 Jan 31;9:52. doi: 10.3389/fphys.2018.00052. eCollection 2018.

Niemann-Pick proteins type C2 (NPC2) are carriers of cholesterol in vertebrates, with a single member in each species. The high sequence conservation between mammals and across vertebrates is related to their common function. In contrast, NPC2 proteins in arthropods...

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Zhu J, Guo M, Ban L, et al. Niemann-Pick C2 Proteins: A New Function for an Old Family. Front Physiol. 2018;9:52doi: 10.3389/fphys.2018.00052.
Zhu, J., Guo, M., Ban, L., Song, L. M., Liu, Y., Pelosi, P., & Wang, G. (2018). Niemann-Pick C2 Proteins: A New Function for an Old Family. Frontiers in physiology, 952. https://doi.org/10.3389/fphys.2018.00052
Zhu, Jiao, et al. "Niemann-Pick C2 Proteins: A New Function for an Old Family." Frontiers in physiology vol. 9 (2018): 52. doi: https://doi.org/10.3389/fphys.2018.00052
Zhu J, Guo M, Ban L, Song LM, Liu Y, Pelosi P, Wang G. Niemann-Pick C2 Proteins: A New Function for an Old Family. Front Physiol. 2018 Jan 31;9:52. doi: 10.3389/fphys.2018.00052. eCollection 2018. PMID: 29472868; PMCID: PMC5810286.
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Effects of cotton plant allelochemicals and nutrients on behavior and development of tobacco budworm.

Journal of chemical ecology

Hedin PA, Parrott WL, Jenkins JN.
PMID: 24259171
J Chem Ecol. 1991 Jun;17(6):1107-21. doi: 10.1007/BF01402937.

Female moths of the tobacco budworm,Heliothis virescens (F.), oviposit in the terminals of the cotton plant,Gossypium hirsutum (L.). The hatched larvae migrate to the terminal area and then to small squares (buds), on which they feed, finally burrowing into...

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Hedin PA, Parrott WL, Jenkins JN. Effects of cotton plant allelochemicals and nutrients on behavior and development of tobacco budworm. J Chem Ecol. 1991;17(6):1107-21doi: 10.1007/BF01402937.
Hedin, P. A., Parrott, W. L., & Jenkins, J. N. (1991). Effects of cotton plant allelochemicals and nutrients on behavior and development of tobacco budworm. Journal of chemical ecology, 17(6), 1107-21. https://doi.org/10.1007/BF01402937
Hedin, P A, et al. "Effects of cotton plant allelochemicals and nutrients on behavior and development of tobacco budworm." Journal of chemical ecology vol. 17,6 (1991): 1107-21. doi: https://doi.org/10.1007/BF01402937
Hedin PA, Parrott WL, Jenkins JN. Effects of cotton plant allelochemicals and nutrients on behavior and development of tobacco budworm. J Chem Ecol. 1991 Jun;17(6):1107-21. doi: 10.1007/BF01402937. PMID: 24259171.
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Possible roles of cotton bud sugars and terpenoids in oviposition by the boll weevil.

Journal of chemical ecology

Hedin PA, McCarty JC.
PMID: 24263592
J Chem Ecol. 1990 Mar;16(3):757-72. doi: 10.1007/BF01016487.

Several cottonGossypium spp. race stocks have been identified that possess resistance to the boll weevilAnthonomus grandis Boh. because oviposition is decreased. In this work, a number of known cotton constituents that influence stimulation of feeding and attractancy for this...

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Hedin PA, McCarty JC. Possible roles of cotton bud sugars and terpenoids in oviposition by the boll weevil. J Chem Ecol. 1990;16(3):757-72doi: 10.1007/BF01016487.
Hedin, P. A., & McCarty, J. C. (1990). Possible roles of cotton bud sugars and terpenoids in oviposition by the boll weevil. Journal of chemical ecology, 16(3), 757-72. https://doi.org/10.1007/BF01016487
Hedin, P A, and McCarty, J C. "Possible roles of cotton bud sugars and terpenoids in oviposition by the boll weevil." Journal of chemical ecology vol. 16,3 (1990): 757-72. doi: https://doi.org/10.1007/BF01016487
Hedin PA, McCarty JC. Possible roles of cotton bud sugars and terpenoids in oviposition by the boll weevil. J Chem Ecol. 1990 Mar;16(3):757-72. doi: 10.1007/BF01016487. PMID: 24263592.
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Induction of Terpenoid Synthesis in Cotton Roots and Control of Rhizoctonia solani by Seed Treatment with Trichoderma virens.

Phytopathology

Howell CR, Hanson LE, Stipanovic RD, Puckhaber LS.
PMID: 18944616
Phytopathology. 2000 Mar;90(3):248-52. doi: 10.1094/PHYTO.2000.90.3.248.

ABSTRACT Research on the mechanisms employed by the biocontrol agent Trichoderma virens to suppress cotton (Gossypium hirsutum) seedling disease incited by Rhizoctonia solani has shown that mycoparasitism and antibiotic production are not major contributors to successful biological control. In...

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Howell CR, Hanson LE, Stipanovic RD, et al. Induction of Terpenoid Synthesis in Cotton Roots and Control of Rhizoctonia solani by Seed Treatment with Trichoderma virens. Phytopathology. 2000;90(3):248-52doi: 10.1094/PHYTO.2000.90.3.248.
Howell, C. R., Hanson, L. E., Stipanovic, R. D., & Puckhaber, L. S. (2000). Induction of Terpenoid Synthesis in Cotton Roots and Control of Rhizoctonia solani by Seed Treatment with Trichoderma virens. Phytopathology, 90(3), 248-52. https://doi.org/10.1094/PHYTO.2000.90.3.248
Howell, C R, et al. "Induction of Terpenoid Synthesis in Cotton Roots and Control of Rhizoctonia solani by Seed Treatment with Trichoderma virens." Phytopathology vol. 90,3 (2000): 248-52. doi: https://doi.org/10.1094/PHYTO.2000.90.3.248
Howell CR, Hanson LE, Stipanovic RD, Puckhaber LS. Induction of Terpenoid Synthesis in Cotton Roots and Control of Rhizoctonia solani by Seed Treatment with Trichoderma virens. Phytopathology. 2000 Mar;90(3):248-52. doi: 10.1094/PHYTO.2000.90.3.248. PMID: 18944616.
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Effects of dietary gossypol on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls.

Theriogenology

Chenoweth PJ, Risco CA, Larsen RE, Velez J, Tran T, Chase CC.
PMID: 16727507
Theriogenology. 1994;42(1):1-13. doi: 10.1016/0093-691x(94)90657-5.

Eight young reproductively normal Brahman bulls (average age and bodyweight 20 months and 500 kg, respectively) received either cottonseed meal delivering 8.2 g free gossypol/bull/d (treatment group, n=4) or soybean meal (control group, n=4) for 12 wk. After adjustment...

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Chenoweth PJ, Risco CA, Larsen RE, et al. Effects of dietary gossypol on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls. Theriogenology. 1994;42(1):1-13doi: 10.1016/0093-691x(94)90657-5.
Chenoweth, P. J., Risco, C. A., Larsen, R. E., Velez, J., Tran, T., & Chase, C. C. (1994). Effects of dietary gossypol on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls. Theriogenology, 42(1), 1-13. https://doi.org/10.1016/0093-691x(94)90657-5
Chenoweth, P J, et al. "Effects of dietary gossypol on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls." Theriogenology vol. 42,1 (1994): 1-13. doi: https://doi.org/10.1016/0093-691x(94)90657-5
Chenoweth PJ, Risco CA, Larsen RE, Velez J, Tran T, Chase CC. Effects of dietary gossypol on aspects of semen quality, sperm morphology and sperm production in young Brahman bulls. Theriogenology. 1994;42(1):1-13. doi: 10.1016/0093-691x(94)90657-5. PMID: 16727507.
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Effects of diets containing gossypol on spermatogenic tissues of young bulls.

Theriogenology

Arshami J, Ruttle JL.
PMID: 16726493
Theriogenology. 1988 Sep;30(3):507-16. doi: 10.1016/0093-691x(88)90200-2.

Eighteen yearling beef bulls were used in a study to determine the effects of diets containing gossypol on spermatogenic tissues, Sertoli cells and Leydig cells. Bulls were randomly assigned to one of three (n = 6) isonitrogenous diet groups...

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Arshami J, Ruttle JL. Effects of diets containing gossypol on spermatogenic tissues of young bulls. Theriogenology. 1988;30(3):507-16doi: 10.1016/0093-691x(88)90200-2.
Arshami, J., & Ruttle, J. L. (1988). Effects of diets containing gossypol on spermatogenic tissues of young bulls. Theriogenology, 30(3), 507-16. https://doi.org/10.1016/0093-691x(88)90200-2
Arshami, J, and Ruttle, J L. "Effects of diets containing gossypol on spermatogenic tissues of young bulls." Theriogenology vol. 30,3 (1988): 507-16. doi: https://doi.org/10.1016/0093-691x(88)90200-2
Arshami J, Ruttle JL. Effects of diets containing gossypol on spermatogenic tissues of young bulls. Theriogenology. 1988 Sep;30(3):507-16. doi: 10.1016/0093-691x(88)90200-2. PMID: 16726493.
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Oxidative and phosphorylative activities of mitochondria isolated from cotton hypocotyls.

Plant physiology

Killion DD, Grooms S, Frans RE.
PMID: 16657001
Plant Physiol. 1968 Dec;43(12):1996-2000. doi: 10.1104/pp.43.12.1996.

Mitochondria isolated from 2 strains of cotton plant hypocotyls (Gossypium hirsutum L. var. Rex smooth leaf and Rex glandless) were examined for their oxidative phosphorylation activities. Bovine serum albumin at a relatively high concentration was essential in the extraction...

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Killion DD, Grooms S, Frans RE. Oxidative and phosphorylative activities of mitochondria isolated from cotton hypocotyls. Plant Physiol. 1968;43(12):1996-2000doi: 10.1104/pp.43.12.1996.
Killion, D. D., Grooms, S., & Frans, R. E. (1968). Oxidative and phosphorylative activities of mitochondria isolated from cotton hypocotyls. Plant physiology, 43(12), 1996-2000. https://doi.org/10.1104/pp.43.12.1996
Killion, D D, et al. "Oxidative and phosphorylative activities of mitochondria isolated from cotton hypocotyls." Plant physiology vol. 43,12 (1968): 1996-2000. doi: https://doi.org/10.1104/pp.43.12.1996
Killion DD, Grooms S, Frans RE. Oxidative and phosphorylative activities of mitochondria isolated from cotton hypocotyls. Plant Physiol. 1968 Dec;43(12):1996-2000. doi: 10.1104/pp.43.12.1996. PMID: 16657001; PMCID: PMC1087117.
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GOSSYPOL--A TOXIC SUBSTANCE IN COTTONSEED. A PRELIMINARY NOTE.

Science (New York, N.Y.)

Withers WA, Carruth FE.
PMID: 17789059
Science. 1915 Feb 26;41(1052):324. doi: 10.1126/science.41.1052.324-a.

No abstract available.

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Withers WA, Carruth FE. GOSSYPOL--A TOXIC SUBSTANCE IN COTTONSEED. A PRELIMINARY NOTE. Science. 1915;41(1052):324doi: 10.1126/science.41.1052.324-a.
Withers, W. A., & Carruth, F. E. (1915). GOSSYPOL--A TOXIC SUBSTANCE IN COTTONSEED. A PRELIMINARY NOTE. Science (New York, N.Y.), 41(1052), 324. https://doi.org/10.1126/science.41.1052.324-a
Withers, W A, and Carruth, F E. "GOSSYPOL--A TOXIC SUBSTANCE IN COTTONSEED. A PRELIMINARY NOTE." Science (New York, N.Y.) vol. 41,1052 (1915): 324. doi: https://doi.org/10.1126/science.41.1052.324-a
Withers WA, Carruth FE. GOSSYPOL--A TOXIC SUBSTANCE IN COTTONSEED. A PRELIMINARY NOTE. Science. 1915 Feb 26;41(1052):324. doi: 10.1126/science.41.1052.324-a. PMID: 17789059.
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Gateways to clinical trials.

Methods and findings in experimental and clinical pharmacology

Tomillero A, Moral MA.
PMID: 19557204
Methods Find Exp Clin Pharmacol. 2009 May;31(4):263-98. doi: 10.1358/mf.2009.31.4.1373959.

(-)-Gossypol; Abacavir sulfate/lamivudine, ACAM-1000, ACE-011, Agomelatine, AGS-004, Alemtuzumab, Alvocidib hydrochloride, AMG-317, Amlodipine, Aripiprazole, Atazanavir sulfate, Azacitidine; Becatecarin, Belinostat, Bevacizumab, BMS-387032, BMS-690514, Bortezomib; Casopitant mesylate, Cetuximab, Choline fenofibrate, CK-1827452, Clofarabine, Conivaptan hydrochloride; Dabigatran etexilate, DADMe-Immucillin-H, Darbepoetin alfa, Darunavir, Dasatinib, DC-WT1,...

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Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009;31(4):263-98doi: 10.1358/mf.2009.31.4.1373959.
Tomillero, A., & Moral, M. A. (2009). Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology, 31(4), 263-98. https://doi.org/10.1358/mf.2009.31.4.1373959
Tomillero, A, and Moral, M A. "Gateways to clinical trials." Methods and findings in experimental and clinical pharmacology vol. 31,4 (2009): 263-98. doi: https://doi.org/10.1358/mf.2009.31.4.1373959
Tomillero A, Moral MA. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2009 May;31(4):263-98. doi: 10.1358/mf.2009.31.4.1373959. PMID: 19557204.
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In vitro anti-trichomonad effectiveness of a gossypol-metronidazol blend.

International journal of antimicrobial agents

Teresa González-Garza M, Said-Fernández S.
PMID: 18611820
Int J Antimicrob Agents. 1997 Jun;9(1):57-60. doi: 10.1016/s0924-8579(97)00026-5.

With the aid of the Basic Sequential Analytical Simplex Method the in vitro anti-trichomonad effectiveness of several metronidazole/gossypol blends was determined. While the combination that produced 50% of growth inhibition on trichomonad cultures (IC50) contained 15.1 microM gossypol and...

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Teresa González-Garza M, Said-Fernández S. In vitro anti-trichomonad effectiveness of a gossypol-metronidazol blend. Int J Antimicrob Agents. 1997;9(1):57-60doi: 10.1016/s0924-8579(97)00026-5.
Teresa González-Garza, M., & Said-Fernández, S. (1997). In vitro anti-trichomonad effectiveness of a gossypol-metronidazol blend. International journal of antimicrobial agents, 9(1), 57-60. https://doi.org/10.1016/s0924-8579(97)00026-5
Teresa González-Garza, M, and Said-Fernández, S. "In vitro anti-trichomonad effectiveness of a gossypol-metronidazol blend." International journal of antimicrobial agents vol. 9,1 (1997): 57-60. doi: https://doi.org/10.1016/s0924-8579(97)00026-5
Teresa González-Garza M, Said-Fernández S. In vitro anti-trichomonad effectiveness of a gossypol-metronidazol blend. Int J Antimicrob Agents. 1997 Jun;9(1):57-60. doi: 10.1016/s0924-8579(97)00026-5. PMID: 18611820.
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Showing 1 to 12 of 156 entries