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The use of peptide analogs for the treatment of gastrointestinal, pancreatic, liver and urinary bladder cancers.

Hormone molecular biology and clinical investigation

Szepeshazi K, Block NL, Schally AV.
PMID: 25961976
Horm Mol Biol Clin Investig. 2010 Jan 01;1(3):103-10. doi: 10.1515/HMBCI.2010.018.

Peptide hormones can influence the development and growth of many cancers which are not considered classical hormone-dependent tumors. Analogs of somatostatin, bombesin/gastrin-releasing peptide (GRP), luteinizing hormone-releasing hormone (LH-RH) and growth hormone-releasing hormone (GH-RH) can interfere with receptors on tumor...

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Szepeshazi K, Block NL, Schally AV. The use of peptide analogs for the treatment of gastrointestinal, pancreatic, liver and urinary bladder cancers. Horm Mol Biol Clin Investig. 2010;1(3):103-10doi: 10.1515/HMBCI.2010.018.
Szepeshazi, K., Block, N. L., & Schally, A. V. (2010). The use of peptide analogs for the treatment of gastrointestinal, pancreatic, liver and urinary bladder cancers. Hormone molecular biology and clinical investigation, 1(3), 103-10. https://doi.org/10.1515/HMBCI.2010.018
Szepeshazi, Karoly, et al. "The use of peptide analogs for the treatment of gastrointestinal, pancreatic, liver and urinary bladder cancers." Hormone molecular biology and clinical investigation vol. 1,3 (2010): 103-10. doi: https://doi.org/10.1515/HMBCI.2010.018
Szepeshazi K, Block NL, Schally AV. The use of peptide analogs for the treatment of gastrointestinal, pancreatic, liver and urinary bladder cancers. Horm Mol Biol Clin Investig. 2010 Jan 01;1(3):103-10. doi: 10.1515/HMBCI.2010.018. PMID: 25961976.
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Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice.

Biology of sex differences

Quinnies KM, Bonthuis PJ, Harris EP, Shetty SR, Rissman EF.
PMID: 25987976
Biol Sex Differ. 2015 Apr 28;6:8. doi: 10.1186/s13293-015-0026-x. eCollection 2015.

BACKGROUND: Sex differences in pituitary growth hormone (GH) are well documented and coordinate maturation and growth. GH and its receptor are also produced in the brain where they may impact cognitive function and synaptic plasticity, and estradiol produces Gh...

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Quinnies KM, Bonthuis PJ, Harris EP, et al. Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice. Biol Sex Differ. 2015;6:8doi: 10.1186/s13293-015-0026-x.
Quinnies, K. M., Bonthuis, P. J., Harris, E. P., Shetty, S. R., & Rissman, E. F. (2015). Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice. Biology of sex differences, 68. https://doi.org/10.1186/s13293-015-0026-x
Quinnies, Kayla M, et al. "Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice." Biology of sex differences vol. 6 (2015): 8. doi: https://doi.org/10.1186/s13293-015-0026-x
Quinnies KM, Bonthuis PJ, Harris EP, Shetty SR, Rissman EF. Neural growth hormone: regional regulation by estradiol and/or sex chromosome complement in male and female mice. Biol Sex Differ. 2015 Apr 28;6:8. doi: 10.1186/s13293-015-0026-x. eCollection 2015. PMID: 25987976; PMCID: PMC4434521.
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Peptide hormones: Review of current and emerging uses by nasal delivery.

Advanced drug delivery reviews

Pontiroli AE.
PMID: 10837581
Adv Drug Deliv Rev. 1998 Jan 05;29(1):81-87. doi: 10.1016/s0169-409x(97)00062-8.

The family of clinically available peptide hormones (PHs) is expanding in an exponential way, and advancement of knowledge of the basic mechanisms of action of PHs has led to multiplication of the possible clinical indications of already known PHs,...

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Pontiroli AE. Peptide hormones: Review of current and emerging uses by nasal delivery. Adv Drug Deliv Rev. 1998;29(1):81-87doi: 10.1016/s0169-409x(97)00062-8.
Pontiroli, A. E. (1998). Peptide hormones: Review of current and emerging uses by nasal delivery. Advanced drug delivery reviews, 29(1), 81-87. https://doi.org/10.1016/s0169-409x(97)00062-8
Pontiroli. "Peptide hormones: Review of current and emerging uses by nasal delivery." Advanced drug delivery reviews vol. 29,1 (1998): 81-87. doi: https://doi.org/10.1016/s0169-409x(97)00062-8
Pontiroli AE. Peptide hormones: Review of current and emerging uses by nasal delivery. Adv Drug Deliv Rev. 1998 Jan 05;29(1):81-87. doi: 10.1016/s0169-409x(97)00062-8. PMID: 10837581.
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Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

Prakash A, Goa KL.
PMID: 18031173
BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007.

UNLABELLED: Sermorelin, a 29 amino acid analogue of human growth hormone-releasing hormone (GHRH), is the shortest synthetic peptide with full biological activity of GHRH. Intravenous and subcutaneous sermorelin specifically stimulate growth hormone secretion from the anterior pituitary. Hormone responses...

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Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999;12(2):139-57doi: 10.2165/00063030-199912020-00007.
Prakash, A., & Goa, K. L. (1999). Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 12(2), 139-57. https://doi.org/10.2165/00063030-199912020-00007
Prakash, A, and Goa, K L. "Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency." BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy vol. 12,2 (1999): 139-57. doi: https://doi.org/10.2165/00063030-199912020-00007
Prakash A, Goa KL. Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency. BioDrugs. 1999 Aug;12(2):139-57. doi: 10.2165/00063030-199912020-00007. PMID: 18031173.
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Small molecule mimetics of GHRP-6.

Expert opinion on investigational drugs

DeVita RJ.
PMID: 15989584
Expert Opin Investig Drugs. 1997 Dec;6(12):1839-43. doi: 10.1517/13543784.6.12.1839.

In 1981, Bowers reported that xenobiotic peptides, derived from the Leu- and Met- enkephalins, demonstrated novel growth hormone (GH) secretory activity. The most potent peptide reported, GH releasing peptide-6 (GHRP-6), was shown to release GH by a different pathway...

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DeVita RJ. Small molecule mimetics of GHRP-6. Expert Opin Investig Drugs. 1997;6(12):1839-43doi: 10.1517/13543784.6.12.1839.
DeVita, R. J. (1997). Small molecule mimetics of GHRP-6. Expert opinion on investigational drugs, 6(12), 1839-43. https://doi.org/10.1517/13543784.6.12.1839
DeVita, R J. "Small molecule mimetics of GHRP-6." Expert opinion on investigational drugs vol. 6,12 (1997): 1839-43. doi: https://doi.org/10.1517/13543784.6.12.1839
DeVita RJ. Small molecule mimetics of GHRP-6. Expert Opin Investig Drugs. 1997 Dec;6(12):1839-43. doi: 10.1517/13543784.6.12.1839. PMID: 15989584.
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Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro.

Journal of neuroendocrinology

Tsagarakis S, Ge F, Rees LH, Besser GM, Grossman A.
PMID: 19210470
J Neuroendocrinol. 1989 Apr 01;1(2):129-33. doi: 10.1111/j.1365-2826.1989.tb00091.x.

Abstract While extensive evidence suggests that adrenoceptors play an important role in the control of growth hormone in the rat, there are few studies involving the direct measurement of growth hormone-releasing hormone (GHRH). We have therefore developed a radioimmunoassay...

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Tsagarakis S, Ge F, Rees LH, et al. Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro. J Neuroendocrinol. 1989;1(2):129-33doi: 10.1111/j.1365-2826.1989.tb00091.x.
Tsagarakis, S., Ge, F., Rees, L. H., Besser, G. M., & Grossman, A. (1989). Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro. Journal of neuroendocrinology, 1(2), 129-33. https://doi.org/10.1111/j.1365-2826.1989.tb00091.x
Tsagarakis, S, et al. "Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro." Journal of neuroendocrinology vol. 1,2 (1989): 129-33. doi: https://doi.org/10.1111/j.1365-2826.1989.tb00091.x
Tsagarakis S, Ge F, Rees LH, Besser GM, Grossman A. Stimulation of Alpha-Adrenoceptors Facilitates the Release of Growth Hormone-Releasing Hormone from Rat Hypothalamus in vitro. J Neuroendocrinol. 1989 Apr 01;1(2):129-33. doi: 10.1111/j.1365-2826.1989.tb00091.x. PMID: 19210470.
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Development and validation of a two-site immunochemiluminometric assay for rat growth hormone-releasing hormone.

Journal of neuroendocrinology

Page MD, Lewis MD, Lewis BM, Weeks I, Scanion MF.
PMID: 19210413
J Neuroendocrinol. 1989 Dec 01;1(6):433-6. doi: 10.1111/j.1365-2826.1989.tb00143.x.

Abstract We describe the development and validation of a two-site immunochemiluminometric assay for rat growth hormone-releasing hormone (GHRH) based on the affinity purification of polyclonal rabbit antisera to rat GHRH using a human 1-29 GHRH affinity column. Assay sensitivity...

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Page MD, Lewis MD, Lewis BM, et al. Development and validation of a two-site immunochemiluminometric assay for rat growth hormone-releasing hormone. J Neuroendocrinol. 1989;1(6):433-6doi: 10.1111/j.1365-2826.1989.tb00143.x.
Page, M. D., Lewis, M. D., Lewis, B. M., Weeks, I., & Scanion, M. F. (1989). Development and validation of a two-site immunochemiluminometric assay for rat growth hormone-releasing hormone. Journal of neuroendocrinology, 1(6), 433-6. https://doi.org/10.1111/j.1365-2826.1989.tb00143.x
Page, M D, et al. "Development and validation of a two-site immunochemiluminometric assay for rat growth hormone-releasing hormone." Journal of neuroendocrinology vol. 1,6 (1989): 433-6. doi: https://doi.org/10.1111/j.1365-2826.1989.tb00143.x
Page MD, Lewis MD, Lewis BM, Weeks I, Scanion MF. Development and validation of a two-site immunochemiluminometric assay for rat growth hormone-releasing hormone. J Neuroendocrinol. 1989 Dec 01;1(6):433-6. doi: 10.1111/j.1365-2826.1989.tb00143.x. PMID: 19210413.
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Electrical stimulation of specific brainstem nuclei suppresses growth hormone-releasing hormone-induced growth hormone secretion in the pentobarbital anaesthetized rat.

Journal of neuroendocrinology

Koibuchi N, Kato M, Kakegawa T, Suzuki M.
PMID: 19210457
J Neuroendocrinol. 1989 Jun 01;1(3):209-14. doi: 10.1111/j.1365-2826.1989.tb00105.x.

Abstract To clarify the neural mechanism related to suppression of growth hormone (GH) secretion, biphasic electrical stimulation was delivered into several brainstem nuclei in the pentobarbital anaesthetized rat. A concentric bipolar stimulating electrode was implanted chronically one week prior...

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Koibuchi N, Kato M, Kakegawa T, et al. Electrical stimulation of specific brainstem nuclei suppresses growth hormone-releasing hormone-induced growth hormone secretion in the pentobarbital anaesthetized rat. J Neuroendocrinol. 1989;1(3):209-14doi: 10.1111/j.1365-2826.1989.tb00105.x.
Koibuchi, N., Kato, M., Kakegawa, T., & Suzuki, M. (1989). Electrical stimulation of specific brainstem nuclei suppresses growth hormone-releasing hormone-induced growth hormone secretion in the pentobarbital anaesthetized rat. Journal of neuroendocrinology, 1(3), 209-14. https://doi.org/10.1111/j.1365-2826.1989.tb00105.x
Koibuchi, N, et al. "Electrical stimulation of specific brainstem nuclei suppresses growth hormone-releasing hormone-induced growth hormone secretion in the pentobarbital anaesthetized rat." Journal of neuroendocrinology vol. 1,3 (1989): 209-14. doi: https://doi.org/10.1111/j.1365-2826.1989.tb00105.x
Koibuchi N, Kato M, Kakegawa T, Suzuki M. Electrical stimulation of specific brainstem nuclei suppresses growth hormone-releasing hormone-induced growth hormone secretion in the pentobarbital anaesthetized rat. J Neuroendocrinol. 1989 Jun 01;1(3):209-14. doi: 10.1111/j.1365-2826.1989.tb00105.x. PMID: 19210457.
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Molecular genetics of pituitary tumours.

Trends in endocrinology and metabolism: TEM

Farrell WE, Clayton RN.
PMID: 18406230
Trends Endocrinol Metab. 1998 Jan-Feb;9(1):20-6. doi: 10.1016/s1043-2760(98)00006-x.

The last several years have seen a significant increase in our understanding of the molecular and biochemical changes associated with pituitary tumour initiation and progression. The combined data, from several groups, now allow a tentative map to be drawn...

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Farrell WE, Clayton RN. Molecular genetics of pituitary tumours. Trends Endocrinol Metab. 1998;9(1):20-6doi: 10.1016/s1043-2760(98)00006-x.
Farrell, W. E., & Clayton, R. N. (1998). Molecular genetics of pituitary tumours. Trends in endocrinology and metabolism: TEM, 9(1), 20-6. https://doi.org/10.1016/s1043-2760(98)00006-x
Farrell, W E, and Clayton, R N. "Molecular genetics of pituitary tumours." Trends in endocrinology and metabolism: TEM vol. 9,1 (1998): 20-6. doi: https://doi.org/10.1016/s1043-2760(98)00006-x
Farrell WE, Clayton RN. Molecular genetics of pituitary tumours. Trends Endocrinol Metab. 1998 Jan-Feb;9(1):20-6. doi: 10.1016/s1043-2760(98)00006-x. PMID: 18406230.
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Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH).

International journal of oncology

Pinski J, Schally A, Jungwirth A, Groot K, Halmos G, Armatis P, Zarandi M, Vadillobuenfil M.
PMID: 21541617
Int J Oncol. 1996 Dec;9(6):1099-105. doi: 10.3892/ijo.9.6.1099.

Insulin-like growth factors-I and-II (IGF-I and IGF-II) may be involved in the proliferation of human lung carcinomas. The purpose of this study was to investigate the effects of two potent antagonists of growth hormone-releasing hormone (GH-RH), MZ-4-71 and MZ-5-156...

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Pinski J, Schally A, Jungwirth A, et al. Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). Int J Oncol. 1996;9(6):1099-105doi: 10.3892/ijo.9.6.1099.
Pinski, J., Schally, A., Jungwirth, A., Groot, K., Halmos, G., Armatis, P., Zarandi, M., & Vadillobuenfil, M. (1996). Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). International journal of oncology, 9(6), 1099-105. https://doi.org/10.3892/ijo.9.6.1099
Pinski, J, et al. "Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)." International journal of oncology vol. 9,6 (1996): 1099-105. doi: https://doi.org/10.3892/ijo.9.6.1099
Pinski J, Schally A, Jungwirth A, Groot K, Halmos G, Armatis P, Zarandi M, Vadillobuenfil M. Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). Int J Oncol. 1996 Dec;9(6):1099-105. doi: 10.3892/ijo.9.6.1099. PMID: 21541617.
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Modulation of growth axis gene expression by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the weaning Holtzman rat.

Endocrine

Chaffin CL, Brogan RS, Peterson RE, Hutz RJ, Wehrenberg WB.
PMID: 21153102
Endocrine. 1996 Oct;5(2):129-34. doi: 10.1007/BF02738697.

While thein utero and lactational effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on both male and female reproductive systems appear to be severe, little is known about its effects on the developing growth axis. The objective of this study was to describe...

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Chaffin CL, Brogan RS, Peterson RE, et al. Modulation of growth axis gene expression by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the weaning Holtzman rat. Endocrine. 1996;5(2):129-34doi: 10.1007/BF02738697.
Chaffin, C. L., Brogan, R. S., Peterson, R. E., Hutz, R. J., & Wehrenberg, W. B. (1996). Modulation of growth axis gene expression by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the weaning Holtzman rat. Endocrine, 5(2), 129-34. https://doi.org/10.1007/BF02738697
Chaffin, C L, et al. "Modulation of growth axis gene expression by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the weaning Holtzman rat." Endocrine vol. 5,2 (1996): 129-34. doi: https://doi.org/10.1007/BF02738697
Chaffin CL, Brogan RS, Peterson RE, Hutz RJ, Wehrenberg WB. Modulation of growth axis gene expression by in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the weaning Holtzman rat. Endocrine. 1996 Oct;5(2):129-34. doi: 10.1007/BF02738697. PMID: 21153102.
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A review of the use of somatostatin analogs in oncology.

OncoTargets and therapy

Keskin O, Yalcin S.
PMID: 23667314
Onco Targets Ther. 2013 Apr 26;6:471-83. doi: 10.2147/OTT.S39987. Print 2013.

Somatostatin is a neuropeptide produced by paracrine cells that are located throughout the gastrointestinal tract, lung, and pancreas, and is also found in various locations of the nervous system. It exerts neural control over many physiological functions including inhibition...

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Keskin O, Yalcin S. A review of the use of somatostatin analogs in oncology. Onco Targets Ther. 2013;6:471-83doi: 10.2147/OTT.S39987.
Keskin, O., & Yalcin, S. (2013). A review of the use of somatostatin analogs in oncology. OncoTargets and therapy, 6471-83. https://doi.org/10.2147/OTT.S39987
Keskin, Ozge, and Yalcin, Suayib. "A review of the use of somatostatin analogs in oncology." OncoTargets and therapy vol. 6 (2013): 471-83. doi: https://doi.org/10.2147/OTT.S39987
Keskin O, Yalcin S. A review of the use of somatostatin analogs in oncology. Onco Targets Ther. 2013 Apr 26;6:471-83. doi: 10.2147/OTT.S39987. Print 2013. PMID: 23667314; PMCID: PMC3650572.
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Showing 1 to 12 of 138 entries