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Showing 1 to 12 of 29 entries
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Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Wang X, Su YR, Petersen PS, Bien S, Schmit SL, Drew DA, Albanes D, Berndt SI, Brenner H, Campbell PT, Casey G, Chang-Claude J, Gallinger SJ, Gruber SB, Haile RW, Harrison TA, Hoffmeister M, Jacobs EJ, Jenkins MA, Joshi AD, Li L, Lin Y, Lindor NM, Marchand LL, Martin V, Milne R, Maclnnis R, Moreno V, Nan H, Newcomb PA, Potter JD, Rennert G, Rennert H, Slattery ML, Thibodeau SN, Weinstein SJ, Woods MO, Chan AT, White E, Hsu L, Peters U.
PMID: 32651213
Cancer Epidemiol Biomarkers Prev. 2020 Sep;29(9):1800-1808. doi: 10.1158/1055-9965.EPI-19-1018. Epub 2020 Jul 10.

BACKGROUND: Regular use of nonsteroidal anti-inflammatory drugs (NSAID) is associated with lower risk of colorectal cancer. Genome-wide interaction analysis on single variants (G × E) has identified several SNPs that may interact with NSAIDs to confer colorectal cancer risk,...

Physical activity, well-being, and priorities of older women during the COVID-19 pandemic: a survey of Women's Health Initiative Strong and Healthy (WHISH) intervention participants.

Translational behavioral medicine

Wegner L, Mendoza-Vasconez AS, Mackey S, McGuire V, To C, White B, King AC, Stefanick ML.
PMID: 34633465
Transl Behav Med. 2021 Dec 14;11(12):2155-2163. doi: 10.1093/tbm/ibab122.

Sheltering-in-place, social distancing, and other strategies to minimize COVID-19 transmission may impact physical activity (PA) and well-being in older adults. To assess self-reported PA changes, well-being, and priorities of older women across the USA early in the COVID-19 pandemic....

Associations of Angiotensin-Converting Enzyme Inhibitor or Angiotensin Receptor Blocker Use with Colorectal Cancer Risk in the Women's Health Initiative.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Brasky TM, Flores KF, Larson JC, Newton AM, Shadyab AH, Watanabe JH, Lane DS, Thomson CA, LaCroix AZ.
PMID: 33627382
Cancer Epidemiol Biomarkers Prev. 2021 May;30(5):1029-1032. doi: 10.1158/1055-9965.EPI-20-1401. Epub 2021 Feb 24.

BACKGROUND: Use of angiotensin-converting enzyme inhibitors (ACEi) and angiotensin receptor blockers (ARB) has been postulated to reduce cancer risk by inhibition of tumor progression, vascularization, and metastasis. The renin-angiotensin system is upregulated in colorectal cancers; however, the association of...

DXA Versus Clinical Measures of Adiposity as Predictors of Cardiometabolic Diseases and All-Cause Mortality in Postmenopausal Women.

Mayo Clinic proceedings

Laddu DR, Qin F, Hedlin H, Stefanick ML, Manson JE, Zaslavsky O, Eaton C, Martin LW, Rohan T, Assimes TL.
PMID: 34479738
Mayo Clin Proc. 2021 Nov;96(11):2831-2842. doi: 10.1016/j.mayocp.2021.04.027. Epub 2021 Aug 31.

OBJECTIVE: To investigate whether dual-energy x-ray absorptiometry (DXA) estimates of adiposity improve risk prediction for cardiometabolic diseases over traditional surrogates, body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) in older women.PATIENTS AND METHODS: We analyzed up...

Genome-wide Association Analysis of Proinflammatory Cytokines and Gene-lifestyle Interaction for Invasive Breast Cancer Risk: The WHI dbGaP Study.

Cancer prevention research (Philadelphia, Pa.)

Jung SY, Scott PA, Papp JC, Sobel EM, Pellegrini M, Yu H, Han S, Zhang ZF.
PMID: 32928877
Cancer Prev Res (Phila). 2021 Jan;14(1):41-54. doi: 10.1158/1940-6207.CAPR-20-0256. Epub 2020 Sep 14.

Immune-related etiologic pathways to influence invasive breast cancer risk may interact with lifestyle factors, but the interrelated molecular genetic pathways are incompletely characterized. We used data from the Women's Health Initiative Database for Genotypes and Phenotypes Study including 16,088...

Lipoprotein particles and size, total and high molecular weight adiponectin, and leptin in relation to incident coronary heart disease among severely obese postmenopausal women: The Women's Health Initiative Observational Study.

BBA clinical

Mackey RH, McTigue KM, Chang YF, Barinas-Mitchell E, Evans RW, Tinker LF, Lewis CE, Manson JE, Stefanick ML, Howard BV, Phillips LS, Liu S, Kulick D, Kuller LH.
PMID: 25825692
BBA Clin. 2015 Jun;3:243-250. doi: 10.1016/j.bbacli.2015.03.005.

BACKGROUND: We hypothesized that higher concentrations of LDL particles (LDL-P) and leptin, and lower concentrations of HDL particles (HDL-P), and total and high molecular weight (HMW) adiponectin, would predict incident coronary heart disease (CHD) among severely obese postmenopausal women.METHODS:...

Physical activity, well-being, and priorities of older women during the COVID-19 pandemic: a survey of Women's Health Initiative Strong and Healthy (WHISH) intervention participants.

Translational behavioral medicine

Wegner L, Mendoza-Vasconez AS, Mackey S, McGuire V, To C, White B, King AC, Stefanick ML.
PMID: 34633465
Transl Behav Med. 2021 Dec 14;11(12):2155-2163. doi: 10.1093/tbm/ibab122.

Sheltering-in-place, social distancing, and other strategies to minimize COVID-19 transmission may impact physical activity (PA) and well-being in older adults. To assess self-reported PA changes, well-being, and priorities of older women across the USA early in the COVID-19 pandemic....

PM.

Neurology

Younan D, Wang X, Casanova R, Barnard R, Gaussoin SA, Saldana S, Petkus AJ, Beavers DP, Resnick SM, Manson JE, Serre ML, Vizuete W, Henderson VW, Sachs BC, Salinas JA, Gatz M, Espeland MA, Chui HC, Shumaker SA, Rapp SR, Chen JC.
PMID: 33208540
Neurology. 2020 Nov 18; doi: 10.1212/WNL.0000000000011149. Epub 2020 Nov 18.

OBJECTIVE: To examine whether late-life exposure to PMMETHODS: AD pattern similarity (AD-PS) scores, developed by supervised machine learning and validated with MRI data from the AD Neuroimaging Initiative, was used to capture high-dimensional gray matter atrophy in brain areas...

Genetic Signatures of Glucose Homeostasis: Synergistic Interplay With Long-Term Exposure to Cigarette Smoking in Development of Primary Colorectal Cancer Among African American Women.

Clinical and translational gastroenterology

Jung SY.
PMID: 34608882
Clin Transl Gastroenterol. 2021 Oct 05;12(10):e00412. doi: 10.14309/ctg.0000000000000412.

INTRODUCTION: Insulin resistance (IR)/glucose intolerance is a critical biologic mechanism for the development of colorectal cancer (CRC) in postmenopausal women. Whereas IR and excessive adiposity are more prevalent in African American (AA) women than in White women, AA women...

DXA Versus Clinical Measures of Adiposity as Predictors of Cardiometabolic Diseases and All-Cause Mortality in Postmenopausal Women.

Mayo Clinic proceedings

Laddu DR, Qin F, Hedlin H, Stefanick ML, Manson JE, Zaslavsky O, Eaton C, Martin LW, Rohan T, Assimes TL.
PMID: 34479738
Mayo Clin Proc. 2021 Nov;96(11):2831-2842. doi: 10.1016/j.mayocp.2021.04.027. Epub 2021 Aug 31.

OBJECTIVE: To investigate whether dual-energy x-ray absorptiometry (DXA) estimates of adiposity improve risk prediction for cardiometabolic diseases over traditional surrogates, body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) in older women.PATIENTS AND METHODS: We analyzed up...

Genome-wide homozygosity and risk of four non-Hodgkin lymphoma subtypes.

Journal of translational genetics and genomics

Moore A, Machiela MJ, Machado M, Wang SS, Kane E, Slager SL, Zhou W, Carrington M, Lan Q, Milne RL, Birmann BM, Adami HO, Albanes D, Arslan AA, Becker N, Benavente Y, Bisanzi S, Boffetta P, Bracci PM, Brennan P, Brooks-Wilson AR, Canzian F, Caporaso N, Clavel J, Cocco P, Conde L, Cox DG, Cozen W, Curtin K, De Vivo I, de Sanjose S, Foretova L, Gapstur SM, Ghesquières H, Giles GG, Glenn M, Glimelius B, Gao C, Habermann TM, Hjalgrim H, Jackson RD, Liebow M, Link BK, Maynadie M, McKay J, Melbye M, Miligi L, Molina TJ, Monnereau A, Nieters A, North KE, Offit K, Patel AV, Piro S, Ravichandran V, Riboli E, Salles G, Severson RK, Skibola CF, Smedby KE, Southey MC, Spinelli JJ, Staines A, Stewart C, Teras LR, Tinker LF, Travis RC, Vajdic CM, Vermeulen RCH, Vijai J, Weiderpass E, Weinstein S, Doo NW, Zhang Y, Zheng T, Chanock SJ, Rothman N, Cerhan JR, Dean M, Camp NJ, Yeager M, Berndt SI.
PMID: 34622145
J Transl Genet Genom. 2021;5:200-217. doi: 10.20517/jtgg.2021.08. Epub 2021 Jun 17.

AIM: Recessive genetic variation is thought to play a role in non-Hodgkin lymphoma (NHL) etiology. Runs of homozygosity (ROH), defined based on long, continuous segments of homozygous SNPs, can be used to estimate both measured and unmeasured recessive genetic...

Longitudinal physical performance and blood pressure changes in older women: Findings form the women's health initiative.

Archives of gerontology and geriatrics

Laddu DR, LaMonte MJ, Haring B, Kim H, Cawthon P, Bea JW, Banack H, Cauley JA, Allison MA, Martin LW, LeBoff MS, Stefanick ML, Phillips SA, Ma J.
PMID: 34826770
Arch Gerontol Geriatr. 2022 Jan-Feb;98:104576. doi: 10.1016/j.archger.2021.104576. Epub 2021 Nov 16.

BACKGROUND: This study evaluated the association between changes in physical performance and blood pressure (BP) (e.g., systolic [SBP], diastolic [DBP], pulse pressure) in older women.METHODS: 5627 women (mean age 69.8 ± 3.7 y) with grip strength, chair stand, gait...

Showing 1 to 12 of 29 entries