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Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Wang X, Su YR, Petersen PS, Bien S, Schmit SL, Drew DA, Albanes D, Berndt SI, Brenner H, Campbell PT, Casey G, Chang-Claude J, Gallinger SJ, Gruber SB, Haile RW, Harrison TA, Hoffmeister M, Jacobs EJ, Jenkins MA, Joshi AD, Li L, Lin Y, Lindor NM, Marchand LL, Martin V, Milne R, Maclnnis R, Moreno V, Nan H, Newcomb PA, Potter JD, Rennert G, Rennert H, Slattery ML, Thibodeau SN, Weinstein SJ, Woods MO, Chan AT, White E, Hsu L, Peters U.
PMID: 32651213
Cancer Epidemiol Biomarkers Prev. 2020 Sep;29(9):1800-1808. doi: 10.1158/1055-9965.EPI-19-1018. Epub 2020 Jul 10.

BACKGROUND: Regular use of nonsteroidal anti-inflammatory drugs (NSAID) is associated with lower risk of colorectal cancer. Genome-wide interaction analysis on single variants (G × E) has identified several SNPs that may interact with NSAIDs to confer colorectal cancer risk,...

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Wang X, Su YR, Petersen PS, et al. Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2020;29(9):1800-1808doi: 10.1158/1055-9965.EPI-19-1018.
Wang, X., Su, Y. R., Petersen, P. S., Bien, S., Schmit, S. L., Drew, D. A., Albanes, D., Berndt, S. I., Brenner, H., Campbell, P. T., Casey, G., Chang-Claude, J., Gallinger, S. J., Gruber, S. B., Haile, R. W., Harrison, T. A., Hoffmeister, M., Jacobs, E. J., Jenkins, M. A., Joshi, A. D., Li, L., Lin, Y., Lindor, N. M., Marchand, L. L., Martin, V., Milne, R., Maclnnis, R., Moreno, V., Nan, H., Newcomb, P. A., Potter, J. D., Rennert, G., Rennert, H., Slattery, M. L., Thibodeau, S. N., Weinstein, S. J., Woods, M. O., Chan, A. T., White, E., Hsu, L., & Peters, U. (2020). Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 29(9), 1800-1808. https://doi.org/10.1158/1055-9965.EPI-19-1018
Wang, Xiaoliang, et al. "Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. 29,9 (2020): 1800-1808. doi: https://doi.org/10.1158/1055-9965.EPI-19-1018
Wang X, Su YR, Petersen PS, Bien S, Schmit SL, Drew DA, Albanes D, Berndt SI, Brenner H, Campbell PT, Casey G, Chang-Claude J, Gallinger SJ, Gruber SB, Haile RW, Harrison TA, Hoffmeister M, Jacobs EJ, Jenkins MA, Joshi AD, Li L, Lin Y, Lindor NM, Marchand LL, Martin V, Milne R, Maclnnis R, Moreno V, Nan H, Newcomb PA, Potter JD, Rennert G, Rennert H, Slattery ML, Thibodeau SN, Weinstein SJ, Woods MO, Chan AT, White E, Hsu L, Peters U. Exploratory Genome-Wide Interaction Analysis of Nonsteroidal Anti-inflammatory Drugs and Predicted Gene Expression on Colorectal Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2020 Sep;29(9):1800-1808. doi: 10.1158/1055-9965.EPI-19-1018. Epub 2020 Jul 10. PMID: 32651213; PMCID: PMC7556991.
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Genetic architectures of proximal and distal colorectal cancer are partly distinct.

Gut

Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA, Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U.
PMID: 33632709
Gut. 2021 Jul;70(7):1325-1334. doi: 10.1136/gutjnl-2020-321534. Epub 2021 Feb 25.

OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics...

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Huyghe JR, Harrison TA, Bien SA, et al. Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut. 2021;70(7):1325-1334doi: 10.1136/gutjnl-2020-321534.
Huyghe, J. R., Harrison, T. A., Bien, S. A., Hampel, H., Figueiredo, J. C., Schmit, S. L., Conti, D. V., Chen, S., Qu, C., Lin, Y., Barfield, R., Baron, J. A., Cross, A. J., Diergaarde, B., Duggan, D., Harlid, S., Imaz, L., Kang, H. M., Levine, D. M., Perduca, V., Perez-Cornago, A., Sakoda, L. C., Schumacher, F. R., Slattery, M. L., Toland, A. E., van Duijnhoven, F. J. B., Van Guelpen, B., Agudo, A., Albanes, D., Alonso, M. H., Anderson, K., Arnau-Collell, C., Arndt, V., Banbury, B. L., Bassik, M. C., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Caan, B. J., Campbell, P. T., Carr, P. R., Castells, A., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Curtis, K. R., de la Chapelle, A., Easton, D. F., English, D. R., Feskens, E. J. M., Gala, M., Gallinger, S. J., Gauderman, W. J., Giles, G. G., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hoffmeister, M., Hopper, J. L., Hsu, W. L., Huang, W. Y., Hudson, T. J., Jenab, M., Jenkins, M. A., Joshi, A. D., Keku, T. O., Kooperberg, C., Kühn, T., Küry, S., Le Marchand, L., Lejbkowicz, F., Li, C. I., Li, L., Lieb, W., Lindblom, A., Lindor, N. M., Männistö, S., Markowitz, S. D., Milne, R. L., Moreno, L., Murphy, N., Nassir, R., Offit, K., Ogino, S., Panico, S., Parfrey, P. S., Pearlman, R., Pharoah, P. D. P., Phipps, A. I., Platz, E. A., Potter, J. D., Prentice, R. L., Qi, L., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Schafmayer, C., Schoen, R. E., Seminara, D., Song, M., Su, Y. R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Trichopoulou, A., Ulrich, C. M., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Wolk, A., Woods, M. O., Wu, A. H., Abecasis, G. R., Nickerson, D. A., Scacheri, P. C., Kundaje, A., Casey, G., Gruber, S. B., Hsu, L., Moreno, V., Hayes, R. B., Newcomb, P. A., & Peters, U. (2021). Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut, 70(7), 1325-1334. https://doi.org/10.1136/gutjnl-2020-321534
Huyghe, Jeroen R, et al. "Genetic architectures of proximal and distal colorectal cancer are partly distinct." Gut vol. 70,7 (2021): 1325-1334. doi: https://doi.org/10.1136/gutjnl-2020-321534
Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA, Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U. Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut. 2021 Jul;70(7):1325-1334. doi: 10.1136/gutjnl-2020-321534. Epub 2021 Feb 25. PMID: 33632709; PMCID: PMC8223655.
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The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation.

Frontiers in genetics

Indencleef K, Hoskens H, Lee MK, White JD, Liu C, Eller RJ, Naqvi S, Wehby GL, Moreno Uribe LM, Hecht JT, Long RE, Christensen K, Deleyiannis FW, Walsh S, Shriver MD, Richmond S, Wysocka J, Peeters H, Shaffer JR, Marazita ML, Hens G, Weinberg SM, Claes P.
PMID: 33692830
Front Genet. 2021 Feb 22;12:626403. doi: 10.3389/fgene.2021.626403. eCollection 2021.

Unaffected relatives of individuals with non-syndromic cleft lip with or without cleft palate (NSCL/P) show distinctive facial features. The presence of this facial endophenotype is potentially an expression of underlying genetic susceptibility to NSCL/P in the larger unselected population....

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Indencleef K, Hoskens H, Lee MK, et al. The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation. Front Genet. 2021;12:626403doi: 10.3389/fgene.2021.626403.
Indencleef, K., Hoskens, H., Lee, M. K., White, J. D., Liu, C., Eller, R. J., Naqvi, S., Wehby, G. L., Moreno Uribe, L. M., Hecht, J. T., Long, R. E., Christensen, K., Deleyiannis, F. W., Walsh, S., Shriver, M. D., Richmond, S., Wysocka, J., Peeters, H., Shaffer, J. R., Marazita, M. L., Hens, G., Weinberg, S. M., & Claes, P. (2021). The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation. Frontiers in genetics, 12626403. https://doi.org/10.3389/fgene.2021.626403
Indencleef, Karlijne, et al. "The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation." Frontiers in genetics vol. 12 (2021): 626403. doi: https://doi.org/10.3389/fgene.2021.626403
Indencleef K, Hoskens H, Lee MK, White JD, Liu C, Eller RJ, Naqvi S, Wehby GL, Moreno Uribe LM, Hecht JT, Long RE, Christensen K, Deleyiannis FW, Walsh S, Shriver MD, Richmond S, Wysocka J, Peeters H, Shaffer JR, Marazita ML, Hens G, Weinberg SM, Claes P. The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation. Front Genet. 2021 Feb 22;12:626403. doi: 10.3389/fgene.2021.626403. eCollection 2021. PMID: 33692830; PMCID: PMC7937973.
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Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer.

Oncotarget

Loveday C, Litchfield K, Levy M, Holroyd A, Broderick P, Kote-Jarai Z, Dunning AM, Muir K, Peto J, Eeles R, Easton DF, Dudakia D, Orr N, Pashayan N, Reid A, Huddart RA, Houlston RS, Turnbull C.
PMID: 29560096
Oncotarget. 2017 Dec 07;9(16):12630-12638. doi: 10.18632/oncotarget.23117. eCollection 2018 Feb 27.

Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number of loci influencing TGCT risk....

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Loveday C, Litchfield K, Levy M, et al. Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. Oncotarget. 2017;9(16):12630-12638doi: 10.18632/oncotarget.23117.
Loveday, C., Litchfield, K., Levy, M., Holroyd, A., Broderick, P., Kote-Jarai, Z., Dunning, A. M., Muir, K., Peto, J., Eeles, R., Easton, D. F., Dudakia, D., Orr, N., Pashayan, N., Reid, A., Huddart, R. A., Houlston, R. S., & Turnbull, C. (2018). Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. Oncotarget, 9(16), 12630-12638. https://doi.org/10.18632/oncotarget.23117
Loveday, Chey, et al. "Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer." Oncotarget vol. 9,16 (2018): 12630-12638. doi: https://doi.org/10.18632/oncotarget.23117
Loveday C, Litchfield K, Levy M, Holroyd A, Broderick P, Kote-Jarai Z, Dunning AM, Muir K, Peto J, Eeles R, Easton DF, Dudakia D, Orr N, Pashayan N, Reid A, Huddart RA, Houlston RS, Turnbull C. Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. Oncotarget. 2017 Dec 07;9(16):12630-12638. doi: 10.18632/oncotarget.23117. eCollection 2018 Feb 27. PMID: 29560096; PMCID: PMC5849160.
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Association of germline variation with the survival of women with .

NPJ breast cancer

Muranen TA, Khan S, Fagerholm R, Aittomäki K, Cunningham JM, Dennis J, Leslie G, McGuffog L, Parsons MT, Simard J, Slager S, Soucy P, Easton DF, Tischkowitz M, Spurdle AB, Schmutzler RK, Wappenschmidt B, Hahnen E, Hooning MJ, Singer CF, Wagner G, Thomassen M, Pedersen IS, Domchek SM, Nathanson KL, Lazaro C, Rossing CM, Andrulis IL, Teixeira MR, James P, Garber J, Weitzel JN, Jakubowska A, Yannoukakos D, John EM, Southey MC, Schmidt MK, Antoniou AC, Chenevix-Trench G, Blomqvist C, Nevanlinna H.
PMID: 32964118
NPJ Breast Cancer. 2020 Sep 10;6:44. doi: 10.1038/s41523-020-00185-6. eCollection 2020.

Germline genetic variation has been suggested to influence the survival of breast cancer patients independently of tumor pathology. We have studied survival associations of genetic variants in two etiologically unique groups of breast cancer patients, the carriers of germline...

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Muranen TA, Khan S, Fagerholm R, et al. Association of germline variation with the survival of women with . NPJ Breast Cancer. 2020;6:44doi: 10.1038/s41523-020-00185-6.
Muranen, T. A., Khan, S., Fagerholm, R., Aittomäki, K., Cunningham, J. M., Dennis, J., Leslie, G., McGuffog, L., Parsons, M. T., Simard, J., Slager, S., Soucy, P., Easton, D. F., Tischkowitz, M., Spurdle, A. B., Schmutzler, R. K., Wappenschmidt, B., Hahnen, E., Hooning, M. J., Singer, C. F., Wagner, G., Thomassen, M., Pedersen, I. S., Domchek, S. M., Nathanson, K. L., Lazaro, C., Rossing, C. M., Andrulis, I. L., Teixeira, M. R., James, P., Garber, J., Weitzel, J. N., Jakubowska, A., Yannoukakos, D., John, E. M., Southey, M. C., Schmidt, M. K., Antoniou, A. C., Chenevix-Trench, G., Blomqvist, C., & Nevanlinna, H. (2020). Association of germline variation with the survival of women with . NPJ breast cancer, 644. https://doi.org/10.1038/s41523-020-00185-6
Muranen, Taru A, et al. "Association of germline variation with the survival of women with ." NPJ breast cancer vol. 6 (2020): 44. doi: https://doi.org/10.1038/s41523-020-00185-6
Muranen TA, Khan S, Fagerholm R, Aittomäki K, Cunningham JM, Dennis J, Leslie G, McGuffog L, Parsons MT, Simard J, Slager S, Soucy P, Easton DF, Tischkowitz M, Spurdle AB, Schmutzler RK, Wappenschmidt B, Hahnen E, Hooning MJ, Singer CF, Wagner G, Thomassen M, Pedersen IS, Domchek SM, Nathanson KL, Lazaro C, Rossing CM, Andrulis IL, Teixeira MR, James P, Garber J, Weitzel JN, Jakubowska A, Yannoukakos D, John EM, Southey MC, Schmidt MK, Antoniou AC, Chenevix-Trench G, Blomqvist C, Nevanlinna H. Association of germline variation with the survival of women with . NPJ Breast Cancer. 2020 Sep 10;6:44. doi: 10.1038/s41523-020-00185-6. eCollection 2020. PMID: 32964118; PMCID: PMC7483417.
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The PAX1 locus at 20p11 is a potential genetic modifier for bilateral cleft lip.

HGG advances

Curtis SW, Chang D, Lee MK, Shaffer JR, Indencleef K, Epstein MP, Cutler DJ, Murray JC, Feingold E, Beaty TH, Claes P, Weinberg SM, Marazita ML, Carlson JC, Leslie EJ.
PMID: 33817668
HGG Adv. 2021 Apr 08;2(2). doi: 10.1016/j.xhgg.2021.100025.

Nonsyndromic orofacial clefts (OFCs) are a common birth defect and are phenotypically heterogenous in the structure affected by the cleft - cleft lip (CL) and cleft lip and palate (CLP) - as well as other features, such as the...

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Curtis SW, Chang D, Lee MK, et al. The PAX1 locus at 20p11 is a potential genetic modifier for bilateral cleft lip. HGG Adv. 2021;2(2)doi: 10.1016/j.xhgg.2021.100025.
Curtis, S. W., Chang, D., Lee, M. K., Shaffer, J. R., Indencleef, K., Epstein, M. P., Cutler, D. J., Murray, J. C., Feingold, E., Beaty, T. H., Claes, P., Weinberg, S. M., Marazita, M. L., Carlson, J. C., & Leslie, E. J. (2021). The PAX1 locus at 20p11 is a potential genetic modifier for bilateral cleft lip. HGG advances, 2(2), . https://doi.org/10.1016/j.xhgg.2021.100025
Curtis, Sarah W, et al. "The PAX1 locus at 20p11 is a potential genetic modifier for bilateral cleft lip." HGG advances vol. 2,2 (2021). doi: https://doi.org/10.1016/j.xhgg.2021.100025
Curtis SW, Chang D, Lee MK, Shaffer JR, Indencleef K, Epstein MP, Cutler DJ, Murray JC, Feingold E, Beaty TH, Claes P, Weinberg SM, Marazita ML, Carlson JC, Leslie EJ. The PAX1 locus at 20p11 is a potential genetic modifier for bilateral cleft lip. HGG Adv. 2021 Apr 08;2(2). doi: 10.1016/j.xhgg.2021.100025. PMID: 33817668; PMCID: PMC8018676.
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A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk.

International journal of cancer

Liu D, Zhu J, Zhou D, Nikas EG, Mitanis NT, Sun Y, Wu C, Mancuso N, Cox NJ, Wang L, Freedland SJ, Haiman CA, Gamazon ER, Nikas JB, Wu L.
PMID: 34520569
Int J Cancer. 2022 Jan 01;150(1):80-90. doi: 10.1002/ijc.33808. Epub 2021 Sep 25.

A large proportion of heritability for prostate cancer risk remains unknown. Transcriptome-wide association study combined with validation comparing overall levels will help to identify candidate genes potentially playing a role in prostate cancer development. Using data from the Genotype-Tissue...

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Liu D, Zhu J, Zhou D, et al. A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk. Int J Cancer. 2021;150(1):80-90doi: 10.1002/ijc.33808.
Liu, D., Zhu, J., Zhou, D., Nikas, E. G., Mitanis, N. T., Sun, Y., Wu, C., Mancuso, N., Cox, N. J., Wang, L., Freedland, S. J., Haiman, C. A., Gamazon, E. R., Nikas, J. B., & Wu, L. (2022). A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk. International journal of cancer, 150(1), 80-90. https://doi.org/10.1002/ijc.33808
Liu, Duo, et al. "A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk." International journal of cancer vol. 150,1 (2022): 80-90. doi: https://doi.org/10.1002/ijc.33808
Liu D, Zhu J, Zhou D, Nikas EG, Mitanis NT, Sun Y, Wu C, Mancuso N, Cox NJ, Wang L, Freedland SJ, Haiman CA, Gamazon ER, Nikas JB, Wu L. A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk. Int J Cancer. 2022 Jan 01;150(1):80-90. doi: 10.1002/ijc.33808. Epub 2021 Sep 25. PMID: 34520569; PMCID: PMC8595764.
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Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5-6.0 Hz polyspike waves.

Molecular genetics & genomic medicine

Wight JE, Nguyen VH, Medina MT, Patterson C, Durón RM, Molina Y, Lin YC, Martínez-Juárez IE, Ochoa A, Jara-Prado A, Tanaka M, Bai D, Aftab S, Bailey JN, Delgado-Escueta AV.
PMID: 27066514
Mol Genet Genomic Med. 2016 Jan 23;4(2):197-210. doi: 10.1002/mgg3.195. eCollection 2016 Mar.

Juvenile myoclonic epilepsy (JME), the most common genetic epilepsy, remains enigmatic because it is considered one disease instead of several diseases. We ascertained three large multigenerational/multiplex JME pedigrees from Honduras with differing JME subsyndromes, including Childhood Absence Epilepsy evolving...

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Wight JE, Nguyen VH, Medina MT, et al. Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5-6.0 Hz polyspike waves. Mol Genet Genomic Med. 2016;4(2):197-210doi: 10.1002/mgg3.195.
Wight, J. E., Nguyen, V. H., Medina, M. T., Patterson, C., Durón, R. M., Molina, Y., Lin, Y. C., Martínez-Juárez, I. E., Ochoa, A., Jara-Prado, A., Tanaka, M., Bai, D., Aftab, S., Bailey, J. N., & Delgado-Escueta, A. V. (2016). Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5-6.0 Hz polyspike waves. Molecular genetics & genomic medicine, 4(2), 197-210. https://doi.org/10.1002/mgg3.195
Wight, Jenny E, et al. "Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5-6.0 Hz polyspike waves." Molecular genetics & genomic medicine vol. 4,2 (2016): 197-210. doi: https://doi.org/10.1002/mgg3.195
Wight JE, Nguyen VH, Medina MT, Patterson C, Durón RM, Molina Y, Lin YC, Martínez-Juárez IE, Ochoa A, Jara-Prado A, Tanaka M, Bai D, Aftab S, Bailey JN, Delgado-Escueta AV. Chromosome loci vary by juvenile myoclonic epilepsy subsyndromes: linkage and haplotype analysis applied to epilepsy and EEG 3.5-6.0 Hz polyspike waves. Mol Genet Genomic Med. 2016 Jan 23;4(2):197-210. doi: 10.1002/mgg3.195. eCollection 2016 Mar. PMID: 27066514; PMCID: PMC4799870.
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Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth.

Pediatric research

Hong X, Surkan PJ, Zhang B, Keiser A, Ji Y, Ji H, Burd I, Bustamante-Helfrich B, Ogunwole SM, Tang WY, Liu L, Pearson C, Cerda S, Zuckerman B, Hao L, Wang X.
PMID: 32726798
Pediatr Res. 2021 May;89(6):1549-1556. doi: 10.1038/s41390-020-1093-1. Epub 2020 Jul 29.

BACKGROUND: Maternal stress is potentially a modifiable risk factor for spontaneous preterm birth (sPTB). However, epidemiologic findings on the maternal stress-sPTB relationship have been inconsistent.METHODS: To investigate whether the maternal stress-sPTB associations may be modified by genetic susceptibility, we...

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Hong X, Surkan PJ, Zhang B, et al. Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth. Pediatr Res. 2020;89(6):1549-1556doi: 10.1038/s41390-020-1093-1.
Hong, X., Surkan, P. J., Zhang, B., Keiser, A., Ji, Y., Ji, H., Burd, I., Bustamante-Helfrich, B., Ogunwole, S. M., Tang, W. Y., Liu, L., Pearson, C., Cerda, S., Zuckerman, B., Hao, L., & Wang, X. (2021). Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth. Pediatric research, 89(6), 1549-1556. https://doi.org/10.1038/s41390-020-1093-1
Hong, Xiumei, et al. "Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth." Pediatric research vol. 89,6 (2021): 1549-1556. doi: https://doi.org/10.1038/s41390-020-1093-1
Hong X, Surkan PJ, Zhang B, Keiser A, Ji Y, Ji H, Burd I, Bustamante-Helfrich B, Ogunwole SM, Tang WY, Liu L, Pearson C, Cerda S, Zuckerman B, Hao L, Wang X. Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth. Pediatr Res. 2021 May;89(6):1549-1556. doi: 10.1038/s41390-020-1093-1. Epub 2020 Jul 29. PMID: 32726798; PMCID: PMC8400921.
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A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

Nounu A, Greenhough A, Heesom KJ, Richmond RC, Zheng J, Weinstein SJ, Albanes D, Baron JA, Hopper JL, Figueiredo JC, Newcomb PA, Lindor NM, Casey G, Platz EA, Le Marchand L, Ulrich CM, Li CI, van Duijnhoven FJB, Gsur A, Campbell PT, Moreno V, Vodicka P, Vodickova L, Brenner H, Chang-Claude J, Hoffmeister M, Sakoda LC, Slattery ML, Schoen RE, Gunter MJ, Castellví-Bel S, Kim HR, Kweon SS, Chan AT, Li L, Zheng W, Bishop DT, Buchanan DD, Giles GG, Gruber SB, Rennert G, Stadler ZK, Harrison TA, Lin Y, Keku TO, Woods MO, Schafmayer C, Van Guelpen B, Gallinger S, Hampel H, Berndt SI, Pharoah PDP, Lindblom A, Wolk A, Wu AH, White E, Peters U, Drew DA, Scherer D, Bermejo JL, Williams AC, Relton CL.
PMID: 33318029
Cancer Epidemiol Biomarkers Prev. 2021 Mar;30(3):564-575. doi: 10.1158/1055-9965.EPI-20-1176. Epub 2020 Dec 14.

BACKGROUND: Evidence for aspirin's chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of action is not well-understood. We combined a proteomic approach with Mendelian randomization (MR) to identify possible new aspirin targets that decrease CRC risk.METHODS:...

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Nounu A, Greenhough A, Heesom KJ, et al. A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2020;30(3):564-575doi: 10.1158/1055-9965.EPI-20-1176.
Nounu, A., Greenhough, A., Heesom, K. J., Richmond, R. C., Zheng, J., Weinstein, S. J., Albanes, D., Baron, J. A., Hopper, J. L., Figueiredo, J. C., Newcomb, P. A., Lindor, N. M., Casey, G., Platz, E. A., Le Marchand, L., Ulrich, C. M., Li, C. I., van Duijnhoven, F. J. B., Gsur, A., Campbell, P. T., Moreno, V., Vodicka, P., Vodickova, L., Brenner, H., Chang-Claude, J., Hoffmeister, M., Sakoda, L. C., Slattery, M. L., Schoen, R. E., Gunter, M. J., Castellví-Bel, S., Kim, H. R., Kweon, S. S., Chan, A. T., Li, L., Zheng, W., Bishop, D. T., Buchanan, D. D., Giles, G. G., Gruber, S. B., Rennert, G., Stadler, Z. K., Harrison, T. A., Lin, Y., Keku, T. O., Woods, M. O., Schafmayer, C., Van Guelpen, B., Gallinger, S., Hampel, H., Berndt, S. I., Pharoah, P. D. P., Lindblom, A., Wolk, A., Wu, A. H., White, E., Peters, U., Drew, D. A., Scherer, D., Bermejo, J. L., Williams, A. C., & Relton, C. L. (2021). A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 30(3), 564-575. https://doi.org/10.1158/1055-9965.EPI-20-1176
Nounu, Aayah, et al. "A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer." Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology vol. 30,3 (2021): 564-575. doi: https://doi.org/10.1158/1055-9965.EPI-20-1176
Nounu A, Greenhough A, Heesom KJ, Richmond RC, Zheng J, Weinstein SJ, Albanes D, Baron JA, Hopper JL, Figueiredo JC, Newcomb PA, Lindor NM, Casey G, Platz EA, Le Marchand L, Ulrich CM, Li CI, van Duijnhoven FJB, Gsur A, Campbell PT, Moreno V, Vodicka P, Vodickova L, Brenner H, Chang-Claude J, Hoffmeister M, Sakoda LC, Slattery ML, Schoen RE, Gunter MJ, Castellví-Bel S, Kim HR, Kweon SS, Chan AT, Li L, Zheng W, Bishop DT, Buchanan DD, Giles GG, Gruber SB, Rennert G, Stadler ZK, Harrison TA, Lin Y, Keku TO, Woods MO, Schafmayer C, Van Guelpen B, Gallinger S, Hampel H, Berndt SI, Pharoah PDP, Lindblom A, Wolk A, Wu AH, White E, Peters U, Drew DA, Scherer D, Bermejo JL, Williams AC, Relton CL. A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2021 Mar;30(3):564-575. doi: 10.1158/1055-9965.EPI-20-1176. Epub 2020 Dec 14. PMID: 33318029; PMCID: PMC8086774.
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The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites.

Molecular genetics and metabolism reports

O'Reilly J, Pangilinan F, Hokamp K, Ueland PM, Brosnan JT, Brosnan ME, Brody LC, Molloy AM.
PMID: 29988937
Mol Genet Metab Rep. 2018 Jun 11;16:20-22. doi: 10.1016/j.ymgmr.2018.05.006. eCollection 2018 Sep.

The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by...

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O'Reilly J, Pangilinan F, Hokamp K, et al. The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites. Mol Genet Metab Rep. 2018;16:20-22doi: 10.1016/j.ymgmr.2018.05.006.
O'Reilly, J., Pangilinan, F., Hokamp, K., Ueland, P. M., Brosnan, J. T., Brosnan, M. E., Brody, L. C., & Molloy, A. M. (2018). The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites. Molecular genetics and metabolism reports, 1620-22. https://doi.org/10.1016/j.ymgmr.2018.05.006
O'Reilly, Jessica, et al. "The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites." Molecular genetics and metabolism reports vol. 16 (2018): 20-22. doi: https://doi.org/10.1016/j.ymgmr.2018.05.006
O'Reilly J, Pangilinan F, Hokamp K, Ueland PM, Brosnan JT, Brosnan ME, Brody LC, Molloy AM. The impact of common genetic variants in the mitochondrial glycine cleavage system on relevant metabolites. Mol Genet Metab Rep. 2018 Jun 11;16:20-22. doi: 10.1016/j.ymgmr.2018.05.006. eCollection 2018 Sep. PMID: 29988937; PMCID: PMC6034155.
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Genetic architectures of proximal and distal colorectal cancer are partly distinct.

Gut

Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA, Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U.
PMID: 33632709
Gut. 2021 Jul;70(7):1325-1334. doi: 10.1136/gutjnl-2020-321534. Epub 2021 Feb 25.

OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision prevention, including individualized screening recommendations and the discovery of novel drug targets and repurposable drug candidates for chemoprevention. Known differences in molecular characteristics...

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Huyghe JR, Harrison TA, Bien SA, et al. Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut. 2021;70(7):1325-1334doi: 10.1136/gutjnl-2020-321534.
Huyghe, J. R., Harrison, T. A., Bien, S. A., Hampel, H., Figueiredo, J. C., Schmit, S. L., Conti, D. V., Chen, S., Qu, C., Lin, Y., Barfield, R., Baron, J. A., Cross, A. J., Diergaarde, B., Duggan, D., Harlid, S., Imaz, L., Kang, H. M., Levine, D. M., Perduca, V., Perez-Cornago, A., Sakoda, L. C., Schumacher, F. R., Slattery, M. L., Toland, A. E., van Duijnhoven, F. J. B., Van Guelpen, B., Agudo, A., Albanes, D., Alonso, M. H., Anderson, K., Arnau-Collell, C., Arndt, V., Banbury, B. L., Bassik, M. C., Berndt, S. I., Bézieau, S., Bishop, D. T., Boehm, J., Boeing, H., Boutron-Ruault, M. C., Brenner, H., Brezina, S., Buch, S., Buchanan, D. D., Burnett-Hartman, A., Caan, B. J., Campbell, P. T., Carr, P. R., Castells, A., Castellví-Bel, S., Chan, A. T., Chang-Claude, J., Chanock, S. J., Curtis, K. R., de la Chapelle, A., Easton, D. F., English, D. R., Feskens, E. J. M., Gala, M., Gallinger, S. J., Gauderman, W. J., Giles, G. G., Goodman, P. J., Grady, W. M., Grove, J. S., Gsur, A., Gunter, M. J., Haile, R. W., Hampe, J., Hoffmeister, M., Hopper, J. L., Hsu, W. L., Huang, W. Y., Hudson, T. J., Jenab, M., Jenkins, M. A., Joshi, A. D., Keku, T. O., Kooperberg, C., Kühn, T., Küry, S., Le Marchand, L., Lejbkowicz, F., Li, C. I., Li, L., Lieb, W., Lindblom, A., Lindor, N. M., Männistö, S., Markowitz, S. D., Milne, R. L., Moreno, L., Murphy, N., Nassir, R., Offit, K., Ogino, S., Panico, S., Parfrey, P. S., Pearlman, R., Pharoah, P. D. P., Phipps, A. I., Platz, E. A., Potter, J. D., Prentice, R. L., Qi, L., Raskin, L., Rennert, G., Rennert, H. S., Riboli, E., Schafmayer, C., Schoen, R. E., Seminara, D., Song, M., Su, Y. R., Tangen, C. M., Thibodeau, S. N., Thomas, D. C., Trichopoulou, A., Ulrich, C. M., Visvanathan, K., Vodicka, P., Vodickova, L., Vymetalkova, V., Weigl, K., Weinstein, S. J., White, E., Wolk, A., Woods, M. O., Wu, A. H., Abecasis, G. R., Nickerson, D. A., Scacheri, P. C., Kundaje, A., Casey, G., Gruber, S. B., Hsu, L., Moreno, V., Hayes, R. B., Newcomb, P. A., & Peters, U. (2021). Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut, 70(7), 1325-1334. https://doi.org/10.1136/gutjnl-2020-321534
Huyghe, Jeroen R, et al. "Genetic architectures of proximal and distal colorectal cancer are partly distinct." Gut vol. 70,7 (2021): 1325-1334. doi: https://doi.org/10.1136/gutjnl-2020-321534
Huyghe JR, Harrison TA, Bien SA, Hampel H, Figueiredo JC, Schmit SL, Conti DV, Chen S, Qu C, Lin Y, Barfield R, Baron JA, Cross AJ, Diergaarde B, Duggan D, Harlid S, Imaz L, Kang HM, Levine DM, Perduca V, Perez-Cornago A, Sakoda LC, Schumacher FR, Slattery ML, Toland AE, van Duijnhoven FJB, Van Guelpen B, Agudo A, Albanes D, Alonso MH, Anderson K, Arnau-Collell C, Arndt V, Banbury BL, Bassik MC, Berndt SI, Bézieau S, Bishop DT, Boehm J, Boeing H, Boutron-Ruault MC, Brenner H, Brezina S, Buch S, Buchanan DD, Burnett-Hartman A, Caan BJ, Campbell PT, Carr PR, Castells A, Castellví-Bel S, Chan AT, Chang-Claude J, Chanock SJ, Curtis KR, de la Chapelle A, Easton DF, English DR, Feskens EJM, Gala M, Gallinger SJ, Gauderman WJ, Giles GG, Goodman PJ, Grady WM, Grove JS, Gsur A, Gunter MJ, Haile RW, Hampe J, Hoffmeister M, Hopper JL, Hsu WL, Huang WY, Hudson TJ, Jenab M, Jenkins MA, Joshi AD, Keku TO, Kooperberg C, Kühn T, Küry S, Le Marchand L, Lejbkowicz F, Li CI, Li L, Lieb W, Lindblom A, Lindor NM, Männistö S, Markowitz SD, Milne RL, Moreno L, Murphy N, Nassir R, Offit K, Ogino S, Panico S, Parfrey PS, Pearlman R, Pharoah PDP, Phipps AI, Platz EA, Potter JD, Prentice RL, Qi L, Raskin L, Rennert G, Rennert HS, Riboli E, Schafmayer C, Schoen RE, Seminara D, Song M, Su YR, Tangen CM, Thibodeau SN, Thomas DC, Trichopoulou A, Ulrich CM, Visvanathan K, Vodicka P, Vodickova L, Vymetalkova V, Weigl K, Weinstein SJ, White E, Wolk A, Woods MO, Wu AH, Abecasis GR, Nickerson DA, Scacheri PC, Kundaje A, Casey G, Gruber SB, Hsu L, Moreno V, Hayes RB, Newcomb PA, Peters U. Genetic architectures of proximal and distal colorectal cancer are partly distinct. Gut. 2021 Jul;70(7):1325-1334. doi: 10.1136/gutjnl-2020-321534. Epub 2021 Feb 25. PMID: 33632709; PMCID: PMC8223655.
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