Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 94 entries
Sorted by: Best Match Show Resources per page
Scientific Contributions of Population-Based Studies to Cardiovascular Epidemiology in the GWAS Era.

Frontiers in cardiovascular medicine

Lieb W, Vasan RS.
PMID: 29930944
Front Cardiovasc Med. 2018 Jun 07;5:57. doi: 10.3389/fcvm.2018.00057. eCollection 2018.

Longitudinal, well phenotyped, population-based cohort studies offer unique research opportunities in the context of genome-wide association studies (GWAS), including GWAS for new-onset (incident) cardiovascular disease (CVD) events, the assessment of gene x lifestyle interactions, and evaluating the incremental predictive...

Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability.

Cardiovascular research

Koay YC, Chen YC, Wali JA, Luk AWS, Li M, Doma H, Reimark R, Zaldivia MTK, Habtom HT, Franks AE, Fusco-Allison G, Yang J, Holmes A, Simpson SJ, Peter K, O'Sullivan JF.
PMID: 32267921
Cardiovasc Res. 2021 Jan 21;117(2):435-449. doi: 10.1093/cvr/cvaa094.

AIMS: The microbiome-derived metabolite trimethylamine-N-oxide (TMAO) has attracted major interest and controversy both as a diagnostic biomarker and therapeutic target in atherothrombosis.METHODS AND RESULTS: Plasma TMAO increased in mice on 'unhealthy' high-choline diets and notably also on 'healthy' high-fibre...

Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk.

JCI insight

Ngo D, Benson MD, Long JZ, Chen ZZ, Wang R, Nath AK, Keyes MJ, Shen D, Sinha S, Kuhn E, Morningstar JE, Shi X, Peterson BD, Chan C, Katz DH, Tahir UA, Farrell LA, Melander O, Mosley JD, Carr SA, Vasan RS, Larson MG, Smith JG, Wang TJ, Yang Q, Gerszten RE.
PMID: 33591955
JCI Insight. 2021 Mar 08;6(5). doi: 10.1172/jci.insight.144392.

Recent advances in proteomic technologies have made high-throughput profiling of low-abundance proteins in large epidemiological cohorts increasingly feasible. We investigated whether aptamer-based proteomic profiling could identify biomarkers associated with future development of type 2 diabetes (T2DM) beyond known risk...

The genetics of circulating BDNF: towards understanding the role of BDNF in brain structure and function in middle and old ages.

Brain communications

Li S, Weinstein G, Zare H, Teumer A, Völker U, Friedrich N, Knol MJ, Satizabal CL, Petyuk VA, Adams HHH, Launer LJ, Bennett DA, De Jager PL, Grabe HJ, Ikram MA, Gudnason V, Yang Q, Seshadri S.
PMID: 33345186
Brain Commun. 2020 Oct 28;2(2):fcaa176. doi: 10.1093/braincomms/fcaa176. eCollection 2020.

Brain-derived neurotrophic factor (BDNF) plays an important role in brain development and function. Substantial amounts of BDNF are present in peripheral blood, and may serve as biomarkers for Alzheimer's disease incidence as well as targets for intervention to reduce...

High-throughput digitization of analog human echocardiography data.

MethodsX

Kwan AC, Salto G, Demosthenes E, Lehman BT, Osypiuk E, Stantchev P, Vasan RS, Cheng S.
PMID: 33665148
MethodsX. 2020 Nov 26;7:101159. doi: 10.1016/j.mex.2020.101159. eCollection 2020.

Echocardiographic imaging has been acquired in historical longitudinal cohorts of cardiovascular disease. Many cohorts were established prior to digital recording of echocardiography, and thus have preserved their archival imaging on Video Home System (VHS) tapes. These tapes require large...

Arteriosclerosis, Atherosclerosis, and Cardiovascular Health: Joint Relations to the Incidence of Cardiovascular Disease.

Hypertension (Dallas, Tex. : 1979)

Vasan RS, Pan S, Larson MG, Mitchell GF, Xanthakis V.
PMID: 34601961
Hypertension. 2021 Nov;78(5):1232-1240. doi: 10.1161/HYPERTENSIONAHA.121.18075. Epub 2021 Oct 04.

[Figure: see text].

Aortic Root Diameter and Arterial Stiffness: Conjoint Relations to the Incidence of Cardiovascular Disease in the Framingham Heart Study.

Hypertension (Dallas, Tex. : 1979)

Vasan RS, Song RJ, Xanthakis V, Mitchell GF.
PMID: 34601969
Hypertension. 2021 Nov;78(5):1278-1286. doi: 10.1161/HYPERTENSIONAHA.121.17702. Epub 2021 Oct 04.

[Figure: see text].

Reply.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Long MT, Naimi TS.
PMID: 31926338
Clin Gastroenterol Hepatol. 2020 Jun;18(7):1651-1652. doi: 10.1016/j.cgh.2020.01.001. Epub 2020 Jan 08.

No abstract available.

Blood cancer discovery

Beauchamp EM, Leventhal M, Bernard E, Hoppe ER, Todisco G, Creignou M, Gallì A, Castellano CA, McConkey M, Tarun A, Wong W, Schenone M, Stanclift C, Tanenbaum B, Malolepsza E, Nilsson B, Bick AG, Weinstock JS, Miller M, Niroula A, Dunford A, Taylor-Weiner A, Wood T, Barbera A, Anand S, Psaty BM, Desai P, Cho MH, Johnson AD, Loos R, MacArthur DG, Lek M, Neuberg DS, Lage K, Carr SA, Hellstrom-Lindberg E, Malcovati L, Papaemmanuil E, Stewart C, Getz G, Bradley RK, Jaiswal S, Ebert BL.
PMID: 34568833
Blood Cancer Discov. 2021 Sep;2(5):500-517. doi: 10.1158/2643-3230.BCD-20-0224. Epub 2021 Jul 14.

Clonal hematopoiesis results from somatic mutations in cancer driver genes in hematopoietic stem cells. We sought to identify novel drivers of clonal expansion using an unbiased analysis of sequencing data from 84,683 persons and identified common mutations in the...

Association between ABO haplotypes and the risk of venous thrombosis: impact on disease risk estimation.

Blood

Goumidi L, Thibord F, Wiggins KL, Li-Gao R, Brown MR, van Hylckama Vlieg A, Souto JC, Soria JM, Ibrahim-Kosta M, Saut N, Daian D, Olaso R, Amouyel P, Debette S, Boland A, Bailly P, Morrison AC, Mook-Kanamori DO, Deleuze JF, Johnson A, de Vries PS, Sabater-Lleal M, Chiaroni J, Smith NL, Rosendaal FR, Chasman DI, Trégouët DA, Morange PE.
PMID: 33512453
Blood. 2021 Apr 29;137(17):2394-2402. doi: 10.1182/blood.2020008997.

Genetic risk score (GRS) analysis is a popular approach to derive individual risk prediction models for complex diseases. In venous thrombosis (VT), such type of analysis shall integrate information at the ABO blood group locus, which is one of...

Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify .

Annals of the rheumatic diseases

Boer CG, Yau MS, Rice SJ, Coutinho de Almeida R, Cheung K, Styrkarsdottir U, Southam L, Broer L, Wilkinson JM, Uitterlinden AG, Zeggini E, Felson D, Loughlin J, Young M, Capellini TD, Meulenbelt I, van Meurs JB.
PMID: 33055079
Ann Rheum Dis. 2020 Oct 14; doi: 10.1136/annrheumdis-2020-217834. Epub 2020 Oct 14.

BACKGROUND: Despite recent advances in the understanding of the genetic architecture of osteoarthritis (OA), only two genetic loci have been identified for OA of the hand, in part explained by the complexity of the different hand joints and heterogeneity...

Epigenetic mutation load is weakly correlated with epigenetic age acceleration.

Aging

Yan Q, Paul KC, Lu AT, Kusters C, Binder AM, Horvath S, Ritz B.
PMID: 32991324
Aging (Albany NY). 2020 Sep 29;12(18):17863-17894. doi: 10.18632/aging.103950. Epub 2020 Sep 29.

DNA methylation (DNAm) age estimators are widely used to study aging-related conditions. It is not yet known whether DNAm age is associated with the accumulation of stochastic epigenetic mutations (SEMs), which reflect dysfunctions of the epigenetic maintenance system. Here,...

Showing 1 to 12 of 94 entries