Advanced Search
Display options
Filter resources
Text Availability
Article type
Publication date
Species
Language
Sex
Age
Showing 1 to 12 of 34 entries
Sorted by: Best Match Show Resources per page
DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function.

Clinical epigenetics

Matías-García PR, Ward-Caviness CK, Raffield LM, Gao X, Zhang Y, Wilson R, Gào X, Nano J, Bostom A, Colicino E, Correa A, Coull B, Eaton C, Hou L, Just AC, Kunze S, Lange L, Lange E, Lin X, Liu S, Nwanaji-Enwerem JC, Reiner A, Shen J, Schöttker B, Vokonas P, Zheng Y, Young B, Schwartz J, Horvath S, Lu A, Whitsel EA, Koenig W, Adamski J, Winkelmann J, Brenner H, Baccarelli AA, Gieger C, Peters A, Franceschini N, Waldenberger M.
PMID: 34078457
Clin Epigenetics. 2021 Jun 02;13(1):121. doi: 10.1186/s13148-021-01082-w.

BACKGROUND: The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiological changes reflected in methylation status. Several studies have linked DNAmAA to morbidity and mortality,...

Associations between everyday discrimination and sleep quality and duration among African-Americans over time in the Jackson Heart Study.

Sleep

Johnson DA, Lewis TT, Guo N, Jackson CL, Sims M, Wilson JG, Diez Roux AV, Williams DR, Redline S.
PMID: 34197610
Sleep. 2021 Dec 10;44(12). doi: 10.1093/sleep/zsab162.

STUDY OBJECTIVES: African-Americans have a high burden of poor sleep, yet, psychosocial determinants (e.g. discrimination) are understudied. We investigated longitudinal associations between everyday discrimination and sleep quality and duration among African-Americans (N = 3404) in the Jackson Heart Study.METHODS:...

Effect of Sickle Cell Trait and .

Clinical journal of the American Society of Nephrology : CJASN

Reiner AP, Raffield LM, Franceschini N, Auer PL, Lange EM, Nickerson DA, Zakai NA, Correa A, Olson N.
PMID: 33268503
Clin J Am Soc Nephrol. 2021 Feb 08;16(2):287-289. doi: 10.2215/CJN.12100720. Epub 2020 Dec 02.

No abstract available.

Polygenic Scores for Height in Admixed Populations.

G3 (Bethesda, Md.)

Bitarello BD, Mathieson I.
PMID: 32878958
G3 (Bethesda). 2020 Nov 05;10(11):4027-4036. doi: 10.1534/g3.120.401658.

Polygenic risk scores (PRS) use the results of genome-wide association studies (GWAS) to predict quantitative phenotypes or disease risk at an individual level, and provide a potential route to the use of genetic data in personalized medical care. However,...

Multiomic Profiling in Black and White Populations Reveals Novel Candidate Pathways in Left Ventricular Hypertrophy and Incident Heart Failure Specific to Black Adults.

Circulation. Genomic and precision medicine

Katz DH, Tahir UA, Ngo D, Benson MD, Gao Y, Shi X, Nayor M, Keyes MJ, Larson MG, Hall ME, Correa A, Sinha S, Shen D, Herzig M, Yang Q, Robbins JM, Chen ZZ, Cruz DE, Peterson B, Vasan RS, Wang TJ, Wilson JG, Gerszten RE.
PMID: 34019435
Circ Genom Precis Med. 2021 Jun;14(3):e003191. doi: 10.1161/CIRCGEN.120.003191. Epub 2021 May 21.

BACKGROUND: Increased left ventricular (LV) mass is associated with adverse cardiovascular events including heart failure (HF). Both increased LV mass and HF disproportionately affect Black individuals. To understand the underlying mechanisms, we undertook a proteomic screen in a Black...

Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer's disease and myocardial infarction.

Human molecular genetics

Palmer ND, Kahali B, Kuppa A, Chen Y, Du X, Feitosa MF, Bielak LF, O'Connell JR, Musani SK, Guo X, Smith AV, Ryan KA, Eirksdottir G, Allison MA, Bowden DW, Budoff MJ, Carr JJ, Chen YI, Taylor KD, Correa A, Crudup BF, Halligan B, Yang J, Kardia SLR, Launer LJ, Fu YP, Mosley TH, Norris JM, Terry JG, O'Donnell CJ, Rotter JI, Wagenknecht LE, Gudnason V, Province MA, Peyser PA, Speliotes EK.
PMID: 33856023
Hum Mol Genet. 2021 Jul 09;30(15):1443-1456. doi: 10.1093/hmg/ddab096.

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the largest multiethnic investigation of...

Maintaining Normal Blood Pressure Across the Life Course: The JHS.

Hypertension (Dallas, Tex. : 1979)

Hardy ST, Sakhuja S, Jaeger BC, Oparil S, Akinyelure OP, Spruill TM, Kalinowski J, Butler M, Anstey DE, Elfassy T, Tajeu GS, Allen NB, Reges O, Sims M, Shimbo D, Muntner P.
PMID: 33745299
Hypertension. 2021 May 05;77(5):1490-1499. doi: 10.1161/HYPERTENSIONAHA.120.16278. Epub 2021 Mar 22.

[Figure: see text].

Plasma adipokines and glycaemic progression among African Americans: Findings from the Jackson Heart Study.

Diabetic medicine : a journal of the British Diabetic Association

Kaze AD, Musani SK, Bidulescu A, Joseph JJ, Correa A, Ndumele CE, Bertoni AG, Ahima RS, Golden SH, Echouffo-Tcheugui JB.
PMID: 33236370
Diabet Med. 2021 May;38(5):e14465. doi: 10.1111/dme.14465. Epub 2020 Dec 25.

AIM: To evaluate the association between plasma biomarkers including leptin, adiponectin, adiponectin-to-leptin ratio and high-sensitivity C-reactive protein (hsCRP) with risk of glycaemic progression and incident dysglycaemia (pre-diabetes or diabetes) in a community-based sample of African American (AAs).METHODS: We analysed...

Perceived home sleep environment: associations of household-level factors and in-bed behaviors with actigraphy-based sleep duration and continuity in the Jackson Heart Sleep Study.

Sleep

Johnson DA, Jackson CL, Guo N, Sofer T, Laden F, Redline S.
PMID: 34283244
Sleep. 2021 Nov 12;44(11). doi: 10.1093/sleep/zsab163.

STUDY OBJECTIVES: In an older African-American sample (n = 231) we tested associations of the household environment and in-bed behaviors with sleep duration, efficiency, and wakefulness after sleep onset (WASO).METHODS: Older adult participants completed a household-level sleep environment questionnaire,...

Stress and Depression Are Associated With Life's Simple 7 Among African Americans With Hypertension: Findings From the Jackson Heart Study.

American journal of hypertension

Langford AT, Butler M, Booth JN, Jin P, Bress AP, Tanner RM, Kalinowski J, Blanc J, Seixas A, Shimbo D, Sims M, Ogedegbe G, Spruill TM.
PMID: 34272853
Am J Hypertens. 2021 Dec 01;34(12):1311-1321. doi: 10.1093/ajh/hpab116.

BACKGROUND: The American Heart Association created the Life's Simple 7 (LS7) metrics to promote cardiovascular health (CVH) by achieving optimal levels of blood pressure, cholesterol, blood sugar, physical activity, diet, weight, and smoking status. The degree to which psychosocial...

Associations between everyday discrimination and sleep quality and duration among African-Americans over time in the Jackson Heart Study.

Sleep

Johnson DA, Lewis TT, Guo N, Jackson CL, Sims M, Wilson JG, Diez Roux AV, Williams DR, Redline S.
PMID: 34197610
Sleep. 2021 Dec 10;44(12). doi: 10.1093/sleep/zsab162.

STUDY OBJECTIVES: African-Americans have a high burden of poor sleep, yet, psychosocial determinants (e.g. discrimination) are understudied. We investigated longitudinal associations between everyday discrimination and sleep quality and duration among African-Americans (N = 3404) in the Jackson Heart Study.METHODS:...

Electrocardiogram machine learning for detection of cardiovascular disease in African Americans: the Jackson Heart Study.

European heart journal. Digital health

Pollard JD, Haq KT, Lutz KJ, Rogovoy NM, Paternostro KA, Soliman EZ, Maher J, Lima JAC, Musani SK, Tereshchenko LG.
PMID: 34048510
Eur Heart J Digit Health. 2021 Jan 20;2(1):137-151. doi: 10.1093/ehjdh/ztab003. eCollection 2021 Mar.

AIMS: Almost half of African American (AA) men and women have cardiovascular disease (CVD). Detection of prevalent CVD in community settings would facilitate secondary prevention of CVD. We sought to develop a tool for automated CVD detection.METHODS AND RESULTS:...

Showing 1 to 12 of 34 entries