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Showing 1 to 6 of 6 entries
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Antinociceptive effects of topical mepivacaine in a rat model of HIV-associated peripheral neuropathic pain.

Journal of pain research

Sagen J, Castellanos DA, Hama AT.
PMID: 27350758
J Pain Res. 2016 Jun 06;9:361-71. doi: 10.2147/JPR.S104397. eCollection 2016.

BACKGROUND: A consequence of HIV infection is sensory neuropathy, a debilitating condition that degrades the quality of life of HIV patients. Furthermore, life-extending antiretroviral treatment may exacerbate HIV sensory neuropathy. Analgesics that relieve other neuropathic pains show little or...

Reversal of Cognitive Impairment in gp120 Transgenic Mice by the Removal of the p75 Neurotrophin Receptor.

Frontiers in cellular neuroscience

Speidell A, Asuni GP, Avdoshina V, Scognamiglio S, Forcelli P, Mocchetti I.
PMID: 31543761
Front Cell Neurosci. 2019 Aug 30;13:398. doi: 10.3389/fncel.2019.00398. eCollection 2019.

Activation of the p75 neurotrophin receptor (p75NTR), by the proneurotrophin brain-derived neurotrophic factor (proBDNF), triggers loss of synapses and promotes neuronal death. These pathological features are also caused by the human immunodeficiency virus-1 (HIV) envelope protein gp120, which increases...

7-Chlorokynurenate Ameliorates Neuronal Injury Mediated by HIV Envelope Protein gp120 in Rodent Retinal Cultures.

The European journal of neuroscience

Lipton SA.
PMID: 12106405
Eur J Neurosci. 1992;4(12):1411-1415. doi: 10.1111/j.1460-9568.1992.tb00167.x.

Prior studies with in vitro model systems have suggested that at least part of the neurological manifestations of AIDS may stem from neuronal injury involving the HIV-1 coat protein gp120. This form of neuronal damage is most probably mediated...

The α7-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response.

Clinical & translational immunology

Delgado-Vélez M, Báez-Pagán CA, Gerena Y, Quesada O, Santiago-Pérez LI, Capó-Vélez CM, Wojna V, Meléndez L, León-Rivera R, Silva W, Lasalde-Dominicci JA.
PMID: 26719799
Clin Transl Immunology. 2015 Dec 11;4(12):e53. doi: 10.1038/cti.2015.31. eCollection 2015 Dec.

Antiretroviral therapy partially restores the immune system and markedly increases life expectancy of HIV-infected patients. However, antiretroviral therapy does not restore full health. These patients suffer from poorly understood chronic inflammation that causes a number of AIDS and non-AIDS...

Co-receptor signaling in the pathogenesis of neuroHIV.

Retrovirology

Nickoloff-Bybel EA, Festa L, Meucci O, Gaskill PJ.
PMID: 34429135
Retrovirology. 2021 Aug 24;18(1):24. doi: 10.1186/s12977-021-00569-x.

The HIV co-receptors, CCR5 and CXCR4, are necessary for HIV entry into target cells, interacting with the HIV envelope protein, gp120, to initiate several signaling cascades thought to be important to the entry process. Co-receptor signaling may also promote...

Automated detection of conformational epitopes using phage display Peptide sequences.

Bioinformatics and biology insights

Negi SS, Braun W.
PMID: 20140073
Bioinform Biol Insights. 2009 Jul 01;3:71-81. doi: 10.4137/bbi.s2745.

BACKGROUND: Precise determination of conformational epitopes of neutralizing antibodies represents a key step in the rational design of novel vaccines. A powerful experimental method to gain insights on the physical chemical nature of conformational epitopes is the selection of...

Showing 1 to 6 of 6 entries