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Showing 1 to 12 of 784 entries
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Data of intracellular insulin protein reduced by autophagy in INS-1E cells.

Data in brief

Kim HS, Yoo YM.
PMID: 27536716
Data Brief. 2016 Jul 14;8:1151-6. doi: 10.1016/j.dib.2016.07.008. eCollection 2016 Sep.

Autophagy appears to be involved in maintaining normal intracellular insulin content by accelerating the insulin degradation rate in β-cells (Marsh et al., 2007) [1]. 2-deoxy-d-glucose (2-DG) is metabolized by hexokinase, and acts as an inhibitor of glycolysis. 2-DG triggers...

Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion.

Oncotarget

Pavo N, Lukovic D, Zlabinger K, Lorant D, Goliasch G, Winkler J, Pils D, Auer K, Ankersmit HJ, Giricz Z, Sárközy M, Jakab A, Garamvölgyi R, Emmert MY, Hoerstrup SP, Hausenloy DJ, Ferdinandy P, Maurer G, Gyöngyösi M.
PMID: 28978029
Oncotarget. 2017 Jun 12;8(40):67227-67240. doi: 10.18632/oncotarget.18438. eCollection 2017 Sep 15.

We have previously shown that distal anterior wall ischemia/reperfusion induces gene expression changes in the proximal anterior myocardial area, involving genes responsible for cardiac remodeling. Here we investigated the molecular signals of the ischemia non-affected remote lateral and posterior...

Retraction: Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria.

Journal of cell science

Shulga N, Wilson-Smith R, Pastorino JG.
PMID: 27369360
J Cell Sci. 2016 Jul 01;129(13):2684. doi: 10.1242/jcs.193631.

No abstract available.

Present status of clinical deployment of glucokinase activators.

Journal of diabetes investigation

Nakamura A, Terauchi Y.
PMID: 25802718
J Diabetes Investig. 2015 Mar;6(2):124-32. doi: 10.1111/jdi.12294. Epub 2014 Nov 10.

Glucokinase is one of four members of the hexokinase family of enzymes. Its expression is limited to the major organs (such as the pancreas, liver, brain and the gastrointestinal tract) that are thought to have an integrated role in...

Insulin signaling in skeletal muscle of HIV-infected patients in response to endurance and strength training.

Physiological reports

Broholm C, Mathur N, Hvid T, Grøndahl TS, Frøsig C, Pedersen BK, Lindegaard B.
PMID: 24303139
Physiol Rep. 2013 Aug;1(3):e00060. doi: 10.1002/phy2.60. Epub 2013 Aug 22.

Human immunodeficiency virus (HIV)-infected patients with lipodystrophy have decreased insulin-stimulated glucose uptake. Both endurance and resistance training improve insulin-stimulated glucose uptake in skeletal muscle of HIV-infected patients, but the mechanisms are unknown. This study aims to identify the molecular...

Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.

Genes & cancer

Zhang Q, Zhang Y, Zhang P, Chao Z, Xia F, Jiang C, Zhang X, Jiang Z, Liu H.
PMID: 25053988
Genes Cancer. 2014 Mar;5(3):100-12. doi: 10.18632/genesandcancer.9.

Hexokinase II (HKII), a key enzyme of glycolysis, is widely over-expressed in cancer cells. 3-bromopyruvate (3-BrPA), an inhibitor of HK II, has been proposed as a specific antitumor agent. Autophagy is a process that regulates the balance between protein...

Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells.

Experimental and therapeutic medicine

Eleftheriadis T, Pissas G, Antoniadi G, Liakopoulos V, Stefanidis I.
PMID: 26640580
Exp Ther Med. 2015 Nov;10(5):1959-1966. doi: 10.3892/etm.2015.2763. Epub 2015 Sep 22.

Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the present study was to evaluate the effects of Krebs'...

Methodological limitations in determining astrocytic gene expression.

Frontiers in endocrinology

Peng L, Guo C, Wang T, Li B, Gu L, Wang Z.
PMID: 24324456
Front Endocrinol (Lausanne). 2013 Nov 25;4:176. doi: 10.3389/fendo.2013.00176.

Traditionally, astrocytic mRNA and protein expression are studied by in situ hybridization (ISH) and immunohistochemically. This led to the concept that astrocytes lack aralar, a component of the malate-aspartate-shuttle. At least similar aralar mRNA and protein expression in astrocytes...

MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia.

Frontiers in cellular neuroscience

Guest PC, Iwata K, Kato TA, Steiner J, Schmitt A, Turck CW, Martins-de-Souza D.
PMID: 26029051
Front Cell Neurosci. 2015 May 12;9:180. doi: 10.3389/fncel.2015.00180. eCollection 2015.

Schizophrenia is a debilitating mental disorder, affecting more than 30 million people worldwide. As a multifactorial disease, the underlying causes of schizophrenia require analysis by multiplex methods such as proteomics to allow identification of whole protein networks. Previous post-mortem...

Expression of Arabidopsis FCS-Like Zinc finger genes is differentially regulated by sugars, cellular energy level, and abiotic stress.

Frontiers in plant science

Jamsheer K M, Laxmi A.
PMID: 26442059
Front Plant Sci. 2015 Sep 24;6:746. doi: 10.3389/fpls.2015.00746. eCollection 2015.

Cellular energy status is an important regulator of plant growth, development, and stress mitigation. Environmental stresses ultimately lead to energy deficit in the cell which activates the SNF1-RELATED KINASE 1 (SnRK1) signaling cascade which eventually triggering a massive reprogramming...

Overexpression of ErbB2 renders breast cancer cells susceptible to 3-BrPA through the increased dissociation of hexokinase II from mitochondrial outer membrane.

Oncology letters

Gao S, Chen X, Jin H, Ren S, Liu Z, Fang X, Zhang G.
PMID: 26893781
Oncol Lett. 2016 Feb;11(2):1567-1573. doi: 10.3892/ol.2015.4043. Epub 2015 Dec 21.

ErbB2 is known to upregulate glycolysis in breast cancer, however, the precise mechanisms remain unclear. In the present study, ErbB2 upregulated Hexokinase II (HK II) activity by increasing the binding of HK II to the mitochondrial outer membrane. Dysregulated...

Comparative and genetic studies of isozymes in resynthesized and cultivated Brassica napus L., B. campestris L. and B. alboglabra Bailey.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

Chen BY, Heneen WK, Simonsen V.
PMID: 24232800
Theor Appl Genet. 1989 May;77(5):673-9. doi: 10.1007/BF00261242.

Enzyme electrophoresis was used to compare newly resynthesized Brassica napus with its actual parental diploid species, B. campestris and B. alboglabra. Comparisons were also made with cultivated B. napus. Of the eight enzyme systems assayed, four were monomorphic (hexokinase,...

Showing 1 to 12 of 784 entries