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Showing 1 to 12 of 13 entries
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Chain gangs: new aspects of hyaluronan metabolism.

Biochemistry research international

Erickson M, Stern R.
PMID: 22216413
Biochem Res Int. 2012;2012:893947. doi: 10.1155/2012/893947. Epub 2011 Dec 18.

Hyaluronan is a matrix polymer prominent in tissues undergoing rapid growth, development, and repair, in embryology and during malignant progression. It reaches 10(7) Daltons in size but also exists in fragmented forms with size-specific actions. It has intracellular forms...

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Erickson M, Stern R. Chain gangs: new aspects of hyaluronan metabolism. Biochem Res Int. 2011;2012:893947doi: 10.1155/2012/893947.
Erickson, M., & Stern, R. (2012). Chain gangs: new aspects of hyaluronan metabolism. Biochemistry research international, 2012893947. https://doi.org/10.1155/2012/893947
Erickson, Michael, and Stern, Robert. "Chain gangs: new aspects of hyaluronan metabolism." Biochemistry research international vol. 2012 (2012): 893947. doi: https://doi.org/10.1155/2012/893947
Erickson M, Stern R. Chain gangs: new aspects of hyaluronan metabolism. Biochem Res Int. 2012;2012:893947. doi: 10.1155/2012/893947. Epub 2011 Dec 18. PMID: 22216413; PMCID: PMC3246691.
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Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins.

Journal of clinical medicine

Hsieh CS, Tsai CT, Chen YH, Chang SN, Hwang JJ, Chuang EY, Wu IH.
PMID: 30544995
J Clin Med. 2018 Dec 11;7(12). doi: 10.3390/jcm7120537.

Lower extremities varicose veins (VV) are among the most easily recognized venous abnormalities. The genetic mechanism of VV is largely unknown. In this study, we sought to explore the global expressional change of VV and identify novel genes that...

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Hsieh CS, Tsai CT, Chen YH, et al. Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins. J Clin Med. 2018;7(12)doi: 10.3390/jcm7120537.
Hsieh, C. S., Tsai, C. T., Chen, Y. H., Chang, S. N., Hwang, J. J., Chuang, E. Y., & Wu, I. H. (2018). Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins. Journal of clinical medicine, 7(12), . https://doi.org/10.3390/jcm7120537
Hsieh, Chia-Shan, et al. "Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins." Journal of clinical medicine vol. 7,12 (2018). doi: https://doi.org/10.3390/jcm7120537
Hsieh CS, Tsai CT, Chen YH, Chang SN, Hwang JJ, Chuang EY, Wu IH. Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins. J Clin Med. 2018 Dec 11;7(12). doi: 10.3390/jcm7120537. PMID: 30544995; PMCID: PMC6306753.
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Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.

World journal of biological chemistry

Triggs-Raine B, Natowicz MR.
PMID: 26322170
World J Biol Chem. 2015 Aug 26;6(3):110-20. doi: 10.4331/wjbc.v6.i3.110.

Hyaluronan is a rapidly turned over component of the vertebrate extracellular matrix. Its levels are determined, in part, by the hyaluronan synthases, HAS1, HAS2, and HAS3, and three hyaluronidases, HYAL1, HYAL2 and HYAL3. Hyaluronan binding proteins also regulate hyaluronan...

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Triggs-Raine B, Natowicz MR. Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism. World J Biol Chem. 2015;6(3):110-20doi: 10.4331/wjbc.v6.i3.110.
Triggs-Raine, B., & Natowicz, M. R. (2015). Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism. World journal of biological chemistry, 6(3), 110-20. https://doi.org/10.4331/wjbc.v6.i3.110
Triggs-Raine, Barbara, and Natowicz, Marvin R. "Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism." World journal of biological chemistry vol. 6,3 (2015): 110-20. doi: https://doi.org/10.4331/wjbc.v6.i3.110
Triggs-Raine B, Natowicz MR. Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism. World J Biol Chem. 2015 Aug 26;6(3):110-20. doi: 10.4331/wjbc.v6.i3.110. PMID: 26322170; PMCID: PMC4549756.
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Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors.

Glycobiology

Tsitrina AA, Krasylov IV, Maltsev DI, Andreichenko IN, Moskvina VS, Ivankov DN, Bulgakova EV, Nesterchuk M, Shashkovskaya V, Dashenkova NO, Khilya VP, Mikaelyan A, Kotelevtsev Y.
PMID: 33978736
Glycobiology. 2021 Sep 09;31(8):959-974. doi: 10.1093/glycob/cwab038.

Elevated plasma levels of hyaluronic acid (HA) is a disease marker in liver pathology and other inflammatory disorders. Inhibition of HA synthesis with coumarin 4-methylumbelliferone (4MU) has a beneficial effect in animal models of fibrosis, inflammation, cancer and metabolic...

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Tsitrina AA, Krasylov IV, Maltsev DI, et al. Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors. Glycobiology. 2021;31(8):959-974doi: 10.1093/glycob/cwab038.
Tsitrina, A. A., Krasylov, I. V., Maltsev, D. I., Andreichenko, I. N., Moskvina, V. S., Ivankov, D. N., Bulgakova, E. V., Nesterchuk, M., Shashkovskaya, V., Dashenkova, N. O., Khilya, V. P., Mikaelyan, A., & Kotelevtsev, Y. (2021). Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors. Glycobiology, 31(8), 959-974. https://doi.org/10.1093/glycob/cwab038
Tsitrina, Alexandra A, et al. "Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors." Glycobiology vol. 31,8 (2021): 959-974. doi: https://doi.org/10.1093/glycob/cwab038
Tsitrina AA, Krasylov IV, Maltsev DI, Andreichenko IN, Moskvina VS, Ivankov DN, Bulgakova EV, Nesterchuk M, Shashkovskaya V, Dashenkova NO, Khilya VP, Mikaelyan A, Kotelevtsev Y. Inhibition of hyaluronan secretion by novel coumarin compounds and chitin synthesis inhibitors. Glycobiology. 2021 Sep 09;31(8):959-974. doi: 10.1093/glycob/cwab038. PMID: 33978736; PMCID: PMC8434796.
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Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles.

International journal of cell biology

Rilla K, Koistinen A.
PMID: 26448759
Int J Cell Biol. 2015;2015:769163. doi: 10.1155/2015/769163. Epub 2015 Sep 10.

Hyaluronan is a linear sugar polymer synthesized by three isoforms of hyaluronan synthases (HAS1, 2, and 3) that forms a hydrated scaffold around cells and is an essential component of the extracellular matrix. The morphological changes of cells induced...

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Rilla K, Koistinen A. Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles. Int J Cell Biol. 2015;2015:769163doi: 10.1155/2015/769163.
Rilla, K., & Koistinen, A. (2015). Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles. International journal of cell biology, 2015769163. https://doi.org/10.1155/2015/769163
Rilla, Kirsi, and Koistinen, Arto. "Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles." International journal of cell biology vol. 2015 (2015): 769163. doi: https://doi.org/10.1155/2015/769163
Rilla K, Koistinen A. Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles. Int J Cell Biol. 2015;2015:769163. doi: 10.1155/2015/769163. Epub 2015 Sep 10. PMID: 26448759; PMCID: PMC4581547.
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Negative regulation between the expression levels of receptor for hyaluronic acid-mediated motility and hyaluronan leads to cell migration in pancreatic cancer.

Oncology letters

Cheng XB, Wang S, Yang H, Tong H, Shi G, Wu L, Zhou J, Shi L, Li H, Ren S, Zhou Y, Sato N.
PMID: 32963605
Oncol Lett. 2020 Nov;20(5):199. doi: 10.3892/ol.2020.12060. Epub 2020 Sep 04.

Receptor for hyaluronic acid (HA)-mediated motility (RHAMM) expression is upregulated in pancreatic ductal adenocarcinoma (PDAC). In the present study, small interfering RNA knockdown was used to investigate the regulatory mechanism and function of RHAMM in PDAC cells. Reverse transcription-quantitative...

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Cheng XB, Wang S, Yang H, et al. Negative regulation between the expression levels of receptor for hyaluronic acid-mediated motility and hyaluronan leads to cell migration in pancreatic cancer. Oncol Lett. 2020;20(5):199doi: 10.3892/ol.2020.12060.
Cheng, X. B., Wang, S., Yang, H., Tong, H., Shi, G., Wu, L., Zhou, J., Shi, L., Li, H., Ren, S., Zhou, Y., & Sato, N. (2020). Negative regulation between the expression levels of receptor for hyaluronic acid-mediated motility and hyaluronan leads to cell migration in pancreatic cancer. Oncology letters, 20(5), 199. https://doi.org/10.3892/ol.2020.12060
Cheng, Xiao-Bo, et al. "Negative regulation between the expression levels of receptor for hyaluronic acid-mediated motility and hyaluronan leads to cell migration in pancreatic cancer." Oncology letters vol. 20,5 (2020): 199. doi: https://doi.org/10.3892/ol.2020.12060
Cheng XB, Wang S, Yang H, Tong H, Shi G, Wu L, Zhou J, Shi L, Li H, Ren S, Zhou Y, Sato N. Negative regulation between the expression levels of receptor for hyaluronic acid-mediated motility and hyaluronan leads to cell migration in pancreatic cancer. Oncol Lett. 2020 Nov;20(5):199. doi: 10.3892/ol.2020.12060. Epub 2020 Sep 04. PMID: 32963605; PMCID: PMC7491089.
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The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases.

Cytotechnology

Terazawa S, Nakajima H, Tobita K, Imokawa G.
PMID: 24590928
Cytotechnology. 2015 Aug;67(4):609-20. doi: 10.1007/s10616-014-9707-2. Epub 2014 Mar 04.

Although it has been reported that levels of hyaluronan are decreased in the dermis of aged skin, little is known about the cellular mechanism(s) underlying that hyaluronan deficiency. Since hyaluronan is produced by dermal fibroblasts and is secreted into...

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Terazawa S, Nakajima H, Tobita K, et al. The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases. Cytotechnology. 2014;67(4):609-20doi: 10.1007/s10616-014-9707-2.
Terazawa, S., Nakajima, H., Tobita, K., & Imokawa, G. (2015). The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases. Cytotechnology, 67(4), 609-20. https://doi.org/10.1007/s10616-014-9707-2
Terazawa, Shuko, et al. "The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases." Cytotechnology vol. 67,4 (2015): 609-20. doi: https://doi.org/10.1007/s10616-014-9707-2
Terazawa S, Nakajima H, Tobita K, Imokawa G. The decreased secretion of hyaluronan by older human fibroblasts under physiological conditions is mainly associated with the down-regulated expression of hyaluronan synthases but not with the expression levels of hyaluronidases. Cytotechnology. 2015 Aug;67(4):609-20. doi: 10.1007/s10616-014-9707-2. Epub 2014 Mar 04. PMID: 24590928; PMCID: PMC4474994.
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4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions.

Oncology letters

Cheng XB, Sato N, Kohi S, Koga A, Hirata K.
PMID: 29725394
Oncol Lett. 2018 May;15(5):6297-6301. doi: 10.3892/ol.2018.8147. Epub 2018 Mar 01.

Hyaluronic acid (HA) in tumor stroma promotes tumor invasion and progression. 4-Methylumbelliferone (4-MU) is a potent HA synthesis inhibitor. In the present study, the effects of 4-MU on enhanced HA synthesis and cell migration in pancreatic ductal adenocarcinoma (PDAC)...

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Cheng XB, Sato N, Kohi S, et al. 4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions. Oncol Lett. 2018;15(5):6297-6301doi: 10.3892/ol.2018.8147.
Cheng, X. B., Sato, N., Kohi, S., Koga, A., & Hirata, K. (2018). 4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions. Oncology letters, 15(5), 6297-6301. https://doi.org/10.3892/ol.2018.8147
Cheng, Xiao-Bo, et al. "4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions." Oncology letters vol. 15,5 (2018): 6297-6301. doi: https://doi.org/10.3892/ol.2018.8147
Cheng XB, Sato N, Kohi S, Koga A, Hirata K. 4-Methylumbelliferone inhibits enhanced hyaluronan synthesis and cell migration in pancreatic cancer cells in response to tumor-stromal interactions. Oncol Lett. 2018 May;15(5):6297-6301. doi: 10.3892/ol.2018.8147. Epub 2018 Mar 01. PMID: 29725394; PMCID: PMC5920249.
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Divergent Temporal Expression of Hyaluronan Metabolizing Enzymes and Receptors with Craniotomy vs. Controlled-Cortical Impact Injury in Rat Brain: A Pilot Study.

Frontiers in neurology

Xing G, Ren M, Verma A.
PMID: 25309501
Front Neurol. 2014 Sep 11;5:173. doi: 10.3389/fneur.2014.00173. eCollection 2014.

Traumatic brain injury (TBI) triggers many secondary changes in tissue biology, which ultimately determine the extent of injury and clinical outcome. Hyaluronan [hyaluronic acid (HA)] is a protective cementing gel present in the intercellular spaces whose degradation has been...

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Xing G, Ren M, Verma A. Divergent Temporal Expression of Hyaluronan Metabolizing Enzymes and Receptors with Craniotomy vs. Controlled-Cortical Impact Injury in Rat Brain: A Pilot Study. Front Neurol. 2014;5:173doi: 10.3389/fneur.2014.00173.
Xing, G., Ren, M., & Verma, A. (2014). Divergent Temporal Expression of Hyaluronan Metabolizing Enzymes and Receptors with Craniotomy vs. Controlled-Cortical Impact Injury in Rat Brain: A Pilot Study. Frontiers in neurology, 5173. https://doi.org/10.3389/fneur.2014.00173
Xing, Guoqiang, et al. "Divergent Temporal Expression of Hyaluronan Metabolizing Enzymes and Receptors with Craniotomy vs. Controlled-Cortical Impact Injury in Rat Brain: A Pilot Study." Frontiers in neurology vol. 5 (2014): 173. doi: https://doi.org/10.3389/fneur.2014.00173
Xing G, Ren M, Verma A. Divergent Temporal Expression of Hyaluronan Metabolizing Enzymes and Receptors with Craniotomy vs. Controlled-Cortical Impact Injury in Rat Brain: A Pilot Study. Front Neurol. 2014 Sep 11;5:173. doi: 10.3389/fneur.2014.00173. eCollection 2014. PMID: 25309501; PMCID: PMC4161003.
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Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets.

Matrix biology plus

Gebe JA, Gooden MD, Workman G, Nagy N, Bollyky PL, Wight TN, Vernon RB.
PMID: 33718858
Matrix Biol Plus. 2020 Dec 30;9:100052. doi: 10.1016/j.mbplus.2020.100052. eCollection 2021 Feb.

The extracellular matrix glycosaminoglycan hyaluronan (HA) accumulates in human and mouse islets during the onset of autoimmune type 1 diabetes (T1D). HA plays a critical role in T1D pathogenesis, as spontaneous disease is blocked in mice fed the HA...

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Gebe JA, Gooden MD, Workman G, et al. Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets. Matrix Biol Plus. 2020;9:100052doi: 10.1016/j.mbplus.2020.100052.
Gebe, J. A., Gooden, M. D., Workman, G., Nagy, N., Bollyky, P. L., Wight, T. N., & Vernon, R. B. (2021). Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets. Matrix biology plus, 9100052. https://doi.org/10.1016/j.mbplus.2020.100052
Gebe, John A, et al. "Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets." Matrix biology plus vol. 9 (2021): 100052. doi: https://doi.org/10.1016/j.mbplus.2020.100052
Gebe JA, Gooden MD, Workman G, Nagy N, Bollyky PL, Wight TN, Vernon RB. Modulation of hyaluronan synthases and involvement of T cell-derived hyaluronan in autoimmune responses to transplanted islets. Matrix Biol Plus. 2020 Dec 30;9:100052. doi: 10.1016/j.mbplus.2020.100052. eCollection 2021 Feb. PMID: 33718858; PMCID: PMC7930869.
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Hyaluronic Acid in the Third Millennium.

Polymers

Fallacara A, Baldini E, Manfredini S, Vertuani S.
PMID: 30960626
Polymers (Basel). 2018 Jun 25;10(7). doi: 10.3390/polym10070701.

Since its first isolation in 1934, hyaluronic acid (HA) has been studied across a variety of research areas. This unbranched glycosaminoglycan consisting of repeating disaccharide units of

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Fallacara A, Baldini E, Manfredini S, et al. Hyaluronic Acid in the Third Millennium. Polymers (Basel). 2018;10(7)doi: 10.3390/polym10070701.
Fallacara, A., Baldini, E., Manfredini, S., & Vertuani, S. (2018). Hyaluronic Acid in the Third Millennium. Polymers, 10(7), . https://doi.org/10.3390/polym10070701
Fallacara, Arianna, et al. "Hyaluronic Acid in the Third Millennium." Polymers vol. 10,7 (2018). doi: https://doi.org/10.3390/polym10070701
Fallacara A, Baldini E, Manfredini S, Vertuani S. Hyaluronic Acid in the Third Millennium. Polymers (Basel). 2018 Jun 25;10(7). doi: 10.3390/polym10070701. PMID: 30960626; PMCID: PMC6403654.
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C1q-HA Matrix Regulates the Local Synthesis of Hyaluronan in Malignant Pleural Mesothelioma by Modulating HAS3 Expression.

Cancers

Vidergar R, Balduit A, Zacchi P, Agostinis C, Mangogna A, Belmonte B, Grandolfo M, Salton F, Biolo M, Zanconati F, Confalonieri M, Bulla R.
PMID: 33499323
Cancers (Basel). 2021 Jan 22;13(3). doi: 10.3390/cancers13030416.

Increased hyaluronic acid (HA) production is often associated with cancer progression. In malignant pleural mesothelioma (MPM), HA is found at elevated levels in pleural effusions and sera of patients, and it has been widely debated whether MPM cells are...

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Vidergar R, Balduit A, Zacchi P, et al. C1q-HA Matrix Regulates the Local Synthesis of Hyaluronan in Malignant Pleural Mesothelioma by Modulating HAS3 Expression. Cancers (Basel). 2021;13(3)doi: 10.3390/cancers13030416.
Vidergar, R., Balduit, A., Zacchi, P., Agostinis, C., Mangogna, A., Belmonte, B., Grandolfo, M., Salton, F., Biolo, M., Zanconati, F., Confalonieri, M., & Bulla, R. (2021). C1q-HA Matrix Regulates the Local Synthesis of Hyaluronan in Malignant Pleural Mesothelioma by Modulating HAS3 Expression. Cancers, 13(3), . https://doi.org/10.3390/cancers13030416
Vidergar, Romana, et al. "C1q-HA Matrix Regulates the Local Synthesis of Hyaluronan in Malignant Pleural Mesothelioma by Modulating HAS3 Expression." Cancers vol. 13,3 (2021). doi: https://doi.org/10.3390/cancers13030416
Vidergar R, Balduit A, Zacchi P, Agostinis C, Mangogna A, Belmonte B, Grandolfo M, Salton F, Biolo M, Zanconati F, Confalonieri M, Bulla R. C1q-HA Matrix Regulates the Local Synthesis of Hyaluronan in Malignant Pleural Mesothelioma by Modulating HAS3 Expression. Cancers (Basel). 2021 Jan 22;13(3). doi: 10.3390/cancers13030416. PMID: 33499323; PMCID: PMC7865933.
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