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Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations.

Allergy, asthma & immunology research

Kaplan AP.
PMID: 28913986
Allergy Asthma Immunol Res. 2017 Nov;9(6):477-482. doi: 10.4168/aair.2017.9.6.477.

The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine...

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Kaplan AP. Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations. Allergy Asthma Immunol Res. 2017;9(6):477-482doi: 10.4168/aair.2017.9.6.477.
Kaplan, A. P. (2017). Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations. Allergy, asthma & immunology research, 9(6), 477-482. https://doi.org/10.4168/aair.2017.9.6.477
Kaplan, Allen P. "Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations." Allergy, asthma & immunology research vol. 9,6 (2017): 477-482. doi: https://doi.org/10.4168/aair.2017.9.6.477
Kaplan AP. Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations. Allergy Asthma Immunol Res. 2017 Nov;9(6):477-482. doi: 10.4168/aair.2017.9.6.477. PMID: 28913986; PMCID: PMC5603475.
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ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs.

Hospital pharmacy

Cohen MR, Smetzer JL.
PMID: 28515501
Hosp Pharm. 2017 Apr;52(4):249-252. doi: 10.1310/hpj5204-249.

These medication errors have occurred in health care facilities at least once. They will happen again-perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors...

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Cohen MR, Smetzer JL. ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs. Hosp Pharm. 2017;52(4):249-252doi: 10.1310/hpj5204-249.
Cohen, M. R., & Smetzer, J. L. (2017). ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs. Hospital pharmacy, 52(4), 249-252. https://doi.org/10.1310/hpj5204-249
Cohen, Michael R, and Smetzer, Judy L. "ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs." Hospital pharmacy vol. 52,4 (2017): 249-252. doi: https://doi.org/10.1310/hpj5204-249
Cohen MR, Smetzer JL. ISMP Medication Error Report Analysis: Potential Issues with New Basal Insulin/GLP-1 Fixed Combinations Hydroxyzine-Hydroxyurea Mix-up Concomitant Use of Entresto and ACE Inhibitors Can Lead to Serious Outcomes More Outpatient Oral Cancer Drugs Should Be in Blister Packs. Hosp Pharm. 2017 Apr;52(4):249-252. doi: 10.1310/hpj5204-249. PMID: 28515501; PMCID: PMC5424826.
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Incidence and Management of Rash in Telaprevir-Treated Patients.

The Annals of pharmacotherapy

Smith MA, Johnson HJ, Chopra KB, Dunn MA, Ulrich AM, Mohammad RA.
PMID: 24939632
Ann Pharmacother. 2014 Sep;48(9):1166-1171. doi: 10.1177/1060028014539274. Epub 2014 Jun 17.

BACKGROUND: Telaprevir-induced rash is a common, therapy-limiting adverse drug event (ADE) for patients with hepatitis c virus (HCV) infection. Given the similarity between telaprevir and simeprevir, real-world management of rash during treatment with an NS3/4A protease inhibitor and its...

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Smith MA, Johnson HJ, Chopra KB, et al. Incidence and Management of Rash in Telaprevir-Treated Patients. Ann Pharmacother. 2014;48(9):1166-1171doi: 10.1177/1060028014539274.
Smith, M. A., Johnson, H. J., Chopra, K. B., Dunn, M. A., Ulrich, A. M., & Mohammad, R. A. (2014). Incidence and Management of Rash in Telaprevir-Treated Patients. The Annals of pharmacotherapy, 48(9), 1166-1171. https://doi.org/10.1177/1060028014539274
Smith, Michael A, et al. "Incidence and Management of Rash in Telaprevir-Treated Patients." The Annals of pharmacotherapy vol. 48,9 (2014): 1166-1171. doi: https://doi.org/10.1177/1060028014539274
Smith MA, Johnson HJ, Chopra KB, Dunn MA, Ulrich AM, Mohammad RA. Incidence and Management of Rash in Telaprevir-Treated Patients. Ann Pharmacother. 2014 Sep;48(9):1166-1171. doi: 10.1177/1060028014539274. Epub 2014 Jun 17. PMID: 24939632.
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QT interval prolongation and torsade de pointes: Synergistic effect of flecainide and H1 receptor antagonists.

Journal of pharmacology & pharmacotherapeutics

Acosta-Materán C, Díaz-Oliva E, Fernández-Rodríguez D, Hernández-Afonso J.
PMID: 27440957
J Pharmacol Pharmacother. 2016 Apr-Jun;7(2):102-5. doi: 10.4103/0976-500X.184776.

A high percentage of patients having atrial fibrillation (AF) presents with paroxysmal AF. Flecainide, the prototypic class Ic anti-arrhythmic drug is the most effective drug to maintain sinus rhythm in this subgroup of patients, though the drug has potential...

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Acosta-Materán C, Díaz-Oliva E, Fernández-Rodríguez D, et al. QT interval prolongation and torsade de pointes: Synergistic effect of flecainide and H1 receptor antagonists. J Pharmacol Pharmacother. 2016;7(2):102-5doi: 10.4103/0976-500X.184776.
Acosta-Materán, C., Díaz-Oliva, E., Fernández-Rodríguez, D., & Hernández-Afonso, J. (2016). QT interval prolongation and torsade de pointes: Synergistic effect of flecainide and H1 receptor antagonists. Journal of pharmacology & pharmacotherapeutics, 7(2), 102-5. https://doi.org/10.4103/0976-500X.184776
Acosta-Materán, Carlos, et al. "QT interval prolongation and torsade de pointes: Synergistic effect of flecainide and H1 receptor antagonists." Journal of pharmacology & pharmacotherapeutics vol. 7,2 (2016): 102-5. doi: https://doi.org/10.4103/0976-500X.184776
Acosta-Materán C, Díaz-Oliva E, Fernández-Rodríguez D, Hernández-Afonso J. QT interval prolongation and torsade de pointes: Synergistic effect of flecainide and H1 receptor antagonists. J Pharmacol Pharmacother. 2016 Apr-Jun;7(2):102-5. doi: 10.4103/0976-500X.184776. PMID: 27440957; PMCID: PMC4936076.
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Recurrent small intestinal ileus due to valsartan; compulsive behaviors related to rasagiline use; lacosamide-induced acute pancreatitis; brief psychotic disorder after abrupt withdrawal of hydroxyzine; hydroxyurea-associated acral erythema; penicillamine-induced degenerative dermatosis.

Hospital pharmacy

Mancano MA.
PMID: 25477561
Hosp Pharm. 2014 Nov;49(10):902-6. doi: 10.1310/hpj4910-902.

The purpose of this feature is to heighten awareness of specific adverse drug reactions (ADRs), discuss methods of prevention, and promote reporting of ADRs to the US Food and Drug Administration's (FDA's) MedWatch program (800-FDA-1088). If you have reported...

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Mancano MA. Recurrent small intestinal ileus due to valsartan; compulsive behaviors related to rasagiline use; lacosamide-induced acute pancreatitis; brief psychotic disorder after abrupt withdrawal of hydroxyzine; hydroxyurea-associated acral erythema; penicillamine-induced degenerative dermatosis. Hosp Pharm. 2014;49(10):902-6doi: 10.1310/hpj4910-902.
Mancano, M. A. (2014). Recurrent small intestinal ileus due to valsartan; compulsive behaviors related to rasagiline use; lacosamide-induced acute pancreatitis; brief psychotic disorder after abrupt withdrawal of hydroxyzine; hydroxyurea-associated acral erythema; penicillamine-induced degenerative dermatosis. Hospital pharmacy, 49(10), 902-6. https://doi.org/10.1310/hpj4910-902
Mancano, Michael A. "Recurrent small intestinal ileus due to valsartan; compulsive behaviors related to rasagiline use; lacosamide-induced acute pancreatitis; brief psychotic disorder after abrupt withdrawal of hydroxyzine; hydroxyurea-associated acral erythema; penicillamine-induced degenerative dermatosis." Hospital pharmacy vol. 49,10 (2014): 902-6. doi: https://doi.org/10.1310/hpj4910-902
Mancano MA. Recurrent small intestinal ileus due to valsartan; compulsive behaviors related to rasagiline use; lacosamide-induced acute pancreatitis; brief psychotic disorder after abrupt withdrawal of hydroxyzine; hydroxyurea-associated acral erythema; penicillamine-induced degenerative dermatosis. Hosp Pharm. 2014 Nov;49(10):902-6. doi: 10.1310/hpj4910-902. PMID: 25477561; PMCID: PMC4252212.
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Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug.

Pharmacology research & perspectives

Schlit AF, Delaunois A, Colomar A, Claudio B, Cariolato L, Boev R, Valentin JP, Peters C, Sloan VS, Bentz JWG.
PMID: 28480041
Pharmacol Res Perspect. 2017 Apr 21;5(3):e00309. doi: 10.1002/prp2.309. eCollection 2017 Jun.

Several noncardiac drugs have been linked to cardiac safety concerns, highlighting the importance of post-marketing surveillance and continued evaluation of the benefit-risk of long-established drugs. Here, we examine the risk of QT prolongation and/or torsade de pointes (TdP) associated...

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Schlit AF, Delaunois A, Colomar A, et al. Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug. Pharmacol Res Perspect. 2017;5(3):e00309doi: 10.1002/prp2.309.
Schlit, A. F., Delaunois, A., Colomar, A., Claudio, B., Cariolato, L., Boev, R., Valentin, J. P., Peters, C., Sloan, V. S., & Bentz, J. W. G. (2017). Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug. Pharmacology research & perspectives, 5(3), e00309. https://doi.org/10.1002/prp2.309
Schlit, Anne-Françoise, et al. "Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug." Pharmacology research & perspectives vol. 5,3 (2017): e00309. doi: https://doi.org/10.1002/prp2.309
Schlit AF, Delaunois A, Colomar A, Claudio B, Cariolato L, Boev R, Valentin JP, Peters C, Sloan VS, Bentz JWG. Risk of QT prolongation and torsade de pointes associated with exposure to hydroxyzine: re-evaluation of an established drug. Pharmacol Res Perspect. 2017 Apr 21;5(3):e00309. doi: 10.1002/prp2.309. eCollection 2017 Jun. PMID: 28480041; PMCID: PMC5415947.
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PATIENT/CARERS' RECOLLECTION OF MEDICINES RELATED INFORMATION FROM AN OUT-PATIENT CLINIC APPOINTMENT.

Archives of disease in childhood

Aston J, Patel N, Smuels J, Aujla T, Malesi G, Huynh C, Wilson K, Terry D.
PMID: 27540235
Arch Dis Child. 2016 Sep;101(9):e2. doi: 10.1136/archdischild-2016-311535.53.

AIM: To identify what medicines related information children/young people or their parents/carers are able to recall following an out-patient clinic appointment.METHOD: A convenience sample of patients' prescribed at least one new long-term (>6 weeks) medicine were recruited from a...

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Aston J, Patel N, Smuels J, et al. PATIENT/CARERS' RECOLLECTION OF MEDICINES RELATED INFORMATION FROM AN OUT-PATIENT CLINIC APPOINTMENT. Arch Dis Child. 2016;101(9):e2doi: 10.1136/archdischild-2016-311535.53.
Aston, J., Patel, N., Smuels, J., Aujla, T., Malesi, G., Huynh, C., Wilson, K., & Terry, D. (2016). PATIENT/CARERS' RECOLLECTION OF MEDICINES RELATED INFORMATION FROM AN OUT-PATIENT CLINIC APPOINTMENT. Archives of disease in childhood, 101(9), e2. https://doi.org/10.1136/archdischild-2016-311535.53
Aston, Jeff, et al. "PATIENT/CARERS' RECOLLECTION OF MEDICINES RELATED INFORMATION FROM AN OUT-PATIENT CLINIC APPOINTMENT." Archives of disease in childhood vol. 101,9 (2016): e2. doi: https://doi.org/10.1136/archdischild-2016-311535.53
Aston J, Patel N, Smuels J, Aujla T, Malesi G, Huynh C, Wilson K, Terry D. PATIENT/CARERS' RECOLLECTION OF MEDICINES RELATED INFORMATION FROM AN OUT-PATIENT CLINIC APPOINTMENT. Arch Dis Child. 2016 Sep;101(9):e2. doi: 10.1136/archdischild-2016-311535.53. PMID: 27540235.
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Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses.

Journal of veterinary pharmacology and therapeutics

Paine SW, Aldurdunji M, Garth-Greeves A, Muir T, Hincks PR.
PMID: 34469007
J Vet Pharmacol Ther. 2022 Jan;45(1):46-53. doi: 10.1111/jvp.13010. Epub 2021 Sep 01.

Hydroxyzine and cetirizine are first- and second-generation oral antihistamine drugs, respectively, used to treat allergic reactions in horses. Cetirizine is also a metabolite of hydroxyzine, which may lead to complexities in regulating their use in equine sporting events. The...

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Paine SW, Aldurdunji M, Garth-Greeves A, et al. Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. J Vet Pharmacol Ther. 2021;45(1):46-53doi: 10.1111/jvp.13010.
Paine, S. W., Aldurdunji, M., Garth-Greeves, A., Muir, T., & Hincks, P. R. (2022). Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. Journal of veterinary pharmacology and therapeutics, 45(1), 46-53. https://doi.org/10.1111/jvp.13010
Paine, Stuart W, et al. "Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses." Journal of veterinary pharmacology and therapeutics vol. 45,1 (2022): 46-53. doi: https://doi.org/10.1111/jvp.13010
Paine SW, Aldurdunji M, Garth-Greeves A, Muir T, Hincks PR. Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses. J Vet Pharmacol Ther. 2022 Jan;45(1):46-53. doi: 10.1111/jvp.13010. Epub 2021 Sep 01. PMID: 34469007.
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Lethal self-administration of propofol and atracurium.

Journal of forensic sciences

Drevin G, Briet M, Ferec S, Rossi LH, Jousset N, Abbara C.
PMID: 34586645
J Forensic Sci. 2021 Sep 29; doi: 10.1111/1556-4029.14903. Epub 2021 Sep 29.

Acute propofol intoxications appear rare and remain primarily related to the acquisition of the material from the hospital. In this study, two cases of suicide following self-administration of a propofol-atracurium combination are presented as well as other propofol-related fatalities,...

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Drevin G, Briet M, Ferec S, et al. Lethal self-administration of propofol and atracurium. J Forensic Sci. 2021;doi: 10.1111/1556-4029.14903.
Drevin, G., Briet, M., Ferec, S., Rossi, L. H., Jousset, N., & Abbara, C. (2021). Lethal self-administration of propofol and atracurium. Journal of forensic sciences, . https://doi.org/10.1111/1556-4029.14903
Drevin, Guillaume, et al. "Lethal self-administration of propofol and atracurium." Journal of forensic sciences vol. (2021). doi: https://doi.org/10.1111/1556-4029.14903
Drevin G, Briet M, Ferec S, Rossi LH, Jousset N, Abbara C. Lethal self-administration of propofol and atracurium. J Forensic Sci. 2021 Sep 29; doi: 10.1111/1556-4029.14903. Epub 2021 Sep 29. PMID: 34586645.
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Stiff-person syndrome in a patient with comorbid bipolar and panic disorders: A case report and literature review.

The mental health clinician

Patel K, Stummer L, Patel K.
PMID: 32420007
Ment Health Clin. 2020 May 07;10(3):95-99. doi: 10.9740/mhc.2020.05.095. eCollection 2020 May.

Stiff-person syndrome (SPS) is a neurologic disorder characterized by muscle stiffness, rigidity, and muscle spasms, and it can increase a patient's risk for falls. It is recognized as a rare disease with limited clinical guidelines to manage the condition...

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Patel K, Stummer L, Patel K. Stiff-person syndrome in a patient with comorbid bipolar and panic disorders: A case report and literature review. Ment Health Clin. 2020;10(3):95-99doi: 10.9740/mhc.2020.05.095.
Patel, K., Stummer, L., & Patel, K. (2020). Stiff-person syndrome in a patient with comorbid bipolar and panic disorders: A case report and literature review. The mental health clinician, 10(3), 95-99. https://doi.org/10.9740/mhc.2020.05.095
Patel, Karishma, et al. "Stiff-person syndrome in a patient with comorbid bipolar and panic disorders: A case report and literature review." The mental health clinician vol. 10,3 (2020): 95-99. doi: https://doi.org/10.9740/mhc.2020.05.095
Patel K, Stummer L, Patel K. Stiff-person syndrome in a patient with comorbid bipolar and panic disorders: A case report and literature review. Ment Health Clin. 2020 May 07;10(3):95-99. doi: 10.9740/mhc.2020.05.095. eCollection 2020 May. PMID: 32420007; PMCID: PMC7213949.
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Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study.

Journal of clinical medicine

Sánchez-Rico M, Limosin F, Vernet R, Beeker N, Neuraz A, Blanco C, Olfson M, Lemogne C, Meneton P, Daniel C, Paris N, Gramfort A, Lemaitre G, De La Muela P, Salamanca E, Bernaux M, Bellamine A, Burgun A, Hoertel N, On Behalf Of Ap-Hp/Université de Paris/Inserm Covid-Research Collaboration/Ap-Hp Covid Cdr Initiativ.
PMID: 34945186
J Clin Med. 2021 Dec 15;10(24). doi: 10.3390/jcm10245891.

(1) Background: Based on its antiviral activity, anti-inflammatory properties, and functional inhibition effects on the acid sphingomyelinase/ceramide system (FIASMA), we sought to examine the potential usefulness of the H1 antihistamine hydroxyzine in patients hospitalized for COVID-19. (2) Methods: In...

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Sánchez-Rico M, Limosin F, Vernet R, et al. Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study. J Clin Med. 2021;10(24)doi: 10.3390/jcm10245891.
Sánchez-Rico, M., Limosin, F., Vernet, R., Beeker, N., Neuraz, A., Blanco, C., Olfson, M., Lemogne, C., Meneton, P., Daniel, C., Paris, N., Gramfort, A., Lemaitre, G., De La Muela, P., Salamanca, E., Bernaux, M., Bellamine, A., Burgun, A., Hoertel, N., & On Behalf Of Ap-Hp/Université de Paris/Inserm Covid-Research Collaboration/Ap-Hp Covid Cdr Initiativ. (2021). Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study. Journal of clinical medicine, 10(24), . https://doi.org/10.3390/jcm10245891
Sánchez-Rico, Marina, et al. "Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study." Journal of clinical medicine vol. 10,24 (2021). doi: https://doi.org/10.3390/jcm10245891
Sánchez-Rico M, Limosin F, Vernet R, Beeker N, Neuraz A, Blanco C, Olfson M, Lemogne C, Meneton P, Daniel C, Paris N, Gramfort A, Lemaitre G, De La Muela P, Salamanca E, Bernaux M, Bellamine A, Burgun A, Hoertel N, On Behalf Of Ap-Hp/Université de Paris/Inserm Covid-Research Collaboration/Ap-Hp Covid Cdr Initiativ. Hydroxyzine Use and Mortality in Patients Hospitalized for COVID-19: A Multicenter Observational Study. J Clin Med. 2021 Dec 15;10(24). doi: 10.3390/jcm10245891. PMID: 34945186.
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Conscious Sedation Efficacy of 0.3 and 0.5 mg/kg Oral Midazolam for Three to Six Year-Old Uncooperative Children Undergoing Dental Treatment: A Clinical Trial.

Journal of dentistry (Tehran, Iran)

Ghajari MF, Ansari G, Hasanbeygi L, Shayeghi S.
PMID: 27928238
J Dent (Tehran). 2016 Mar;13(2):101-107.

OBJECTIVES: Midazolam with variable dosages has been used to induce sedation in pediatric dentistry. The aim of this study was to compare the efficacy of two dosages of oral midazolam for conscious sedation of children undergoing dental treatment.MATERIALS AND...

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Ghajari MF, Ansari G, Hasanbeygi L, et al. Conscious Sedation Efficacy of 0.3 and 0.5 mg/kg Oral Midazolam for Three to Six Year-Old Uncooperative Children Undergoing Dental Treatment: A Clinical Trial. J Dent (Tehran). 2016;13(2):101-107
Ghajari, M. F., Ansari, G., Hasanbeygi, L., & Shayeghi, S. (2016). Conscious Sedation Efficacy of 0.3 and 0.5 mg/kg Oral Midazolam for Three to Six Year-Old Uncooperative Children Undergoing Dental Treatment: A Clinical Trial. Journal of dentistry (Tehran, Iran), 13(2), 101-107.
Ghajari, Masoud Fallahinejad, et al. "Conscious Sedation Efficacy of 0.3 and 0.5 mg/kg Oral Midazolam for Three to Six Year-Old Uncooperative Children Undergoing Dental Treatment: A Clinical Trial." Journal of dentistry (Tehran, Iran) vol. 13,2 (2016): 101-107.
Ghajari MF, Ansari G, Hasanbeygi L, Shayeghi S. Conscious Sedation Efficacy of 0.3 and 0.5 mg/kg Oral Midazolam for Three to Six Year-Old Uncooperative Children Undergoing Dental Treatment: A Clinical Trial. J Dent (Tehran). 2016 Mar;13(2):101-107. PMID: 27928238; PMCID: PMC5139927.
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