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Showing 1 to 12 of 15 entries
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Agmatine Induces Rat Prostate Relaxation through Activation of Peripheral Imidazoline I2 -Receptors.

Lower urinary tract symptoms

Lee LM, Lin CH, Chung HH, Cheng JT, Chen IH, Tong YC.
PMID: 26663246
Low Urin Tract Symptoms. 2013 Jan;5(1):39-43. doi: 10.1111/j.1757-5672.2012.00158.x. Epub 2012 Apr 30.

OBJECTIVES: The effect of agmatine on prostate contractility as well as the roles of imidazoline receptors and potassium channels in this action were studied using isolated Wistar rat prostate tissue.METHODS: Rat prostate strips were pre-contracted with 1 µmol/L phenylephrine...

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Lee LM, Lin CH, Chung HH, et al. Agmatine Induces Rat Prostate Relaxation through Activation of Peripheral Imidazoline I2 -Receptors. Low Urin Tract Symptoms. 2012;5(1):39-43doi: 10.1111/j.1757-5672.2012.00158.x.
Lee, L. M., Lin, C. H., Chung, H. H., Cheng, J. T., Chen, I. H., & Tong, Y. C. (2013). Agmatine Induces Rat Prostate Relaxation through Activation of Peripheral Imidazoline I2 -Receptors. Lower urinary tract symptoms, 5(1), 39-43. https://doi.org/10.1111/j.1757-5672.2012.00158.x
Lee, Liang-Ming, et al. "Agmatine Induces Rat Prostate Relaxation through Activation of Peripheral Imidazoline I2 -Receptors." Lower urinary tract symptoms vol. 5,1 (2013): 39-43. doi: https://doi.org/10.1111/j.1757-5672.2012.00158.x
Lee LM, Lin CH, Chung HH, Cheng JT, Chen IH, Tong YC. Agmatine Induces Rat Prostate Relaxation through Activation of Peripheral Imidazoline I2 -Receptors. Low Urin Tract Symptoms. 2013 Jan;5(1):39-43. doi: 10.1111/j.1757-5672.2012.00158.x. Epub 2012 Apr 30. PMID: 26663246.
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Imidazoline receptors: possible involvement in the pathophysiology and treatment of depression.

Human psychopharmacology

Halaris A, Piletz JE.
PMID: 12404600
Hum Psychopharmacol. 2001 Jan;16(1):65-69. doi: 10.1002/hup.185.

Imidazoline receptors (IR), a novel family of non-adrenergic receptors, are present in brain, especially the limbic system, and platelets among other organs. Their functions include central mediation of blood pressure control and possibly modulation of affective symptomatology. Studies of...

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Halaris A, Piletz JE. Imidazoline receptors: possible involvement in the pathophysiology and treatment of depression. Hum Psychopharmacol. 2001;16(1):65-69doi: 10.1002/hup.185.
Halaris, A., & Piletz, J. E. (2001). Imidazoline receptors: possible involvement in the pathophysiology and treatment of depression. Human psychopharmacology, 16(1), 65-69. https://doi.org/10.1002/hup.185
Halaris, Angelos, and Piletz, John E. "Imidazoline receptors: possible involvement in the pathophysiology and treatment of depression." Human psychopharmacology vol. 16,1 (2001): 65-69. doi: https://doi.org/10.1002/hup.185
Halaris A, Piletz JE. Imidazoline receptors: possible involvement in the pathophysiology and treatment of depression. Hum Psychopharmacol. 2001 Jan;16(1):65-69. doi: 10.1002/hup.185. PMID: 12404600.
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Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome.

Pediatric emergency care

Minhaj FS, Schult RF, Dvorak P, Nacca N.
PMID: 30973502
Pediatr Emerg Care. 2019 Apr 09; doi: 10.1097/PEC.0000000000001819. Epub 2019 Apr 09.

Amphetamine toxicity typically presents with hypertension and tachycardia. Conversely, clonidine acts as an agonist at central α2 and imidazoline receptors, which may cause brief initial hypertension followed by hypotension and bradycardia in overdose. We report a case of mixed...

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Minhaj FS, Schult RF, Dvorak P, et al. Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatr Emerg Care. 2019;doi: 10.1097/PEC.0000000000001819.
Minhaj, F. S., Schult, R. F., Dvorak, P., & Nacca, N. (2019). Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatric emergency care, . https://doi.org/10.1097/PEC.0000000000001819
Minhaj, Faisal Syed, et al. "Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome." Pediatric emergency care vol. (2019). doi: https://doi.org/10.1097/PEC.0000000000001819
Minhaj FS, Schult RF, Dvorak P, Nacca N. Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatr Emerg Care. 2019 Apr 09; doi: 10.1097/PEC.0000000000001819. Epub 2019 Apr 09. PMID: 30973502.
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Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome.

Pediatric emergency care

Minhaj FS, Schult RF, Dvorak P, Nacca N.
PMID: 30973502
Pediatr Emerg Care. 2021 Dec 01;37(12):e1721-e1723. doi: 10.1097/PEC.0000000000001819.

ABSTRACT: Amphetamine toxicity typically presents with hypertension and tachycardia. Conversely, clonidine acts as an agonist at central α2 and imidazoline receptors, which may cause brief initial hypertension followed by hypotension and bradycardia in overdose. We report a case of...

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Minhaj FS, Schult RF, Dvorak P, et al. Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatr Emerg Care. 2021;37(12):e1721-e1723doi: 10.1097/PEC.0000000000001819.
Minhaj, F. S., Schult, R. F., Dvorak, P., & Nacca, N. (2021). Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatric emergency care, 37(12), e1721-e1723. https://doi.org/10.1097/PEC.0000000000001819
Minhaj, Faisal Syed, et al. "Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome." Pediatric emergency care vol. 37,12 (2021): e1721-e1723. doi: https://doi.org/10.1097/PEC.0000000000001819
Minhaj FS, Schult RF, Dvorak P, Nacca N. Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatr Emerg Care. 2021 Dec 01;37(12):e1721-e1723. doi: 10.1097/PEC.0000000000001819. PMID: 30973502.
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Imidazoline receptors: new targets for antihyperglycaemic drugs.

Expert opinion on investigational drugs

Morgan NG.
PMID: 15992117
Expert Opin Investig Drugs. 1999 May;8(5):575-84. doi: 10.1517/13543784.8.5.575.

In both animal models of Type 2 diabetes and in man, it has been evident for many years that certain imidazoline drugs can stimulate insulin secretion and improve glycaemia. This suggests that they may be useful new reagents for...

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Morgan NG. Imidazoline receptors: new targets for antihyperglycaemic drugs. Expert Opin Investig Drugs. 1999;8(5):575-84doi: 10.1517/13543784.8.5.575.
Morgan, N. G. (1999). Imidazoline receptors: new targets for antihyperglycaemic drugs. Expert opinion on investigational drugs, 8(5), 575-84. https://doi.org/10.1517/13543784.8.5.575
Morgan, N G. "Imidazoline receptors: new targets for antihyperglycaemic drugs." Expert opinion on investigational drugs vol. 8,5 (1999): 575-84. doi: https://doi.org/10.1517/13543784.8.5.575
Morgan NG. Imidazoline receptors: new targets for antihyperglycaemic drugs. Expert Opin Investig Drugs. 1999 May;8(5):575-84. doi: 10.1517/13543784.8.5.575. PMID: 15992117.
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Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors.

Journal of cardiovascular pharmacology

Ishihara M, Kojima A, Ding WG, Kitagawa H, Matsuura H.
PMID: 34448469
J Cardiovasc Pharmacol. 2021 Dec 01;78(6):826-838. doi: 10.1097/FJC.0000000000001133.

ABSTRACT: Dexmedetomidine (DEX), an α2-adrenoreceptor (α2-AR) and imidazoline receptor agonist, is most often used for the sedation of patients in the intensive care unit. Its administration is associated with an increased incidence of bradycardia; however, the precise mechanism of...

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Ishihara M, Kojima A, Ding WG, et al. Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors. J Cardiovasc Pharmacol. 2021;78(6):826-838doi: 10.1097/FJC.0000000000001133.
Ishihara, M., Kojima, A., Ding, W. G., Kitagawa, H., & Matsuura, H. (2021). Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors. Journal of cardiovascular pharmacology, 78(6), 826-838. https://doi.org/10.1097/FJC.0000000000001133
Ishihara, Mariko, et al. "Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors." Journal of cardiovascular pharmacology vol. 78,6 (2021): 826-838. doi: https://doi.org/10.1097/FJC.0000000000001133
Ishihara M, Kojima A, Ding WG, Kitagawa H, Matsuura H. Dexmedetomidine Exerts a Negative Chronotropic Action on Sinoatrial Node Cells Through the Activation of Imidazoline Receptors. J Cardiovasc Pharmacol. 2021 Dec 01;78(6):826-838. doi: 10.1097/FJC.0000000000001133. PMID: 34448469.
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Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome.

Pediatric emergency care

Minhaj FS, Schult RF, Dvorak P, Nacca N.
PMID: 30973502
Pediatr Emerg Care. 2021 Dec 01;37(12):e1721-e1723. doi: 10.1097/PEC.0000000000001819.

ABSTRACT: Amphetamine toxicity typically presents with hypertension and tachycardia. Conversely, clonidine acts as an agonist at central α2 and imidazoline receptors, which may cause brief initial hypertension followed by hypotension and bradycardia in overdose. We report a case of...

Cite
Minhaj FS, Schult RF, Dvorak P, et al. Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatr Emerg Care. 2021;37(12):e1721-e1723doi: 10.1097/PEC.0000000000001819.
Minhaj, F. S., Schult, R. F., Dvorak, P., & Nacca, N. (2021). Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatric emergency care, 37(12), e1721-e1723. https://doi.org/10.1097/PEC.0000000000001819
Minhaj, Faisal Syed, et al. "Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome." Pediatric emergency care vol. 37,12 (2021): e1721-e1723. doi: https://doi.org/10.1097/PEC.0000000000001819
Minhaj FS, Schult RF, Dvorak P, Nacca N. Amphetamine and Clonidine Toxicity Resulting in Posterior Reversible Encephalopathy Syndrome. Pediatr Emerg Care. 2021 Dec 01;37(12):e1721-e1723. doi: 10.1097/PEC.0000000000001819. PMID: 30973502.
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Modification of naloxone-precipitated withdrawal symptoms in mice by drugs acting on alpha(2)-adrenoceptors.

Behavioural pharmacology

Sharif SI, El-Kadi AO.
PMID: 11224426
Behav Pharmacol. 1996 Aug;7(4):334-340. doi: 10.1097/00008877-199608000-00004.

Modification of naloxone-precipitated withdrawal symptoms by drugs acting on alpha-adrenoceptors was investigated in morphine-dependent mice. Clonidine (0.05-1mg/kg) attenuated most withdrawal symptoms, but potentiated withdrawal hypothermia. Jumping was attenuated by doses of clonidine up to 0.3mg/kg, but markedly potentiated by...

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Sharif SI, El-Kadi AO. Modification of naloxone-precipitated withdrawal symptoms in mice by drugs acting on alpha(2)-adrenoceptors. Behav Pharmacol. 1996;7(4):334-340doi: 10.1097/00008877-199608000-00004.
Sharif, S. I., & El-Kadi, A. O. (1996). Modification of naloxone-precipitated withdrawal symptoms in mice by drugs acting on alpha(2)-adrenoceptors. Behavioural pharmacology, 7(4), 334-340. https://doi.org/10.1097/00008877-199608000-00004
Sharif, S.I., and El-Kadi, A.O.S.. "Modification of naloxone-precipitated withdrawal symptoms in mice by drugs acting on alpha(2)-adrenoceptors." Behavioural pharmacology vol. 7,4 (1996): 334-340. doi: https://doi.org/10.1097/00008877-199608000-00004
Sharif SI, El-Kadi AO. Modification of naloxone-precipitated withdrawal symptoms in mice by drugs acting on alpha(2)-adrenoceptors. Behav Pharmacol. 1996 Aug;7(4):334-340. doi: 10.1097/00008877-199608000-00004. PMID: 11224426.
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Neuroprotective effects of receptor imidazoline 2 and its endogenous ligand agmatine.

Neuroscience bulletin

Qiu WW, Zheng RY.
PMID: 17704848
Neurosci Bull. 2006 May;22(3):187-91.

Receptor imidazoline 2 (I₂) is one of the imidazoline receptors with high affinity for [³H]-idazoxan. Receptor I₂, being classified into I(₂A) and I(₂B) subtypes, is mainly localized to the outer membrane of mitochondria in liver, kidney and brain. Receptor...

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Qiu WW, Zheng RY. Neuroprotective effects of receptor imidazoline 2 and its endogenous ligand agmatine. Neurosci Bull. 2006;22(3):187-91
Qiu, W. W., & Zheng, R. Y. (2006). Neuroprotective effects of receptor imidazoline 2 and its endogenous ligand agmatine. Neuroscience bulletin, 22(3), 187-91.
Qiu, Wei-Wen, and Zheng, Rong-Yuan. "Neuroprotective effects of receptor imidazoline 2 and its endogenous ligand agmatine." Neuroscience bulletin vol. 22,3 (2006): 187-91.
Qiu WW, Zheng RY. Neuroprotective effects of receptor imidazoline 2 and its endogenous ligand agmatine. Neurosci Bull. 2006 May;22(3):187-91. PMID: 17704848.
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Discriminative stimulus properties of ethoxy idazoxan.

Journal of psychopharmacology (Oxford, England)

Jordan S, Jackson HC, Nutt DJ, Handley SL.
PMID: 22297762
J Psychopharmacol. 1995 Jan;9(3):228-33. doi: 10.1177/026988119500900305.

The technique of drug discrimination was used to examine the ability of the highly selective α(2)-adrenoceptor antagonist ethoxy idazoxan, which has negligible affinity for α( 1)-adrenoceptors or I(2) imidazoline receptors, to produce an interoceptive discriminable stimulus or cue in...

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Jordan S, Jackson HC, Nutt DJ, et al. Discriminative stimulus properties of ethoxy idazoxan. J Psychopharmacol. 1995;9(3):228-33doi: 10.1177/026988119500900305.
Jordan, S., Jackson, H. C., Nutt, D. J., & Handley, S. L. (1995). Discriminative stimulus properties of ethoxy idazoxan. Journal of psychopharmacology (Oxford, England), 9(3), 228-33. https://doi.org/10.1177/026988119500900305
Jordan, S, et al. "Discriminative stimulus properties of ethoxy idazoxan." Journal of psychopharmacology (Oxford, England) vol. 9,3 (1995): 228-33. doi: https://doi.org/10.1177/026988119500900305
Jordan S, Jackson HC, Nutt DJ, Handley SL. Discriminative stimulus properties of ethoxy idazoxan. J Psychopharmacol. 1995 Jan;9(3):228-33. doi: 10.1177/026988119500900305. PMID: 22297762.
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Activation of imidazoline-I3 receptors ameliorates pancreatic damage.

Clinical and experimental pharmacology & physiology

Li Y, Cheng KC, Asakawa A, Amitani H, Takimoto Y, Runtuwene J, Inui A.
PMID: 26112210
Clin Exp Pharmacol Physiol. 2015 Sep;42(9):964-971. doi: 10.1111/1440-1681.12441.

Agmatine, an endogenous ligand of imidazoline receptors, is reported to exhibit anti-hyperglycaemic and many other effects. It has been established that the imidazoline I3 receptor is involved in insulin secretion. The current study characterizes the role of the imidazoline...

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Li Y, Cheng KC, Asakawa A, et al. Activation of imidazoline-I3 receptors ameliorates pancreatic damage. Clin Exp Pharmacol Physiol. 2015;42(9):964-971doi: 10.1111/1440-1681.12441.
Li, Y., Cheng, K. C., Asakawa, A., Amitani, H., Takimoto, Y., Runtuwene, J., & Inui, A. (2015). Activation of imidazoline-I3 receptors ameliorates pancreatic damage. Clinical and experimental pharmacology & physiology, 42(9), 964-971. https://doi.org/10.1111/1440-1681.12441
Li, Yingxiao, et al. "Activation of imidazoline-I3 receptors ameliorates pancreatic damage." Clinical and experimental pharmacology & physiology vol. 42,9 (2015): 964-971. doi: https://doi.org/10.1111/1440-1681.12441
Li Y, Cheng KC, Asakawa A, Amitani H, Takimoto Y, Runtuwene J, Inui A. Activation of imidazoline-I3 receptors ameliorates pancreatic damage. Clin Exp Pharmacol Physiol. 2015 Sep;42(9):964-971. doi: 10.1111/1440-1681.12441. PMID: 26112210.
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Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation.

ACS medicinal chemistry letters

Del Bello F, Bargelli V, Cifani C, Gratteri P, Bazzicalupi C, Diamanti E, Giannella M, Mammoli V, Matucci R, Micioni Di Bonaventura MV, Piergentili A, Quaglia W, Pigini M.
PMID: 26005521
ACS Med Chem Lett. 2015 Apr 03;6(5):496-501. doi: 10.1021/acsmedchemlett.5b00115. eCollection 2015 May 14.

Pharmacological studies have suggested that I1-imidazoline receptors are involved in the regulation of cardiovascular function and that selective I1-agonists, devoid of the side effects associated with the common hypotensive α2-adrenoreceptor agonists, might be considered as a second generation of...

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Del Bello F, Bargelli V, Cifani C, et al. Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation. ACS Med Chem Lett. 2015;6(5):496-501doi: 10.1021/acsmedchemlett.5b00115.
Del Bello, F., Bargelli, V., Cifani, C., Gratteri, P., Bazzicalupi, C., Diamanti, E., Giannella, M., Mammoli, V., Matucci, R., Micioni Di Bonaventura, M. V., Piergentili, A., Quaglia, W., & Pigini, M. (2015). Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation. ACS medicinal chemistry letters, 6(5), 496-501. https://doi.org/10.1021/acsmedchemlett.5b00115
Del Bello, Fabio, et al. "Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation." ACS medicinal chemistry letters vol. 6,5 (2015): 496-501. doi: https://doi.org/10.1021/acsmedchemlett.5b00115
Del Bello F, Bargelli V, Cifani C, Gratteri P, Bazzicalupi C, Diamanti E, Giannella M, Mammoli V, Matucci R, Micioni Di Bonaventura MV, Piergentili A, Quaglia W, Pigini M. Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation. ACS Med Chem Lett. 2015 Apr 03;6(5):496-501. doi: 10.1021/acsmedchemlett.5b00115. eCollection 2015 May 14. PMID: 26005521; PMCID: PMC4434467.
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Showing 1 to 12 of 15 entries