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Showing 1 to 12 of 18 entries
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Interferon and interferon inducers in the treatment of malignancies.

The Journal of general physiology

Levy HB, Riley F, Margolis S.
PMID: 19873670
J Gen Physiol. 1970 Jul 01;56(1):238-48. doi: 10.1085/jgp.56.1.238.

The mechanism of the antitumor action of polyinosinic-polycytidylic acid is probably multifaceted. The compound induces the synthesis of interferon, and interferon probably is active against some tumors. Poly I:poly C alters protein and RNA synthesis in tissue culture. It...

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Levy HB, Riley F, Margolis S. Interferon and interferon inducers in the treatment of malignancies. J Gen Physiol. 1970;56(1):238-48doi: 10.1085/jgp.56.1.238.
Levy, H. B., Riley, F., & Margolis, S. (1970). Interferon and interferon inducers in the treatment of malignancies. The Journal of general physiology, 56(1), 238-48. https://doi.org/10.1085/jgp.56.1.238
Levy, H B, et al. "Interferon and interferon inducers in the treatment of malignancies." The Journal of general physiology vol. 56,1 (1970): 238-48. doi: https://doi.org/10.1085/jgp.56.1.238
Levy HB, Riley F, Margolis S. Interferon and interferon inducers in the treatment of malignancies. J Gen Physiol. 1970 Jul 01;56(1):238-48. doi: 10.1085/jgp.56.1.238. PMID: 19873670; PMCID: PMC2225867.
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Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors.

Journal for immunotherapy of cancer

Tenesaca S, Vasquez M, Alvarez M, Otano I, Fernandez-Sendin M, Di Trani CA, Ardaiz N, Gomar C, Bella A, Aranda F, Medina-Echeverz J, Melero I, Berraondo P.
PMID: 34321273
J Immunother Cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2020-001587.

BACKGROUND: Modified vaccinia virus Ankara (MVA) are genetically engineered non-replicating viral vectors. Intratumoral administration of MVA induces a cyclic GMP-AMP synthase-mediated type I interferon (IFN) response and the production of high levels of the transgenes engineered into the viral...

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Tenesaca S, Vasquez M, Alvarez M, et al. Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors. J Immunother Cancer. 2021;9(7)doi: 10.1136/jitc-2020-001587.
Tenesaca, S., Vasquez, M., Alvarez, M., Otano, I., Fernandez-Sendin, M., Di Trani, C. A., Ardaiz, N., Gomar, C., Bella, A., Aranda, F., Medina-Echeverz, J., Melero, I., & Berraondo, P. (2021). Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors. Journal for immunotherapy of cancer, 9(7), . https://doi.org/10.1136/jitc-2020-001587
Tenesaca, Shirley, et al. "Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors." Journal for immunotherapy of cancer vol. 9,7 (2021). doi: https://doi.org/10.1136/jitc-2020-001587
Tenesaca S, Vasquez M, Alvarez M, Otano I, Fernandez-Sendin M, Di Trani CA, Ardaiz N, Gomar C, Bella A, Aranda F, Medina-Echeverz J, Melero I, Berraondo P. Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors. J Immunother Cancer. 2021 Jul;9(7). doi: 10.1136/jitc-2020-001587. PMID: 34321273; PMCID: PMC8320251.
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Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression.

Journal for immunotherapy of cancer

Natoli M, Gallon J, Lu H, Amgheib A, Pinato DJ, Mauri FA, Marafioti T, Akarca AU, Ullmo I, Ip J, Aboagye EO, Brown R, Karadimitris A, Ghaem-Maghami S.
PMID: 33436485
J Immunother Cancer. 2021 Jan;9(1). doi: 10.1136/jitc-2020-001519.

BACKGROUND: Endogenous retroviruses (ERVs) play a role in a variety of biological processes, including embryogenesis and cancer. DNA methyltransferase inhibitors (DNMTi)-induced ERV expression triggers interferon responses in ovarian cancer cells via the viral sensing machinery. Baseline expression of ERVs...

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Natoli M, Gallon J, Lu H, et al. Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression. J Immunother Cancer. 2021;9(1)doi: 10.1136/jitc-2020-001519.
Natoli, M., Gallon, J., Lu, H., Amgheib, A., Pinato, D. J., Mauri, F. A., Marafioti, T., Akarca, A. U., Ullmo, I., Ip, J., Aboagye, E. O., Brown, R., Karadimitris, A., & Ghaem-Maghami, S. (2021). Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression. Journal for immunotherapy of cancer, 9(1), . https://doi.org/10.1136/jitc-2020-001519
Natoli, Marina, et al. "Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression." Journal for immunotherapy of cancer vol. 9,1 (2021). doi: https://doi.org/10.1136/jitc-2020-001519
Natoli M, Gallon J, Lu H, Amgheib A, Pinato DJ, Mauri FA, Marafioti T, Akarca AU, Ullmo I, Ip J, Aboagye EO, Brown R, Karadimitris A, Ghaem-Maghami S. Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression. J Immunother Cancer. 2021 Jan;9(1). doi: 10.1136/jitc-2020-001519. PMID: 33436485; PMCID: PMC7805370.
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Interferon and interferon inducers in protozoal infections.

The Journal of general physiology

Jahiel RI.
PMID: 19873669
J Gen Physiol. 1970 Jul 01;56(1):227-37. doi: 10.1085/jgp.56.1.227.

Several interferon inducers (Newcastle disease virus, statolon, and poly rI:poly rC) as well as exogenous mouse interferon protect mice from sporozoite-induced Plasmodium berghei malaria, as long as they are administered before the end of the preerythrocytic phase of development...

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Jahiel RI. Interferon and interferon inducers in protozoal infections. J Gen Physiol. 1970;56(1):227-37doi: 10.1085/jgp.56.1.227.
Jahiel, R. I. (1970). Interferon and interferon inducers in protozoal infections. The Journal of general physiology, 56(1), 227-37. https://doi.org/10.1085/jgp.56.1.227
Jahiel, R I. "Interferon and interferon inducers in protozoal infections." The Journal of general physiology vol. 56,1 (1970): 227-37. doi: https://doi.org/10.1085/jgp.56.1.227
Jahiel RI. Interferon and interferon inducers in protozoal infections. J Gen Physiol. 1970 Jul 01;56(1):227-37. doi: 10.1085/jgp.56.1.227. PMID: 19873669; PMCID: PMC2225874.
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Double-stranded polynucleotides as interferon inducers.

The Journal of general physiology

Field AK, Tytell AA, Lampson GP, Nemes MM, Hilleman MR.
PMID: 19873677
J Gen Physiol. 1970 Jul 01;56(1):90-6. doi: 10.1085/jgp.56.1.90.

A discussion of factors considered influential in making a polynucleotide an efficient inducer of interferon was presented. These factors were double-strandedness of the polynucleotides, the sugar moiety of the polynucleotides, thermal stability, resistance to enzymatic degradation, and molecular size...

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Field AK, Tytell AA, Lampson GP, et al. Double-stranded polynucleotides as interferon inducers. J Gen Physiol. 1970;56(1):90-6doi: 10.1085/jgp.56.1.90.
Field, A. K., Tytell, A. A., Lampson, G. P., Nemes, M. M., & Hilleman, M. R. (1970). Double-stranded polynucleotides as interferon inducers. The Journal of general physiology, 56(1), 90-6. https://doi.org/10.1085/jgp.56.1.90
Field, A K, et al. "Double-stranded polynucleotides as interferon inducers." The Journal of general physiology vol. 56,1 (1970): 90-6. doi: https://doi.org/10.1085/jgp.56.1.90
Field AK, Tytell AA, Lampson GP, Nemes MM, Hilleman MR. Double-stranded polynucleotides as interferon inducers. J Gen Physiol. 1970 Jul 01;56(1):90-6. doi: 10.1085/jgp.56.1.90. PMID: 19873677; PMCID: PMC2225865.
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Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings.

Oncoimmunology

Gungor B, Yagci FC, Gursel I, Gursel M.
PMID: 25610738
Oncoimmunology. 2014 Jul 03;3(7):e950166. doi: 10.4161/21624011.2014.950166. eCollection 2014.

Type I interferon inducers may potentially be engineered to function as antiviral and anticancer agents, or alternatively, vaccine adjuvants, all of which may have clinical applications. We recently described a simple strategy to convert a Toll-like receptor 9 (TLR9)...

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Gungor B, Yagci FC, Gursel I, et al. Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings. Oncoimmunology. 2014;3(7):e950166doi: 10.4161/21624011.2014.950166.
Gungor, B., Yagci, F. C., Gursel, I., & Gursel, M. (2014). Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings. Oncoimmunology, 3(7), e950166. https://doi.org/10.4161/21624011.2014.950166
Gungor, Bilgi, et al. "Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings." Oncoimmunology vol. 3,7 (2014): e950166. doi: https://doi.org/10.4161/21624011.2014.950166
Gungor B, Yagci FC, Gursel I, Gursel M. Forging a potent vaccine adjuvant: CpG ODN/cationic peptide nanorings. Oncoimmunology. 2014 Jul 03;3(7):e950166. doi: 10.4161/21624011.2014.950166. eCollection 2014. PMID: 25610738; PMCID: PMC4292235.
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STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer.

Journal for immunotherapy of cancer

Lee SJ, Yang H, Kim WR, Lee YS, Lee WS, Kong SJ, Lee HJ, Kim JH, Cheon J, Kang B, Chon HJ, Kim C.
PMID: 34145029
J Immunother Cancer. 2021 Jun;9(6). doi: 10.1136/jitc-2020-002195.

BACKGROUND: Peritoneal carcinomatosis is a fatal clinical presentation of colon cancer, characterized by unresponsiveness to conventional anticancer therapies, including immune checkpoint inhibitors. Here, we elucidated the immune-evasion mechanisms during the peritoneal carcinomatosis of colon cancer and developed a novel...

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Lee SJ, Yang H, Kim WR, et al. STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer. J Immunother Cancer. 2021;9(6)doi: 10.1136/jitc-2020-002195.
Lee, S. J., Yang, H., Kim, W. R., Lee, Y. S., Lee, W. S., Kong, S. J., Lee, H. J., Kim, J. H., Cheon, J., Kang, B., Chon, H. J., & Kim, C. (2021). STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer. Journal for immunotherapy of cancer, 9(6), . https://doi.org/10.1136/jitc-2020-002195
Lee, Seung Joon, et al. "STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer." Journal for immunotherapy of cancer vol. 9,6 (2021). doi: https://doi.org/10.1136/jitc-2020-002195
Lee SJ, Yang H, Kim WR, Lee YS, Lee WS, Kong SJ, Lee HJ, Kim JH, Cheon J, Kang B, Chon HJ, Kim C. STING activation normalizes the intraperitoneal vascular-immune microenvironment and suppresses peritoneal carcinomatosis of colon cancer. J Immunother Cancer. 2021 Jun;9(6). doi: 10.1136/jitc-2020-002195. PMID: 34145029; PMCID: PMC8215239.
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Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Rickettsia akari.

Infection and immunity

Kazar J, Krautwurst PA, Gordon FB.
PMID: 16558061
Infect Immun. 1971 Jun;3(6):819-24. doi: 10.1128/iai.3.6.819-824.1971.

The effect of mouse interferon (IF) on the multiplication of Rickettsia akari in homologous (L-929) cell cultures and the effect of IF inducers on R. akari infection in mice were investigated. There was a reduction in the proportion of...

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Kazar J, Krautwurst PA, Gordon FB. Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Rickettsia akari. Infect Immun. 1971;3(6):819-24doi: 10.1128/iai.3.6.819-824.1971.
Kazar, J., Krautwurst, P. A., & Gordon, F. B. (1971). Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Rickettsia akari. Infection and immunity, 3(6), 819-24. https://doi.org/10.1128/iai.3.6.819-824.1971
Kazar, J, et al. "Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Rickettsia akari." Infection and immunity vol. 3,6 (1971): 819-24. doi: https://doi.org/10.1128/iai.3.6.819-824.1971
Kazar J, Krautwurst PA, Gordon FB. Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Rickettsia akari. Infect Immun. 1971 Jun;3(6):819-24. doi: 10.1128/iai.3.6.819-824.1971. PMID: 16558061; PMCID: PMC416244.
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Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy.

Biochemistry (Moscow) Supplement. Series B, Biomedical chemistry

Danilenko ED, Belkina AO, Sysoeva GM.
PMID: 32288939
Biochem Mosc Suppl B Biomed Chem. 2019;13(4):308-323. doi: 10.1134/S1990750819040036. Epub 2019 Dec 04.

No abstract available.

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Danilenko ED, Belkina AO, Sysoeva GM. Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy. Biochem Mosc Suppl B Biomed Chem. 2019;13(4):308-323doi: 10.1134/S1990750819040036.
Danilenko, E. D., Belkina, A. O., & Sysoeva, G. M. (2019). Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy. Biochemistry (Moscow) Supplement. Series B, Biomedical chemistry, 13(4), 308-323. https://doi.org/10.1134/S1990750819040036
Danilenko, E D, et al. "Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy." Biochemistry (Moscow) Supplement. Series B, Biomedical chemistry vol. 13,4 (2019): 308-323. doi: https://doi.org/10.1134/S1990750819040036
Danilenko ED, Belkina AO, Sysoeva GM. Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy. Biochem Mosc Suppl B Biomed Chem. 2019;13(4):308-323. doi: 10.1134/S1990750819040036. Epub 2019 Dec 04. PMID: 32288939; PMCID: PMC7104317.
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Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis.

Infection and immunity

Kazar J, Gillmore JD, Gordon FB.
PMID: 16558062
Infect Immun. 1971 Jun;3(6):825-32. doi: 10.1128/iai.3.6.825-832.1971.

The effect of mouse interferon (IF) on the multiplication of Chlamydia trachomatis (strain MRC-1/G) in homologous (L-929) cell cultures and the effect of the IF inducers Newcastle disease virus (NDV) and polyriboinosinic acid-polyribocytidylic acid complex (poly I:C) on the...

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Kazar J, Gillmore JD, Gordon FB. Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis. Infect Immun. 1971;3(6):825-32doi: 10.1128/iai.3.6.825-832.1971.
Kazar, J., Gillmore, J. D., & Gordon, F. B. (1971). Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis. Infection and immunity, 3(6), 825-32. https://doi.org/10.1128/iai.3.6.825-832.1971
Kazar, J, et al. "Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis." Infection and immunity vol. 3,6 (1971): 825-32. doi: https://doi.org/10.1128/iai.3.6.825-832.1971
Kazar J, Gillmore JD, Gordon FB. Effect of Interferon and Interferon Inducers on Infections with a Nonviral Intracellular Microorganism, Chlamydia trachomatis. Infect Immun. 1971 Jun;3(6):825-32. doi: 10.1128/iai.3.6.825-832.1971. PMID: 16558062; PMCID: PMC416245.
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Inhibition by estrone of the antiviral protection and interferon elicited by interferon inducers in mice.

Infection and immunity

Giron DJ, Allen PT, Pindak FF, Schmidt JP.
PMID: 16557971
Infect Immun. 1971 Feb;3(2):318-22. doi: 10.1128/iai.3.2.318-322.1971.

The susceptibility of mice to infection with MM virus is markedly increased after treatment with the sex hormone estrone. Studies were undertaken to determine if either suppression of production or interference with the action of interferon was involved in...

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Giron DJ, Allen PT, Pindak FF, et al. Inhibition by estrone of the antiviral protection and interferon elicited by interferon inducers in mice. Infect Immun. 1971;3(2):318-22doi: 10.1128/iai.3.2.318-322.1971.
Giron, D. J., Allen, P. T., Pindak, F. F., & Schmidt, J. P. (1971). Inhibition by estrone of the antiviral protection and interferon elicited by interferon inducers in mice. Infection and immunity, 3(2), 318-22. https://doi.org/10.1128/iai.3.2.318-322.1971
Giron, D J, et al. "Inhibition by estrone of the antiviral protection and interferon elicited by interferon inducers in mice." Infection and immunity vol. 3,2 (1971): 318-22. doi: https://doi.org/10.1128/iai.3.2.318-322.1971
Giron DJ, Allen PT, Pindak FF, Schmidt JP. Inhibition by estrone of the antiviral protection and interferon elicited by interferon inducers in mice. Infect Immun. 1971 Feb;3(2):318-22. doi: 10.1128/iai.3.2.318-322.1971. PMID: 16557971; PMCID: PMC416149.
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Protection of mice against bacterial infection by interferon inducers.

Infection and immunity

Pindak FF.
PMID: 16557727
Infect Immun. 1970 Mar;1(3):271-3. doi: 10.1128/iai.1.3.271-273.1970.

Antibacterial effect of known interferon inducers was investigated. Intraperitoneal injection of statolon or pyran markedly enhanced the survival of mice challenged with Klebsiella pneumoniae. The sparing effect of these two interferon inducers resembled that of bacterial endotoxin. Significant protection...

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Pindak FF. Protection of mice against bacterial infection by interferon inducers. Infect Immun. 1970;1(3):271-3doi: 10.1128/iai.1.3.271-273.1970.
Pindak, F. F. (1970). Protection of mice against bacterial infection by interferon inducers. Infection and immunity, 1(3), 271-3. https://doi.org/10.1128/iai.1.3.271-273.1970
Pindak, F F. "Protection of mice against bacterial infection by interferon inducers." Infection and immunity vol. 1,3 (1970): 271-3. doi: https://doi.org/10.1128/iai.1.3.271-273.1970
Pindak FF. Protection of mice against bacterial infection by interferon inducers. Infect Immun. 1970 Mar;1(3):271-3. doi: 10.1128/iai.1.3.271-273.1970. PMID: 16557727; PMCID: PMC415891.
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Showing 1 to 12 of 18 entries