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Showing 1 to 12 of 180 entries
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The CombiRx trial of combined therapy with interferon and glatiramer acetate in relapsing remitting MS: Design and baseline characteristics.

Multiple sclerosis and related disorders

Lindsey JW, Scott TF, Lynch SG, Cofield SS, Nelson F, Conwit R, Gustafson T, Cutter GR, Wolinsky JS, Lublin FD.
PMID: 25876935
Mult Scler Relat Disord. 2012 Apr;1(2):81-6. doi: 10.1016/j.msard.2012.01.006. Epub 2012 Feb 23.

BACKGROUND: Interferon-β1a (IFNB) and glatiramer acetate (GA) are distinct therapies which are both partially effective for relapsing MS. It is not known if combining the two treatments would be more effective.OBJECTIVE: To review the rationale, design, and baseline characteristics...

Interferon beta-1a-induced morphea.

JAAD case reports

Bezalel SA, Strober BE, Ferenczi K.
PMID: 27075128
JAAD Case Rep. 2014 Oct 05;1(1):15-7. doi: 10.1016/j.jdcr.2014.10.002. eCollection 2015 Jan.

No abstract available.

Financial and Clinical Implications of Intramuscular Versus Subcutaneous Interferon Beta-1a in Portugal, Based on the Findings from the Cochrane Collaboration Review of First-Line Treatments for Relapsing-Remitting Multiple Sclerosis.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research

Silverio N, Sequeira L, Meletiche D.
PMID: 27200931
Value Health. 2014 Nov;17(7):A396. doi: 10.1016/j.jval.2014.08.887. Epub 2014 Oct 26.

No abstract available.

Profile of PEGylated interferon beta in the treatment of relapsing-remitting multiple sclerosis.

Therapeutics and clinical risk management

Cocco E, Marrosu MG.
PMID: 26056458
Ther Clin Risk Manag. 2015 May 08;11:759-66. doi: 10.2147/TCRM.S69123. eCollection 2015.

Several treatments are currently available for relapsing-remitting multiple sclerosis. Among them, interferon (IFN) beta remains a valid treatment approach because of its good benefit/risk profile. Due to the need for frequent administration (weekly, at a minimum), the use of...

Appropriate use of interferon beta-1a in multiple sclerosis.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy

Jacobs L, Brownscheidle CM.
PMID: 18031126
BioDrugs. 1999 Mar;11(3):155-63. doi: 10.2165/00063030-199911030-00002.

Multiple sclerosis (MS), a chronic inflammatory demyelinating disease of the central nervous system, is the most common crippling neurological disease of young adults in the US. The 2 basic clinical forms of the disease (relapsing and progressive), which can...

Dose and Frequency of Administration of Interferon-beta Affect its Efficacy in Multiple Sclerosis.

Clinical drug investigation

Sharief MK.
PMID: 17535068
Clin Drug Investig. 2003;23(9):551-9. doi: 10.2165/00044011-200323090-00001.

Data reviewed in this article demonstrate that both interferon-beta-1a (IFNbeta-1a) and interferon-beta-1b (IFNbeta-1b) show a dose-response relationship in multiple sclerosis at current clinical doses. Moreover, the efficacy of these therapies is probably dependent on their frequent administration to maintain...

Alemtuzumab versus interferon beta-1a in early multiple sclerosis.

Current neurology and neuroscience reports

Bourdette D, Yadav V.
PMID: 19664362
Curr Neurol Neurosci Rep. 2009 Sep;9(5):341-2. doi: 10.1007/s11910-009-0062-1.

No abstract available.

Patient satisfaction following transition from the original to the new formulation of subcutaneous interferon beta-1a in relapsing multiple sclerosis: a randomized, two-arm, open-label, Phase IIIb study.

Patient preference and adherence

Camu W, Hadjout K, Latour S, Pöhlau D, Masri S.
PMID: 20517473
Patient Prefer Adherence. 2010 May 13;4:127-33. doi: 10.2147/ppa.s10468.

OBJECTIVE: To assess satisfaction with the serum-free formulation of subcutaneous (sc) interferon (IFN) beta-1a among patients with relapsing multiple sclerosis (MS).METHODS: Patients with relapsing MS who had been receiving sc IFN beta-1a for at least 6 months, were transitioned...

Oral fingolimod for relapsing-remitting multiple sclerosis Evaluation of: Kappos L, Radue E-M, O'Connor P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med 2010;362:387-401; and Cohen JA, Barkhof F, Comi G, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med 2010;362:402-15.

Expert opinion on pharmacotherapy

Doggrell SA.
PMID: 20408749
Expert Opin Pharmacother. 2010 Jul;11(10):1777-81. doi: 10.1517/14656566.2010.481671.

Most people with multiple sclerosis (MS) have the relapsing-remitting type. The objective was to evaluate two clinical trials of fingolimod in relapsing MS. FREEDOMS (FTY720 Research Evaluation Effects of Daily Oral therapy in Multiple Sclerosis), a Phase III placebo-controlled...

Long-term outcomes of peginterferon beta-1a in multiple sclerosis: results from the ADVANCE extension study, ATTAIN.

Therapeutic advances in neurological disorders

Newsome SD, Scott TF, Arnold DL, Nelles G, Hung S, Cui Y, Shang S, Naylor ML, Kremenchutzky M.
PMID: 30181778
Ther Adv Neurol Disord. 2018 Aug 28;11:1756286418791143. doi: 10.1177/1756286418791143. eCollection 2018.

BACKGROUND: ADVANCE was a phase III trial of the efficacy and safety of subcutaneous peginterferon beta-1a 125 µg every 2 or 4 weeks in patients with relapsing-remitting multiple sclerosis (RRMS). ATTAIN was a 2-year extension study of ADVANCE. The...

Real-life outcomes of teriflunomide treatment in patients with relapsing multiple sclerosis: TAURUS-MS observational study.

Therapeutic advances in neurological disorders

Kallmann BA, Tiel-Wilck K, Kullmann JS, Engelmann U, Chan A.
PMID: 30944584
Ther Adv Neurol Disord. 2019 Mar 27;12:1756286419835077. doi: 10.1177/1756286419835077. eCollection 2019.

BACKGROUND: Teriflunomide is a once-daily oral immunomodulatory agent approved for the treatment of relapsing-remitting multiple sclerosis (MS). We aimed to obtain data on the effectiveness, tolerability, and subject satisfaction with teriflunomide (Aubagio®) under clinical practice conditions in unselected MS...

Idiopathic Thrombocytopenic Purpura: A Rare Syndrome with Alemtuzumab, Review of Monitoring Protocol.

Cureus

Sarvepalli D, Rashid MU, Ullah W, Zafar Y, Khan M.
PMID: 31720183
Cureus. 2019 Sep 20;11(9):e5715. doi: 10.7759/cureus.5715.

Alemtuzumab, a humanized monoclonal antibody that targets surface molecule CD52, causes rapid and complete depletion of circulating T- and B-lymphocytes through antibody-dependent cell-mediated and complement-mediated cytotoxicity. Alemtuzumab has demonstrated superior efficacy compared to subcutaneous interferon beta-1a (SC IFNB-1a) in...

Showing 1 to 12 of 180 entries