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Showing 1 to 12 of 1122 entries
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The Complete Genome Sequence of Escherichia coli K-12

k-12

Plunkett G, Perna NT.
GSID: QuiXuX72_fgJ
FR Blattner, G Plunkett III, CA Bloch, NT Perna… - science, 1997 - science.org

… coli K-12 was the earliest organism to be suggested as a candidate for whole genome … one of the isoleucine-valine biosynthesis pathways in all K-12 isolates (9). Finally, almost all … It will be interesting to compare strain...

Amino acids inhibit kynurenic acid formation via suppression of kynurenine uptake or kynurenic acid synthesis in rat brain in vitro.

SpringerPlus

Sekine A, Okamoto M, Kanatani Y, Sano M, Shibata K, Fukuwatari T.
PMID: 25674503
Springerplus. 2015 Feb 01;4:48. doi: 10.1186/s40064-015-0826-9. eCollection 2015.

The tryptophan metabolite, kynurenic acid (KYNA), is a preferential antagonist of the α7 nicotinic acetylcholine receptor at endogenous brain concentrations. Recent studies have suggested that increase of brain KYNA levels is involved in psychiatric disorders such as schizophrenia and...

Diabetes Associated Metabolomic Perturbations in NOD Mice.

Metabolomics : Official journal of the Metabolomic Society

Grapov D, Fahrmann J, Hwang J, Poudel A, Jo J, Periwal V, Fiehn O, Hara M.
PMID: 25755629
Metabolomics. 2015 Apr;11(2):425-437. doi: 10.1007/s11306-014-0706-2.

Non-obese diabetic (NOD) mice are a widely-used model oftype1 diabetes (T1D). However, not all animals develop overt diabetes. This study examined the circulating metabolomic profiles of NOD mice progressing or not progressing to T1D. Total beta-cell mass was quantified...

The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH).

Hepatology international

Kakazu E, Kondo Y, Ninomiya M, Kimura O, Nagasaki F, Ueno Y, Shimosegawa T.
PMID: 26201790
Hepatol Int. 2013 Jun;7(2):577-85. doi: 10.1007/s12072-012-9395-y. Epub 2012 Aug 14.

BACKGROUND AND AIMS: The peroxisome proliferator-activated receptor-γ (PPAR-γ) ligand, piglitazone, enhances the degradation of branched-chain amino acids (BCAAs) in adipose tissue. However, it remains unknown whether pioglitazone influences the plasma amino acids (AA) profile in patients with nonalcoholic steatohepatitis...

Analysis on the metabolite composition of serum samples from patients with papillary thyroid carcinoma using nuclear magnetic resonance.

International journal of clinical and experimental medicine

Zhao WX, Wang B, Zhang LY, Yan SY, Yang YH.
PMID: 26770396
Int J Clin Exp Med. 2015 Oct 15;8(10):18013-22. eCollection 2015.

OBJECTIVE: Analysis of the metabolic differences among the papillary thyroid carcinoma (group T) patients, benign thyroid tumor patients (group B) and healthy controls (group H) by nuclear magnetic resonance hydrogen spectrum.METHODS: collect twenty serum specimens each from group T,...

HLA-Bw4-I-80 Isoform Differentially Influences Clinical Outcome As Compared to HLA-Bw4-T-80 and HLA-A-Bw4 Isoforms in Rituximab or Dinutuximab-Based Cancer Immunotherapy.

Frontiers in immunology

Erbe AK, Wang W, Reville PK, Carmichael L, Kim K, Mendonca EA, Song Y, Hank JA, London WB, Naranjo A, Hong F, Hogarty MD, Maris JM, Park JR, Ozkaynak MF, Miller JS, Gilman AL, Kahl B, Yu AL, Sondel PM.
PMID: 28659916
Front Immunol. 2017 Jun 12;8:675. doi: 10.3389/fimmu.2017.00675. eCollection 2017.

Killer-cell immunoglobulin-like receptors (KIRs) are a family of glycoproteins expressed primarily on natural killer cells that can regulate their function. Inhibitory KIRs recognize MHC class I molecules (KIR-ligands) as ligands. We have reported associations of KIRs and KIR-ligands for...

Biosynthesis and Regulation of the Branched-Chain Amino Acids†.

EcoSal Plus

Salmon KA, Yang CR, Hatfield GW.
PMID: 26443574
EcoSal Plus. 2006 Jan;2(1). doi: 10.1128/ecosalplus.3.6.1.5.

This review focuses on more recent studies concerning the systems biology of branched-chain amino acid biosynthesis, that is, the pathway-specific and global metabolic and genetic regulatory networks that enable the cell to adjust branched-chain amino acid synthesis rates to...

Acute supplementation of valine reduces fatigue during swimming exercise in rats.

Bioscience, biotechnology, and biochemistry

Tsuda Y, Iwasawa K, Yamaguchi M.
PMID: 29475409
Biosci Biotechnol Biochem. 2018 May;82(5):856-861. doi: 10.1080/09168451.2018.1438168. Epub 2018 Feb 23.

We investigated the respective effects of the acute supplementation of valine, leucine, and isoleucine on metabolism-related markers by administering a swimming exercise test to rats. As a behavioral analysis, we evaluated the effect of valine and that of leucine...

N-Aryl Isoleucine Derivatives as Angiotensin II AT2 Receptor Ligands.

ChemistryOpen

Behrends M, Wallinder C, Wieckowska A, Guimond MO, Hallberg A, Gallo-Payet N, Larhed M.
PMID: 24808993
ChemistryOpen. 2014 Apr;3(2):65-75. doi: 10.1002/open.201300040. Epub 2014 Mar 13.

A novel series of ligands for the recombinant human AT2 receptor has been synthesized utilizing a fast and efficient palladium-catalyzed procedure for aminocarbonylation as the key reaction. Molybdenum hexacarbonyl [Mo(CO)6] was employed as the carbon monoxide source, and controlled...

Prions in variably protease-sensitive prionopathy: an update.

Pathogens (Basel, Switzerland)

Zou WQ, Gambetti P, Xiao X, Yuan J, Langeveld J, Pirisinu L.
PMID: 25437202
Pathogens. 2013 Jul 05;2(3):457-71. doi: 10.3390/pathogens2030457.

Human prion diseases, including sporadic, familial, and acquired forms such as Creutzfeldt-Jakob disease (CJD), are caused by prions in which an abnormal prion protein (PrPSc) derived from its normal cellular isoform (PrPC) is the only known component. The recently-identified...

Lysine metabolism in a barley mutant resistant to S(2-aminoethyl)cysteine.

Planta

Bright SW, Featherstone LC, Miflin BJ.
PMID: 24318338
Planta. 1979 Oct;146(5):629-33. doi: 10.1007/BF00388843.

Lysine and S(2-aminoethyl)cysteine (AEC) metabolism were investigated in normal barley (Hordeum vulgare L. cv. Bomi) and a hemozygous recessive AEC-resistant mutant (R906). Feedback regulation of lysine and threonine synthesis from [(14)C] acetate was unimpaired in plants of the mutant...

Purification and Characterization of Bacteriocin Produced by Lactobacillus brevis UN Isolated from Dhulliachar: a Traditional Food Product of North East India.

Indian journal of microbiology

Gautam N, Sharma N, Ahlawat OP.
PMID: 25320420
Indian J Microbiol. 2014 Jun;54(2):185-9. doi: 10.1007/s12088-013-0427-7. Epub 2013 Oct 01.

A bacteriocin producing strain Lactobacillus brevis UN isolated from Dulliachar-a salted pickle and identified by biochemical and molecular methods. L. brevis UN was found to produce bacteriocin with broad spectrum activity against spoilage causing/food borne pathogens viz. L. monocytogenes,...

Showing 1 to 12 of 1122 entries