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Showing 1 to 5 of 5 entries
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The Potential of Intralesional Rose Bengal to Stimulate T-Cell Mediated Anti-Tumor Responses.

Journal of clinical & cellular immunology

Maker AV, Prabhakar B, Pardiwala K.
PMID: 26618054
J Clin Cell Immunol. 2015 Aug;6(4). doi: 10.4172/2155-9899.1000343. Epub 2015 Jul 22.

Rose Bengal (RB) is a red synthetic dye that was initially used in the garment industry and has been used safely for decades as a corneal stain by ophthalmologists. Antineoplastic properties of RB have also been observed, though the...

Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.

Cell death discovery

Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV.
PMID: 27648301
Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016.

Colon cancer is a leading cause of cancer-related mortality for which targeted therapy is needed; however, trials using apoptosis-inducing ligand monotherapy to overcome resistance to apoptosis have not shown clinical responses. Since colon cancer cells selectively uptake and rapidly...

Symptomatic Massive Splenomegaly in Persistent Polyclonal B-cell Lymphocytosis Requiring Splenectomy.

Open journal of clinical & medical case reports

Bhagwandin SB, Weisenberg ES, Ozer H, Maker AV.
PMID: 26693179
Open J Clin Med Case Rep. 2015;1(3). Epub 2015 Jun 29.

INTRODUCTION: Persistent polyclonal B-cell lymphocytosis (PPBL) is a rare lymphoproliferative hematological disease characterized by binucleated lymphocytes, CD 19CASE PRESENTATION: We present a case of PPBL in a young man with massive splenomegaly that mimicked isolated splenic lymphoma requiring splenectomy...

Precise identification of immunotherapeutic targets for solid malignancies using clues within the tumor microenvironment-Evidence to turn on the LIGHT.

Oncoimmunology

Maker AV.
PMID: 26942091
Oncoimmunology. 2015 Aug 12;5(1):e1069937. doi: 10.1080/2162402X.2015.1069937. eCollection 2016.

Targeted immunotherapy for solid gastrointestinal malignancies is challenging due to a lack of identified tumor antigens. Therefore, a strategy that supports and expands tumor infiltrating lymphocytes in the tumor microenvironment may allow these tumor-reactive T-cells to incite an antitumor...

Targeting cancer with tumor-specific therapeutic strategies-metabolic reprogramming beyond the Warburg effect.

Translational cancer research

Grippo P, Maker AV.
PMID: 28868241
Transl Cancer Res. 2017 May;6:S585-S586. doi: 10.21037/tcr.2017.05.13.

No abstract available.

Showing 1 to 5 of 5 entries