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Showing 1 to 12 of 20 entries
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Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community.

medRxiv : the preprint server for health sciences

Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Consortium C, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu C, Havlir D, Greenhouse B.
PMID: 32839781
medRxiv. 2020 Aug 17; doi: 10.1101/2020.08.15.20175786.

BACKGROUND: The absence of systematic surveillance for SARS-CoV-2 has curtailed accurate appraisal of transmission intensity. Our objective was to perform case detection of an entire rural community to quantify SARS-CoV-2 transmission using PCR and antibody testing.METHODS: We conducted a...

Impact of COVID-19 on routine malaria indicators in Uganda: An interrupted time series analysis.

Research square

Namuganga JF, Briggs J, Roh ME, Okiring J, Kisambira Y, Sserwanga A, Kapisi JA, Arinaitwe E, Ebong C, Ssewanyana I, Greenhouse B, Maiteki-Ssebuguzi C, Kamya MR, Staedke SG, Dorsey G, Nankabirwa JI.
PMID: 34426808
Res Sq. 2021 Aug 18; doi: 10.21203/rs.3.rs-819495/v1.

Background In March 2020, the government of Uganda implemented a strict lockdown policy in response to the COVID-19 pandemic. We performed an interrupted time series analysis (ITSA) to assess whether major changes in healthcare seeking behavior, malaria burden, and...

multiSero: open multiplex-ELISA platform for analyzing antibody responses to SARS-CoV-2 infection.

medRxiv : the preprint server for health sciences

Byrum JR, Waltari E, Janson O, Guo SM, Folkesson J, Chhun BB, Vinden J, Ivanov IE, Forst ML, Li H, Larson AG, Wu W, Tato CM, McCutcheon KM, Peluso MJ, Henrich TJ, Deeks SG, Prakash M, Greenhouse B, Pak JE, Mehta SB.
PMID: 34013298
medRxiv. 2021 May 11; doi: 10.1101/2021.05.07.21249238.

Serology has provided valuable diagnostic and epidemiological data on antibody responses to SARS-CoV-2 in diverse patient cohorts. Deployment of high content, multiplex serology platforms across the world, including in low and medium income countries, can accelerate longitudinal epidemiological surveys....

SARS-CoV-2 serology across scales: a framework for unbiased seroprevalence estimation incorporating antibody kinetics and epidemic recency.

medRxiv : the preprint server for health sciences

Takahashi S, Peluso MJ, Hakim J, Turcios K, Janson O, Routledge I, Busch MP, Hoh R, Tai V, Kelly JD, Martin JN, Deeks SG, Henrich TJ, Greenhouse B, Rodríguez-Barraquer I.
PMID: 34545373
medRxiv. 2021 Sep 14; doi: 10.1101/2021.09.09.21263139.

Serosurveys are a key resource for measuring SARS-CoV-2 cumulative incidence. A growing body of evidence suggests that asymptomatic and mild infections (together making up over 95% of all infections) are associated with lower antibody titers than severe infections. Antibody...

B Cell Receptor Repertoire Analysis in Malaria-Naive and Malaria-Experienced Individuals Reveals Unique Characteristics of Atypical Memory B Cells.

mSphere

Braddom AE, Bol S, Gonzales SJ, Reyes RA, Musinguzi K, Nankya F, Ssewanyana I, Greenhouse B, Bunnik EM.
PMID: 34523978
mSphere. 2021 Oct 27;6(5):e0072621. doi: 10.1128/mSphere.00726-21. Epub 2021 Sep 15.

Malaria, caused by parasites of the

SARS-CoV-2 antibody magnitude and detectability are driven by disease severity, timing, and assay.

Science advances

Peluso MJ, Takahashi S, Hakim J, Kelly JD, Torres L, Iyer NS, Turcios K, Janson O, Munter SE, Thanh C, Donatelli J, Nixon CC, Hoh R, Tai V, Fehrman EA, Hernandez Y, Spinelli MA, Gandhi M, Palafox MA, Vallari A, Rodgers MA, Prostko J, Hackett J, Trinh L, Wrin T, Petropoulos CJ, Chiu CY, Norris PJ, DiGermanio C, Stone M, Busch MP, Elledge SK, Zhou XX, Wells JA, Shu A, Kurtz TW, Pak JE, Wu W, Burbelo PD, Cohen JI, Rutishauser RL, Martin JN, Deeks SG, Henrich TJ, Rodriguez-Barraquer I, Greenhouse B.
PMID: 34330709
Sci Adv. 2021 Jul 30;7(31). doi: 10.1126/sciadv.abh3409. Print 2021 Jul.

Interpretation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serosurveillance studies is limited by poorly defined performance of antibody assays over time in individuals with different clinical presentations. We measured antibody responses in plasma samples from 128 individuals over...

Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2.

medRxiv : the preprint server for health sciences

Routledge I, Takahashi S, Epstein A, Hakim J, Janson O, Turcios K, Vinden J, Risos JT, Baniqued MR, Pham L, Di Germanio C, Busch M, Kushel M, Greenhouse B, Rodríguez-Barraquer I.
PMID: 34642695
medRxiv. 2021 Oct 20; doi: 10.1101/2021.10.06.21264573.

BACKGROUND: As COVID-19 vaccines continue to be rolled-out, the "double burden" of health disparities in both exposure to infection and vaccination coverage intersect to determine the current and future patterns of infection, immunity, and mortality. Serology provides a unique...

Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2.

medRxiv : the preprint server for health sciences

Routledge I, Takahashi S, Epstein A, Hakim J, Janson O, Turcios K, Vinden J, Risos JT, Baniqued MR, Pham L, Di Germanio C, Busch M, Kushel M, Greenhouse B, Rodríguez-Barraquer I.
PMID: 34642695
medRxiv. 2021 Oct 20; doi: 10.1101/2021.10.06.21264573.

BACKGROUND: As COVID-19 vaccines continue to be rolled-out, the "double burden" of health disparities in both exposure to infection and vaccination coverage intersect to determine the current and future patterns of infection, immunity, and mortality. Serology provides a unique...

Using sero-epidemiology to monitor disparities in vaccination and infection with SARS-CoV-2.

medRxiv : the preprint server for health sciences

Routledge I, Takahashi S, Epstein A, Hakim J, Janson O, Turcios K, Vinden J, Risos JT, Baniqued MR, Pham L, Di Germanio C, Busch M, Kushel M, Greenhouse B, Rodríguez-Barraquer I.
PMID: 34642695
medRxiv. 2021 Oct 20; doi: 10.1101/2021.10.06.21264573.

BACKGROUND: As COVID-19 vaccines continue to be rolled-out, the "double burden" of health disparities in both exposure to infection and vaccination coverage intersect to determine the current and future patterns of infection, immunity, and mortality. Serology provides a unique...

Longitudinal analysis of FcRL5 expression and clonal relationships among classical and atypical memory B cells following malaria.

Malaria journal

Gonzales SJ, Bol S, Braddom AE, Sullivan R, Reyes RA, Ssewanyana I, Eggers E, Greenhouse B, Bunnik EM.
PMID: 34758841
Malar J. 2021 Nov 10;20(1):435. doi: 10.1186/s12936-021-03970-1.

BACKGROUND: Chronic and frequently recurring infectious diseases, such as malaria, are associated with expanded populations of atypical memory B cells (MBCs). These cells are different from classical MBCs by the lack of surface markers CD21 and CD27 and increased...

SARS-CoV-2 PCR and antibody testing for an entire rural community: methods and feasibility of high-throughput testing procedures.

Archives of public health = Archives belges de sante publique

Appa A, Chamie G, Sawyer A, Baltzell K, Dippell K, Ribeiro S, Duarte E, Vinden J, Consortium C, Kramer-Feldman J, Rahdari S, MacIntosh D, Nicholson K, Im J, Havlir D, Greenhouse B.
PMID: 34233752
Arch Public Health. 2021 Jul 07;79(1):125. doi: 10.1186/s13690-021-00647-8.

BACKGROUND: Early in the pandemic, inadequate SARS-CoV-2 testing limited understanding of transmission. Chief among barriers to large-scale testing was unknown feasibility, particularly in non-urban areas. Our objective was to report methods of high-volume, comprehensive SARS-CoV-2 testing, offering one model...

SARS-CoV-2 PCR and antibody testing for an entire rural community: methods and feasibility of high-throughput testing procedures.

medRxiv : the preprint server for health sciences

Appa A, Chamie G, Sawyer A, Baltzell K, Dippel K, Ribeiro S, Duarte E, Vinden J, Consortium C, Kramer-Feldman J, Rahdari S, MacIntosh D, Nicholson K, Im J, Havlir D, Greenhouse B.
PMID: 32511482
medRxiv. 2020 May 30; doi: 10.1101/2020.05.29.20116426.

High-volume, community-wide ascertainment of SARS-CoV-2 prevalence by PCR and antibody testing was successfully performed using a community-led, drive-through model with strong operational support, well-trained testing units, and an effective technical platform.

Showing 1 to 12 of 20 entries